牙科树脂渗透氧化锆陶瓷材料的制备与性能研究

目的 制备一种牙科树脂渗透氧化锆陶瓷（polymer infiltrated zirconia ceramic network,PICN）材料,检测其机械性能。方法 制备纯氧化锆陶瓷、纯树脂以及4种不同孔隙率的陶瓷支架,实验组的陶瓷支架用树脂进行渗透得到陶瓷树脂复合材料（PICN）。通过三点弯曲强度实验检测材料的弯曲强度和弹性模量,采用单边切口梁法检测断裂韧性,通过纳米压痕系统测得材料的硬度以及用扫描电镜观测材料的显微结构。结果 树脂渗透氧化锆陶瓷（PICN）材料的弯曲强度值为135~266 MPa,弹性模量值为41.3~99.3GPa,断裂韧性值为2.20~4.04 MPam1/2,硬度值为1.93~10.83GPa。扫描电镜显示PICN材料中树脂在陶瓷孔隙内渗透完全。结论 这类树脂渗透氧化锆陶瓷材料的机械性能与人类天然牙釉质和牙本质相似,在口腔修复领域具有良好的应用前景。     

含聚合单体微胶囊的牙科新型自修复抗菌复合树脂合成初探

目的 合成含聚合单体微胶囊的牙科新型自修复抗菌复合树脂,并探讨相关性能,为其进一步临床应用提供参考.方法 制备含聚合单体三乙二醇二甲基丙烯酸酯的微胶囊,分别以0、2.5％、5.0％、7.5％及10.0％质量分数添加至含长链烷基季铵盐新型纳米二氧化硅抗菌填料的复合树脂中,生成含聚合单体微胶囊的牙科新型自修复抗菌复合树脂(新型树脂组),以纳米瓷化复合树脂(Tetric N-Ceram)为对照.三点弯曲实验检测各组树脂弯曲强度和弹性模量(每组样本量为6);单刃V形切口梁法测试各组树脂断裂韧性及自修复效率(每组样本量为6),同时进行扫描电镜观察.结果 引入7.5％聚合单体微胶囊时,新型树脂组弯曲强度和弹性模量分别为(96.4±14.3) MPa和(6.2±1.1) GPa,与对照组[分别为(99.1±1 1.9) MPa和(6.1±1.1)GPa]差异均无统计学意义(P＞0.05);当聚合单体微胶囊质量分数为7.5％和10.0％时,新型树脂的自修复效率分别为(66.8±7.0)％和(79.3±9.7)％;扫描电镜示愈合面有黑色不规则薄膜覆盖.结论 含聚合单体微胶囊的牙科新型自修复抗菌复合树脂具有较强的自修复功能,展示了良好的临床应用前景.     

含长链烷基季铵盐的纳米抗菌无机填料的合成及其在牙科复合树脂中的应用研究

目的 设计合成新型的含长链烷基季铵盐的纳米抗菌无机填料,以赋予牙科复合树脂更优良的抗菌性能。方法 在分子设计和筛选的基础上,制备了长链烷基季铵盐修饰的纳米抗菌二氧化硅填料,并对填料的抗菌性能进行评价。为进一步提高抗菌填料与树脂的结合力,采用硅烷偶联剂对抗菌填料表面进行了处理,并用红外光谱法对其结构特征进行分析;然后将新型纳米抗菌无机填料加入牙科复合树脂中,观察其在复合树脂基体中的分散情况,同时与商品化的Tetric N-Ceram纳米瓷化复合树脂进行对比;并以变异链球菌为对象,研究复合树脂的抗菌性能。结果 长链烷基季铵盐成功接枝到纳米二氧化硅颗粒表面;新型纳米抗菌无机填料的抗菌性能优于含短链烷基季铵盐的抗菌无机填料;偶联处理后的纳米抗菌无机填料在树脂基体中分散均匀,与树脂结合紧密,与Tetric N-Ceram纳米瓷化复合树脂类似;改性后的复合树脂抗菌性能良好。结论 含长链烷基季铵盐的纳米抗菌无机填料抗菌性能良好,经过表面偶联处理后可以很好地与牙科复合树脂共混,提高了牙科复合树脂的抗菌性能。     

