加味左归丸联合雌孕激素序贯治疗对早发性卵巢功能不全患者子宫动脉血流动力学、氧化应激和免疫因子的影响

摘要 目的：探讨加味左归丸联合雌孕激素序贯治疗对早发性卵巢功能不全（POI）患者子宫动脉血流动力学、氧化应激和免疫因子的影响。方法：纳入我院2019年10月-2021年10月期间收治的100例POI患者,按照随机数字表法分为对照组（雌孕激素序贯治疗,50例）和研究组（加味左归丸联合雌孕激素序贯治疗,50例）。对比两组中医证候积分、子宫动脉血流动力学、氧化应激指标、性激素指标和免疫因子指标。结果：两组治疗后月经周期、月经量、腰膝酸软、潮热盗汗、头晕耳鸣、阴道干涩、失眠多梦、五心烦热、性欲降低评分均下降,且研究组低于对照组（P<0.05）。两组治疗后子宫动脉收缩期峰值流速（Vmax）升高,搏动指数（PI）、阻力指数（RI）下降,且研究组的变化程度大于对照组（P<0.05）。两组治疗后血清丙二醛（MDA）下降,谷胱甘肽过氧化物酶（GSH-Px）、超氧化物歧化酶（SOD）升高,且研究组的变化程度大于对照组（P<0.05）。两组治疗后雌二醇（E2）升高,促黄体生成素（LH）、促卵泡生成激素（FSH）下降,且研究组的变化程度大于对照组（P<0.05）。两组治疗后NK细胞、CD8⁺下降,CD3⁺、CD4⁺、CD4⁺/CD8⁺升高,且研究组的变化程度大于对照组（P<0.05）。结论：加味左归丸联合雌孕激素序贯治疗POI患者,可有效改善子宫动脉血流动力学、性激素、氧化应激和免疫功能,促进患者恢复。     

麒麟丸联合炔雌醇环丙孕酮对多囊卵巢综合征致不孕症患者子宫内膜容受性、血清性激素和氧化应激水平的影响

摘要 目的：探讨麒麟丸联合炔雌醇环丙孕酮对多囊卵巢综合征（PCOS）致不孕症患者子宫内膜容受性、血清性激素和氧化应激水平的影响。方法：选取我院于2018年1月~2020年1月期间收治的PCOS致不孕症患者460例,符合要求的患者按照随机数字表法分为对照组和研究组,各为230例。对照组患者予以炔雌醇环丙孕酮治疗,研究组予以麒麟丸联合炔雌醇环丙孕酮治疗,对比两组疗效、子宫内膜容受性、性激素、氧化应激、排卵率、妊娠率和不良反应。结果：研究组的临床总有效率较对照组更高（P<0.05）。研究组治疗后子宫动脉搏动指数（PI）、子宫动脉血流阻力指数（RI）低于对照组,子宫内膜厚度大于对照组（P<0.05）。研究组治疗后促卵泡激素（FSH）和黄体生成素（LH）低于对照组,雌二醇（E2）高于对照组（P<0.05）。研究组治疗后丙二醛（MDA）、活性氧物质（ROS）低于对照组,过氧化物歧化酶（SOD）高于对照组（P<0.05）。随访6个月后,研究组的妊娠率、排卵率明显高于对照组（P<0.05）。两组不良反应发生率组间对比无差异（P>0.05）。结论：麒麟丸联合炔雌醇环丙孕酮治疗PCOS致不孕症患者,可以有效改善患者子宫内膜容受性、血清性激素和氧化应激状态,提高妊娠率、排卵率,安全有效。     

