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1.
《Asian Pacific journal of cancer prevention》2006,7(3):460-462
Liver cancer is one of the leading causes of cancer death in Mongolia. Since 1982-1986 , when HCC became themost frequent cancer among the Mongolian population, the rate has been increasing continuously. In the period2000-2005 years 35.3%of all newly registered cancer cases were liver cancers, with an incidence rate of 51.3 per100,000 population. Compared to the previous 5 year period, the rate increased by 11%. The objective here was toanalyze hepatitis B (HBV) and C virus (HCV)-related HCC cases and to evaluate the possibility of tumor marker(AFP) testing for early detection in Mongolia. Sera from a total of 513 patients with chronic liver diseases, livercirrhosis and HCC were analyzed for liver function (ALAT, ASAT) and hepatitis virus markers (HBsAg, anti-HCV).Sera from 316 patients were also examined for alpha-fetoprotein (AFP) levels. The overall incidence of HBsAg oranti-HCV were very high ( 95.3%) among all patients. Some 33.5% (66/197) of patients with HCC were positive forHBsAg and 45.2% (89/197) for anti-HCV. Moreover, 17.3% ( 34/197) of HCC patients demonstrated co-infectionwith HBV and HCV. AFP levels were elevated in 4.6% (11/238) and 29.5% (23/78) of chronic hepatitis and cirrhosispatients, respectively. In HCC cases, 84.3% (166) of patients had increased level of AFP ranging from 32ng/ml tomore than 400 ng/ml. We conclude that HBV/HCV infection is the main factor related to development of HCC inMongolia and that testing for AFP serum levels is a useful tool for early detection and diagnosis. 相似文献
2.
《Asian Pacific journal of cancer prevention》2013,14(11):6601-6604
Aim: Associations between polymorphisms in miR-146aG>C, miR-196a2C>T and miR-499A>G and riskof HCC, and interaction with HBV infection in a Chinese population, were the target of the present research.Methods: The duplex polymerase-chain-reaction with confronting-two-pair primers (PCR-RFLP) was performedto determine the genotypes of the miR-146aG>C, miR-196a2C>T and miR-499A>G genotypes. Associations ofpolymorphisms with the risk of HCC were estimated by conditional logistic regression analysis. Results: Drinking,family history of cancer, HBsAg and HCV were risk factors for HCC. Multivariate regression analyses showedthat subjects carrying the miR-196a2 CC genotype had significantly increased risk of HCC, with an adjustedOR (95% CI) of 2.18 (1.23-3.80). In addition, cases carrying the miR-196a2 C allele had a 1.64-fold increase inthe risk for HCC (95%CI=1.03-2.49). The miR-196a2 CT and TT genotypes greatly significantly increased therisk of HCC in subjects with HBV infection, with adjusted ORs (95% CI) of 2.02 (1.12-3.68) and 2.69 (1.28-5.71),respectively. Conclusion: Our results demonstrate that miR-196a2 CC genotype and C allele have an importantrole in HCC risk in Chinese, especially in patients with HBV infection. 相似文献
3.
《Asian Pacific journal of cancer prevention》2014,15(18):7563-7567
Background: Hepatocellular carcinoma (HCC) is the first cause of death in cirrhotic patients, mostly dueto viral hepatitis with HCV or HBV infection. This study was performed to estimate the true prevalence ofviral hepatitis-related HCC and the demographic and clinical-pathological associations with the two virustypes. Materials and Methods: This cross sectional observational study enrolled clinical data base of 188 HCCpatients and variables included from baseline were age, sex, area of residence, clinical-pathological featuressuch as underlying co-morbidity, presence or absence of liver cirrhosis, macrovascular involvement, tumorextension and metastasis, liver lobes involved, serum alpha-fetoprotein level, and hepatitis serologies. Results:Overall prevalence of HCV- and HBV-related HCC was 66.0% and 34.0%, respectively. Patients with HCVwere more likely to develop HCC at advanced age (52.4±11.9 vs. 40.7±12.09 years), with highly raised serumAFP levels (≥400ng/ml) 78.2% (HBV 67.1%), large tumor size (HCV-66% >5 cm, HBV-59.3%), and presence ofportal vein thrombosis (8.06%, HBV 1.56%). A binominal multivariate analysis showed that HCV-HCC groupwere more likely to be cirrhotic (OR=0.245, 95%CI: 0.117, 0.516) and had more than two times higher rate ofsolitary macrovascular involvement (OR=2.533, 95%CI: 1.162, 5.521) as compared with HBV associated HCC.Conclusions: Statistically significant variations were observed from baseline to clinical-pathological characteristicsin HCV vs HBV associated HCC. Our study suggests prompt and early screening for high risk patients so thatthe rate of progression of these chronic viral diseases to cirrhosis and cancer can be decreased. 相似文献
4.
