共查询到20条相似文献，搜索用时 46 毫秒
1.
Michel Guillon Cécile Maissa Stéphanie Wong Trisha Patel Renée Garofalo 《Contact lens & anterior eye》2018,41(4):362-368
Purpose
To compare the effects of a hydrogen peroxide (H2O2)-based lens care solution and a polyhexamethylene biguanide (PHMB) multi-purpose solution on the eyelids when used with silicone hydrogel (SiHy) contact lenses.Methods
A total of 74 symptomatic wearers of ACUVUE® OASYS® (senofilcon A; n?=?39) or PureVision® (balafilcon A; n?=?35) contact lenses were randomised 1:1 to either CLEAR CARE® Cleaning & Disinfecting Solution or renu® fresh? multi-purpose solution (n?=?37 each). Assessments of hyperaemia, papillae and lid margin staining of eyelid tissue were evaluated subjectively by a masked investigator at enrolment (with the subjects’ habitual SiHy contact lenses and PHMB-preserved care systems), at dispensing visit (when no lenses were worn) and at 3-months’ follow-up.Results
There were no differences in eyelid assessments between the two lens care groups at dispensing visit (p?=?0.086 to 0.947). After 3 months, the papillae response was significantly less marked with H2O2-based solution than with PHMB-based solution (p?=?0.017). Lid hyperaemia (p?<?0.001) and papillae (p?=?0.002) were also significantly reduced. Although lid hyperaemia was also reduced with PHMB-based solution (p?<?0.001), there was no concurrent decrease in papillae response (p?=?0.051). No improvements were found in eyelid margin staining either over time or between the two lens care groups.Conclusion
In symptomatic contact lens wearers, a H2O2-based lens care solution used with senofilcon A and balafilcon A lenses was better tolerated by eyelid tissues than was a PHMB-based solution and led to a decrease in clinical markers of eyelid inflammation. 相似文献2.
Negar Babaei Omali Lakshman N. Subbaraman Miriam Heynen Alan Ng Chantal Coles-Brennan Zohra Fadli Lyndon Jones 《Contact lens & anterior eye》2018,41(4):329-334
Purpose
To determine and compare the levels of surface versus bulk active lysozyme deposited on several commercially available hydrogel contact lens materials.Methods
Hydrogel contact lens materials [polymacon, omafilcon A, nelfilcon A, nesofilcon A, ocufilcon and etafilcon A with polyvinylpyrrolidone (PVP)] were incubated in an artificial tear solution for 16?h. Total activity was determined using a standard turbidity assay. The surface activity of the deposited lysozyme was determined using a modified turbidity assay. The amount of active lysozyme present within the bulk of the lens material was calculated by determining the difference between the total and surface active lysozyme.Results
The etafilcon A materials showed the highest amount of total lysozyme activity (519?±?8?μg/lens, average of Moist and Define), followed by the ocufilcon material (200?±?5?μg/lens) and these two were significantly different from each other (p?<?0.05). The amount of surface active lysozyme on etafilcon and ocufilcon lens materials was significantly higher than that found on all other lenses (p?<?0.05). There was no active lysozyme quantified in the bulk of the nelfilcon material, as all of the active lysozyme was found on the surface (1.7?±?0.3?μg/lens). In contrast, no active lysozyme was quantified on the surface of polymacon, with all of the active lysozyme found in the bulk of the lens material (0.6?±?0.6?μg/lens).Conclusions
The surface and bulk activity of lysozyme deposited on contact lenses is material dependent. Lysozyme deposited on ionic, high water content lens materials such as etafilcon A show significantly higher surface and bulk activity than many other hydrogel lens materials. 相似文献3.
