内镜下醋酸染色联合窄带光成像诊断早期胃癌及癌前病变的价值研究

目的探讨内镜下醋酸染色联合窄带光成像应用于早期胃癌及癌前病变诊断的价值。方法将2017年2月至2018年8月漯河市中心医院收治的100例早期胃癌及癌前病变患者作为研究对象,100例患者均接受内镜下醋酸染色联合窄带光成像技术检查,记录二者单纯及联合检查所得图像质量,将相关数据与病理诊断对比后得出结论。结果联合应用内镜下醋酸染色、窄带光成像技术检查所得图像清晰度评分结果最高,差异有统计学意义(P0.05);与病理检查结果比较,联合应用内镜下醋酸染色、窄带光成像技术检查对早期胃癌及癌前病变的检出符合率(94.00%)高于单纯内镜窄带光成像(69.00%)、内镜下醋酸染色(71.00%),差异有统计学意义(P0.05)。结论联合应用内镜下醋酸染色、窄带光成像技术诊断早期胃癌及癌前病变具有较高的临床应用价值。     

内镜窄带成像联合醋酸及亚甲蓝染色在早期胃癌及癌前病变中的诊断价值

目的探讨内镜窄带成像(NBI)联合醋酸及亚甲蓝染色在早期胃癌及癌前病变中的诊断价值。方法回顾性分析2018年6～8月河北省沧州市人民医院收治的72例胃黏膜可疑病变患者的临床资料,所有患者均分别经常规胃镜(常规胃镜组)、单纯NBI(NBI组)、NBI联合醋酸及亚甲蓝染色(联合组)检查,对比不同检查的图像质量及诊断价值。结果联合组患者的病变轮廓、黏膜腺管开口形态、浅表毛细血管结构评分3分率最高,分别为72. 2%、65. 3%、63. 9%,与其他两组比较,差异具有统计学意义(P 0. 05)。参照病理检查结果,联合组的准确率、灵敏度、特异度及阳性预测值最高,分别为93. 1%、94. 1%、92. 1%、91. 4%,且其假阴性率最低为5. 9%,与其他两组比较更具有临床诊断价值。结论 NBI结合醋酸及亚甲蓝染色在早期胃癌及癌前病变检查的影像学图像较常规胃镜和单纯NBI更为清晰,且具有更高的临床诊断价值。     

窄带成像放大内镜在胃平坦凹陷型病变中的误诊分析

目的:分析胃平坦凹陷型病变在窄带成像放大内镜(NBI)中的表现及误诊原因。方法:选取2016年11月～2018年4月在我院消化内镜中心胃镜下诊断为平坦凹陷型病灶的165例患者作为研究对象,对所有患者行常规胃镜检查、白光检查及NBI放大检查,随后在NBI下行靶向活检,比较所有内镜下平坦凹陷型病灶在NBI放大内镜下的诊断结果与活检病理结果。结果:以病理诊断为金标准,窄带成像放大内镜诊断的准确率为91.74%,误诊率为5.97%,漏诊率3.48%;单因素分析表明,因内镜医师操作的熟练程度较低且无早期胃癌规范化培训、患者萎缩性胃炎伴灶性萎缩和伴幽门螺旋杆菌感染造成的误诊率高于其他患者,差异有统计学意义,P0.05;多因素分析表明,内镜医师操作的熟练程度、早期胃癌规范化培训、萎缩性胃炎伴灶性萎缩和幽门螺旋杆菌感染是影响窄带成像放大内镜在胃平坦凹陷型病灶中误诊的因素。结论:内镜医师操作的熟练程度、早期胃癌规范化培训、萎缩性胃炎伴灶性萎缩和幽门螺旋杆菌感染会影响窄带成像放大内镜在胃平坦凹陷型病灶中诊断分析结果的准确性。     