含BAG-nMgO的新型牙科复合树脂的抗菌及再矿化性能研究

目的：联合应用生物活性玻璃（BAG）和纳米氧化镁（nMgO）改性牙科光固化复合树脂，以获得兼备优良的抗菌性及再矿化性能的新型牙科复合树脂。方法：将不同含量的BAG(2.5 wt%、7.5 wt%、12.5 wt%)和2.5 wt%nMgO引入牙科光固化复合树脂中，制备成含BAG-nMgO的实验树脂，并以卡瑞斯玛复合树脂作为对照。通过菌落计数、代谢活性分析（MTT）和活/死细菌染色，评价实验树脂的抗变形链球菌（S.mutans）能力；将脱矿人牙牙本质片及实验树脂在模拟体液（SBF）中浸泡21 d后，通过扫描电子显微镜（SEM）和X射线能谱仪（EDS）观察分析脱矿牙本质表面形貌和元素组成，评估实验树脂再矿化特性；通过万能试验机、维氏硬度仪等测试树脂的固化深度、压缩强度及维氏硬度。结果：实验组树脂的抗S.mutans活性显著高于卡瑞斯玛对照组，且与BAG的含量相关；当BAG添加量为7.5 wt%时，脱矿牙本质开始矿化；BAG添加比例为12.5 wt%时，可见厚的矿化层，牙本质小管几乎被完全封闭；实验组的固化深度均显著高于卡瑞斯玛，维氏硬度优于或与其相近，随着BAG比例的增加，各实验组的固化深...     

刷牙对大块和分层充填树脂的表面特性和颜色稳定性的影响

目的 比较刷牙对大块和分层充填复合树脂的表面特性和颜色稳定性的影响。方法 选取基质成分相同的分层复合树脂Amaris和大块复合树脂X-tra fil,分别制备了8个试件,抛光后体外模拟刷牙1h,对比刷牙前、后两者的表面光泽度（GU）、表面粗糙度（Ra）以及颜色变化情况,并观察两者表面的显微形貌。结果 刷牙前、后Amaris的GU值均显著高于X-tra fil（P<0.001和P=0.018）。刷牙前Amaris的Ra值显著低于X-tra fil（P<0.001）,但是刷牙后其Ra值却显著高于X-tra fil（P<0.001）。X-tra fil刷牙前后色差（Δ E）显著低于Amaris（P<0.001）。结论 大块树脂能较好的耐受机械刷牙的磨耗并具有更好的颜色稳定性。     

2种复合树脂修复前牙龋损的临床效果评估

目的 探讨2种复合树脂修复前牙龋损的临床效果。方法 选取100例前牙龋损患者，依据随机数字法将其分为实验组与对照组，每组各50例。实验组应用复合树脂多层充填技术和3 M-Z350（A2/A3）纳米复合树脂充填，对照组选用卡瑞斯玛光固化复合树脂充填， 1年后比较2组的修复成功率、不良反应及患者满意度。结果 实验组的美观满意度、治疗成功率均高于对照组（P<0.05） ；实验组不良反应发生率低于对照组（P<0.05）。结论 纳米复合树脂材料可大大提高前牙龋损患者美观满意度，提高修复成功率，减少不良反应的发生情况，值得临床推广应用。     

