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河北省磁县食管癌早诊早治普查流程探讨 总被引:1,自引:6,他引:1
[目的]探索一条科学的筛查工作方法及可持续发展食管癌防治新模式,降低食管癌发病率和死亡率。[方法]制定“磁县食管癌早诊早治普查工作流程”,应用电子内窥镜检查:食管和胃采用食管黏膜加碘染色指示性多点活检。以2007年磁县已普查2个村1214例居民为对象。[结果]普查覆盖人数7149人,40~69岁实际人数1971人,实际普查1214例.顺应性61.59%。阳性检出率:轻度不典型增生16.9%、中度不典型增生6.0%、重度不典型增生及原位癌2.5%、黏膜内癌0.3%、浸润癌0.3%;重度不典型增生及原位癌行内镜黏膜切除治疗率达86.7%,浸润癌进行手术和其它治疗,治疗率100%。[结论]“磁县食管癌早诊早治普查工作流程”可有效提高普查顺应性、早治率,降低食管癌发病率和死亡率。 相似文献
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[目的]探索一条科学的筛查工作方法及可持续发展食管癌防治新模式,降低内镜检查的风险,防止并发症的发生,提高普查顺应性和阳性率。[方法]按照磁县食管癌早诊早治普查工作流程和国家《食管癌早诊早治项目技术方案》,应用电子内镜检查加碘染色加多点指示性活检技术,对2005~2010年40~69岁人群共10914例食管癌普查。[结果]活检10291例,活检率94.29%,严重并发症发生率为0.12%。普查顺应性约为60%。并发症35例,其中出血13例,咽喉损伤10例,肠痉挛5例,下颌关节脱臼5例,碘过敏1例,唾液腺肿胀1例。[结论]建立一支技术过硬的食管癌早诊早治普查队伍,按照食管癌早诊早治普查工作流程,遵守国家《食管癌早诊早治项目技术方案》可有效地降低内镜检查的并发症,提高普查顺应性和阳性率。 相似文献
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为贯彻落实《中国癌症预防与控制规划纲要(20014—2010)》,卫生部疾病控制司确定了我国首批子宫颈癌和食管癌早诊早治示范基地。食管癌早诊早治示范基地:河南省林州市(河南省林州市食管癌防治研究所、肿瘤医院),河北省磁县(河北省肿瘤研究所、磁县肿瘤医院);子宫颈癌早诊早治示范基地:深圳市(深圳市妇幼保健院、北京大学深圳医院、深圳慢性病防治院), 相似文献
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辽宁庄河胃癌早诊早治工作进展 总被引:1,自引:0,他引:1
[目的]探讨可持续开展癌症预防和早诊早治工作及基层肿瘤防治队伍能力建设的成功经验.[方法]总结胃癌早诊早治示范基地项目实施及进展情况,并进行资料分析.[结果]庄河现场胃癌早诊早治工作取得明显效果,早诊率80%.治疗率99%,诊断及治疗时效率均为100%.现场防治队伍能力建设取得长足进步.[结论]各级地方政府高度重视及大力支持是保证早诊早治项目顺利实施的关键,上级技术支撑单位的技术传、帮、带是保证技术方案落实到位的关键,基层肿瘤防治队伍能力建设是保证早诊早治项目可持续发展的关键. 相似文献
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食管癌是我国常见的消化道恶性肿瘤之一,严重威胁我国居民生命健康。食管癌高风险人群接受筛查和早诊早治能够有效降低食管癌的发病率和死亡率。制定符合中国国情的食管癌筛查与早诊早治指南,将促进中国食管癌筛查的同质性和规范性,提高食管癌筛查的效果。中国食管癌筛查与早诊早治指南受国家卫生健康委员会疾病预防控制局的委托与指导,由国家癌症中心发起,联合多学科专家,整合食管癌筛查与早诊早治领域的国内外研究进展,同时考虑中国国情和食管癌筛查的实际经验,根据世界卫生组织推荐的指南制定原则和方法,针对食管癌筛查过程中的筛查人群、技术、流程等给出了基于证据的推荐,旨在保证食管癌筛查与早诊早治效果,为中国的食管癌防控提供科学依据。 相似文献
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Farrell JJ van Rijnsoever M Elsaleh H 《Cancer biomarkers : section A of Disease markers》2005,1(2-3):157-175
The role of early detection in cancer has shown improved survival for certain cancers, including colon cancer, cervical cancer and breast cancer. The possibility for early detection of pancreatic cancer may be realized by an improved understanding of the histology and molecular genetics of precursor lesions and cancerous lesions in pancreatic cancer and the development of sensitive and specific screening tests (both invasive and non-invasive) to detect early pancreatic cancer. The NIH-NCI Early Detection Research Network (EDRN) in Pancreatic Cancer has been focussed on the development and validation of new biomarkers for the detection of early pancreatic cancer. This review will focus on our understanding of the histologic and molecular model of pancreatic carcinogenesis, current strategies and limitations of screening for pancreatic cancer and the development and validation of new biomarkers for the early detection of pancreatic cancer. 相似文献
