强脉冲光(IPL)治疗面部皮肤光老化460例临床分析

目的：将先进的强脉冲光(IPL)技术应用于面部皮肤光老化的治疗，评价强脉冲光非侵入性嫩肤术对面部光老化皮肤的治疗效果。方法：对460例面部皮肤光老化患者用光子嫩肤仪在18-40J／cm^2能量密度范围内施行非侵入性光子嫩肤术、结果：面部光老化皮肤经强脉冲光非侵入性光子嫩肤治疗后，所有面部光老化表现如皱纹、色素沉着、毛细血管扩张、毛孔粗大等都显现出明显的改善，经临床观察及随访，满意率87．6％。结论：强脉冲光非侵入性光子嫩肤术治疗面部皮肤光老化患者满意率高，副作用较少。     

光子嫩肤仪对亚洲人光损害皮肤的全面部嫩肤治疗

目的 应用最新光子嫩肤设备治疗亚洲人皮肤的由光损伤导致的各种表现，新的设备中配备了560nm的治疗手具和接触冷却，以改进疗效。方法 用光子嫩肤配合接触冷却共治疗了73例患者，每例治疗5次或5次以上，每次治疗的间隔为3—4周。在第3次和第5次治疗后，患者和医生对疗效进行评价。评价内容包括5个方面：色素沉着、毛细血管扩张、细小皱纹、皮肤质地和总体改善情况。此外还进行了皮肤组织病理学检查。结果 改善程度按照百分比划为5个等级，分别评价色素沉着的改善、毛细血管扩张减轻、细小皱纹减轻、皮肤质地好转和总体改各的程度。患者和医生的主观评价进行合并，计算平均结果。治疗5次后，80％以上的患者色素沉着、毛细么管扩张、细小皱纹、皮肤质地和总体改善程度均达到了60％。皮肤组织病理学检查发现I型胶原和Ⅲ型胶原染色增强。结论 应用最新光子嫩肤仪在亚洲人的嫩肤治疗中表明该疗法不仅有效，而且比其他有损伤性治疗发生的合并症少，安全有效。     

强脉冲光治疗面部皮肤光老化65例

目的:探讨强脉冲光(IPL)治疗面部皮肤光老化的临床疗效。方法:采用波长为400~1200nm的GP666B型光子嫩肤仪治疗65例面部皮肤光老化患者,5次为一个疗程,每次治疗间隔时间10天,每位患者治疗前后对比拍照、记录参数并进行临床疗效评估。结果:65例患者中各种病变的有效率分别为:色素沉着斑76.36%,微细皱纹93.02%,毛细血管扩张94.67%。结论:IPL治疗面部光老化有良好疗效。     

光子嫩肤仪对亚洲人光损害皮肤的全面部嫩肤治疗

目的应用最新光子嫩肤设备治疗亚洲人皮肤的由光损伤导致的各种表现,新的设备中配备了560?nm的治疗手具和接触冷却,以改进疗效.方法用光子嫩肤配合接触冷却共治疗了73例患者,每例治疗5次或5次以上,每次治疗的间隔为3～4周.在第3次和第5次治疗后,患者和医生对疗效进行评价.评价内容包括5个方面色素沉着、毛细血管扩张、细小皱纹、皮肤质地和总体改善情况.此外还进行了皮肤组织病理学检查.结果改善程度按照百分比划为5个等级,分别评价色素沉着的改善、毛细血管扩张减轻、细小皱纹减轻、皮肤质地好转和总体改善的程度.患者和医生的主观评价进行合并,计算平均结果.治疗5次后,80%以上的患者色素沉着、毛细血管扩张、细小皱纹、皮肤质地和总体改善程度均达到了60%.皮肤组织病理学检查发现Ⅰ型胶原和Ⅲ型胶原染色增强.结论应用最新光子嫩肤仪在亚洲人的嫩肤治疗中表明该疗法不仅有效,而且比其他有损伤性治疗发生的合并症少,安全有效.     