Abdel-Rahman N. Zekri Enas R. El-Sisi Zeinab F. Abdallah Alaa Ismail Ahmed Barakat Barakat 《Journal of the Egyptian National Cancer Institute》2017,29(1):19-24
Aim
Identifying the genetic expression profile of CD133+ cells from HCC patients compared to CD133+ cells from healthy volunteers that may contribute in hepatocarcinogenesis process.Method
Circulating CD133+ cells were sorted from the peripheral blood of HCC patients as well as from healthy volunteers using magnetic activated cell sorting. The differential expression profile of stem cell related genes was performed using the Stem Cell PCR profiling assay.Results
Data analysis of stem cells related genes in CD133+ cells of the HCC group compared to the control group showed that; CCND2, COL1A1, CTNNA1, DLL3, JAG1, KRT15, MYC, NOTCH2, T and TERT were up-regulated (fold change = 80, 68.6, 6.67, 7.22, 3.8, 15.2, 14.5, 105.6, 26.6 and 99 respectively while only CD3D was down-regulated (fold change = 0.055) in HCC patients. However, after application of Beferroni correction to adjust P-value; KRT15 was the only gene that was significantly over expressed in CD133+ cells of HCC compared to control group (P-value = 0.012).Conclusion
KRT15 can be used to differentiate between circulating CD133+ cells from HCC group and control group. However, further study may be needed to confirm on the protein level. 相似文献5.
《Asian Pacific journal of cancer prevention》2015,16(8):3479-3483
Objective: Patients with hepatocellular carcinoma (HCC) in stage Barcelona Clinic Liver Cancer (BCLC)-Awere grouped based on whether they were accompanied with hepatitis B virus (HBV) infection or not so as toexplore the clinical characteristics and prognostic conditions of HCC patients with non-HBV/hepatitis C virus(HCV). Materials and Methods: Clinical data of 64 stage BCLC-A HCC patients with non-HBV/HCV infection(observation group) who received radical hepatectomy in the Affiliated Cancer Hospital of Guangxi MedicalUniversity from January, 2006 to November, 2014 were retrospectively analyzed and compared with those of409 stage BCLC-A HCC patients with HBV infection (control group) in corresponding period. Results: Thepostoperative 1-, 3- and 5-year recurrent rates of the observation group were 25%, 38.6% and 48.8%, withpostoperative mean and median disease-free survival time being 49.1 months and 62.0 months, respectively.Additionally, the postoperative 1-, 3- and 5-year survival rates of observation group were 90.1%, 72.7% and62.0%, with the mean and median survival times being 54.4 months and 70.0 months, respectively. Conclusions:The 1-year recurrent rate is the highest in HCC patients with non-HBV/HCV, and almost half of the patientshave recurrence within 1 year, after which the recurrent rate decreases along with the time. 相似文献
6.
Hatem A El-MezayenMohamed El-KassasFathy M El-TaweelFateheya M. MetwallyNoha A. GhonaimRasha F. Zahran 《Asian Pacific journal of cancer prevention》2022,23(7):2541-2549
Purpose: Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and a global health problem. It is often diagnosed at advanced stage where hopeless for effective therapies. Identification of more reliable biomarkers for early detection of HCC is urgently needed. circulating tumor cells (CTCs) represent a unique liquid biopsy carrying comprehensive biological information of the primary tumor. Herein, we sought to develop a novel score based on the combination of the most significant CTCs biomarkers with and routine laboratory tests for accurate detection of HCC. Methods: Cytokeratin 18 (CK18), Cytokeratin 19 (CK19), albumin, platelets count, and α-fetoprotein were assayed in HCC patients (42), liver cirrhosis patients (83) and healthy control (20). Results: Areas under receiving operating curve (AUCs) were calculated and used for construction on novel score. A novel score named HCC-CTCs = AFP (U/L) × 0.08 - Albumin (g/dl) × 84 + CK 18 % × 2.9 + CK19 × 3.1- Platelets count (×109)/L× 0.75– 510. HCC-CTCs score produce AUC of 1 for differentiate patients with HCC from those with liver cirrhosis with sensitivity and specificity of a cut-off 0. Conclusions: HCC-CTCs score could replace AFP during screening of HCV patients and early detection of HCC. 相似文献
7.
