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记述采自海南省太阳隼[虫忽]属1新种:华氏太阳隼[虫忽]Heliocypha huai.sp.nov.和采自贵州省印度隼[虫忽]属1新种:赤水印度隼[虫忽]Indocypha chishuiensis,sp.nov.。模式标本保存于浙江自然博物馆昆虫标本室。 相似文献
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记述采自贵州省雷公山的大属1新种:铲形大Magalestes palaceus,sp.nov.,模式标本保存于浙江自然博物馆昆虫标本室。 相似文献
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记述采自广东省原科1新种:华氏齿原Prodasineura huai,sp.nov.和采自浙江省科1新种:大磐山斑Pseudagrion daponshanensis,sp.nov.,模式标本保存于浙江自然博物馆昆虫标本室。 相似文献
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记述采自广东省原[虫怱]科1新种:华氏齿原[虫怱]Prodasineura huai sp.nov.和采自浙江省[虫怱]科1新种:大磐山斑[虫怱]Pseudagrion daponshanensis,sp.nov.,模式标本保存于浙江自然博物馆昆虫标本室。 相似文献
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记述粉蚧科1新属1新种,即拟锯粉蚧属Paraserrolecanium gen.nov.及其模式种箭竹拟锯粉蚧P.fargesii sp.nov.。新种模式标本采自陕西省凤县天台山一种箭竹Fargesia sp.叶鞘下茎上,保存在北京林业大学昆虫标本室。 相似文献
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旋涡虫属一新种(单肠目,隐头吻亚目,多囊科) 总被引:4,自引:0,他引:4
报道采自中国广东湛江的淡水旋涡虫属1新种:中国旋涡虫Gyratrix sinensis sp.nov.对新种涡虫的形态特征作了详细描述,并与旋涡虫属近似种进行了比较. 相似文献
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描述了采自云南西双版纳热带雨林的蟹蛛1新属:副泥蟹蛛属Paraborboropactus gen.nov.及3新种:郑氏副泥蟹蛛,新种Paraborboropactus zhengi sp.nov.,豆荚副泥蟹蛛,新种 Paraborboropactus leguminaceus sp.nov.以及菱形副泥蟹蛛,新种Paraborboropactus rhombus sp.nov,.模式标本均保存在中国科学院动物研究所. 相似文献
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Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis
It has now been over twenty years since a novel herpesviral genome was identified in Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi's sarcoma-associated herpesvirus(KSHV; also known as human herpesvirus 8(HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis. 相似文献
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正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases 相似文献
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Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme
responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare
the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show
that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by
distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of
demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least
one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of
the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable
potent antiproliferative synthetic drugs. 相似文献
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A.A. Zakeyah J. Whitt C. Duke D.F. Gilmore D.G. Meeker M.S. Smeltzer M.A. Alam 《Bioorganic & medicinal chemistry letters》2018,28(17):2914-2919
Microbial resistance to antibiotics is an unresolved global concern, which needs urgent and coordinated action. One of the guidelines of the Centers for Disease Control and Preventions (CDC) to combat antibiotic resistance is the development of new antibiotics to treat drug-resistant bacteria. In our effort to find new antibiotics, we report the synthesis and antimicrobial studies of 30 new pyrazole derivatives. These novel molecules have been synthesized by using readily available starting materials and benign reaction conditions. Some of these molecules have shown activity with MIC values as low as 0.78?µg/mL against four bacterial strains; Staphylococcus aureus, methicillin-resistant S. aureus, Bacillus subtilis, and Acinetobacter baumannii. Furthermore, active molecules are non-toxic to mammalian cell line. 相似文献
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The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle. 相似文献
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Zsófia Czudor Mária Balogh Péter Bánhegyi Sándor Boros Nóra Breza Judit Dobos Márk Fábián Zoltán Horváth Eszter Illyés Péter Markó Anna Sipos Csaba Szántai-Kis Bálint Szokol László Őrfi 《Bioorganic & medicinal chemistry letters》2018,28(4):769-773
Cyclin-dependent kinases (CDKs) and Polo-like kinases (PLKs) play key role in the regulation of the cell cycle. The aim of our study was originally the further development of our recently discovered polo-like kinase 1 (PLK1) inhibitors. A series of new 2,4-disubstituted pyrimidine derivatives were synthesized around the original hit, but their PLK1 inhibitory activity was very poor. However the novel compounds showed nanomolar CDK9 inhibitory activity and very good antiproliferative effect on multiple myeloma cell lines (RPMI-8226). 相似文献