光子嫩肤仪对亚洲人光损害皮肤的全面部嫩肤治疗

目的　应用最新光子嫩肤设备治疗亚洲人皮肤的由光损伤导致的各种表现 ,新的设备中配备了 5 6 0nm的治疗手具和接触冷却 ,以改进疗效。方法　用光子嫩肤配合接触冷却共治疗了 73例患者 ,每例治疗 5次或 5次以上 ,每次治疗的间隔为 3～ 4周。在第 3次和第 5次治疗后 ,患者和医生对疗效进行评价。评价内容包括 5个方面 :色素沉着、毛细血管扩张、细小皱纹、皮肤质地和总体改善情况。此外还进行了皮肤组织病理学检查。结果　改善程度按照百分比划为 5个等级 ,分别评价色素沉着的改善、毛细血管扩张减轻、细小皱纹减轻、皮肤质地好转和总体改善的程度。患者和医生的主观评价进行合并 ,计算平均结果。治疗 5次后 ,80 %以上的患者色素沉着、毛细血管扩张、细小皱纹、皮肤质地和总体改善程度均达到了 6 0 %。皮肤组织病理学检查发现Ⅰ型胶原和Ⅲ型胶原染色增强。结论　应用最新光子嫩肤仪在亚洲人的嫩肤治疗中表明该疗法不仅有效 ,而且比其他有损伤性治疗发生的合并症少 ,安全有效     

强脉冲光治疗皮肤色素性疾病的临床观察

目的 光子嫩肤技术是用强脉冲光改善皮肤光老化的非剥脱治疗；对皮肤色素病有较好疗效。观察强脉冲光对颜面常见色素性皮肤病的短期疗效。方法 应用强脉冲光对患者面部照射，治疗波长为560nm，治疗脉宽为2．4～6ms，每个光斑2～3脉冲，能量密度24～36J／cm^2。每隔3周治疗一次，5～6次为一个疗程。每次治疗前采集皮损图像。按痊愈、显效、有效及无效4级做出评价。结果 受治患者综合疗效有不同程度改善。色素性疾病中，雀斑和脂溢角化病的疗效最明显。毛细血管扩张也有显著疗效。其他色素病有不同程度消退。经半年以上随访未见复发。结论 强脉冲光可治疗毛细血管扩张以及多种色素性皮肤损害，改善皮肤外观。其优势为无创伤。痛苦小，不影响工作。     

强脉冲光联合Q开关532nm激光治疗面部皮肤光老化疗效观察

目的：探讨强脉冲光联合Q开关532nm激光治疗面部皮肤光老化的临床疗效。方法：将128例患者根据光老化皮肤损害的不同选择不同的波长及模式进行1个疗程（4～6次）的强脉冲光治疗,2周后使用Q开关532nm激光对疗效欠佳的皮损进行局部治疗,4周后进行疗效评价。结果：经过强脉冲光和激光联合治疗后,128例患者的光老化皮肤损害均有不同程度的改善,其中以毛细血管扩张、色素沉着、皮肤质地的改善最为明显,治疗的总有效率均达到90%以上,细小皱纹及毛孔粗大的总有效率也达到了73.81%、71.15%。结论：强脉冲光联合Q开关532nm激光治疗面部光老化,疗效可靠,并发症少,是一种理想的非侵入性治疗面部皮肤光老化的方法。     

光子嫩肤技术治疗面部皮肤光老化200例临床疗效分析

目的:探讨光子嫩肤技术治疗面部皮肤光老化的临床疗效。方法:将200例皮肤光老化患者分为三组。第一、二组采用Lumenis One强脉冲光子嫩肤仪560nm波长,双脉冲,脉宽为3.0~5.0nm,脉冲延迟时间为20~30ms,能量密度为15~25J/cm2;第三组采用640nm波长,三脉冲,脉宽为3.0~6.0nm,脉冲延迟时间为25~35ms,能量密度为18~25J/cm2进行治疗,经过6次治疗后判定疗效。结果:三组患者在合适的波长、脉冲宽度、延迟时间、能量密度下经过6次治疗,有效率分别88.75%、80.0%、81.8%,在6个月内随访显示4例皮损加重,但皮损加重程度均较轻且面积不超过原皮损面积的1/3。结论:光子嫩肤技术对皮肤光老化具有良好的效果,不良反应小,复发率低,是一种安全、可靠的治疗方法,值得临床推广应用。     

