奥硝唑治疗成人牙周炎疗效观察

目的　对比评价奥硝唑、替硝唑对成人牙周炎的临床治疗效果。方法　应用刚果红染色计数、全自动生成酶分析等方法 ,检测两组患者局部用药前后各项临床指标、细菌学指标及生化指标的变化 ,对比评价两种药物对成人牙周炎的治疗作用。结果　奥硝唑总有效率 90 0 0 % ,替硝唑总有效率 73 33%。结论　奥硝唑治疗成人牙周炎效果更显著。     

牙周组织再生术-正畸联合治疗牙周炎患者的初步研究

目的 通过比较治疗前后牙周组织健康指数的变化,探讨牙周组织再生术联合正畸治疗牙周炎患者的疗效,为成人牙周病患者的治疗提供临床参考.方法 选择成人患者11例,包含17颗具有角形牙槽骨吸收的患牙,患牙同时存在不同程度的咬合创伤.对其进行牙周组织再生术联合正畸治疗,分别记录再生性手术前后以及联合治疗后的牙周袋探诊深度与临床附着丧失,应用SPSS 13.0统计软件对治疗前后的牙周指数进行配对t检验.结果 患牙完成再生性手术后,垂直骨缺损侧探诊深度由（5.91±1.05）mm减小为（3.02±1.09）mm,临床附着丧失则从（7.02±1.81） mm减小到（3.83±1.55）mm,患牙6位点平均PPD以及CAL也都明显减小,改变均具有统计学意义;随后的正畸治疗,解除了患牙的咬合创伤,并使得临床附着丧失减小到（3.37±1.22）mm,差异有统计学意义.结论 牙周组织再生术与正畸联合治疗,对于具有角形牙槽骨吸收且伴有（殆）创伤的患牙,不但能够解决创伤问题,且改善了牙周组织健康,使得患者功能和美观均得到了显著提高,是一种安全有效的治疗方法.     

奥硝唑药条治疗成人牙周炎的临床分析

目的:观察奥硝唑药条治疗成人牙周炎的临床疗效。方法:局部应用奥硝唑药条治疗成人牙周炎患者 32例 32个牙,并以同一患者应用替硝唑药条治疗的另一牙作为对照组,观察两组用药前后各项临床指标的变化。结果:基线及奥硝唑治疗后第 30天牙龈指数 (GI)、菌斑指数 (PLI)、牙周袋深度 (PD)、疼痛程度(PS)分别为 1. 65±0. 80、2. 83±0. 66、7. 11±0. 70、2. 18±0. 58和 1. 00±0. 40、1. 13±0. 52、3. 21±1. 20、1. 09±0. 60,经方差分析,均P<0. 01,有显著性差异;探诊出血(BOP)位点百分率由 98. 96%降至 41. 67%。奥硝唑与替硝唑治疗后第 30天GI、PLI、PD、PS分别为 1. 00±0. 40、1. 13±0. 52、3. 21±1. 20、1. 09±0. 60和 1. 28±0.60、1. 48±0. 65、4. 00±1. 35、1. 27±0. 68,经t检验,除PSP( =0. 2658) >0. 05,余均P<0. 05;BOP位点百分率分别为 41. 67%和 68. 75%,经卡方检验,P( =0. 0003) <0. 05,有显著统计学意义。结论:奥硝唑局部治疗牙周炎是一个好的方法。     

牙周炎患牙根面处理与牙周组织再生

牙周炎患牙根面处理与牙周组织再生广州铁路中心医院口腔科（５１００８０）黎慧瑜华西医科大学口腔医院杨美薷牙周新附着形成是牙周组织愈合的关键。牙周炎时，由于细菌及其毒性产物的作用，使牙周炎患牙暴露的根面引起一系列的病理性改变，失去原有的生物学特性。牙周炎...     