SiO2粒径分布对牙科复合树脂性能影响

目的研究SiO2粒径分布对牙科复合树脂无机填料的填充量和物理机械性能的影响。方法采用经硅烷表面修饰的气相法纳米SiO2(NS)和微米SiO2(MS),通过调整两者相对质量比,与双酚A双甲氧基缩水甘油酯牙科树脂单体共混,制备了一系列牙科复合树脂M50N20,M55N15,M58N12,M60N10,M63N07,研究了不同SiO2粒径分布对无机填料的填充量,以及复合树脂维氏硬度、三点弯曲强度和断面形貌的影响。结果复合树脂中填料的填充量取决于无机填料的分布及比表面大小,当MS/NS=58/12时,复合树脂的无机填料填充量达到84wt%。M58N12表现出最高的三点弯曲强度(153.2MPa)以及维氏硬度(102.3MPa)。复合树脂断面的SEM形貌分析表明,纳米SiO2与复合树脂基体有较好的粘合作用。结论复合树脂中SiO2粒径分布对物理机械性能以及无机填料的填充量有较显著的影响。     

瓷块厚度及透光性对树脂水门汀固化硬度的影响

目的 研究瓷块的厚度和透光性对不同类型树脂水门汀固化硬度的影响,为临床的全瓷粘接提供参考。方法 选择三种树脂水门汀Choice2,Duolink,RelyX Ultimate Clicker,分别通过不同厚度（0.5 mm、1.0 mm、1.5 mm、2.0 mm）的高透（HT）和低透（LT）的IPS e.max Presss瓷块,用800 mw/cm²高强度LED灯进行光照固化。三种树脂水门汀透过盖玻片照射的试件作为对照组。在固化后30 min和24 h通过显微硬度仪测量固化后树脂的表面努氏硬度值。评价瓷块厚度和透光性对树脂水门汀固化硬度的影响。结果 Choice 2固化后的努氏硬度值在各个厚度及透光度下与对照组相比均显著降低。Duolink和RelyX Ultimate固化后的努氏硬度值在HT瓷块厚度达到2.0mm时,实验组与对照组相比显著降低。在LT瓷块中,当厚度达到1.5 mm时,实验组硬度值即显著降低。结论 当IPS e.max Presss低透瓷块达到1.5 mm厚度,高透瓷块达到2.0 mm厚度时,树脂水门汀的固化硬度会显著降低,从而影响全瓷修复体的粘接效果。     

纳米增韧牙科复合树脂的研究

目的：研究纳米二氧化锆、纳米金刚石为功能填料加入到以钡玻璃粉为主填料的光固化牙科复合树脂中,观察树脂挠曲强度的变化.方法：采用双酚A-甲基丙烯酸缩水甘油酯（Bis-GMA）和二甲基丙烯酸三甘醇酯（TEGDMA）为树脂基质,钡玻璃粉（BG）为主填料,选择纳米二氧化锆,纳米金刚石为功能填料,采用原位聚合法生成光固化牙科树脂,万能材料试验机测试其挠曲强度.结果：纳米二氧化锆和纳米金刚石之间不存在交互效应.不同浓度纳米二氧化锆之间有显著差异,不含纳米二氧化锆的树脂挠曲强度显著高于含5%纳米二氧化锆树脂的挠曲强度.不同浓度纳米金刚石之间有显著差异,含0.2%纳米金刚石的树脂挠曲强度显著高于含0.1%纳米金刚石树脂的挠曲强度.结论：含5%纳米二氧化锆、0.2%纳米金刚石的复合树脂颜色美观,其挠曲强度能达到相应的国家标准及ISO标准,能满足临床需要.     

树脂直接修复后边缘密合性的影响因素分析

目的 探讨树脂直接修复洞型边缘密合性的影响因素,为临床操作提供指导。方法 取新鲜离体磨牙40颗（N₁=40）,制备近中面（或远中面）长方形窝洞后随机分为8组（n₁=5）,采用正交实验评价边缘精修方法（A）、粘接剂（B）和复合树脂（C）对微渗漏的影响。另取新鲜离体上中切牙10颗（N₂=10）,随机分为MT、KS两组（n₂=5）,MT组MANI TF-12EF车针处理釉质表面,KS组KaVo SONICflex气动超声工作尖处理釉质表面,用于粗糙度检测。结果 影响微渗漏的因素主次关系为：复合树脂>粘接剂>边缘精修方法。最优组合为A：气动超声工作尖精修釉质边缘,B：ENA bond SE粘接剂,C：ENA HRi复合树脂。KS组表面粗糙度显著小于MT组（P < 0.001）。结论 边缘精修方法、粘接剂和复合树脂是影响树脂直接修复洞型后边缘密合性的因素。     