血清OC、TSP-1、ANGPTL2与多囊卵巢综合征患者胰岛素抵抗、性激素和卵巢间质血流的关系研究

摘要 目的：分析血清骨钙素（OC）、血小板反应蛋白-1（TSP-1）、血管生成素样蛋白2（ANGPTL2）与多囊卵巢综合征（PCOS）患者胰岛素抵抗（IR）、性激素和卵巢间质血流的关系。方法：选取2020年1月～2022年4月内蒙古自治区人民医院收治的125例PCOS患者（PCOS组）,根据稳态模型评估（HOMA）-IR分为IR组68例和非IR组57例,另选取同期67例体检健康成年女性（对照组）。收集研究对象HOMA-IR和性激素、卵巢间质血流指标,采用酶联免疫吸附法检测血清OC、TSP-1、ANGPTL2水平。比较PCOS组与对照组、IR组与非IR组之间性激素、卵巢间质血流指标、血清OC、TSP-1、ANGPTL2水平的差异。采用Pearson/Spearman相关性分析法分析PCOS患者血清OC、TSP-1、ANGPTL2水平与HOMA-IR、性激素和卵巢间质血流指标的相关性。结果：PCOS组HOMA-IR、黄体生成素（LH）、LH/促卵泡生成素（FSH）、睾酮（T）、收缩期峰值速度（PSV）、ANGPTL2水平高于对照组,搏动指数（PI）和阻力指数（RI）、OC、TSP-1水平低于对照组（P＜0.05）。IR组LH、LH/FSH、T、PSV、ANGPTL2水平高于非IR组,PI、RI、OC、TSP-1水平低于非IR组（P＜0.05）。Pearson/Spearman相关性分析显示,PCOS患者血清OC、TSP-1水平与HOMA-IR、LH、LH/FSH、T、PSV呈负相关,与PI、RI呈正相关（P＜0.05）;血清ANGPTL2水平与PCOS患者HOMA-IR、LH、LH/FSH、T、PSV呈正相关,与PI、RI呈负相关（P＜0.05）。结论：血清OC、TSP-1在PCOS患者血清中低表达,ANGPTL2在PCOS患者血清中高表达,三者与PCOS患者IR、性激素和卵巢间质血流密切相关。     

彩色多普勒超声联合性激素对性早熟女童的诊断价值及其相关性分析

摘要 目的：探讨彩色多普勒超声联合性激素对性早熟女童的诊断价值及其相关性分析。方法：选择2017年10月至2019年10月我院收治的性早熟女童80例,根据促性腺激素释放激素（GnRH）激发试验结果将其分为中枢性性早熟（CPP）组（n=31）,外周性性早熟（PPP）组49例（n=49）。比较两组女童的彩色多普勒超声检查结果及性激素水平,分析卵巢容积、子宫容积与性激素的相关性,并分析子宫容积、卵巢容积及FSH峰值、LH峰值、LH峰值/ FSH峰值在性早熟女童中的鉴别诊断价值。结果：CPP组女童卵巢容积、卵泡个数、最大卵泡直径、子宫容积、子宫内膜厚度、乳腺低回声团厚度均显著高于PPP组女童（P<0.05）。CPP组女童促卵泡生成素（FSH）基础值、FSH峰值、促黄体生成素（LH）基础值、LH峰值、LH峰值/ FSH峰值均显著高于PPP组女童（P<0.05）。CPP组女童卵巢容积、子宫容积与LH峰值、LH峰值/FSH峰值呈正相关（P<0.05）,PPP组女童卵巢容积、子宫容积与性激素水平无相关性（P>0.05）,两组LH峰值与LH峰值/FSH峰值均呈正相关（P<0.05）。ROC曲线分析显示,子宫容积、卵巢容积、LH峰值、FSH峰值、LH峰值/ FSH峰值鉴别诊断性早熟女童的曲线下面积分别为0.834,0.804,0.753,0.802,0.873。结论：彩色多普勒超声和性激素能够为性早熟女童病情的鉴别提供重要的临床信息,两者结合应用有助于提高性早熟女童的诊断价值。     