Purpose
To evaluate the tolerability of and subject and investigator satisfaction with delefilcon A (DAILIES TOTAL1®) daily disposable contact lenses in first-time contact lens wearers.Methods
This European multicenter, open-label, single-arm, two-week trial enrolled first-time contact lens wearers and fitted them with delefilcon A contact lenses. Assessments were made at dispensing and at Weeks 1 and 2. Subject-reported outcomes included comfort, quality of vision, convenience, and intent to purchase, which were ranked by agreement responses. Investigator-reported outcomes included slit-lamp biomicroscopy findings and lens fit satisfaction.Results
Ninety-two subjects were included in the per protocol dataset. Mean scores at Weeks 1 and 2 for subject-reported quality of vision and ocular comfort were significantly higher with delefilcon A contact lenses than with the subjects’ habitual spectacles during the day, at the end of the day, and overall (all p?≤?0.02). Ninety-one percent of subjects reported that their study lenses were more comfortable than expected, 98% agreed that they were convenient to use, and 92% were interested in purchasing the lenses (all p?<?0.001). Investigators reported that study lenses had an acceptable fit in at least 97% of subjects.Conclusions
Practitioners can expect favorable outcomes when transitioning first-time contact lens wearers from spectacles to delefilcon A daily disposable contact lenses. 相似文献4.
The effect of rebamipide ophthalmic suspension on ocular surface mucins in soft contact lens wearers
Chika Shigeyasu Masakazu Yamada Yoko Akune Masaki Fukui 《Contact lens & anterior eye》2018,41(4):357-361
Purpose
To evaluate the changes in ocular surface mucins with 2%rebamipide ophthalmic suspension treatment in soft contact lens (SCL) wearers. Rebamipide suspension is a mucin secretagogue approved for the treatment of dry eye syndrome in Japan. In this study, the fluorescence intensity of wheat germ agglutinin conjugate of fluorescein (F-WGA) was used as a marker of membrane-associated mucins, and sialic acid concentration in tear fluids as a marker of secreted mucins.Methods
Thirty-two eyes of 16 SCL wearers with discomfort were treated with rebamipide suspension at a dose of one drop in each eye four times daily for two weeks. The parameters of clinical efficacy were tear break-up time, fluorescein staining scores for the cornea and conjunctiva, and Schirmer test values. Fluorescence intensities in the central cornea were measured by fluorophotometry after the application of 5% F-WGA solution. Tears collected by Schirmer test strips were analyzed by high-performance liquid chromatography, and the concentrations of sialic acid, total protein, and the four major tear proteins, namely secretory IgA, lactoferrin, lipocalin-1, and lysozyme were measured.Results
Significant increases in F-WGA fluorescence intensities (p?<?0.005) were seen in the corneal surfaces. Sialic acid concentrations increased over time; however, the differences were not statistically significant. Except for a slight increase in kerato-conjunctival staining scores (p?<?0.05) and secretory IgA (p?<?0.05), no other significant differences were seen among clinical parameters or tear proteins.Conclusions
Topical application of rebamipide suspension significantly increased F-WGA intensity, a marker of membrane-associated mucins in SCL wearers. 相似文献5.
Michael T.M. Wang Kalaivarny Ganesalingam Chee Seang Loh Trisha Alberquerque Suhaila Al-Kanani Stuti L. Misra Jennifer P. Craig 《Contact lens & anterior eye》2017,40(1):53-58
Purpose
To assess the effects of two weeks of regular phospholipid liposomal spray application on lipid layer grade, tear film stability, subjective comfort, visual acuity, and lipid deposition in silicone hydrogel contact lens wearers.Methods
Thirty-one existing contact lens wearers were enrolled and fitted with two week planned replacement silicone hydrogel contact lenses (Acuvue® Oasys®) in a prospective, randomized, paired-eye, investigator-masked trial. A phospholipid liposomal spray (Tears Again®) was applied to one eye (randomized) four times daily for two weeks. LogMAR high contrast visual acuity (VA), low contrast glare acuity (LCGA), non-invasive tear film break-up time (NIBUT), and lipid layer grade (LLG) were measured at baseline and day 14, in both treated and control eyes. Subjective comfort relative to baseline, and spectrofluorophotometric assessment of contact lens surface lipid deposition were also assessed on day 14.Results
All measurements did not differ at baseline between treated and control eyes. Lipid layer thickness and tear film stability were increased on day 14 in treated eyes (all p < 0.05), but not in control eyes (all p > 0.05). A greater proportion of participants reported improved comfort in the treated eye relative to the control eye (p = 0.002). There were no significant differences in visual acuity or in contact lens surface lipid deposition, between treated and control eyes, on day 14 (all p > 0.05).Conclusion
The phospholipid liposomal spray increased tear film stability, lipid layer thickness and subjective comfort in silicone hydrogel contact lens wearers, without adversely affecting visual acuity or contact lens surface lipid deposition. 相似文献6.