强脉冲光治疗皮肤色素性疾病的临床观察

目的　光子嫩肤技术是用强脉冲光改善皮肤光老化的非剥脱治疗 ;对皮肤色素病有较好疗效。观察强脉冲光对颜面常见色素性皮肤病的短期疗效。方法　应用强脉冲光对患者面部照射 ,治疗波长为 5 6 0nm ,治疗脉宽为2 .4～ 6ms,每个光斑 2～ 3脉冲 ,能量密度 2 4～ 36J/cm2 。每隔 3周治疗一次 ,5～ 6次为一个疗程。每次治疗前采集皮损图像。按痊愈、显效、有效及无效 4级做出评价。结果　受治患者综合疗效有不同程度改善。色素性疾病中 ,雀斑和脂溢角化病的疗效最明显 ,毛细血管扩张也有显著疗效。其他色素病有不同程度消退。经半年以上随访未见复发。结论　强脉冲光可治疗毛细血管扩张以及多种色素性皮肤损害 ,改善皮肤外观。其优势为无创伤 ,痛苦小 ,不影响工作     

强脉冲光子嫩肤治疗面部雀斑

目的 应用强脉冲光子嫩肤仪治疗面部雀斑，研究适合亚洲人的去除雀斑的治疗参数。方法 采用波长介于560～1200nm的Quantum SR的皇后光子嫩肤仪治疗面部雀斑216例，每3～5次为一疗程，两次间隔时间3周，观察临床效果和复发率。结果 针对每例患者治疗前后的对比照片，进行临床疗效评价，总结出安全、有效的适合亚洲人的治疗参数。结论 强脉冲光子嫩肤对雀斑的选择性治疗，非介入、无创伤、无需休息、效果明显、复发率低，优于传统方法，可推广用于雀斑的临床治疗。     

Hair removal with intense pulsed light

The use of light and laser for hair removal has evolved during the past few years. Laser systems such as the ruby laser (694 nm), alexandrite laser (755 nm), diode laser (810 nm) and neodymium:yttrium-aluminium-garnet (Nd:YAG) laser (1,064 nm) are commonly used in hair removal. However, permanent hair removal has been difficult to achieve using lasers owing to the long growth/rest cycle of normal human hair follicles. There is still an increasing demand for safer and more efficient hair removal techniques. The latest and most effective choice in the treatment of hair removal is non-coherent intense pulsed light (IPL), which is both efficient and safe for hair removal. A group of 210 patients with skin type III–V were treated for superfluous hair in different areas of the body (face, extremities, axillae, bikini line and back) for three to five sessions at 6-week intervals using IPL. There was a significant hair reduction of about 80% with no side effects and minimal complications. Follow-up was done 6 months after the last session. In conclusion, IPL is very effective and safe for hair removal.     

Full-face photorejuvenation of photodamaged skin by intense pulsed light with integrated contact cooling: initial experiences in Asian patients

BACKGROUND AND OBJECTIVES: For Asian skin, recent "non-ablative" skin rejuvenation techniques have become the focus of attention for darker complected patients. In our earlier research, we have shown that intense pulsed light (IPL) technology can be applied to Asian skin with a high degree of safety and efficacy. In this study, we performed full-face photorejuvenation using a new IPL device incorporating a 560 nm filter and integrated contact cooling system for the improvement of various symptoms associated with photoaging in Asian patients. STUDY DESIGN/MATERIALS AND METHODS: A total of 73 patients were treated with a series of five or more full-face treatments at 3-4 week intervals using IPL with integrated contact cooling. One month after the third and fifth treatments, the patient and the treating physicians subjectively evaluated improvement in five areas-in pigmentation, telangiectasia, fine wrinkles, skin texture, and over-all improvement. In addition, histological changes were evaluated. RESULTS: Pigmentation improvement, telangiectasia reduction, fine wrinkle reduction, smoother skin texture, and over-all improvement were evaluated according to five grades of percentage improvement. In addition, the subjective rating by the patients and the physicians was averaged, and the combined results were evaluated. After the fifth treatment, a combined rating of greater than 60% improvement was given to more than 80% of patients for pigmentation improvement, telangiectasia reduction or removal, smoother skin texture, and overall improvement. Histological evaluations showed strong staining of Type I and Type III collagen. Complications were minor and transitory, with burning sensations and erythema in only two patients. CONCLUSION: Full-face photorejuvenation for Asian patients using this device is not only effective but is also associated with fewer post-treatment complications than other more invasive modalities. We conclude that IPL photorejuvenation can be the basis for safe and effective skin rejuvenation in Asian patients.     