血清SIRT1水平与射血分数保留的心力衰竭患者炎性因子、氧化应激的相关性分析及对预后的影响研究

摘要 目的：探讨血清去乙酰化酶1（SIRT1） 水平与射血分数保留的心力衰竭（HFpEF）患者炎性因子、氧化应激的相关性,分析SIRT1预测HFpEF患者预后的价值。方法：选择2019年10月至2021年6月青岛阜外心血管病医院收治的190例HFpEF患者为HFpEF组,92例心功能正常的健康体检志愿者为对照组。HFpEF患者出院后随访12个月,统计随访期间不良心血管事件发生情况,多因素Logistic回归分析HFpEF患者预后不良的影响因素。结果：HFpEF组血清SIRT1水平低于对照组（P＜0.05）,白细胞介素（IL）-6、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）、丙二醛（MDA）、晚期氧化蛋白产物（AOPP）水平高于对照组（P＜0.05）。HFpEF患者血清SIRT1水平与IL-6、TNF-α、CRP、MDA、AOPP呈负相关（r=-0.496、-0.502、-0.419、-0.533、-0.542,P＜0.05）。190例患者2例失访,余188例HFpEF患者中41例预后不良,147例预后良好。预后不良组美国纽约心脏病协会（NYHA）Ⅳ级比例、IL-6、TNF-α、CRP、MDA、AOPP、N末端B型利钠肽前体（NT-proBNP）水平、左室收缩末期内径（LVEDS）、左室舒张末期内径（LVEDD）、二尖瓣舒张早期血流峰值（E）与舒张晚期血流峰值（A）（E/A）高于预后良好组（P＜0.05）,血清SIRT1水平、左心室射血分数（LVEF）低于预后良好组（P＜0.05）。高IL-6、高MDA、高NT-proBNP是HFpEF患者预后不良的危险因素（P＜0.05）,SIRT1是HFpEF患者预后不良的保护因素（P＜0.05）。结论：HFpEF患者血清SIRT1水平降低,与HFpEF患者炎症反应、氧化应激以及预后不良的发生有关,可作为HFpEF患者预后评估的辅助指标。     

血清25(OH)D、AMH和INHB联合检测在卵巢储备功能低下患者体外受精-胚胎移植妊娠结局中的应用价值

摘要 目的：血清25-羟维生素D[25(OH)D]、抗苗勒管激素（AMH）和抑制素B（INHB）联合检测在卵巢储备功能低下（DOR）患者体外受精-胚胎移植（IVR-ET）妊娠结局中的应用价值。方法：选择2019年8月~2021年10月我院行IVR-ET助孕的DOR患者292例,根据助孕后的妊娠结局分为妊娠组（n=158）和未妊娠组（n=134）,比较两组临床资料及血清25(OH)D、AMH和INHB水平,应用受试者工作特征（ROC）曲线评价血清25(OH)D、AMH和INHB单独及联合检测对妊娠失败的预测价值。应用单因素、多因素Logisitic回归分析妊娠失败的影响因素。结果：妊娠组血清25(OH)D、AMH、INHB水平显著高于未妊娠组（P<0.05）。ROC曲线分析显示,血清25(OH)D、AMH、INHB及三者联合检验对DOR患者IVR-ET妊娠失败的预测的曲线下面积（AUC）分别为0.714（0.631~0.802）、0.801（0.731~0.852）、0.634（0.578~0.741）、0.853（0.806~0.913）,三者联合检验对DOR患者IVR-ET妊娠失败预测AUC高于单独检验。单因素分析显示未妊娠组窦卵泡个数<5、获卵个数<8、卵泡刺激素（FSH）/黄体生成激素(LH)≥1.8、血清25(OH)D≤25.05 μg/L、血清AMH≤1.08 ng/mL、血清INHB≤84.28 pg/mL比例显著高于妊娠组（P<0.05）。多因素Logistic回归分析显示FSH/LH≥1.8、血清25(OH)D≤25.05 μg/L、血清AMH≤1.08 ng/mL、血清INHB≤84.28 pg/mL是DOR患者IVR-ET妊娠失败的危险因素（P＜0.05）。结论：血清25(OH)D、AMH和INHB 水平较低与DOR患者IVR-ET妊娠失败有关,且联合检测上述指标水平对患者IVR-ET妊娠失败有较高的辅助预测价值。     