ME-NBI联合靛胭脂染色对早期胃癌诊断效能的影响

目的:探究高清放大胃镜与内镜窄带成像技术联合靛胭脂染色对早期胃癌诊断效能的影响。方法:选取2016年5月～2018年10月就诊的357例疑似早期胃癌患者,行普通胃镜、高清放大胃镜与内镜窄带成像技术联合靛胭脂染色检查。以病理诊断结果为金标准,对比普通胃镜、高清放大胃镜与内镜窄带成像技术联合靛胭脂染色诊断早期胃癌的结果、诊断效能及病变轮廓清晰度。结果:357例疑似早期胃癌患者病理诊断阳性54例,阴性303例;普通胃镜检出阳性49例,阴性308例;高清放大胃镜与内镜窄带成像技术联合靛胭脂染色检出阳性75例,阴性282例。高清放大胃镜与内镜窄带成像技术联合靛胭脂染色诊断早期胃癌敏感度96.30%,阴性预测值99.29%,准确度93.00%分别较普通胃镜的53.70%、91.88%、87.39%高(P<0.05);两种检查方法特异度、阳性预测值比较,差异无统计学意义(P>0.05)。高清放大胃镜与内镜窄带成像技术联合靛胭脂染色诊断早期胃癌病变轮廓清晰度优于普通胃镜(P<0.05)。结论:与普通胃镜检查相比,高清放大胃镜与内镜窄带成像技术联合靛胭脂染色诊断早期胃癌可清晰显示病变轮廓,具有较高诊断效能。     

胃镜下联合染色观察方法对癌前病变及早期胃癌检出率的影响

目的对比分析普通白光胃镜与联合染色(电子染色+靛胭脂染色)胃镜在早期胃癌和胃癌前病变检出中的差异。方法回顾性分析该院行胃镜检查的患者314例,分为观察组和对照组。观察组(n=157)在普通白光的基础上,用电子染色[内镜窄带成像(NBI)]技术观察胃黏膜变化,对可疑病变行化学技术(靛胭脂染色)染色后,再观察胃黏膜形态色泽的变化,着色异常的黏膜取活检送病理检查;对照组(n=157)采取普通白光胃镜观察胃黏膜,对黏膜异常者(红、白、凸、凹)取活检送病理检查。结果观察组诊断早期胃癌3例,低级别上皮内瘤变54例,高级别上皮内瘤变13例,阳性检出率为10.19%;对照组诊断早期胃癌1例,低级别上皮内瘤变42例,高级别上皮内瘤变7例,阳性检出率为5.10%,两组检出率比较,差异有统计学意义(X~2=8.29,P=0.041)。结论内镜下联合染色技术(电子染色+靛胭脂染色)可明显提高早期胃癌和癌前病变的检出率。     

内镜窄带成像技术在大肠息肉样病变诊断中的价值

目的将内镜窄带成像技术(NBI)、染色内镜检查结果与病理学检查结果进行对比,探讨NBI在大肠息肉样病变诊断中的价值。方法选择2010年6月～2011年3月行结肠镜检查发现大肠息肉样病变的患者46例。分别采用常规模式、NBI模式及染色方法对病变进行黏膜表面细微腺管开口(pit)形态分型及微血管(CP)形态分型,与病理检查结果进行比较分析。结果在46例患者发现息肉样病变54个。NBI与普通内镜对病变轮廓、pit及CP图像清晰度比较差异均有显著性(P0.01),NBI明显优于普通内镜。NBI与染色内镜对病变轮廓与CP的显示差异均有显著性(P0.01),NBI优于染色内镜;两者在病变表面pit的观察方面差异无显著性(P0.05)。NBI内镜下pit分型对大肠肿瘤性病变诊断的准确率、敏感性、特异性分别为90.7%、90.9%和90.0%,CP分型对大肠肿瘤性病变诊断的准确率、敏感性、特异性分别为92.6%、95.3%和81.8%。结论 NBI内镜能更为清晰地显示大肠息肉样病变轮廓、腺管开口及微血管形态;能较好地区分大肠肿瘤与非肿瘤性病变;操作转换简单易行。     