Photorejuvenation for Asian Skin by Intense Pulsed Light

BACKGROUND: Dermabrasion and deep chemical peeling are used in the treatment of photoaged skin. These ablative procedures are effective enough to produce a certain improvement but have often caused postinflammatory hyperpigmentation among Asian patients. To avoid such adverse effects, a new, nonablative procedure has been sought. OBJECTIVE: To determine the effectiveness of photorejuvenation for Asian skin using intense pulsed light (IPL). The specific parameters used, improvement ratios, side-effects, and downtime required are also discussed. METHODS: Ninety-seven patients were treated for photoaging using IPL. The cutoff filters of 550 nm and 570 nm were utilized for three to six treatments at intervals of 2 to 3 weeks. RESULTS: Treatment results were evaluated and rated by both patients and physicians at the end of the third treatment based on improvement in pigmentation, telangiectasia, and skin texture. A combined rating of "good" or "excellent" was given to more than 90% of the patients for pigmentation, more than 83% for telangiectasia, and more than 65% for skin texture. There were some minor complications in four cases: one had erythema that continued to the next day and three had minor blisters leaving no marks. CONCLUSION: Photorejuvenation using IPL is a completely safe and effective procedure even for Asian skin. It will be increasingly used for skin rejuvenation in the future.     

强脉冲光及Nd:YAG(1064nm)激光治疗皮肤血管瘤疗效观察

目的:评价应用强脉冲光及Nd:YAG(1064nm)激光治疗皮肤血管瘤的临床效果。方法:回顾并随访2006年1月～2010年12月在笔者科室采用强脉冲光及Nd:YAG(1064nm)激光治疗的476例皮肤血管瘤患者,对其疗效进行分析。结果:随访2年,皮肤浅表血管瘤治愈率为88.4%,有效率为10.7%,深浅混合血管瘤联合药物注射治疗的治愈率为78.4%、有效率为17.6%,副作用轻微。结论:强脉冲光及Nd:YAG(1064nm)激光治疗皮肤血管瘤疗效好、治疗次数少、安全性高,值得推广。     

Intense pulsed light and Nd:YAG laser non-ablative treatment of facial rhytids

BACKGROUND AND OBJECTIVE: The aim of this study was to evaluate the efficacy and safety of the intense pulsed light source (IPL) and the Nd:YAG laser in the treatment of facial rhytids. Both systems can be used in a non-ablative manner and cause a dermal wound. This is thought to stimulate the production of new collagen without epidermal disruption. Non-ablative techniques eliminate the downtime that must be endured by patients treated with ablative methods such as the carbon dioxide and erbium lasers. STUDY DESIGN/MATERIALS AND METHODS: Fifteen subjects with perioral rhytids and Fitzpatrick skin types II and III received three-to-five treatments with the IPL using 590 and 755 nm cut-off filters, and the 1,064-nm Nd:YAG laser. The subjects were evaluated at 2, 4, 8, 12, and 24 weeks after the final treatment for improvement in rhytids and presence of any side effects. RESULTS: At 6 months, the patient satisfaction score (1-10) was comparable in all three groups. Evaluator assessment of improved skin quality was also similar in all three treatment groups. Side effects such as blistering and erythema were most commonly seen in the subjects treated with the IPL. The least discomfort was seen with the Nd:YAG laser. CONCLUSIONS: Although both non-ablative treatment systems improved facial rhytids presumably by causing a non-specific dermal wound, the Nd:YAG laser was better tolerated and produced fewer side effects.     

