新生儿脐血瘦素和胰岛素水平及其临床意义

目的观测不同宫内状况下新生儿脐血瘦素和胰岛素水平，探讨其对胎儿宫内生长发育的调控作用。方法新生儿135例．其中早产小于胎龄儿组（A组）30例，早产适于胎龄儿组（B组）36例，足月小于胎龄儿组（C组）32例，足月适于胎龄儿组（D组）37例。于分娩后采脐静脉血，采用ELISA方法和Access免疫分析系统分别测定血清瘦素和胰岛素水平，进行多元回归相关分析。结果各组新生儿脐血瘦素、胰岛素水平均存在明显差异，基本呈A、C、B、D组由低到高的趋势（F=185．59、195．44，P〈0．01）；A、B、C组Ponderal指数与血清瘦素和胰岛素水平呈正相关。结论脐血瘦素和胰岛素水平与新生儿宫内营养状态相一致，两者参与宫内发育迟缓儿和早产儿宫内生长发育的调控，但不是足月适于胎龄儿生长发育的主要调控因素。     

糖化血清蛋白与胎儿发育及代谢轴关系的研究

目的:通过比较小于胎龄儿(SGA)与适于胎龄儿(AGA)的脐血糖化血清蛋白(GSP)水平,探讨GSP与胎儿发育及代谢轴之间的关系及检测新生儿GSP的意义.方法:以25例SGA为病例组,35例AGA为对照组,测量两组新生儿体格发育指标,检测脐血GSP水平及胰岛素、胰岛素样生长因子-1(IGF-1)等代谢轴相关因素并进行比较.结果:SGA组GSP、胰岛素、IGF-1水平低于对照组,组间差异均具统计学意义(P＜0.05);GSP水平与出生体质量、身高、头围、BMI等体格发育指标呈正相关(r=0.632、0.676、0.628、0.432,P均＜0.05).结论:SGA宫内血糖平均水平低于AGA,并同时存在低胰岛素及低IGF-I状态;GSP可以作为反映胎儿宫内发育情况及营养状态的指标.     

胰岛素样生长因子-1在胎儿生长中的重要作用

目的检测孕产妇、新生儿胰岛素样生长因子-1(Insu lin-like grow th factor-I,IGF-1),探讨小于胎龄儿及宫内发育迟缓儿的发病机制。方法采用放射免疫法检测血清中IGF-1。比较小于胎龄儿与足月胎龄儿,早产孕妇和正常足月孕妇IGF-1含量,了解不同体重、不同胎龄、不同胎盘成熟胎儿及其孕妇母体的IGF-1水平差异。结果IGF-1随胎龄、胎重的增加而增高。表明IGF-1在胎儿生长发育中的重要调节作用。早期改善母体营养,达到改善胎儿宫内营养状况。结论在孕早、中期及时检测IGF-1含量,预防胎儿宫内发育迟缓,产前提高胎儿整体健康水平。     

小于胎龄儿生后3月生长激素和胰岛素样生长因子I变化及临床意义

小于胎龄儿(newborns sm all for gestational age,SGA)是出生体重低于同胎龄正常值的第10百分位数或低于同胎龄正常平均值的2个标准差的一组新生儿,在我国发生率达7.5%,病死率是正常足月儿的8倍[1]。本研究旨在分析小于胎龄儿与适于胎龄儿(newborns appropriate for gestation     

78例小于胎龄儿的临床特点分析

目的分析小于胎龄儿临床基本情况、围生期相关因素和并发症发生情况,为临床预防小于胎龄儿的发生提供参考资料。方法将小于胎龄儿78例和适于胎龄儿120例分为小于胎龄儿组和适于胎龄儿组,统计分析2组新生儿及母亲基本资料、新生儿并发症发生情况。结果 2组新生儿胎龄比较差异无统计学意义(P>0.05);与适于胎龄儿组相比,小于胎龄儿组新生儿女性偏多、住院时间偏长而出生体质量偏低(均P<0.01)。2组胎盘因素、妊娠期糖尿病、母亲内科疾病、高龄产妇比较差异无统计学意义(均P>0.05);与适于胎龄儿组比较,小于胎龄儿组妊娠期高血压、多胎妊娠、羊水过少、胎膜早破和宫内窘迫发生率较高(均P<0.05)。2组新生儿喂养不耐受、颅内出血、呼吸暂停、呼吸窘迫综合征、消化道出血、吸入综合征并发症发生率比较差异无统计学意义(均P>0.05);与适于胎龄儿组比较,小于胎龄儿组新生儿窒息、红细胞增多症、高胆红素血症和低血糖发生率较高(均P<0.05)。结论小于胎龄儿出生体质量低且并发症较多,与母亲健康情况密切相关。加强孕期保健减少小于胎龄儿发生的同时应加强新生儿监护。     

胎儿宫内生长发育与胰岛素样生长因子1及其结合蛋白3关系的研究

目的　探讨新生儿脐血中胰岛素样生长因子 1(IGF 1)和胰岛素样生长因子结合蛋白 3(IGFBP 3)水平与出生双顶径、身长及胎盘质量等生长参数间的关系。方法　分别测定适于胎龄儿 (AGA)组(79例 )与小于胎龄儿 (SGA)组 (2 6例 )的出生时身长、双顶径和胎盘质量 ,用免疫放射法测定脐血IGF 1和IGFBP 3的含量。结果　①两组出生时各生长参数比较均存在统计学差异 ,AGA高于SGA(P <0 .0 0 1)。②出生时身长、双顶径和胎盘质量均与IGF 1和IGFBP 3呈正相关 (均P <0 .0 0 1)。结论　胎儿自身分泌的IGF 1和IGFBP 3与出生时身长、双顶径和胎盘质量生长参数密切相关 ,它们对胎儿的生长发育起着重要的调节作用。IGF 1和IGF 3可作为胎儿宫内生长发育的指标     