窄带成像技术在胃恶性肿瘤临床应用价值

目的 探讨窄带成像技术（NBI）在胃癌及癌前病变诊断中的临床应用价值.方法 选择2008年12月～2009年12月检查早期胃癌及癌前病变患者共60例,采取病例自我对照方法,在无痛麻醉状态下,分别采取普通模式,NBI模式、亚甲蓝染色反复观察病灶,并记录病灶的大小、范围于改变最明显处行活检并行病理检查.比较普通模式、NBI模式及亚甲蓝染色内镜对病变检出率.观察NBI下胃小凹及微血管形态与病理学诊断的关系.结果 亚甲蓝染色及NBI对病变的检出率明显高于普通模式（P〈0.01）,业甲蓝染色检出率高于NBI（P〉0.05）.NBI内镜在对病变轮廓、胃黏膜浅表微血管的观察上,均较普通内镜或亚甲监染色内镜清晰,尤其是对于凹陷性病变的观察则更为清晰.对胃小凹的观察与亚甲监染色内镜无明显差异,均较普通内镜清晰.结论 NBI指导下的活检可进一步提高对消化道癌及癌前病变的靶向准确率.     

早期胃癌52例内镜诊治分析

目的探讨早期胃癌内镜诊断方法的有效性及临床应用价值。方法回顾性分析52例早期胃癌内镜下表现及窄带成像技术(NBI)、靛胭脂染色后病变及周边组织表现特征,对放大模式下病变黏膜微细形态分型并观察微血管形态,于病变处取活检行组织病理学检查,部分经超声内镜检查后行大片黏膜切除术,并将整块标本再送病理检查,结合病理结果评价内镜下早期胃癌各种诊断方法的可靠性。结果 52例早期胃癌胃镜下表现各不相同,其中Ⅰ型16例,Ⅱa型14例、Ⅱb型5例、Ⅱc型10例,Ⅲ型7例;65.4%位于胃窦部(34/52)、15.4%位于胃角(8/52)、11.5%位于窦体交界(6/52)、7.7%位于贲门及贲门下(4/52)。靛胭脂及NBI染色在放大模式下根据腺管开口形态诊断早期胃癌符合率分别为88.46%(46/52)、71.15%(37/52),两者比较差异有显著性,P<0.05;而病变黏膜微血管形态NBI染色明显优于靛胭脂。结论内镜不同诊断方法联合应用可提高早期胃癌诊断率,指导内镜活检的准确性,在临床有较大的应用价值。     

窄带成像下幽门螺杆菌感染时胃黏膜的特点

目的 探讨在放大内镜下应用窄带成像(NBI)技术观察幽门螺杆菌(Hp)感染时胃黏膜微细结构变化的特点.方法 在放大内镜下应用NBI对170例有不同上消化道症状患者的胃黏膜微细结构进行观察和分型.用Warthin-starry银染色和患者血清Hp抗体以检测Hp感染.分析两者之间的相互关系.结果 170例患者中Hp感染阳性者69例,Hp感染阴性101例,胃体下部大弯侧集合静脉分为规则型(R)、不规则型(I)和消失型(D),Hp感染率分别为:6.67%、61.9%和84.75%,其中D及I型感染率明显高于R型,且差异有显著性(P<0.05).胃窦部大弯侧胃小凹形态分为B、C、D、E 4型,Hp感染发生率分别是22.22%、82.69%、27.78%和10.00%,C型感染率最高,与B、D、E 3型比较差异有显著性(P<0.05),B、D、E 3型问差异无显著性.结论 在放大内镜及NBI下Hp感染时胃黏膜微细结构特点是集合静脉不规则、紊乱、模糊甚至消失;胃小凹稀疏延长、迁曲,小凹开口扩大、表面不均匀发红;且图像清晰度显著优于单独应用放大内镜.     