强脉冲光防治瘢痕156例疗效分析

目的:探讨强脉冲光技术在瘢痕防治中的应用价值。方法:采用由两名固定医师及患者共同评价疗效的方式,对2008年7月~2011年9月应用强脉冲光(波长560~1200nm,脉宽3.2~3.6ms,脉冲延时10~30ms,双脉冲模式,能量密度19~26J/cm2)治疗的156例不同病程、部位、色泽以及治疗次数的门诊瘢痕患者进行临床疗效评价。结果:瘢痕病程在1个月内的与大于1个月的疗效比较,差异有统计学意义(P0.05),病程越短,效果越显著。面部瘢痕疗效明显优于其他部位,红色和色素沉着性瘢痕治疗效果好于近肤色的瘢痕。整体疗效随着治疗次数增加而提高,治疗2次与3~5次疗效比较,差异有统计学意义,且治疗3~5次效果最满意,但组间疗效比较无统计学意义(P0.05)。治疗6次后的效果不如4~5次明显。结论:强脉冲光技术无创安全、操作便捷,疗效满意,不失为防治瘢痕的理想选择。     

595nm可调脉宽染料激光与强脉冲光治疗毛细血管扩张

目的：评价595nm可调脉宽染料激光与强脉冲光（IPL）治疗毛细血管扩张的疗效和不良反应。方法：用595nm可调脉宽脉冲染料激光仪与强脉冲光分组治疗毛细血管扩张共326例,按照就诊时间随机单盲将患者分为两组,A组：164例,应用595nm可调脉宽染料激光治疗;B组：162例,应用强脉冲光治疗。根据血管的粗细适当选择脉宽及能量密度,照射病变部位,观察局部治疗皮肤反应,即以照射部位皮肤变为紫灰色,扩张血管消失为适度。每月治疗1次,共治疗1～3次,分析两组患者的疗效和不良反应。结果：164例毛细血管扩张患者,经过595nm可调脉宽V-beam激光1～3次治疗后,85例痊愈,63例显效,总有效率90.2%;IPL组的总有效率在第1、2、3次治疗后分别为3.1%、21.6%和43.2%。与IPL组比较,595nm可调脉宽V-beam激光组的疗效要明显优于IPL组,两者的差异性有明显统计学差异（P〈0.01）。同一类型皮肤与IPL组比较,595nm可调脉宽V-beam激光组的疗效要明显优于IPL组,两者的差异性有明显统计学差异（P〈0.05）。两组治疗后皮肤反应轻微,595nm激光组治疗后会暂时出现局部水肿和紫癜,两组术后色素改变发生率无显著性差异（P〈0.05）。结论：595nm可调脉宽脉冲染料激光治疗毛细血管扩张疗效明显优于强脉冲光,且皮肤反应轻微,疗效确切,临床效果满意。     

Intense Pulsed Light for Hairy Grafts and Flaps

BACKGROUND: Intense pulsed light (IPL) is an effective and safe method of hair removal. OBJECTIVE: To evaluate the clinical response of hairy grafts and flaps of different anatomic areas to an IPL source. METHODS: Four patients (three men, one woman; 17-72 years old) with hairy skin grafts (n = 2) or flaps (n = 2) were included. Donor skin areas included the forehead (n = 1), supraclavicular (n = 1), abdomen (n = 1), and groin (n = 1). Excisional surgery was performed because of basal cell carcinoma (BCC) of the nasal wall (n = 1), squamous cell carcinoma (SCC) of the forehead (n = 1), congenital nevus of the malar region (n = 1), and breast carcinoma (n = 1). The treatment was IPL with the following parameters: wavelength 695-755 nm, pulse width 3.8-4.5 msec, delay 20-30 msec, spot size 10 mm x 45 mm, fluence 38-42 J/cm2, and an interval of 4 weeks. A total of one to six treatment sessions were administered. RESULTS: A progressive decrease in terminal hair and delayed hair growth rate (more than 8 months) were observed in all the patients. Improvement of skin coarseness, pigmentation, and erythema was also observed in the graft and its periphery in one patient. Persistent erythema (more than 48 hours) was the only side effect, observed in one patient. CONCLUSION: IPL is an effective method to depilate hairy grafts and flaps.     

A side-by-side comparative study of 1064 nm Nd:YAG, 810 nm diode and 755 nm alexandrite lasers for treatment of 0.3-3 mm leg veins.