Evaluation of wear behavior of dental restorative materials against zirconia in vitro

ObjectivesTo evaluate two-body wear (2BW) and three-body wear (3BW) of different CAD/CAM and direct restorative materials against zirconia using a dual-axis chewing simulator and an ACTA wear machine.Methods3 CAD-CAM resin-based composite or polymer infiltrated ceramic network blocs, 1 lithium disilicate CAD-CAM ceramic (LS₂), 3 direct resin composites, amalgam and bovine enamel were tested. For 2BW, 8 flat specimens per material were produced, grinded, polished, stored wet (37 °C, 28d) and tested (49 N, 37 °C, 1,200,000 cycles) against zirconia. For 3BW, specimens (n = 10) were stored accordingly, and tested against a zirconia antagonist wheel (3Y-TZP, d = 20 mm, h = 6 mm; 200,000 cycles, F = 15 N, f = 1 Hz, 15% slip) in millet seed suspension. Wear resistance was analysed in a 3D optical non-contact profilometer, measuring vertical wear depth and volume loss for 2BW and mean wear depth and roughness (R_a) for 3BW. Vickers hardness (15 s, HV2) was measured. Statistical analysis was performed using non-parametric tests (Mann-Whitney-U test, p < 0.05).Results2BW and 3BW have a different impact on material surfaces. Similar wear resistance was observed for direct and indirect resin based materials with analogous filler configurations in both methods. Bovine enamel exhibited the best wear resistance in 2BW, but the least wear resistance in 3BW against zirconia. Regarding 2BW, a direct/indirect composite material pair of the same manufacturer showed the significantly highest mean volume losses (2.72/2.85 mm³), followed by LS₂ (1.41 mm³). LS₂ presented the best wear resistance in 3BW (mean wear depth 2.85 µm), combined with the highest mean Vickers hardness (598 MPa). No linear correlation was found between Vickers hardness and both wear testing procedures. The zirconia antagonists showed no recordable signs of wear.SignificanceDental restorative materials behave differently in 2BW and 3BW laboratory testing. Vickers hardness testing alone cannot hold for a correlation with wear behavior of materials. Micromorphological investigation of material composition can reveal insights in wear mechanisms related to variations in filler technologies.     

The effect of a leucite-containing ceramic filler on the abrasive wear of dental composites.

OBJECTIVES: The aim of this study was to evaluate abrasive wear of a dental composite based on a leucite-containing (KAlSi2O2 ceramic filler, and to compare it with the wear of a composite based on commonly used aluminum barium silicate glass filler. METHODS: IPS Empress (Ivoclar-Vivadent) ingots were ball milled, passed through an 800 mesh (ASTM) sieve, and used as the leucite ceramic filler. Experimental composites were prepared by mixing the silane-treated fillers with the resin monomers. The resin consisted of 70 wt% Bis-GMA and 30 wt% TEGDMA containing camphorquinone and DMAEMA as the photoinitiator system. Glass-based composites were also prepared using silane-treated aluminum barium silicate glass fillers and the same resin system. TetricCeram, a commercially available dental composite, was used as control. Spherical specimens of the composites were then prepared and kept in water for 2 weeks to reach equilibrium with water. An abrasive wear test was performed using a device designed in our laboratory and weight loss of the specimens was measured as an abrasion parameter after each 50 h. SEMs were taken from worn and fractured surfaces. Degree-of-conversion of the composites was measured using FTIR spectroscopy. Vickers surface microhardness, flexural strength, and flexural modulus of the composites were also measured. The data were analyzed and compared using ANOVA and Tukey HSD tests (significance level=0.05). RESULTS: The results showed that there were significant differences among the abrasive wear of the composites (p<0.05). The ranking from least to most was as: leucite-based composite相似文献   