内镜窄带成像技术在诊断早期喉癌及其癌前病变中的作用研究

目的探讨窄带成像技术(narrow band imaging,NBI)在内镜诊断早期咽喉恶性肿瘤及癌前病变中的临床应用价值。方法选取2013年6月至2014年3月因主观症状就诊于我院门诊,经电子喉镜检查发现咽喉粘膜异常增生及喉肿物疑似恶性病变的104例患者,分别在白光和NBI模式下观察咽喉部黏膜,记录病变的大小、范围,同时进行NBI分级,并对病灶性质做出预判,对NBI模式下发现的117个病灶均取活检,以病理结果作为诊断金标准,将其他检查结果与之作对照。结果 1.窄带成像技术在对病损轮廓、黏膜表面及粘膜下微血管形态显示方面均明显优于普通白光内镜图像,差异有显著性(P0.05)。2.104例怀疑喉癌或癌前病变的患者中共发现117个病灶,其中白光模式下病变检出率为89.7%,应用NBI模式检出率为99.1%。NBI内镜对咽喉恶性肿瘤及癌前病变诊断的灵敏度为91.4%,而普通白光内镜的灵敏度为74.1%,二者之间的差异有统计学意义。3.NBI分级与病理诊断的关系:声带息肉等良性病变主要表现为NBIⅠ级(10/12),慢性喉炎等炎性病变主要表现为NBIⅡ级(15/19),轻度不典型增生主要表现为NBIⅢ级(10/15),重度不典型增生主要表现为NBIⅣ级(5/7),重度不典型增生及恶性肿瘤主要表现为NBIⅤ级(52/64)。结论与白光模式相比,NBI模式能清晰地显现病变的轮廓及黏膜表层及黏膜下层微血管的各种形态变化,可增强病变的可识别性。内镜窄带成像技术操作简便、安全,较白光模式更易发现细微变化的病灶,亦可使活检阳性率明显提高,在早期咽喉恶性肿瘤及癌前病变的诊断有一定的临床应用价值。     

窄带成像内镜下活检术对扁桃体癌早期诊断的价值评估

目的探讨窄带成像内镜(NBI)下活检术在扁桃体癌早期诊断中的应用价值。方法选取2013年2月-2019年2月该科就诊的220例扁桃体病变患者。其中,手术治疗扁桃体肥大患者120例(Ⅱ度肥大患者80例,Ⅲ度肥大患者40例,均为单侧病变):60例行NBI下活检术,60例行常规活检术;扁桃体癌早期患者100例(均为单侧病变):50例行NBI下活检术,另50例行常规活检术。220例患者均经病理确诊。比较两种方法的灵敏度、特异度、诊断符合率、约登指数、阳性预测值和阴性预测值。结果 NBI下活检和常规活检的灵敏度分别为98.00%和84.00%、特异度分别为100.00%和100.00%、诊断符合率分别为99.09%和92.73%、约登指数分别为98.00%和84.00%。NBI下活检和常规活检阳性预测值为100.00%和100.00%;NBI下活检和常规活检阴性预测值为98.36%和88.24%,两种检测方法的早期扁桃体癌诊断准确率比较,差异有统计学意义(2=5.98,P=0.016)。结论 NBI下活检术对扁桃体癌早期诊断具有较高的灵敏度、特异度、阴性预测值;具有快速、准确的优点,可用于扁桃体癌的筛查和早期诊断。     

内科胸腔镜窄带成像技术联合冷冻活检对不明原因胸腔积液的诊断价值

目的 探讨内科胸腔镜窄带成像技术（NBI）联合胸膜冷冻活检对不明原因胸腔积液的诊断价值。方法 选择113例不明原因胸腔积液患者,应用内科胸腔镜对胸膜病变进行检查,检查过程中,先通过内科胸腔镜白光观察胸膜表面情况,再切换至NBI模式对胸膜表面进行观察,分析不同病变在内科胸腔镜白光及NBI下的形态表现,并在白光及NBI下分别对胸膜表面怀疑病变的部位进行常规钳夹活检及冷冻活检,对比两组患者活检标本诊断准确率、敏感度、特异度及取材直径的情况,同时分析不同活检方式的安全性及并发症情况。结果 NBI联合冷冻活检组的胸膜疾病诊断敏感度、特异度及准确率均高于白光联合冷冻活检组,两组比较,差异均具有统计学意义（P=0.047、P=0.024和P=0.015）;NBI联合钳夹活检组的胸膜疾病诊断敏感度和准确率高于白光联合钳夹活检组,两组敏感度比较,差异有统计学意义（P=0.033）,两组准确率比较,差异无统计学意义（P=0.079）。NBI联合钳夹活检组特异度明显低于白光联合钳夹活检组,差异有统计学意义（P=0.041）。通过NBI对胸膜表面血管情况进行分析,病变血管≥2根的冷冻活检灵敏度、特异度及准确率...     