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Hycanthone, the most potent mutagen in a series of nine thiaxanthenones, is a potent inducer of nuclear immunoreactivity to antinucleoside antibodies in HeLa cells. This response indicates exposure of single-stranded DNA regions. All classes of mutagens thus far tested share this property with hycanthone. Immunoreactivity to antinucleoside antibodies was also induced by brief exposure to hycanthone, 3 microgram/ml, in human fibroblasts from three normal subjects and in fibroblasts from seven patients with DNA repair deficiencies. Unlike those of many other mutagens, the metabolic effects and immunoreactivity induction of hycanthone were readily reversible. No evidence for covalent attachment of [3H]hycanthone to HeLa macromolecules could be found. Induction of DNA repair synthesis could not be detected by autoradiography after exposure of cells to hycanthone. Exposure of single-stranded DNA regions appears to be an important feature of the mechanism of action of hycanthone as a mutagen. Both hycanthone and lucanthone intercalate with DNA, but hycanthone was much less active than was lucanthone in reducing the rapid sedimentation of cell lysate DNA in alkaline sucrose gradients. Similarities and differences, therefore, have been found in the way the potent and the weak mutagen affect DNA of HeLa cells. This may provide clues to understanding the mechanism of mutagenesis by thiaxanthenones and other mutagens. 相似文献
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SHANE THOMPSON 《Journal of Medical Imaging and Radiation Oncology》1984,28(3):272-274
A case of urinary schistosomiasis in a young African boy is presented. The slightly unusual radiological features of this case are described. A brief review of common and more unusual radiological features of the disease is presented. 相似文献
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Early subcutaneous wash-out in acute extravasations 总被引:2,自引:1,他引:2
Schrijvers [1] has published a review article on extravasationinjuries and their treatment. The paper gives guidelines ofprevention, and conservative and late operative treatment. However,the early treatment option of subcutaneous wash-out [2, 3] isneither mentioned nor referenced. Despite this the technique is very successful in our experience,possibly due to an 相似文献
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Early breast cancer 总被引:2,自引:0,他引:2
Suzuki T Toi M Saji S Horiguchi K Aruga T Suzuki E Horiguchi S Funata N Karasawa K Kamata N 《International journal of clinical oncology / Japan Society of Clinical Oncology》2006,11(2):108-119
Breast cancer remains a common disease throughout the world. Here we review new knowledge about early breast cancer obtained
during the past 5 years. The prognosis of early breast cancer is generally favorable. Especially, ductal carcinoma in situ
has been regarded as a non-life-threatening disease. Therefore, early diagnosis and early onset of the treatment has been
important. Early age at menarche, late age at first birth, and late age at menopause are related to breast cancer risk. Examination
by mammography and ultrasonography is still the most effective means of detection for premenopausal and postmenopausal women,
respectively. Additionally, there have been important advances in MRI, sentinel lymph node biopsy, breast-conserving surgery,
partial breast irradiation, neoadjuvant systemic therapy, and adjuvant systemic therapy. Another approach to keeping the disease
under control is the elucidation of breast cancer's molecular biological features. Assessment of potential molecular targets
can lead to early diagnosis and molecular targeted treatment. 相似文献