奥硝唑治疗牙周及冠周化脓性感染的临床研究

目的 :评价奥硝唑片剂治疗牙周及冠周化脓性感染的临床效果。方法 :采用双盲双模拟法将受试药 ,对照药按顺序发放给受试者 ,使用前后各查一次厌氧菌培养 ,血、尿常规及肝肾功能。全部病例观察表验收后揭盲。结果 :受试组和对照组参加人数、性别、年龄、病情、感染类型 ,总用药量 ,疗程均无明显差异 (P >0 .0 5 )。牙周炎、冠周炎 ,受试组治疗有效率 10 0 % ,对照组为 6 8.75 % ,治疗效果优于对照组 (P >0 .0 5 )。细菌清除率受试组为 93.33% ,对照组为 84.6 2 % (P >0 .0 5 )。厌氧菌临床治愈率受试组为 16 .6 6 % ,高于对照组 10 % (P >0 .0 5 )。出现不良反应受试组 1例 ,对照组 3例 (P >0 .0 5 )。实验室结果两组治疗前后基本无变化 (P >0 .0 5 )。结论 :奥硝唑片剂治疗口腔感染是安全有效的。     

奥硝唑治疗牙周及冠周化脓性感染的临床研究

目的：评价奥硝唑片剂治疗牙周及冠周化脓性感染的临床效果,方法：采用双盲双模拟法将受试药,对照药按顺序发放给受试者,使用前后各查一次厌氧菌培养,血,尿常规及肝肾功能,全部病例观察表验收后揭盲,结果：受试组和对照组参加人数,性别,年龄,病情,感染类型,总用药量,疗程均无明显差异（P＜0．05）,牙周炎,冠周炎,受试组治疗有效率100％,对照组为68．75％,治疗效果优于对照组（P＞0．05）,细菌清除率受试组为93．33％,对照组为84．62％（P＜0．05）,厌氧菌临床治愈率受试组为16．66％,高于对照组10％（P＜0．05）,出现不良反应受试组1例,对照组3例（P＞0．05）,实验室结果两组治疗前后基本无变化（P＞0．05）,结论：奥硝唑片剂治疗口腔感染是安全有效的。     

牙周组织再生术联合微螺钉种植体支抗技术治疗老年牙周炎的临床疗效分析

目的:分析牙周组织再生术联合微螺钉种植体支抗技术治疗老年牙周炎的临床疗效.方法:选取2018年11月～2020年11月恩施土家族苗族自治州中心医院收治的126例老年牙周炎患者,采用随机数字表法分为对照组(n=60)和观察组(n=66),对照组给予牙周组织再生术治疗,观察组给予牙周组织再生术联合微螺钉种植体支抗技术治疗,...     

奥硝唑用于口腔厌氧菌感染的临床研究

目的　评价奥硝唑治疗口腔厌氧菌感染疾病的效果。方法　选择口腔厌氧菌感染疾病患者 60例。以替硝唑为对照组 ,采用双盲法 ,对其临床疗效和细菌清除率进行比较。结果　奥硝唑总有效率 83 .3 % ,细菌清除率 91.7% ;替硝唑总有效率 73 .3 % ,细菌清除率 88.4% ,二者间无显著性差异 (P >0 .0 5 )。结论　奥硝唑治疗口腔厌氧菌感染疾病效果显著。     

胶原膜引导牙周组织再生的研究 Ⅰ.动物模型的…

在对２０只犬双侧前磨牙及磨牙建立模拟人类牙周炎模型基础上，进行引导牙周组织再生术（ＧＴＲ），用系列先进客观检测手段评价牙周新附着建成的效果，结果表明引导牙周组织再生术组优于对照组，它是目前最理想的促进牙周新附着的途径和技术。     

自体牙周膜细胞移植对狗牙周组织再生的影响

目的　对应用自体牙周细胞移植结合e PTFE膜引导的牙周组织再生的动物实验进行评价。方法　将 6只成年狗的 36颗牙分为实验组和对照组 ,每组 18颗牙。在人工制造的牙周缺损中 ,进行体外培养的自体牙周细胞移植结合GTR法为实验组 ,单纯应用GTR法为对照组。 6周后切片行牙周组织学观察。结果　实验组新生牙槽骨、牙周膜组织及牙骨质的修复再生效果明显好于对照组 (P <0 0 5 ) ;实验组牙槽骨再生高度平均为 (4 0 0± 0 13)mm ,对照组为 (3 0 9± 0 2 8)mm。结论应用自体牙周膜细胞移植结合e PTFE膜引导牙周组织再生可促进狗牙周组织的再生     

Significance of the platelet-derived growth factor in periodontal tissue regeneration

Aim

The aim was to review the significance of the platelet derived growth factor (PGDF) in periodontal tissue regeneration.