Motohiro Itoi Motozumi Itoi Nathan Efron Philip Morgan Craig Woods 《Contact lens & anterior eye》2018,41(4):369-376
Purpose
To review contact lens prescribing trends in Japan between 2003 and 2016.Methods
An annual survey of contact lens prescribing trends was conducted each year between 2003 and 2016. Japanese ophthalmologists were asked to provide information relating to ten consecutive contact lens fittings between January and March every year.Results
Over the 14 years of the annual survey, data from a total of 64,122 contact lens fits were returned by ophthalmologists. The mean age (±SD) of lens wearers was 30?±?13?years, and 68% were female. The proportion of rigid lens fits decreased over time, from 35.4% in 2003 to 14.7% in 2016. Across this period, daily disposable lens fits increased, representing 46% in 2016. The proportion of toric lenses and multifocal lenses gradually increased, from 6.6% and 1.9% to 12.3% and 5.8%, respectively. Silicone hydrogel material use grew from 0% to 43.2%, while mid and low water content lens materials declined from 54.1% and 28.2% to 36.1% and 8.3%, respectively. Multi-purpose lens care solutions dominated the market over the 14?year survey period.Conclusions
This survey has revealed prescribing trends and preferences in Japan over the past 14 years, with the main changes observed being a decrease in rigid lens use and an increase in the use of silicone hydrogel materials and daily disposable lenses. 相似文献7.
Duygu Acar Irene Teresa Molina-Martínez Miguel Gómez-Ballesteros Manuel Guzmán-Navarro José Manuel Benítez-del-Castillo Rocío Herrero-Vanrell 《Contact lens & anterior eye》2018,41(1):93-96
Purpose
Artificial tears are widely used in the treatment of dry eye disease, although current formulations do not closely resemble natural tears. The purpose of this study was the design and characterization of a novel in situ gelling artificial tear formulation, containing both lipid and aqueous components, in order to resemble natural tears and replenish the tear film.Methods
Liposomes, containing phosphatidylcholine, cholesterol, vitamins A and E, were prepared by the thin-film hydration method. The aqueous phase of the formulation was comprised of gellan gum, hydroxypropyl methylcellulose, levocarnitine, electrolytes (sodium chloride and potassium chloride), trehalose, and borates. The artificial tear was characterized in terms of liposome size, pH, surface tension, and viscosity. In vitro tolerance studies were performed in a human epithelial carcinoma cell line (HeLa) and a murine macrophage cell line (J774). In vivo tolerance was assessed in rabbits.Results
Liposomes presented a unimodal distribution with a mean size of 200.1?±?4.4?nm. The resulting surface tension was 53.4?±?1.1?mN/m (at 33?°C) and the pH was 7.6?±?0.1. The viscosity of the formulation presented a mean value of 4.0?±?0.1?mPa?s within the shear rate interval of 200–1000?s?1 at 33?°C. Cell viability remained higher than 90% in both cell lines. No discomfort or clinical signs were observed in rabbits.Conclusions
The liposome-based and in situ gelling artificial tear formulation presented good tolerance and suitable properties for topical ophthalmic administration. It may be beneficial in the treatment of dry eye disease. 相似文献8.