Nitrogen doped titanium dioxide as an aesthetic antimicrobial filler in dental polymers

ObjectiveTo develop an aesthetic resin composite using a nitrogen-doped titanium dioxide (NTiO₂) filler that possesses antimicrobial properties against cariogenic bacteria.MethodsN-TiO₂ powder was manufactured by calcining commercial TiO₂ with urea. Free radical release from the N-TiO₂ powder under visible light irradiation was analysed using UV-Vis spectrophotometry. The N-TiO₂ powder was incorporated into a dental resin and the photocatalytic activity assessed using a dye under both visible light and dark conditions. Using XTT assay to measure the cellular metabolic activity, the antibacterial properties of the N-TiO₂ /resin composite discs were tested using Streptococcus mutans.ResultsDoping nitrogen of TiO₂ resulted in a band gap shift towards the visible light spectrum, which enabled the powder to release reactive oxygen species when exposed to visible light. When incorporated into a dental resin, the N-TiO₂/resin composite still demonstrated sustained release of reactive oxygen species, maintaining its photocatalytic activity and showing an antibacterial effect towards Streptococcus mutans under visible light conditions.SignificanceN-TiO₂ filled resin composite shows great promise as a potential aesthetic resin based adhesive for orthodontic bonding.     

In vitro dentin demineralization inhibition effects of an experimental fluoridated HEMA and water wetting agent

The ability of fluoride-releasing resins to inhibit dentin demineralization remains controversial. The purpose of this study was to evaluate the caries inhibition of resin composite restorations with an experimental fluoridated hydroxyethyl methyl methacrylate (HEMA) and water wetting agent. Standardized Class V preparations were placed in 40 molars, the gingival margin placed below the cementoenamel junction. Two dentin primers (sodium fluoride, HEMA and water; HEMA and water) were placed in equal numbers of 20 preparations, then One-Step Dental Adhesive (Bisco) was applied as recommended by the manufacturer, followed by the placement of a resin composite restoration. Amalgam restorations with no primer/adhesive were placed in 10 preparations and 10 preparations were restored by placing One-Step Dental Adhesive, then resin composite. All teeth were subjected to an artificial caries challenge (pH 4.4) for 5 days. Results demonstrated the mean areas (microm2 +/- s.d.) of demineralization 100 microm from the restoration/dentin margin to be: amalgam 5,570 +/- 873; One-Step 7,038 +/- 2,099; HEMA and water 6,126 +/- 634; fluoridated HEMA and water 3,411 +/-593. ANOVA and Duncan's test (P < 0.05) demonstrated the fluoridated HEMA and water wetting agent to have significantly less adjacent dentin demineralization than the other three groups. Eighty percent of HEMA and water wetting agent, 80% of One-Step Dental Adhesive and 100% of amalgam restorations demonstrated wall lesions. One hundred percent of restorations with fluoridated HEMA and water wetting agent demonstrated inhibition zones in adjacent dentin.     

Water sorption and dynamic mechanical properties of dentin adhesives with a urethane-based multifunctional methacrylate monomer