血清SF、AMH、APN、NF-κB与肥胖型多囊卵巢综合征不孕患者胰岛素抵抗和IVF-ET助孕妊娠结局的关系研究

摘要 目的：探讨血清铁蛋白（SF）、抗苗勒管激素（AMH）、脂联素（APN）、核因子-κB（NF-κB）与肥胖型多囊卵巢综合征（PCOS）不孕患者胰岛素抵抗（IR）和体外受精-胚胎移植（IVF-ET）助孕妊娠结局的关系。方法：选取2019年1月～2021年1月广西医科大学第一附属医院收治的120例PCOS不孕症患者,根据体重指数（BMI）分为肥胖组（BMI≥28 kg/m²,79例）和非肥胖组（BMI＜28 kg/m²,41例）,肥胖组患者根据IVF-ET妊娠结局分为妊娠失败组47例和妊娠成功组32例。酶联免疫吸附法检测血清AMH、APN、NF-κB、SF水平,计算稳态模型胰岛素抵抗指数（HOMA-IR）,采用Pearson相关系数分析肥胖型PCOS不孕症患者血清AMH、APN、NF-κB、SF水平与HOMA-IR的相关性,采用多因素Logistic回归分析IVF-ET助孕妊娠结局的影响因素。结果：肥胖组血清AMH、NF-κB、SF水平和HOMA-IR高于非肥胖组,APN水平低于非肥胖组（P＜0.05）。Pearson相关性分析显示,肥胖型PCOS不孕症患者的HOMA-IR与血清AMH、NF-κB、SF水平呈正相关（r=0.663、0.734、0.687,均P＜0.05）,与APN水平呈负相关（r=-0.683,P＜0.05）。妊娠失败组黄体生成素（LH）、LH/促卵泡生成素（FSH）比值、HOMA-IR、血清AMH、NF-κB、SF水平均高于妊娠成功组,受精率、优胚率、FSH、APN水平均低于妊娠成功组（P＜0.05）。多因素Logistic回归分析显示,LH、LH/FSH、HOMA-IR、SF、AMH、NF-κB水平升高是肥胖型PCOS不孕症患者IVF-ET妊娠失败的危险因素,APN水平升高是IVF-ET妊娠失败的保护因素（P＜0.05）。结论：肥胖型PCOS不孕症患者血清AMH、NF-κB、SF水平升高,APN水平降低,且与IR和IVF-ET助孕妊娠结局有关。     

乌鲁木齐市及阿克苏地区早发性卵巢功能不全影响因素的多中心研究

摘要 目的：分析新疆乌鲁木齐市及阿克苏地区早发性卵巢功能不全（POI）影响因素。方法：选取2019年1月~2021年12月期间新疆典型地域分布代表的乌鲁木齐市及阿克苏地区不同等级医院妇科收治的POI患者确定为病例组,共计186例。同时选取同期来新疆典型地域分布代表的乌鲁木齐市及阿克苏地区不同等级医院进行体检的200例无POI健康育龄期妇女志愿者作为对照组。采用本次研究自制的调查量表搜集患者的一般资料,采用单因素及多因素Logistic回归分析POI的影响因素。结果：病例组血清基础卵泡刺激素（FSH）、促黄体生成素（LH）水平高于对照组、雌二醇（E2）水平低于对照组（P<0.05）。单因素的研究结果显示,对照组、病例组在民族、居住地、文化水平、是否经常锻炼/劳动、月经量、月经周期是否有规律、是否存在内分泌疾病、是否存在妇科疾病（除POI）、是否盆腔手术、月经天数、月经周期、Zung抑郁自评量表（SDS）得分方面具有统计学差异（P<0.05）。多因素Logistic回归分析结果显示,民族为汉族、学历为大学及以上、月经周期一直无规律、进行过盆腔手术、SDS得分偏高、月经量很少是POI发生的危险因素（P<0.05）,而经常锻炼/劳动是POI发生的保护因素（P<0.05）。结论：新疆乌鲁木齐市及阿克苏地区的POI患者体内性激素紊乱,且其POI的发生受到民族、学历、是否经常锻炼/劳动等多种因素的影响。     

