Wavefront Shaping for Fast Focusing Light through Scattering Media Based on Parallel Wavefront Optimization and Superpixel Method

When light travels in biological tissues,it undergoes multiple scattering and forms speckles,which seriousl.y restricts the penetration depth of optical imaging in biological tissues.With wavefront shaping method,by modulating the wavefront of incident light to compensate for the wavefront aberration,light focusing and scanning imaging through scattering media can be achieved.However,wavefront shaping must be accomplished within the speckle decorrelation time.Considering the short speckle decorrelation time of living tissues,the speed of wavefront shaping is rather essential We propose a new iterative optimization wavefront shaping method to improve the speed of wavefront shaping in which the existing parallel optimization wavefront shaping method is improved and is combined with the superpixel method.Compared with the traditional multi-frequency parallel optimization method,the modulation rate of our method is doubled.Moreover,we combine the high frame rate amplitude modulator,i.e.,the digital micromirror device(DMD),with the superpixel method to replace the traditional phase modulator(i.e.,spatial light modulator),which further increases the optimization speed.In our experiment,when the number of the optical modes is 400,light focusing is achieved with only 1000 DMD superpixel masks and the enhancement factor reaches 223.Our approach provides a new path for fast light focusing through wavefront shaping.     

Rapid measurement of transmission matrix with the sequential semi-definite programming method

This paper puts forward for the first time a combined transmission matrix(TM) method to measure the monochromatic TM of scattering media without a reference beam. This method can be named a sequential semi-definite programming method which combines the sequential algorithm and the semi-definite programming method. Firstly, each part of the TM is calculated respectively in proper sequence. Then every part of TM is combined to form a complete TM in accordance with a certain rule. The phase modulation of the incident light is achieved by using a high speed digital mirror device with the superpixel method. We have experimentally demonstrated that the incident light field is focused at the target through scattering media using the measured TM to optimize the wavefront of the incident light. Compared with the semidefinite programming method, our method takes less computational time and occupies less memory space. The sequential semi-definite programming method shows potential applications in imaging through biological tissues.     

High-contrast imaging based on wavefront shaping to improve low signal-to-noise ratio photoacoustic signals using superpixel method

Photoacoustic(PA) imaging has drawn tremendous research interest for various applications in biomedicine and experienced exponential growth over the past decade. Since the scattering effect of biological tissue on ultrasound is two-to three-orders magnitude weaker than that of light, photoacoustic imaging can effectively improve the imaging depth.However, as the depth of imaging further increases, the incident light is seriously affected by scattering that the generated photoacoustic signal is very weak and the signal-to-noise ratio(SNR) is quite low. Low SNR signals can reduce imaging quality and even cause imaging failure. In this paper, we proposed a new wavefront shaping and imaging method of low SNR photoacoustic signal using digital micromirror device(DMD) based superpixel method. We combined the superpixel method with DMD to modulate the phase and amplitude of the incident light, and the genetic algorithm(GA) was used as the wavefront shaping algorithm. The enhancement of the photoacoustic signal reached 10.46. Then we performed scanning imaging by moving the absorber with the translation stage. A clear image with contrast of 8.57 was obtained while imaging with original photoacoustic signals could not be achieved. The proposed method opens new perspectives for imaging with weak photoacoustic signals.     

四元裂解位相调制实现相干光通过散射介质聚焦

光在不均匀介质中传播会受到散射的干扰,在这些散射材料中,例如粉末、生物组织、亚波长颗粒对入射光多次散射使得出射光无法聚焦,从而在接收平面形成散斑.本文提出四元裂解位相调制方法对入射相干光场进行调制,使其通过散射介质聚焦.此方法利用入射光场全场调制,充分考虑光场单元之间的干涉作用,从整个空间光调制器的调制面开始,逐层进行四元裂解及位相优化.运用此方法在实验中实现了相干光的前向散射和后向散射有效聚焦,这为生物医学领域中通过散射介质成像提供了新的思路和方法.     

Scattering properties of an individual metallic nano-spheroid by the incident polarized light wave

The scattering properties of a metallic nano-spheroid under the illumination of different polarized light waves are investigated using 3D boundary element method. The influences of different geometrical sizes of the nano-spheroid and incident directions of the illuminating light wave on the scattering spectrum are studied for different incident polarized light waves. The results show that the metallic nano-spheroid has two intrinsic resonant modes, corresponding to different polarization states and resonant wavelengths. The scattering enhancement, the resonant wavelength, and the location of the enhanced optical field are strongly dependent on the polarization properties of the illuminating light waves, and they can be modulated by appropriately choosing the polarization directions of the incident light wave.     