Narrow-band imaging in the diagnosis of colorectal mucosal lesions: a pilot study

BACKGROUND AND STUDY AIMS: A newly developed narrow-band imaging (NBI) technique, in which modified optical filters were used in the light source of a video endoscope system, was applied during colonoscopy in a clinical setting. This pilot study evaluated the clinical feasibility of the NBI system for evaluating colorectal lesions. PATIENTS AND METHODS: A total of 43 colorectal lesions in 34 patients were included in the study. The quality of visualization of colorectal lesions and the accuracy of differentiation between neoplastic and non-neoplastic lesions using the NBI system were evaluated in comparison with results from conventional colonoscopy and with chromoendoscopy. RESULTS: For pit pattern delineation, NBI was superior to conventional endoscopy (P < 0.001), but inferior to chromoendoscopy (P < 0.05). NBI achieved better visualization of the mucosal vascular network and of the hue of lesions than conventional endoscopy (P < 0.05). However there was no significant difference between NBI and chromoendoscopy in differentiating neoplastic from non-neoplastic lesions (both techniques had a sensitivity of 100 % and a specificity 75 %). This was better than the results of conventional colonoscopy (sensitivity 83 %, specificity 44 %; P < 0.05 for specificity). CONCLUSIONS: These results suggest that in the examination of colonic lesions the NBI system provides imaging features additional to those of both conventional endoscopy and chromoendoscopy. For distinguishing neoplasms from non-neoplastic lesions, NBI was equivalent to chromoendoscopy.     

Comparison of white-light endoscopy,optical-enhanced and acetic-acid magnifying endoscopy for detecting gastric intestinal metaplasia: A randomized trial

BACKGROUNDGastric intestinal metaplasia (GIM) is a precancerous lesion of the stomach, which severely affects human life and health. Currently, a variety of endoscopic techniques are used to screen/evaluate GIM. Traditional white-light endoscopy (WLE) and acetic-acid chromoendoscopy combined with magnifying endoscopy (ME-AAC) are the interventions of choice due to their diagnostic efficacy for GIM. Optical-enhanced magnifying endoscopy (ME-OE) is a new virtual chromoendoscopy technique to identify GIM, which combines bandwidth-limited light and image enhancement processing technology to enhance the detection of mucosal and vascular details. We hypothesized that ME-OE is superior to WLE and ME-AAC in the evaluation of GIM.AIMTo directly compare the diagnostic value of WLE, ME-AAC, and ME-OE for detection of GIM.METHODSA total of 156 patients were subjected to consecutive upper gastrointestinal endoscopy examinations using WLE, ME-AAC, and ME-OE. Histopathological findings were utilized as the reference standard. Accuracy, sensitivity, specificity, and positive and negative predictive values of the three endoscopy methods in the diagnosis of GIM were evaluated. Moreover, the time to diagnosis with ME-AAC and ME-OE was analyzed. Two experts and two non-experts evaluated the GIM images diagnosed using ME-OE, and diagnostic accuracy and intra- and inter-observer agreement were analyzed.RESULTSGIM was detected in 68 of 156 patients (43.6%). The accuracy of ME-OE was highest (91.7%), followed by ME-AAC (86.5%), while that of WLE (51.9%) was lowest. Per-site analysis showed that the overall diagnostic accuracy of ME-OE was higher than that of ME-AAC (P = 0.011) and WLE (P < 0.001). The average diagnosis time was lower in ME-OE than in ME-AAC (64 ± 7 s vs 151 ± 30 s, P < 0.001). Finally, the inter-observer agreement was strong for both experts (k = 0.862) and non-experts (k = 0.800). The internal consistency was strong for experts (k = 0.713, k = 0.724) and moderate for non-experts (k = 0.667, k = 0.598).CONCLUSIONFor endoscopists, especially experienced endoscopists, ME-OE is an efficient, convenient, and time-saving endoscopic technique that should be used for the diagnosis of GIM.     