为了解河南省原发性肝癌（PHC）发生中HBV、HCV的相互作用，我们应用ELISA法和PCR法对PHC患者及其1：1对照进行了HBV标志物（HBVM）和HCV标志物（HCVM）检测。结果：PHC患者HBVM阳性率为81．25％，对照组HBVM阳性率为9．60％，P＜0.01，OR=70（25．36，193．23）；PHC患者HCVM阳性率为19．79%，对照组HCVM阳性率为8.33％，P＜0.05，OR＝2．57（1．11，5．95）；PHC患者HBVM、HCVM双重阳性率为18．75％，对照组双重阳性率为1.04％，将HBVM和（或）HCVM阳性看成不同的暴露等级与HBVM和HCVM均阴性组进行比较，得到HBV和HCV双重感染时的OR值为83.65，明显高于两者分别感染的OR值（34．85和1．58）之积。结果提示：HBV、HCV在PHC的发生中有显著的病因协同作用。 相似文献
8.
Fabrizio Di Benedetto Giuseppe Tarantino Giorgio Ercolani Umberto Baccarani Roberto Montalti Nicola De Ruvo Massimiliano Berretta Gian Luigi Adani Matteo Zanello Marcello Tavio Nicola Cautero Umberto Tirelli Antonio D. Pinna Giorgio E. Gerunda Giovanni Guaraldi 《The oncologist》2013,18(5):592-599
Background.
The aim of our work is to assess the clinical outcomes of liver transplantation (LT) for hepatocellular carcinoma (HCC) in HIV-coinfected patients. This is a multicenter study involving three Italian transplant centers in northern Italy: University of Modena, University of Bologna, and University of Udine.Patients and Methods.
We compared 30 HIV-positive patients affected by HCC who underwent LT with 125 HIV-uninfected patients who received the same treatment from September 2004 to June 2009. At listing, there were no differences between HIV-infected and -uninfected patients regarding HCC features. Patients outside the University of California, San Francisco criteria (UCSF) were considered eligible for LT if a down-staging program permitted a reduction of tumor burden.Results.
HIV-infected patients were younger, they were more frequently anti-HCV positive, and a higher number of HIV-infected patients presented a coinfection HBV-HCV. Pre-LT treatments (liver resection and or locoregional treatments) were similar between the two groups. Histological characteristics of the tumor were similar in patients with and without HIV infection. No differences were observed in terms of overall survival and HCC recurrence rates.Conclusion.
LT for HCC is a feasible procedure and the presence of HIV does not particularly affect the post-LT outcome. 相似文献9.
《Asian Pacific journal of cancer prevention》2008,9(3):507-510
Background: Hepatitis B virus infection is one of the most important risk factors for hepatocellular carcinoma.Hepatitis B vaccination has been obligatory in the Expanded Program on Immunization (EPI) in Khon Kaensince 1990. Objective: To compare the incidence of hepatocellular carcinoma in children in Khon Kaen provincebefore and after the introduction of national hepatitis B vaccination program. Methods: Cases of liver tumors inchildren under 18, diagnosed during 1985-2007, were retrieved from the population-based cancer registry ofKhon Kaen. Patients were divided into 2 groups, vaccinated and non-vaccinated with hepatitis B vaccine regardingthe year of birth before or after 1990. Patients with diagnosis of liver cancer from any basis of diagnosis inpopulation-based registration, except hepatoblastoma, were included. Patients without verified histology wereassumed as having hepatocellular carcinoma if the age at diagnosis was over 10. Age-standardized incidencerates (ASRs) were analyzed and expressed as numbers per 1,000,000 population. Results: Fifteen patients aged13 to 18 years were included to this study. The mean and median ages at diagnosis were 15.7 and 15 yearsrespectively. Four children had a verified histology (age 14 to 18 years, median and mean = 16). The remaining11 patients were diagnosed based on history & physical examination, radiology and death certificate, at theaged of 13 to 18 years. The ASRs for liver cancer in children over 10 years of age of non-vaccinated and vaccinatedchildren were 0.88 and 0.07 per million respectively (p = 0.039). When calculated by including children at orolder the 5 years of age, the ASRs for non-vaccinated and vaccinated cases were 0.97 and 0.24 per millionrespectively (p = 0.007). Conclusions: The incidence of hepatocellular carcinoma is significantly lower in Thaichildren who receive hepatitis B vaccine at birth. 相似文献
10.