Methods and results

Databases were searched using the following terms in different combinations: “growth factors”, “guided bone regeneration”, “guided tissue regeneration”, “periodontal”, “platelet rich plasma” and “platelet derived growth factor”. Titles and abstracts of articles obtained using the above-described criteria were then screened by the authors and checked for agreement. The next step was to hand-search the reference lists of original and review studies that were found to be relevant in the previous step. PDGF has a stimulatory effect on the DNA replication and chemotaxis of osteoblasts, fibroblasts, leukocytes, monocytes, neutrophils periodontal and alveolar bone cells. Proliferation of mesenchymal stem cells is also promoted by supplement treatment with PDGF. PDGF in combination with other growth factors enhances periodontal tissue repair.

Conclusions

The PDGF plays a significant role in periodontal bone and tissue regeneration.     

Wnt3a促进牙周膜干细胞成骨分化及实验性牙周炎牙槽骨再生的研究

目的:探究Wnt3a对人牙周膜干细胞（periodontal ligament stem cell,PDLSC）增殖、迁移和成骨分化的影响,确定Wnt3a对小鼠实验性牙周炎牙槽骨再生的作用。方法:分别用不同质量浓度的Wnt3a（0、20、100、200、500 μg/L）刺激PDLSC（计为5组）,培养2、4、7或10...     

牙周炎患者基础治疗后牙龈卟啉单胞菌的定植研究

目的 通过对牙周炎患者龈下菌斑中牙龈卟啉单胞菌(Porphyromonas gingivalu,Pg)的检测,探讨慢性牙周炎(chronic periodontitis,CP)和侵袭性牙周炎(aggressive periodontitis,AgP)患者牙周基础治疗后Pg的定植规律.方法 选取90例CP患者和90例AgP患者,在牙周基础治疗前、治疗后6周、12周共采集龈下菌斑样本1620个,运用AmpliFluor终末点定量聚合酶链反应方法 检测Pg含量.结果 治疗后6周CP和AgP组Pg活动位点分别为61(22.6%)和66(24.4%)个,两者差异无统计学意义(P>0.05);治疗后6周Pg活动位点在治疗前检测的牙周临床指数高于Pg静止位点.治疗后12周两组Pg活动位点分别为96(35.6%)和18(6.7%)个,差异有统计学意义(P<0.05);治疗后12周Pg活动位点在治疗后6周时检测的牙周临床指数高于Pg静止位点.结论 在牙周基础治疗后6周时,CP和AgP患者Pg定植均已开始,仉是两组定植规律存在一定差异.在牙周基础治疗后,治疗前牙周组织炎性反应严重的龈下位点Pg易于定植.     

Guided tissue regeneration combined with osseous grafting in suprabony periodontal lesions

The purpose of the present investigation was to evaluate the use of bone grafts in combination with the GTR-procedure in reinstituting periodontal support around teeth with horizontal bone loss. Orthodontic elastic bands were placed around mandibular and maxillary premolars in 3 dogs in order to induce breakdown of the periodontal tissues. When the destruction had reached a level corresponding to approximately half the root length, the elastic bands were removed and the teeth were scaled. After a period with plaque control, mucoperiosteal flaps were elevated on the buccal and lingual aspects of the experimental teeth. The exposed root surfaces were curetted, and a notch was made at the level of the reduced bone crest. In randomly selected test quadrants, Kielbone mixed with fibrin sealant (Tisseel) was placed in the interproximal space and in the bifurcations. Both the buccal and lingual aspect of the test teeth were then covered by a teflon membrane (Zitex) and the raised tissue flaps sutured in a coronally displaced position. The contralateral teeth (controls) were treated the same way, except that fibrin sealant without Kielbone was applied in the bifurcations and the interproximal space prior to the placement of the membranes. The membranes were removed by a 2nd operation after 35 days. Clinically, various complications were observed during healing. The buccal and lingual flap margins consistently failed to join in the interproximal area, and increasing recession of the flap margins and exposure of the membranes, resulting in accumulation of bacterial deposits and food debris, occurred during the period the membranes were maintained.(ABSTRACT TRUNCATED AT 250 WORDS)     

Effectiveness of periodontal treatment on the improvement of inflammatory markers in children