Daniel Wong Julie M. Albietz Huan Tran Cimonette Du Toit Anita Hui Li Tina Yun Jee Han Katrina L. Schmid 《Contact lens & anterior eye》2017,40(6):389-393
Aim
Contact lens induced dry eye affects approximately 50% of contact lens wearers. The aim was to assess the effects of Manuka (Leptospermum sp.) honey eye drops (Optimel, Melcare, Australia) on dry eye in contact lens wearers. The safety of the honey eye drops in contact lens wear and contact lens wearers’ compliance were also evaluated.Design
Prospective, randomised, cross over study, examiner masked, pilot treatment trial.Methods
Twenty-four participants aged 20 to 55 years with contact lens related dry eye were recruited and randomised to two treatment groups; 20 completed the study. One group used Optimel eye drops twice a day for two weeks followed by conventional lubricant (Systane Ultra, Alcon) therapy for two weeks; the other group completed the treatments in the reverse order. Before and after each treatment dry eye symptomology, ocular surface inflammation, and tear quantity and quality were assessed. Participants completed a daily log detailing their usage of treatments and any issues.Results
Dry eye symptoms improved significantly after Optimel treatment. Patients with more severe symptoms at baseline showed a greater improvement in symptoms. No significant differences were observed in the objective signs of dry eye; presumably because of the short treatment duration. Seventy-five% of contact lens wearers reported good adherence to Optimel treatment and 95% reported no issues using this product.Conclusions
Optimel Eye Drops reduce the symptoms of dry eye in contact lens wearers and are safe to use. A longer treatment period to assess the effect on clinical signs of dry eye is required. 相似文献9.
10.
Purpose
Contact lens discomfort remains poorly understood, not least due to lack of associations between clinical signs and symptoms. This study aimed to explore the relationships between osmolarity, comfort and lid wiper epitheliopathy in contact lens wear.Methods
Twenty subjects participated in a randomized, cross-over study where comfilcon A and lotrafilcon A lenses were each worn for 10 days separated by a 7 days washout period. Tear and contact lens osmolarity, ocular symptoms including comfort, tear stability and production, and lid wiper epitheliopathy were measured.Results
Comfort and tear stability decreased and upper lid wiper staining and foreign body sensation increased with lens wear. These were not affected by lens type. A reduction in tear production was seen after 10 days of comfilcon A lens wear. High proportions of lid wiper epitheliopathy were observed at the upper (range 65%–85%) and lower (range 90%–100%) lid margins. Tear and contact lens osmolarity were unaffected by lens wear or type. Contact lens osmolarity was associated with comfort (r = 0.45, p = 0.009). Tear osmolarity moderately correlated with tear stability (r = ?0.53, p = 0.014) and tear production (r = ?0.44, p = 0.012) but not with lid wiper staining.Conclusions
A relationship between comfort and contact lens osmolarity and between tear osmolarity and tear stability and production were found, however, this study was unable to demonstrate an association between comfort and tear osmolarity or lid wiper epitheliopathy. Further studies using contact lenses with a wider range of comfort responses are warranted to investigate these associations further. 相似文献11.
Juan Carlos Montalt Esteban Porcar Enrique España-Gregori Cristina Peris-Martínez 《Contact lens & anterior eye》2018,41(4):351-356
Purpose
To assess the visual quality achieved by fitting corneo-scleral contact lenses (CScL) for keratoconus management.Methods
Thirty patients with keratoconus presented to have CScL fitted because of the unsatisfactory visual quality they experienced with their contact lenses or spectacles. The eye examination included visual acuity assessment, anterior eye biomicroscopy, ocular fundus examination, corneal topographic analysis, endothelial-cell count, contrast sensitivity and aberrometry. The fitting process was performed using a diagnostic trial set. Subjective visual quality and comfort, and contact lens wear time were also reported. Patients were monitored for one year.Results
Three patients discontinued CScL wear before one year. Therefore, 27 eyes of 27 patients (19 male and 8 female) participated in this study. The mean age was 36.1?±?13.1 (mean?±?SD)?years. Statistically significant differences were found in logMAR visual acuity between the best spectacle-corrected vision and after CScL fitting (mean?±?SD, 0.23?±?0.30 and 0.00?±?0.14, respectively; p?<?0.001). The total high-order aberrations decreased significantly (55%), and the spatial frequencies of contrast sensitivity all improved to normal range values of the population. Furthermore, high subjective visual quality and comfort ratings, and prolonged usage times (mean?±?SD, 13.44?±?2.38?h a day) were reported. No adverse ocular effects or clinically relevant changes in corneal parameters, visual quality, comfort or usage time were found one year after wearing CScL.Conclusion
This CScL seems to be safe and healthy, providing optimal visual quality, comfort and prolonged usage times in patients with keratoconus. 相似文献12.