目的检测肝细胞癌（hepatocellular carcinoma，HCC）组织中乙型病毒性肝炎（virus hepatitis type B）表面抗原（HB—sAg）和丙型病毒性肝炎（virus hepatitis type C）核心抗原（HCVAg）的表达。方法应用免疫组织化学法检测78例HCC及癌旁肝组织HBsAg和HCVAg的表达。同时比较患者的HBsAg和HCVAg血清学检测结果。结果HCC及癌旁肝组织中HBsAg和HCVAg阳性及HBsAg和HCVAg双重阳性表达率分别为9.1％、6．4％、2．6％和80．8％、44．9％、29．5％。HCC与癌旁肝组织HBsAg和HCVAg阳性及HBsAg和HCVAg双阳性表达率相互比较有非常显著性差异（P〈0．01）。合并肝硬化组和无肝硬HCC组中HCC与癌旁肝组织HBsAg和HCVAg阳性、HBsAg及HCVAg双阳性表达率相互比较也有非常显著性差异（P〈0．01）。HCC的HBsAg和HCVAg血清学检测的结果与手术标本HBsAg和HCVAg免疫组织化学检测的结果相吻合。结论HCC的发生与HBV和HCV的感染密切相关。 相似文献
11.
Giorgio Perboni Paolo Costa Giovanni Carlo Fibbia Barbara Morandini Alfredo Scalzini Alberto Tagliani Rita Cengarle Enrico Aitini 《The oncologist》2010,15(2):142-145
Background/Aims.
HIV and hepatitis C virus (HCV) share common modes of transmission, resulting in about 33% incidence of coinfection among people infected with HIV. The survival benefit from highly effective antiretroviral therapy (HAART) for HIV infection is resulting in an increased incidence of hepatocellular carcinoma (HCC) in this population. There are no reports to date regarding the coadministration of HAART and sorafenib for hepatocellular carcinoma.Methods.
We report the case of a 42-year-old male patient coinfected with HIV and HCV who developed advanced HCC not amenable to curative therapy. The patient was treated with sorafenib, an oral multikinase inhibitor shown to lead to a longer median survival time and time to progression in patients with advanced HCC. Antiretroviral therapy was continued during sorafenib therapy.Results.
The patient achieved a partial tumor response after 3 months and continued to respond at subsequent assessments. His serum α-fetoprotein normalized from 2,172 IU/ml to 2 IU/ml. He had durable stable disease after 23 months of therapy. Antiretroviral therapy was efficacious (CD4+ lymphocyte count, 377/μl; HIV viremia, <50 copies/ml). The simultaneous administration of these therapies was well tolerated. No grade 3 or 4 toxicities were observed. Exacerbation of pre-existing hypertension, grade 2 diarrhea, and grade 1 skin reaction were observed.Conclusions.
This is the first report in which sorafenib has been successfully used to treat HCC in a patient with HIV–HCV coinfection. 相似文献12.
Thanaa Elsayed HelalAhmed ArefAsmaa Ibrahim GomaaOla NadaMohamed Abd-ElghaffarKhaled FaroukNermine Ahmed Ehsan 《Asian Pacific journal of cancer prevention》2022,23(3):839-849
Objective: Validated markers to predict recurrence after surgical resection of hepatocellular carcinoma (HCC) are needed. Little data is available regarding epithelial-mesenchymal transition (EMT) markers in HCC. The objective of this study was to investigate the expression of EMT markers and their correlation with clinicopathological variables and survival in hepatitis C virus (HCV)-associated HCC. Methods: This longitudinal study included 109 cases of HCV-associated HCC treated with surgical resection. Nine different EMT markers (vimentin, E-cadherin, N-cadherin, Stat3, Snail1, Slug, Twist1, Zeb1 and integrin α5) were evaluated on liver tissue from HCC cases. Twenty fresh HCC samples from the studied cases were used for gene expression of EMT markers by quantitative real time polymerase chain reaction (PCR). Results: EMT markers expression was 71%, 25%, 26%, 27%, 9%, 4%, 72%, 47%, 87% for vimentin, E-cadherin, N-cadherin, Stat3 snail1, slug, twist1, Zeb1 and integrin α5 respectively. EMT mRNA in HCC tissues correlated with protein expression by 50-70%. Vimentin was independent predictor of large tumor size (P=0.001), high risk of recurrence (HRR) (P=0.006) and shorter disease free survival (P=0.03) in multivariate analysis. Reduced E-cadherin was a predictor of HRR (P=0.002). Conclusion: Vimentin and E-cadherin were the most powerful prognostic EMT markers in HCV-associated HCC in prediction of recurrence. 相似文献
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华北地区属黄曲霉毒素低含量区，而乙肝病毒感染则普遍，本实验对该地区２４例石蜡包埋人肝癌和癌旁组织的Ｐ５３蛋白（突变型）进行了免疫组化（ＡＢＣ法）检测。结果显示３３．３％（８／２４）肝癌及其癌旁组织为阳性。说明肝癌抑癌基因Ｐ５３的突变不仅仅发生在黄曲霉毒素高含量区病人，其可能与乙肝病毒感染有关。 相似文献
15.