硫酸镁联合拉贝洛尔对重度子痫前期患者凝血功能、氧化应激及血管内皮功能的影响

摘要 目的：探讨硫酸镁联合拉贝洛尔对重度子痫前期患者凝血功能、氧化应激及血管内皮功能的影响。方法：选择2020年1月~2022年9月期间来安徽医科大学附属巢湖医院就诊的重度子痫前期患者94例。采用随机数字表法将患者分为对照组（硫酸镁治疗,47例）和研究组（硫酸镁联合拉贝洛尔治疗,47例）。两组均于治疗前后观察收缩压（SBP）、舒张压（DBP）、24 h尿蛋白量（24hUP）、凝血功能、氧化应激及血管内皮功能的变化情况,同时观察两组用药安全性。结果：治疗后,研究组SBP、DBP、24hUP低于对照组（P<0.05）。治疗后,研究组内皮素-1（ET-1）低于对照组,一氧化氮（NO）高于对照组（P<0.05）。治疗后,研究组丙二醛（MDA）低于对照组,超氧化物歧化酶（SOD）高于对照组（P<0.05）。治疗后,研究组纤维蛋白原（Fg）、D-二聚体（D-D）低于对照组,凝血酶原时间（PT）、凝血活酶时间（APTT）高于对照组（P<0.05）。两组不良反应发生率对比无差异（P>0.05）。结论：拉贝洛尔联合硫酸镁治疗重度子痫前期患者,可减少24hUP,有效降低血压,改善凝血功能和血管内皮功能,减轻氧化应激损伤。     

多囊卵巢综合征不孕患者性激素水平与免疫失衡及胰岛素抵抗指数的关系研究

摘要 目的：探讨多囊卵巢综合征（PCOS）不孕患者性激素水平与免疫失衡及胰岛素抵抗指数的关系。方法：选取2019年1月～2021年12月于山东中医药大学附属医院就诊的88例PCOS不孕患者作为研究组,同期选取健康体检女性80例作为对照组。检测比较两组的性激素、Th1/Th2免疫相关指标以及稳态模型胰岛素抵抗指数（HOMA-IR）,采用Pearson相关系数分析PCOS不孕患者性激素与Th1/Th2、HOMA-IR的相关性。结果：研究组的血清黄体生成素（LH）、雌二醇（E₂）、睾酮（T）水平及LH/FSH比值均明显高于对照组,而促卵泡激素（FSH）水平低于对照组（P＜0.05）。研究组的外周血干扰素-γ（IFN-γ）水平、Th1细胞比例及Th1/Th2比值均明显高于对照组（P＜0.05）,而两组间白细胞介素-4（IL-4）水平和Th2细胞比例无显著差异（P＞0.05）。研究组的空腹血糖（FPG）、空腹胰岛素（FINS）水平及HOMA-IR均明显高于对照组（P＜0.05）。Pearson相关性分析结果显示,PCOS不孕患者的E₂、T水平、LH/FSH比值与Th1/Th2比值、HOMA-IR均呈正相关（P＜0.05）。结论：PCOS不孕患者存在胰岛素抵抗及免疫失衡,且胰岛素抵抗、免疫失衡与其性激素表达有关。     

Pollen,ovules, and pollination in pea: Success,failure, and resilience in heat

Field pea (Pisum sativum), a major grain legume crop, is autogamous and adapted to temperate climates. The objectives of this study were to investigate effects of high temperature stress on stamen chemical composition, anther dehiscence, pollen viability, pollen interactions with pistil and ovules, and ovule growth and viability. Two cultivars (“CDC Golden” and “CDC Sage”) were exposed to 24/18°C (day/night) continually or to 35/18°C for 4 or 7 days. Heat stress altered stamen chemical composition, with lipid composition of “CDC Sage” being more stable compared with “CDC Golden.” Heat stress reduced pollen viability and the proportion of ovules that received a pollen tube. After 4 days at 35°C, pollen viability in flower buds decreased in “CDC Golden,” but not in “CDC Sage.” After 7 days, partial to full failure of anthers to dehisce resulted in subnormal pollen loads on stigmas. Although growth (ovule size) of fertilized ovules was stimulated by 35°C, heat stress tended to decrease ovule viability. Pollen appears susceptible to stress, but not many grains are needed for successful fertilization. Ovule fertilization and embryos are less susceptible to heat, but further research is warranted to link the exact degree of resilience to stress intensity.     

Love, careers, and heights in France, 2001

Short men are less likely to be married or live in a permanent relationship than their taller counterparts. This pattern is not due to their social status. While blue-collar workers are shorter on average than managers, the effects of height on finding a mate are similar in the two social groups. Being tall is also economically advantageous for men. With identical educational attainment levels, tall men have better careers than short men as they are given greater supervisory responsibilities. In making a commitment, some women might take height into account as an anticipated indicator of future resources of the household. Choice of partner is also influenced by social norms--i.e., partners should be physically well-matched--which is more difficult for shorter men.     