ObjectivesOur previous study showed the synthesis and characterization of a novel urethane-linked trimethacrylate monomer for use as a co-monomer in dentin adhesives. The objective of this work was to further investigate the performance of dentin adhesives containing a new monomer, with particular emphasis on the water sorption and viscoelastic behavior of the crosslinked networks.Materials and methodsDentin adhesives contained 2,2-bis[4-(2-hydroxy-3-methacryloxypropoxy) phenyl]-propane (BisGMA), 2-hydroxyethyl methacrylate (HEMA), and a new multifunctional methacrylate with urethane-linked groups-1,1,1-tri-[4-(methacryloxyethylaminocarbonyloxy)-phenyl]ethane (MPE) and were photo-polymerized in the presence or absence of water. Adhesives were characterized with regard to degree of conversion (DC), viscosity, water sorption/solubility, and dynamic mechanical analysis (DMA) and compared with BisGMA/HEMA controls.ResultsThe experimental adhesives exhibited DC and solubility comparable to that of the control, regardless of the presence or absence of water. All the experimental adhesives tested showed less water sorption, lower tan δ peak heights, and higher rubbery modulus than the control.SignificanceDentin adhesives containing a new multifunctional methacrylate showed better dynamic thermomechanical properties and water sorption relative to controls, without compromising DC and solubility. Thus, MPE, when included as a component of methacrylate dentin adhesives, may provide enhanced durability in the moist environment of the mouth.     

Preparation of silica–poly(methyl methacrylate) composite with a nanoscale dual-network structure and hardness comparable to human enamel

ObjectiveThis study aims to prepare an organic–inorganic composite with a nanoscale dual-network structure composed of a ceramic skeleton and infiltrated resin to mimic the mechanical properties of human enamel.MethodsA porous silica block was obtained by sintering a green body composed of SiO₂ nanoparticles and poly(vinyl alcohol) organic binder. Methyl methacrylate monomers were infiltrated into the porous silica block and thermally polymerized to form poly(methyl methacrylate) (PMMA). A monolithic SiO₂–PMMA composite was obtained, and its nanoscale structure was investigated. Its mechanical properties were characterized by Vickers hardness, elastic modulus, and flexural strength tests.ResultsThe SiO₂–PMMA composite had a nanoscale dual-network structure composed of a silica–ceramic skeleton with PMMA-filled continuous 10–20 nm sized pores. The mechanical properties of the composite depended on the SiO₂ content, which could be adjusted by modifying sintering time of the porous silica block. The mechanical properties of the composite exhibited wide variations with Vickers hardness values of 54–756, elastic moduli of 7–54 GPa, and flexural strengths of 75–120 MPa.SignificanceThe preparation of a SiO₂–PMMA composite with a dual-network structure at the nanoscale was demonstrated, and the composite was characterized with respect to its hardness compatibility with human enamel.     

Development of 3D printed resin reinforced with modified ZrO2 nanoparticles for long-term provisional dental restorations

ObjectiveTo characterize and investigate efficacy of loading functionalized ZrO₂ nanoparticles in 3-dimensional (3D) printed acrylate ester-based resin subjected to accelerated aging in artificial saliva. As well as to evaluate the effect of ZrO₂ nanoparticle volume fraction addition on mechanical and physical properties of printed composite.MethodsFunctionalized ZrO₂ nanoparticles were characterized using TEM and Raman spectroscopy. 3D printed dental resin was reinforced, with ZrO₂ nanoparticles, in the concentration range (0–5 wt.%). The resulted nanocomposites, in term of structure and physical/mechanical properties were evaluated using different mechanical testing, microscopic and spectroscopic techniques.ResultsZrO₂ based nanocomposite was successful and formed composites were more ductile. Degree of conversion was significant at the highest level with blank resin and 1 wt.%. Sorption revealed reduction associated with volume fraction significant to neat resin, however solubility indicated neat and 4 wt.% had the lowest significant dissolution. Vickers represented critical positive correlation with filler content, while nanohardness and elasticity behaved symmetrically and had the maximum strength at 3 wt.% addition. In addition, 3 wt.% showed the highest fracture toughness and modulus. Improvement of flexural strength was significantly linked to filler concentration. Overall properties dramatically were enhanced after 3 months aging in artificial saliva, especially degree of conversion, microhardness, nanoindentation/elasticity, and flexural modulus. However, significant reduction was observed with flexural modulus and fracture toughness.SignificanceThe outcomes suggest that the newly developed 3D printed nanocomposites modified with ZrO₂ nanoparticle have the superior potential and efficacy as long-term provisional dental restoration materials.     