Qiurong Zhu Bi Yang Nan Deng Yifan Li Tingwei Wang Huang Qi Longqian Liu 《Contact lens & anterior eye》2018,41(2):229-233
Purpose
To assess the prevalence and general knowledge of contact lens wearers among college students in Chengdu, a metroplolitan of Chinaand find out the routine habits of use and hygienic conditions when wearing contact lenses.Method
The questionnaire was distributed to 1,600 ametropic participants who were from 8 different universities. Data about demographics, general contact lens handling habits, personal attitudes, hygiene behaviors and eye health conditions were collected. We made the analysis ofthe demographics and wearing of contact lenses. Possible reasons for behaviors related to the care of contact lenses were analyzed.Results
The prevalence of contact lens use was 19.80%. Most users (82.15%) were females. An aesthetic effect was cited as the first reason for using (57.91%). The comfort of eyes was the first consideration (75.76%) when buying. To keep clean and use safe, 86.20% subjects washed hands before handling and 83.50% cleaned the lens carefully after removing. There was significant difference between males and females regarding the replacement of the solution (p = 0.014). 32.66% wears knew the removal of protein deposits. A total of 54.88% were not informed of the potential complications of contact lens. The incidence of ocular discomfort was 44.78%. Only 3.03% of the students paid regular visits to ophthalmic clinics.Conclusion
The prevalence of contact lenses was relatively low in Chengdu. The wears had limited knowledge about using and careof contact lens. More education on standard lens wear and care should be provided to wearers. 相似文献13.
Samuel Abokyi George Manuh Heinz Otchere Alex Ilechie 《Contact lens & anterior eye》2017,40(5):329-334
Background
Despite findings that contact lens wear for vision correction provides better quality of life than spectacles, contact lens use in developing countries is low. This study evaluated knowledge, usage and barriers associated with contact lens wear among spectacle wearers in Cape Coast, Ghana.Method
A cross-sectional survey using a structured questionnaire was conducted on an adult population of spectacle wearers to assess their knowledge of contact lens wear for vision correction. The participants were proportionately sampled from three eye clinics in the Cape Coast Metropolis, Ghana. Questionnaires were either self-administered or completed with the help of a research assistant.Results
Of the 422 participants, only 147 (34.8%) knew of contact lens wear for vision correction. The proportion of spectacle wearers reporting history of contact lens wear was 14 (3.3%). Barriers to contact lens wear reported were satisfaction with vision through spectacles 102 (25.0%), lack of adequate information 111 (27.2%), fear of side effects 94 (23.0%) and cost 78 (19.1%). The younger adults and those with higher number of changes of spectacles were more likely to know of contact lenses.Conclusion
Knowledge and usage of contact lenses among spectacle wearers was low. Contact lens education and demonstration of visual performance through fitting of trial contact lenses on potential candidates may help overcome barriers to contact lens wear. 相似文献14.