AimIt is known that atherosclerosis begins in childhood, a behaviour towards oral health care and metabolic control, since an early age, is essential for patients with cardiovascular disease. The aim of this research was to evaluate the effectiveness of periodontal treatment full-mouth scaling and root planning (FMSRP), applied to children without systemic diseases, correlating with periodontal clinical and blood parameters (lipid profile and inflammatory markers).Materials and methodsThe 29 patients were divided into two groups, group 1 (14) – scaling and rot planning (SRP), group 2 (15) – FMSRP and the follow-up was conducted among 180 days.ResultsThe results showed a significant improvement in clinical periodontal parameters (p < 0.05) in both groups. In the analyzed blood parameters there was a greater evidence, with a significant improvement (p < 0.05), in total cholesterol (TC), triglycerides (TGs), fibrinogen (FGN), and interleukin-6 (IL-6)ConclusionsThus, we suggest that both periodontal treatments were effective in children without any systemic diseases.     

伴2型糖尿病的慢性牙周炎牙周可疑致病菌的检测

目的 检测伴2型糖尿病(diabetes mellitus,DM)的慢性牙周炎(chronic periodontitis,CP)患者龈下菌斑中牙周可疑致病菌的种类和构成,从微生物学角度探讨牙周炎与DM的相互作用机制.方法 采集伴2型DM的CP患者154例(DM组)、不伴DM的单纯CP患者120例(CP组)及40名全身及牙周健康者(N组)的龈下集合菌斑,传统酚-氯仿法提取菌斑DNA,以牙龈卟啉单胞菌(Porphyromonas gingivalis,Pg),伴放线放线杆菌(Actinobacillus actinomycetemcomitans,Aa),具核梭杆菌(Fusobacterium nucleatum,Fn),中间普氏菌(Prevotella intermedia,Pi),福塞坦氏菌(Tannerella forsythia,Tf),齿垢密螺旋体(Treponema denticola,Td)为目标菌,应用以16SrRNA为基础的聚合酶链反应(PCR)技术对龈下菌群进行检测.结果 Pg、Aa、Fn、Pi、Tf、Td在DM组中均可检出;与CP组相比,在性别、年龄、牙周状况基本一致的情况下,轻度牙周炎者DM组Pi的检出率为35%(8/23),CP组为65%(13/20),两组间差异有统计学意义(P<0.05);重度牙周炎者DM组Pg、Aa、Tf的检出率分别为78%(72/92)、27%(25/92)、67%(62/92),CP组分别为58%(35/60)、17%(10/60)、43%(26/60),DM组均显著高于CP组,差异有统计学意义(P<0.05).同时,DM组Aa、Tf PCR产物的平均灰度值(average gradation,AVG)比值显著高于CP组,Pi的AVG比值明显低于CP组,P<0.05.结论 与单纯CP相比,伴2型DM的牙周炎患者龈下菌斑中Pg、Aa、Tf的数量增多,Pi的数量减少.     

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牙周治疗目标的一个重要内容是促使组织不同程度的修复和再生。理想的治疗效果是恢复牙周组织的生理形态,即形成伴有牙周膜中穿通纤维的新生牙骨质,牙槽骨生成。了解牙周不同治疗方法及其后的组织愈合状态,有助于治疗计划的制定和争取最佳的治疗效果。     

Experiences with guided tissue regeneration in the treatment of advanced periodontal disease

Abstract The aim of this study was to evaluate the predictability of guided tissue regeneration (GTR), using ePTFE-membranes (Gore-Tex®) in the treatment of advanced periodontal disease. The study presents long-term results for 88 teeth in 23 patients at least 9 months after membrane surgery. The periodontal lesions included severe horizontal and/or vertical bone loss. The bone level (BL and BL) and the tissue level (TL), a new parameter between cemento-enamel junction and coronal margin of the tissue in the defect, were recorded during surgery: immediately before application of the membrane (BL), after membrane removal (TL) and during a re-entry procedure (BL') 9 to 12 months later. The average tissue gain in the periodontal defect (BL-Tl) at membrane removal was 65.7% (p < 0.001) and the average gain in mineralized tissue at re-entry (BL-BL'), 30.4%, meaning more than 46% of the gained tissue at removal was mineralized at reentry. The decreased amount of mineralized tissue at re-entry in relation to the tissue gain at membrane removal might be due to formation of a so-called long connective tissue attachment or to mineralization-induced shrinkage of the new tissue and some surgical difficulties in coverage of the newly formed tissue. Nevertheless, an absolute gain of 31% mineralized tissue after GTR can provide a marked improvement in the prognosis of a periodontally severely damaged tooth.