Enhanced mechanical properties of ZrO2-Al2O3 dental ceramic composites by altering Al2O3 form

ObjectivesThis study evaluates the difference in physical and mechanical properties of ZrO₂ ceramics, commonly used in dental applications, altered by three different forms of Al₂O₃ content; microparticles (m), nanoparticles (n), and microfiber (f).MethodsThree different types of ZrO₂–Al₂O₃ composites were formed using microparticle (m), nanoparticle (n), or microfibre (f) forms of Al₂O₃. The physical and mechanical properties such as sintering shrinkage, relative density, Vickers hardness, fracture toughness, and biaxial strength were evaluated. A Weibull analysis was performed to assess the strength reliability of the specimens. All data were calculated using the t-test and ANOVA.ResultsThe sintering shrinkage and relative density of all ceramic composite groups were decreased with the addition of Al₂O₃. The mechanical properties of ZrO₂–Al₂O₃ (f) composite were higher than that of ZrO₂–Al₂O₃ (m) composite and ZrO₂–Al₂O₃ (n) composite. The maximum hardness, fracture toughness, and biaxial flexural strength were observed for 10 vol% of Al₂O₃ fibre. When the content of Al₂O₃ fibre in the matrix was increased above 20 vol%, agglomeration occurred and resulted in a decrease of hardness and toughness. The Weibull modulus value of the ZrO₂–Al₂O₃ (f) composite was the lowest compared to that of other groups. However, characteristic strength (σ₀) of ZrO₂–Al₂O₃ (f) the highest value.SignificanceThe current study demonstrated that the addition of right amount of Al₂O₃ microfibre into the ZrO₂ matrix enhanced the mechanical properties of ZrO₂-Al₂O₃ (f) composite, which would be favourable for dental applications.     

Evaluation of physical/mechanical properties of an experimental dental composite modified with a zirconium-based metal-organic framework (MOF) as an innovative dental filler

ObjectivesThis study aimed to modify an experimental dental composite using a synthesized nano-structured methacrylated zirconium-based MOF to enhance physical/mechanical properties.MethodsThe previously known Uio-66-NH₂ MOF was first synthesized and post-modified with Glycidyl Methacrylate (GMA). Fourier Transform Infrared (FTIR) Spectroscopy and CHNS analysis confirmed the post-modification reaction. The prepared filler was investigated by XRD, BET, SEM-EDS, and TEM. The experimental composite was prepared by mixing 60% wt. of resin matrix with 40% wt. of fillers, including silanized silica (SS) or Uio-66-NH-Me (UM). The experimental composites' depth of cure (DPC) was investigated in five groups (G1 =40% SS, G2 =30%SS+10%UM, G3 =20%SS+20%UM, G4 =10%SS+30%UM, G5 =40%UM). Then flexural strength(FS), Elastic Modulus(EM), solubility(S), water sorption(WS), degree of conversion(DC), polymerization shrinkage(PS), and polymerization stress(PSR) of the groups with DPC of more than 1 mm were investigated. Finally, the cytotoxicity of composites was studied.ResultsThe groups with more than 20% wt. UM, filler (G4, G5) had lesser than 1 mm DPC. Therefore, we investigated three groups' physical and mechanical properties with lower than 20% UM filler (G1-G3). Within these groups, G3 has a higher FS, EM (P < 0.05), and lower WS and S (P < 0.05). DC dropped in G2 and G3 compared to G1 (p < 0.05), but there was no significant difference between G2 and G3 (P = 0.594).SignificanceThis new filler is an innovative coupling-agent free filler and can be part of dental filler technology itself. It can also introduce a new group of dental fillers based on MOFs, but it still needs a complete investigation to be widely used.