Magnesium,calcium, copper,and zinc in meals

Meals of 12 diets were prepared from conventional foods with precautions against contamination by metallic elements because of epidemiologic associations between ischemic heart disease and the metabolism of magnesium, calcium, copper, and zinc. Magnesium, calcium, copper, and zinc were measured by atomic absorption spectrometry with satisfactory accuracy and precision. The mean daily amount of copper in the diets was less than the apparent adult requirement. Mean amounts of magnesium and zinc were close to apparent requirements; however, adults consuming amounts less than one standard deviation below these means may be depleting body stores and be at risk of pathology. Magnesium and copper were highly correlated (r=0.849,P=0.0001) in meals. This and other significant correlations probably will prevent the relationships of these elements to ischemic heart disease from being elucidated by epidemiology. Metabolic experiments will be necessary to differentiate among several hypotheses.     

Diet,intestinal morphology,and nitrogen assimilation efficiency in the damselfish,Stegastes lividus,in Guam

Synopsis Analysis of stomach contents of Stegastes lividus revealed a shift from omnivory in juveniles to herbivory in adults. Red algae, primarily Polysiphonia spp., Gelidiopsis intricata and Ceramium spp., formed the bulk of the diet in all size classes. Foraminifera and small crustaceans were of particular importance in the diet of juveniles. Net nitrogen assimilation efficiency of field-fed S. lividus was approximately 61%, and did not vary with fish size. The net assimilation efficiencies of fish fed on Enteromorpha in the laboratory ranged from size-class means of 36–79% for nitrogen and from 29–72% for total organic material, and increased from juveniles to adults. Apparently, juveniles compensate for a lower efficiency in assimilating plant food by including a higher percentage of animal material in their natural diets. The ratios of intestine length to standard length (IL/SL) and to intestine diameter (IL/ID) increased rapidly in juveniles and leveled off in adults. The retention time for ingested food items may only be about one-half as long in juveniles as in adults. The combination of observed IL/ID ratios and estimated retention times proved most valuable in the interpretation of ontogenetic changes in feeding habits and assimilation efficiency.     

Distribution of N,P, K,Ca, Mg,S, Zn,Fe, Mn and Cu in groundnut

Summary Concentration of N, P, K, Ca, Mg and S in summer groundnut crop was higher than in kharif while Zn, Fe, Mn and Cu contents were higher in summer crop. Kernel's N, P and Zn; Leaflet's Ca and Mn; Stem's K and Fe; Root's S and Cu and Petiole's Mg contents were highest. Shell's N, P, K, Mg, S, Zn and Cu; Kernel's Ca, Fe and Mn contents were the least. N, P, K, S, Zn and Cu concentrations decreased linearly as the crop grew. Ca, Mg, Fe and Mn concentrations did not display any distinct pattern. Ca concentration was positively correlated with pod yield in both the seasons.     

Correlations of calcium accumulations in arteries, veins, cartilages, ligaments, and bones in single humans

To show the relationships of calcium accumulation in the thoracic aorta to the other tissues, calcium contents were determined with a microwave-induced plasma-atomic emission spectrometer on arteries, veins, cartilages, ligaments, and bones. These tissues were resected from 18 individuals, consisting of 11 men and 7 women who died in the age range 59–91 yr. As thoracic and abdominal aortas are routinely used for radiographic examination of arterial calcification, they appear to be standard tissues of the calcium accumulation. The calcium accumulations were determined in the femoral artery, the superior and inferior venae cavae, the internal jugular vein, cartilages of the articular disk of the temporomandibular joint and the intervertebral disk, both the ligaments of the anterior cruciate ligament and the ligamentum capitis femoris, and the calcaneus, in contrast with the thoracic aorta. As calcium increased in the thoracic aorta, it increased in the femoral artery, the articular disk of the temporomandibular joint, the intervertebral disk, both ligaments of the anterior cruciate ligament, and the ligamentum capitis femoris, but it did not increase in veins, such as the superior and inferior venae cavae and the internal jugular vein. In contrast, it decreased in the calcaneus.