BACKGROUND: Laser and intense pulsed light device treatments of leg veins have generally yielded disappointing results. Use of longer wavelengths, longer pulse widths, and better cooling devices have recently sparked renewed interests in these methods. OBJECTIVE: To prospectively compare, side by side, a 3-msec cryogen spray-equipped 755 nm alexandrite, a sapphire window cooled super-long-pulse 810 nm diode, and a variable pulse width, cryogen spray-equipped 1064 nm Nd:YAG laser for the treatment of 0.3-3mm leg veins. METHODS: Thirty female volunteers, skin types I-V, age 32-67 years with comparable sets of leg veins were treated with the Nd:YAG laser and either the diode laser, alexandrite laser, or both. In most patients two to three sets of comparable sites were treated. Treatment parameters varied with each laser and according to the size of veins being treated. Patients were examined 1 week after each treatment and at 1, 2, and 3 months after the last treatment. Pre- and posttreatment 35mm photographs were taken. Improvement was judged by two experienced physicians both visually on patients and by comparison of pre- and posttreatment photographs. Results were graded as percent resolution, in five groups, 0%, 0-25%, 25-50%, 50-75%, and 75-100%. RESULTS: In the 22 patients completing the study, 36 leg vein sites were treated with the Nd:YAG laser, 18 leg vein sites were treated with the diode laser, and 12 leg vein sites were treated with the alexandrite laser. Greater than 75% improvement was observed at 88% of the Nd:YAG laser-treated sites, 29% of the diode laser-treated sites, and 33% of the alexandrite laser-treated sites. Greater than 50% improvement was observed at 94% of the Nd:YAG laser-treated sites, 33% of the diode laser-treated sites, and 58% of the alexandrite laser-treated sites. Less than 25% improvement was observed at 6% of the Nd:YAG laser-treated sites, 39% of the diode laser-treated sites, and 33% of the alexandrite laser-treated sites. Pain during treatment was variably perceived by patients, but occasionally sufficient for patients to decline further treatment. Posttreatment purpura and telangiectatic matting were a significant drawback for the alexandrite laser. Transient hemosiderin pigmentation, as seen with sclerotherapy, was common with larger vessels. CONCLUSION: The cryogen spray-equipped 1064 nm Nd:YAG laser was remarkably effective and safe for the treatment of 0.3-3 mm leg veins. The use of topical anesthesia may be needed for some patients. The super-long-pulse 810 nm diode laser gave unpredictable results. Additional refinements of fluence and pulse width could improve its performance. The 3-msec, 755 nm alexandrite laser at fluences of 60-70 J/cm2 and an 8 mm spot can be effective, but inflammatory response, purpura, and matting limit its usefulness. Longer pulse widths might decrease these problems. For leg vein treatment, the 1064 nm wavelength is very safe for type V skin, the 810 nm wavelength at super-long pulse widths of 400-1000 msec is very safe for type IV and marginal for type V skin, and the 755 nm wavelength is limited to nontanned type I-III skin.     

单用强脉冲光、长脉宽Nd:YAG激光以及低能量下两者联合使用治疗微静脉畸形的临床疗效比较

目的:观察单用强脉冲光、长脉宽1064nm Nd:YAG激光以及低能量下两者联合使用治疗微静脉畸形的临床疗效和不良反应。方法:联合应用590～1200nm强脉冲光(能量密度12～16J/cm2,脉宽3.0～5.0ms)以及长脉宽1064nm Nd:YAG激光(能量密度80～90J/cm2,脉宽10～20ms)治疗51例微静脉畸形患者;并与单独应用强脉冲光(能量密度13～20J/cm2)及长脉宽Nd:YAG激光(能量密度120～145J/cm2)治疗结果比较。结果:强脉冲光、长脉宽1064nmNd:YAG激光及低能量下联合使用治疗微静脉畸形的有效率分别为33.1%、40.3%和56.9%,瘢痕发生率分别为0%、10.7%和5.9%。结论:低能量下联合使用强脉冲光及长脉宽1064nm Nd:YAG激光提高了微静脉畸形的有效率,且不良反应小。