AAV5 delivery of CRISPR-Cas9 supports effective genome editing in mouse lung airway

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Gene therapy reforms photoreceptor structure and restores vision in NPHP5-associated Leber congenital amaurosis

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lncRNA ZNF649-AS1 Induces Trastuzumab Resistance by Promoting ATG5 Expression and Autophagy

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HCP5 prevents ubiquitination-mediated UTP3 degradation to inhibit apoptosis by activating c-Myc transcriptional activity

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The rational development of CD5-targeting biepitopic CARs with fully human heavy-chain-only antigen recognition domains

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Targeting Complement C5a Receptor 1 for the Treatment of Immunosuppression in Sepsis

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Inhibition of C5AR1 impairs osteoclast mobilization and prevents bone loss

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Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression

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CCL7 and TGF-β secreted by MSCs play opposite roles in regulating CRC metastasis in a KLF5/CXCL5-dependent manner

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lncRNA HITT inhibits metastasis by attenuating Rab5-mediated endocytosis in lung adenocarcinoma

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PRMT5 regulates RNA m6A demethylation for doxorubicin sensitivity in breast cancer

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XGBoost framework with feature selection for the prediction of RNA N5-methylcytosine sites

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lncRNA lnc-POP1-1 upregulated by VN1R5 promotes cisplatin resistance in head and neck squamous cell carcinoma through interaction with MCM5

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Development of 5-FU-modified tumor suppressor microRNAs as a platform for novel microRNA-based cancer therapeutics

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DDX5 mRNA-targeting antisense oligonucleotide as a new promising therapeutic in combating castration-resistant prostate cancer

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Tumor-derived exosomal microRNA-106b-5p activates EMT-cancer cell and M2-subtype TAM interaction to facilitate CRC metastasis

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Early Phase Clinical Immunogenicity of Valoctocogene Roxaparvovec,an AAV5-Mediated Gene Therapy for Hemophilia A

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sEVs from tonsil-derived mesenchymal stromal cells alleviate activation of hepatic stellate cells and liver fibrosis through miR-486-5p

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Ablation of Immunoproteasome β5i Subunit Suppresses Hypertensive Retinopathy by Blocking ATRAP Degradation in Mice

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DF-MDA: An effective diffusion-based computational model for predicting miRNA-disease association

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