《Asian Pacific journal of cancer prevention》2014,15(18):7725-7730
Hepatocellular carcinoma (HCC) is the third most common cause for cancer death in the world, now beingespecially linked to chronic hepatitis C virus (HCV) infection. This case-control study consisting of 65 HCCpatients and 82 patients with other malignant tumours as controls was conducted to determine the associationof HCV markers with HCC. Serum of each participant was obtained for detection of HCV Ab and RNA byDNA enzyme immunoassay (DEIA). Twenty six per cent (26.0%) of HCC patients had positive anti-HCV whichwas significantly greater than the control group (p=0.001). HCC patients significantly have a risk of exposure toHCV infection almost 3 times than the control group (OR=2.87, 95% C.I=1.1-7). Anti-HCV seropositive rate wassignificantly (p=0.03) higher among old age HCC patients and increases with age. Males with HCC significantlyshowed to have more than 9 times risk of exposure to HCV infection (OR=9.375, 95 % CI=1.299-67.647) thanfemales. HCV-RNA seropositive rate was (70.8%) significantly higher among HCC patients compared to (22.2%)the control group (p=0.019). The most prevalent genotype (as a single or mixed pattern of infection) was HCV-1b. This study detected a significantly higher HCV seropositive rate of antibodies and RNA in HCC patients. 相似文献
16.
《Asian Pacific journal of cancer prevention》2000,1(3):239-245
A population-based case-control study was carried out to investigate risk factors for hepatocellular carcinoma (HCC) in Nagoya, Japan, including hepatitis virus infections, drinking and smoking habits and genetic polymorphisms in aldehyde dehydrogenase2 (ALDH2) and cytochrome P4502E1 (CYP2E1). A total of 84 patients with HCC and 84 sex, age and residence pair-matched controls were recruited for this study. By univariate analysis, hepatitis B virus (HBV) (OR=5.14; 95%CI=2.29-11.6) and hepatitis C virus (HCV)(OR=32.00; 95%CI=7.83-130.7) infections, having a history of blood transfusion (OR=5.25; 95%CI=1.80-15.29), and habitual smoking (OR=2.36; 95%CI=1.17-4.78) were significantly linked to cases; by multivariate analysis, HCV infection (OR=23.5; 95%CI=5.07-108.9) and habitual smoking (OR=5.41; 95%CI=1.10-26.70) were still associated with a significantly increased risk. The c1/c1 genotype of CYP2E1 (odds ratio [OR]= 0.45; 95% confidence interval [CI]=0.21-0.99), detected by Pstl and Rsal digestion was significantly more prevalent in the control group, while 1-1 genotype of ALDH2 (OR=1.24; 95%CI=0.70-2.20) did not demonstrate variation. There were no statistically significant interactions between habitual smoking/drinking and genetic polymorphisms of ALDH2/P4502E1 with reference to HCC development. These findings suggest that viruses, especially HCV infection, and habitual smoking are major independent risk factors, while genetic polymorphisms of ALDH2 and CYP2E1 have only limited contribution to the risk of HCC in Nagoya, Japan. 相似文献
17.
目的 :研究原发性肝癌与其他恶性肿瘤患者HBV及HCV感染率。方法 :对 156例原发性肝癌患者、786例其他恶性肿瘤患者进行乙肝五项指标及抗HCV检测 ,并与 180例健康对照者进行比较。结果 :三组资料的HBV感染率分别为 80 .13%、2 3.92 %和 10 .56% ,差异有显著性 ;HCV感染率分别为5.13%、3.94 %和 2 .78% ,差异无显著性。结论 :原发性肝癌与其他恶性肿瘤患者的HBV感染率明显高于健康对照组 ,HCV感染率与健康对照组相比差异无显著性。 相似文献
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