脐血中IGF-1 与妊娠晚期胎儿生长发育的相关性分析

目的:分析脐血胰岛素样生长因子-1(IGF-1)与妊娠晚期胎儿生长发育的相关性。方法:选取2016年3月~2017年3月我院新生儿96例,依据胎儿体重分为大于胎龄儿组、适于胎龄儿组和小于胎龄儿组各32例。测定三组脐血IGF-1和IGF-1m RNA表达水平,分析IGF-1与新生儿体重的相关性。结果 :大于胎龄儿组脐血中IGF-1、IGF-1 m RNA表达水平明显高于适于胎龄儿组,小于胎龄儿组脐血IGF-1、IGF-1 m RNA表达水平明显低于适于胎龄儿组(P<0.05);脐血IGF-1、IGF-1 m RNA表达水平与新生儿体重呈正相关(分别为r=0.606,P=0.017;r=0.506,P=0.023)。结论:脐血IGF-1、IGF-1 m RNA表达水平与妊娠晚期胎儿生长发育密切相关。     

脐血锌含量测定与胎儿生长发育的相关性

目的探讨脐血锌含量与胎儿生长发育的相关性.方法将86例新生儿按体重分成两组,分别测定两组脐血锌含量,并采用放射免疫分析技术分别测定胰岛素生长因子-1(IGF-1)及胰岛素生长因子结合蛋白-3(IGFBP-3).结果小于胎龄儿组(SGA)脐血锌含量及IGF-1,IGFBP-3水平均显著降低,与适于胎龄儿组(AGA)相比有显著性差异(P＜0.01),且锌浓度随出生体重和胎龄增加的值与IGF-1及IGFBP-3水平呈正相关(P＜0.01).结论锌在胎儿发育期发挥重要作用,孕期缺锌可导致胎儿宫内发育迟缓,因此母亲在孕期应补充适量锌.     

早产适于胎龄儿血清胰岛素样生长因子-1水平的研究

目的 研究早产适于胎龄儿血清胰岛素样生长因子-1(IGF-1)水平,及对胎儿宫内生长发育调控的作用.方法 选择2007年10月～2009年8月在南通大学第二附属医院产科出生的新生儿84例,包括早产适于胎龄儿61例和同期出生的足月适于胎龄儿23例.用放射免疫法(RIA)检测其血清IGF-1水平,并对比其差异性.结果 足月适于胎龄儿血清IGF-1水平为29.34±10.02μg/L,早产适于胎龄儿血清IGF-1水平为23.91士6.60μg/L,两组婴儿血清IGF-1水平差异有统计学显著性意义(P＜0.05);血清IGF-1水平与胎龄、出生体重呈显著正相关(P＜0.01),且随胎龄和体重的增大,血清IGF-1水平明显增高.结论 IGF-1参与早产儿宫内生长发育的调控,可作为评价胎儿生长发育的临床指标.     

胎儿脐动脉血流速度与新生儿结局的关系(附166例分析)

目的 :探讨胎儿脐动脉血流速度与新生儿结局的关系。方法 :对 166名孕妇的脐动脉收缩期峰值 (S)与舒张末期峰值 (D)比值 (S/D比值 )测定结果、新生儿结局进行回顾性分析。结果 :S/D比值异常者 17例 ,其中小于胎龄儿 12例 (70 % ) ,新生儿死亡 3例 (18% ) ;正常 149名中小于胎龄儿7例 (5 % ) ,无新生儿死亡。两组比较有显著性差异。结论 :胎儿脐动脉 S/D比值可作为评估新生儿结局的一个重要指标。     

Tiotidine and cimetidine--kinetics and dynamics

Tiotidine and cimetidine kinetics and dynamics were compared to assess mechanisms of the longer duration of effect of tiotidine in man. Both drugs has similar lag times for absorption. Tiotidine with a meal was more slowly absorbed than when fasting and was also more slowly absorbed than cimetidine with a meal. The elimination rates for both drugs did not differ; they were both approximately 2 to 3 hr. Oral doses of cimetidine achieved areas under the plasma concentration curve approximately three times that of tiotidine but these concentrations were only 1/10 as potent. The cimetidine concentration inducing 50% inhibition of food-stimulated gastric acid secretion was 0.41 +/- 0.04 whereas it was 0.04 +/- 0.003 microgram/ml for tiotidine. The effect of tiotidine lasted longer than that of cimetidine because the doses recommended for use in man resulted in higher concentrations in plasma relative to effective concentration than clinical doses of cimetidine.     

Developments and trends in traditional medicine and complementary and alternative medicine

With the rapid development of society, medical science and technology, although quality of life is enhanced and life expectancy is prolonged, aging, environmental changes and health problems are unavoidable. More and more people, therefore, are concerned about their health and place high demands on medical care. As modern medicine cannot meet all such demands, other medical care systems emerge. Trends in the seeking of medical care show that people are inclined towards natural approaches, so attention is being paid once again to traditional medicine, as well as complementary and alternative medicine. Under the patient-oriented concept, medical personnel have to recognize means of health care while thinking of the individualized and socioeconomic impacts. The purpose of this paper therefore is to provide medical personnel with information on the developments and trends in, knowledge and research with regard to traditional medicine as well as complementary and alternative medicine.