Wide-field imaging through scattering media by scattered light fluorescence microscopy

To obtain images through scattering media, scattered light fluorescence (SLF) microscopy that utilizes the optical memory effect has been developed. However, the small field of view (FOV) of SLF microscopy limits its application. In this paper, we have introduced a re-modulation method to achieve wide-field imaging through scattering media by SLF microscopy. In the re-modulation method, to raster scan the focus across the object plane, the incident wavefront is re-modulated via a spatial light modulator (SLM) in the updated phase compensation calculated using the optimized iterative algorithm. Compared with the conventional optical memory effect method, the re-modulation method can greatly increase the FOV of a SLF microscope. With the phase compensation theoretically calculated, the process of updating the phase compensation of a high speed SLM is fast. The re-modulation method does not increase the imaging time. The re-modulation method is, therefore, expected to make SLF microscopy have much wider applications in biology, medicine and physiology.     

Polarization properties of single metallic nano-spheroid using 3-D boundary element method

The polarization properties of an individual metallic nano-spheroid illuminated by the linearly polarized light are studied based on 3-D boundary element method. The scattering cross sections and the local field enhancements are investigated in detail when the incident lights are with different polarization directions and wavelengths. The numerical results show that the polarization direction of the incident light can strongly influence the scattering spectrum and the enhanced field distribution of the metallic nano-spheroid. The incident light with polarization direction parallel or perpendicular to the major axis can inspire longitudinal or transversal local surface plasmons resonance modes, respectively. The electric field enhancement and distribution around the nano-spheroid can be conveniently tuned by carefully selecting the polarization direction and wavelength of the incident light.     

Frequency bandwidth of light focused through turbid media

We study the effect of frequency detuning on light focused through turbid media. By shaping the wavefront of the incident beam light is focused through an opaque scattering layer. When detuning the laser we observe a gradual decrease of the focus intensity, while the position, size,and shape of the focus remain the same within experimental accuracy. The frequency dependence of the focus intensity follows a measured speckle correlation function. We support our experimental findings with calculations based on transport theory. Our results imply wavefront shaping methods can be generalized to allow focusing of optical pulses in turbid media.     

Active spectral filtering through turbid media

We demonstrate controlled wavelength-dependent light focusing through turbid media using wavefront shaping. Due to the dispersion caused by multiple light scattering, light propagation through turbid media can be independently controlled between different wavelengths. Foci with various wavelengths can be generated by applying different optimized wavefronts to a highly scattering layer. Given the linearity of the transmission matrix, multiple foci with different wavelengths can also be simultaneously constructed.     

Controlling single-photon Fock-state propagation through opaque scattering media

The control of light scattering is essential in many quantum optical experiments. Wavefront shaping is a technique used for ultimate control over wave propagation through multiple-scattering media by adaptive manipulation of incident waves. We control the propagation of single-photon Fock states through opaque scattering media by spatial phase modulation of the incident wavefront. We enhance the probability that a single photon arrives in a target output mode with a factor 30. Our proof-of-principle experiment shows that the propagation of quantum light through multiple-scattering media can be controlled, with prospective applications in quantum communication and quantum cryptography.     

Recent advances in wavefront shaping techniques for biomedical applications

Due to the highly inhomogeneous distributions of refractive indexes, light propagation in complex media such as biological tissue experiences multiple light scattering events. The suppression and control of multiple light scattering events are investigated because they offer the possibility of optical focusing and imaging through biological tissues, and they may open new avenues for diagnosis and treatment of several human diseases. In order to provide insight into how new optical techniques can address the issues of multiple light scattering in biomedical applications, the recent progress in optical wavefront-shaping techniques is summarized.     

Photoacoustic-guided convergence of light through optically diffusive media

We demonstrate that laser beams can be converged toward a light-absorbing target through optically diffusive media by using photoacoustic-guided interferometric focusing. The convergence of light is achieved by shaping the wavefront of the incident light with a deformable mirror to maximize the photoacoustic signal, which is proportional to the scattered light intensity at the light absorber.     