Purpose
To compare the clinical performance of large diameter lenses with optimally fit lenses in the same material and monocurve back surface design.Method
In a four-visit, randomised, bilateral, crossover, study, 25 myopic subjects wore optimum diameter lenses (control) and large diameter lenses (test) in random succession for 1 week each. Both study lenses were made of methafilcon A and of an identical design. Trial fittings with Frequency 55 (Coopervision) lenses modified with a design algorithm were used to determine the appropriate custom-made study lenses.Results
The least squares mean scores (±SE) for overall comfort and end-of-day comfort (0–10 scale) were 7.57?±?0.33 vs. 7.42?±?0.33 (P?=?0.59) and 7.00?±?0.31 vs. 7.27?±?0.32 (P?>?0.05) for the optimum and large diameter lenses, respectively. There were no significant differences in mean (±SE) gradings for limbal hyperaemia (1.23?±?0.11 vs. 1.19?±?0.11, 0–4 scale, P?=?0.60) and corneal staining (1.79?±?0.25 vs. 2.04?±?0.25, P?=?0.39). Conjunctival staining was greater for the optimum lens: 1.80?±?0.28 vs. 0.93?±?0.28 (0–4 scale, P?=?0.001). With regard to lens fit, the large diameter lenses showed significantly less post-blink movement (0.22?±?0.01 vs. 0.16?±?0.01?mm, P?=?0.004), and greater total decentration (0.15?±?0.02 vs. 0.21?±?0.02?mm, P?=?0.010). However, there was no significant difference in the key fit variable of tightness on push-up (46?±?0.69% vs. 48?±?0.69%, 0–100 scale, P?=?0.12).Discussion
The findings suggest that larger than optimal soft lenses may be worn without detriment to either comfort or ocular physiology, provided an optimal fit is otherwise maintained. 相似文献15.
Purpose
The aim of this work was to investigate the locus and extent of vitronectin (Vn) deposition on ex vivo contact lenses and to determine the influence of wear modality together with surface and bulk characteristics of the lens material.Methods
The quantity and location of Vn deposition on the surfaces of contact lens materials was investigated using a novel on-lens cell attachment assay technique.Results
Vn mapping showed that deposition resulted from lens-corneal interaction rather than solely from the tear film. Higher cell counts on the posterior surface of the lenses were determined in comparison to the anterior surface. Overall gross Vn deposition was greater for high water content-low modulus materials (117 ± 4 average cell count per field) than low water content-high modulus materials (88 ± 6 average cell count per field).Conclusions
The role of Vn in plasmin regulation and upregulation is widely recognised. The findings in this paper suggest that the locus of Vn on the contact lens surface, which is affected by material properties such as modulus, is potentially an important factor in the generation of plasmin in the posterior tear film. Consequently, the potential for materials to affect Vn deposition will influence lens-induced inflammatory processes. 相似文献16.
Clara Llorens-Quintana Maryam Mousavi Dorota Szczesna-Iskander D. Robert Iskander 《Contact lens & anterior eye》2018,41(1):18-22
Purpose
To evaluate the effect of two types of daily contact lenses (delefilcon A and omafilcon A) on the tear film and establish whether it is dependent on pre-corneal tear film characteristics using a new method to analyse high-speed videokeratoscopy recordings, as well as to determine the sensitivity of the method in differentiating between contact lens materials on eye.Methods
High-speed videokeratoscopy recordings were analysed using a custom made automated algorithm based on a fractal dimension approach that provides a set of parameters directly related to tear film stability. Fifty-four subjects participated in the study. Baseline measurements, in suppressed and natural blinking conditions, were taken before subjects were fitted with two different daily contact lenses and after four hours of contact lens wear.Results
The method for analysing the stability of the tear film provides alternative parameters to the non-invasive break up time to assess the quality of the pre-corneal and pre-lens tear film. Both contact lenses significantly decreased the quality of the tear film in suppressed and natural blinking conditions (p<0.001). The utilised method was able to distinguish between contact lens materials on eye in suppressed blinking conditions. The pre-corneal tear film characteristics were not correlated with the decrease in pre-lens tear film quality.Conclusion
High-speed videokeratoscopy equipped with an automated method to analyse the dynamics of the tear film is able to distinguish between contact lens materials in vivo. Incorporating the assessment of pre-lens tear film to the clinical practice could aid improving contact lens fitting and understand contact lens comfort. 相似文献17.