窄带成像与放大染色技术在诊断胃癌及癌前病变中的对比研究

目的应用窄带成像技术（NBI）和放大染色技术对胃可疑病变处进行观察,比较两种技术在诊断胃癌及癌前病变中的差异。方法选取2008年10月至12月进行放大胃镜检查患者中胃小凹分型为Ⅲ型以上的40例患者作为研究对象,对可疑病变处依次进行放大胃镜、NBI放大胃镜和放大染色胃镜观察,对三者图像的清晰度、胃小凹分型评价情况以及胃癌和癌前病变诊断情况进行比较。结果在这40例患者中,NBI放大胃镜下观察病变清晰度明显高于放大胃镜下和放大染色胃镜下（P〈0．05）;NBI放大胃镜与放大染色胃镜在胃小凹分型的评价方面,差异无统计学意义（P〉0．05）;NBI放大胃镜对胃癌及癌前病变诊断的准确性、敏感性、特异性与放大染色胃镜比较,差异无统计学意义（P〉0．05）。结论NBI通过对胃小凹形态改变的观察,从而发现可疑病变,精确引导活检,有助于提高胃癌及癌前病变的检出率。     

Significance of pepsinogen in screening for gastric intestinal metaplasia in Guangdong,China

ObjectiveDiagnosis of gastric intestinal metaplasia (GIM) relies on gastroscopy and histopathologic biopsy, but their application in screening for GIM is limited. We aimed to identify serological biomarkers of GIM via screening in Guangdong, China.MethodsCross-sectional field and questionnaire data, demographic information, past medical history, and other relevant data were collected. Blood samples were collected for pepsinogen (PG)I, PGII, gastrin-17, and Helicobacter pylori antibody testing, and gastroscopy and histopathologic biopsy were performed. Single factor and logistic regression analyses were used to evaluate the correlation between these indicators and GIM, and decision tree models were used to determine the cut-off points between indicators.ResultsOf 443 participants enrolled, 87 (19.6%) were diagnosed with GIM. Single factor analysis showed that pepsin indicators (PGI, PGII, and PGI/PGII ratio) and the factors Mandarin as native language, urban residency, hyperlipidemia, and age were associated with GIM. Logistic regression analysis showed that PGI and age were associated with GIM.ConclusionsAge is an important factor for predicting GIM progression; age >60 years increased its risk. Detection of GIM was higher in individuals with PGI levels >127.20 ng/mL, which could be used as a threshold indicating the need to perform gastroscopy and histopathologic biopsy.     

Time trends in the prevalence of Helicobacter pylori infection in patients with peptic ulcer disease: a single-center retrospective study in Shanghai

ObjectiveThe present study aimed to investigate the recent trends in Helicobacter pylori infection associated with peptic ulcer disease in a large population in Shanghai.MethodsWe analyzed the medical records of all patients who had undergone upper gastrointestinal endoscopy (EGD) for uninvestigated dyspepsia at Ren Ji Hospital between 2013 and 2019 to determine the prevalence of H. pylori infection in patients with peptic ulcers.ResultsPeptic ulcers were found in 40,385 of the 383,413 patients who underwent EGD during the study period. Over the 7-year study period, the annual prevalence of H. pylori among patients receiving EGD declined from 32.2% to 26.5%. H. pylori was present in 60% of ulcers and the incidence was higher (66.9%) in duodenal compared with gastric ulcers (48.5%). The proportion of H. pylori-associated gastric ulcers declined from 52.2% to 49.3% and that of H. pylori-positive duodenal ulcers declined from 70.0% to 63.9%.ConclusionThe prevalence of H. pylori-positive peptic ulcers, mainly duodenal ulcers, fell from 2013 to 2019. However, the proportion of non-H. pylori-associated peptic ulcer disease increased, especially in elderly people, possibly due to the use of nonsteroidal anti-inflammatory drugs. Further research is needed to confirm this hypothesis.     