微纳粒子光学散射分析

为实现利用光学方式对微纳尺度粒子性质的研究,探讨了亚微米线及亚微米球对光电磁波的散射效应.微纳米尺度粒子的光学散射,散射粒子尺寸与入射光波长尺寸可满足米氏(Mie)散射条件.利用Matlab数值模拟的方式,将分析结果以模拟图的形式清晰地展现出来.满足尺寸条件的层状粒子以及任意多个散射粒子存在时对电磁波的散射都可采用Mie散射分析方法,并且针对多粒子散射,分析了散射体位于不同位置时对散射造成的影响.通过分析光学散射光场相关的微分散射截面及近场散射电磁场分布,可得出散射光场随散射角度的变化趋势,以及散射光场受各类因素的影响,包括入射光偏振态、散射粒子尺寸、散射粒子结构及粒子构成层数、散射粒子数量等的影响,也包括一些隐含因素对散射光场的影响,如散射粒子与周围介质的相对折射率.本文的科学意义体现在:与入射光波长尺寸可比的亚微米尺度的粒子,可用作传感器,对于其位移的探测可通过光学方式来实现,而由于粒子本身特性对散射光的影响具有一定的参考价值,从而使通过光学方式对机械位移的读出具有更高准确度.研究结果对于光学方式探测亚微米线机械振动具有指导意义.     

Resonant enhancement of inelastic light scattering in strongly correlated materials

We use dynamical mean field theory to find an exact solution for inelastic light scattering in strongly correlated materials such as those near a quantum-critical metal-insulator transition. We evaluate the results for q=0 (Raman) scattering and find that resonant effects can be quite large, and yield a double resonance, a significant enhancement of nonresonant scattering peaks, a joint resonance of both peaks when the incident photon frequency is on the order of U, and the appearance of an isosbestic point in all symmetry channels for an intermediate range of incident photon frequencies.     

Highly enhanced surface plasmon resonance in a coupled silver nanodumbbell

Scattering field interactions and surface plasmon resonance in a coupled silver nanodumbbell (a pair of silver nanosphere connected by a silver nanobar) are simulated by using the three-dimensional finite-element method. The enhancement of scattering cross section which exhibits a blue-shifted is associated with the diameter of the silver nanobar and the wavelength of incident light. Interestingly, the generated optical cloud exceeds two times of the nanodumbbell size which can be turned by varying the diameter of the silver nanobar.     

Theory of Raman scattering in Europium-chalcogenides

The intensity of the spin assisted Raman scattering in the Eu-chalcogenides is calculated using the excited states which were used in the analysis of the optical absorption. Various mechanisms are examined for the Raman scattering. In these mechanisms, the cross effect of the 4f spin-orbit interaction and the exciton-phonon interaction is found to be the most important for the scattering intensity. The characteristics of the Raman scattering from this mechanism are as follows: When the frequency of the incident light is in the tail region of the absorption peak, the polarization of the scattered light is perpendicular to that of the incident light; when the light in the middle region of the absorption peak is applied, the polarization of the incident light is depolarized in the scattered light; the scattering intensity decreases when the spin fluctuation is suppressed by an application of magnetic field or by lowering temperature through the Curie temperature. These characteristics in the Raman scattering have been observed in the experiments.     

Focusing coherent light through opaque strongly scattering media

We report focusing of coherent light through opaque scattering materials by control of the incident wavefront. The multiply scattered light forms a focus with a brightness that is up to a factor of 1000 higher than the brightness of the normal diffuse transmission.     

偏振相移与相位共轭结合的散射光聚焦技术研究

散射介质对光的随机散射作用是制约其光学聚焦和成像的重要因素，光学相位共轭技术能够通过对散射光场共轭还原实现透过散射介质的光学聚焦和成像，其中散射光场相位的获取是共轭还原的核心。阐述了偏振相移的基本原理，将偏振相移与相位共轭技术相结合，设计了新的基于偏振相移的数字光学相位共轭系统。采用633 nm的HeNe激光器作为系统光源，毛玻璃作为散射介质开展散射光聚焦实验研究。实验结果表明:该装置能够成功实现透过散射介质的光学聚焦，其中聚焦点与背景光强的比值可达约400倍。     

Longitudinal intensity distribution near the focus produced by light through scattering media

Speckle pattern is formed when coherent light passes through scattering media. It has been demonstrated that after appropriately optimizing the phase of the incident light, a bright focal spot in the target point can be obtained for the case that the light passes through the scattering medium. However, until now the focused intensity distribution near the focus seems unclear. In this paper we experimentally investigate some factors influencing the longitudinal intensity distribution near the focus in details. It is shown that the desired longitudinal focused intensity distribution can be obtained by optimizing the incident light. The results may have potential applications in particle manipulation and laser processing, etc.     

镍纳米球腔阵列上吸附分子拉曼散射的表面增强效应

通过聚苯乙烯纳米球为模板制备了规则排列的镍纳米球腔阵列。研究结果表明吸附于镍纳米球腔内的对巯基苯胺的拉曼散射可被极大增强。拉曼散射的表面增强被归因于纳米球腔阵列的协同表面等离子体共振与光的耦合导致的电磁场增强以及纳米球腔结构对电磁场的聚焦效应而使球腔内电磁场能量密度的增大。