High-resolution endoscopy plus chromoendoscopy or narrow-band imaging in Barrett's esophagus: a prospective randomized crossover study

BACKGROUND AND STUDY AIMS: High-resolution endoscopy (HRE) may improve the detection of early neoplasia in Barrett's esophagus. Indigo carmine chromoendoscopy (ICC) and narrow-band imaging (NBI) may be useful techniques to complement HRE. The aim of this study was to compare HRE-ICC with HRE-NBI for the detection of high-grade dysplasia or early cancer (HGD/EC) in patients with Barrett's esophagus. PATIENTS AND METHODS: Twenty-eight patients with Barrett's esophagus underwent HRE-ICC and HRE-NBI (separated by 6 - 8 weeks) in a randomized sequence. The two procedures were performed by two different endoscopists, who were blinded to the findings of the other examination. Targeted biopsies were taken from all detected lesions, followed by four-quadrant biopsies at 2-cm intervals. Biopsy evaluation was supervised by a single expert pathologist, who was blinded to the imaging technique used. RESULTS: Fourteen patients were diagnosed with HGD/EC. The sensitivity for HGD/EC was 93 % and 86 % for HRE-ICC and HRE-NBI, respectively. Targeted biopsies had a sensitivity of 79 % with HRE alone. HGD was diagnosed from random biopsies alone in only one patient. ICC and NBI detected a limited number of additional lesions occult to HRE, but these lesions did not alter the sensitivity for identifying patients with HGD/EC. CONCLUSIONS: In most patients with high-grade dysplasia or early cancer in Barrett's esophagus, subtle lesions can be identified with high-resolution endoscopy. Indigo carmine chromoendoscopy and narrow-band imaging are comparable as adjuncts to high-resolution endoscopy.     

窄带成像内镜对咽喉部位肿瘤患者活检中的应用价值

目的探讨窄带成像内镜(NBI)对咽喉部位肿瘤患者活检中的应用价值,为咽喉部位肿瘤的鉴别诊断提供参考。方法共纳入100例怀疑咽喉部位恶性肿瘤的患者作为研究对象,均在普通白光及NBI内镜条件下进行活检,并以最终病理结果为金标准,评价两种检查方法的应用价值。结果 100例怀疑咽喉部位恶性肿瘤患者中,最终病理确诊恶性56例,占56.0%,良性病变44例,占44.0%。普通白光活检正确率60.0%明显低于NBI内镜活检正确率75.0%,比较差异有统计学意义(P0.05)。NBI内镜敏感度为89.3%,特异度为63.6%均明显高于普通白光敏感度为75.0%,特异度为40.9%,比较差异有统计学意义(χ2=3.90,4.56,P=0.048,0.033)。结论 NBI内镜下咽喉部肿瘤为边界清晰的棕色斑点或条索状,活检中选取上述部位可提高恶性肿瘤的诊断敏感度、特异度及正确率。     

Autofluorescence imaging and narrow-band imaging for the detection of early neoplasia in patients with Barrett's esophagus

High-resolution endoscopy (HRE), magnifying endoscopy, auto-fluorescence endoscopy, and narrow-band imaging (NBI) are promising techniques that could improve the detection of early neoplasia and the efficacy of endoscopic surveillance in patients with Barrett's esophagus. HRE improves the detection of lesions by white light, and video autofluorescence imaging (AFI) may have additional value in terms of sensitivity. The strengths ofAFI are its high sensitivity and a high negative predictive value,while potential limitations are its moderate specificity and positive predictive value. NBI enhances the mucosal and vascular patterns (i. e. the mucosal morphology) without the need for chromoendoscopy. The mucosal morphology features may be used to distinguish early neoplasia from nondysplastic Barrett's esophagus. Magnification is required for optimal use of NBI,which is a limitation of this technique. NBI with magnifying endoscopy could, however, be used for targeted inspection of lesions detected first by HRE or AFI. This approach has been shown to reduce the false-positive rate associated with AFI while maintaining its high sensitivity. To date, AFI and NBI have been used separately in two different prototypes, but a prototype endoscope that incorporates all of these techniques has recently become available. It is expected that future refinement of the autofluorescence and narrow-band modules may further increase their diagnostic value and ultimately improve the effectiveness of surveillance of Barrett's esophagus.