Maria Vidal-Rohr James S. Wolffsohn Leon N. Davies Alejandro Cerviño 《Contact lens & anterior eye》2018,41(1):117-121
Aim
Retrospective analysis of different contact lens wearing groups suggests lens surface lubricity is the main factor influencing contact lens comfort. However, the examined commercially available contact lenses differ in material and design as well as surface properties. Hence this study isolates the contribution of lens surface properties using an ultra-thin coating technology.Methods
Nineteen habitual contact lens wearers (21.6 ± 1.7years) wore formofilcon B soft monthly disposable contact lenses with and without coating technology modified surface properties for a month each in a randomised double-masked cross-over study.Objective non-invasive
breakup time (NIKBUT), NIKBUT average and ocular redness (Jenvis grading scale) were evaluated (Keratograph 5M) after 1 week and 1 month of wear. Symptoms were assessed using the Contact Lens Dry Eye Questionnaire (CLDEQ-8); perceived vision quality and subjective lens comfort at insertion, mid-day and end of the day were rated with four Visual Analog Scales.Results
Perceived visual quality (F = 5.049,p = 0.037), contact lens dry eye symptoms (F = 14.408,p = 0.001) and subjective lens comfort (F = 28.447,p < 0.001) were better for coated compared to uncoated lenses. The surface coating postponed the lens dewetting (F = 8.518,p = 0.009) and increased the pre-lens tear film stability (F = 5.626,p = 0.029), but bulbar (F = 0.340,p = 0.567) and limbal (F = 0.110,p = 0.744) redness were similar for both contact lenses. No parameter changed significantly between a weeks’ and months’ wear (p > 0.05). Lens surface wettability and ocular redness were not correlated to changes in symptoms (p > 0.05).Conclusion
As previously hypothesised, enhancing the physical surface properties of a soft contact lens improves subjectively rated wearer comfort, which, in turn, should result in reduced contact lens discontinuation. 相似文献18.
Zhi Chen Jiaqi Zhou Xiaomei Qu Xingtao Zhou Feng Xue 《Contact lens & anterior eye》2018,41(3):263-266
Purpose
To investigate the effect of orthokeratology (ortho-k) lens wear on axial length (AL) growth in juvenile myopic anisometropes.Methods
This retrospective study consisted of two parts. In Part One, 25 anisometropic participants (mean age, 11.2?±?1.9?years; 11 females and 14 males) were fitted with ortho-k lenses in the more myopic eye only, and the rate of AL growth was compared between the ortho-k lens wearing eye and the untreated contralateral eye over an average period of 23.1?±?8.3?months. In Part Two, 8 participants who developed myopia in the contralateral eye received ortho-k treatment in both eyes for an average of 12 months; the rate of AL growth before and after ortho-k treatment in the newly developed myopic eye was compared.Results
In Part One, the rate of AL elongation in the ortho-k treated eye (0.08?±?0.15?mm/year) was significantly slower than in the contralateral eye (0.39?±?0.32?mm/year) (P?<?0.001). At the completion of Part One, 16 out of 25 participants (64%) developed myopia in the initially non-myopic eye. In Part Two, the rate of AL elongation after ortho-k treatment in the newly developed myopic eye (0.20?mm/year) was significantly slower than that before ortho-k treatment in the same eye (0.49?mm/year) (P?=?0.012).Conclusion
Ortho-k treatment slows AL growth in the more myopic eye of anisometropic patients; should the contralateral eye develop myopia in the future, ortho-k is capable of slowing down AL growth in that eye as well. 相似文献19.
Preeji S. Mandathara Fiona J. Stapleton Jim Kokkinakis Mark D.P. Willcox 《Contact lens & anterior eye》2018,41(2):219-223
Purpose
To report the density and morphology of cells that are analogous to corneal Langerhans cells and their associations in keratoconus.Materials and methods
This prospective cross-sectional study included a convenience sample of keratoconus subjects aged between 18-65 years. Corneal topography, assessment of ocular symptoms, tear variables, corneal sensitivity, in-vivo confocal microscopy were performed. The number of Langerhans cells were manually counted and averaged across three central corneal images. Cell morphology was graded on a 0-3 scale, where grade 3 indicates cells with long visible dendrites. Associations of Langerhans cells with other variables were evaluated using Spearman’s correlation.Results
Twenty-one keratoconus subjects with a mean age of 43 ± 11 years were included. Eighty-one percent of them were males, 48% had mild keratoconus and 52% were contact lens wearers. Langerhans cells were present in the central cornea in 91% of subjects. Median cell density was 15 cells/mm2(IQR: 3-21). Cell morphology of grades 2 or 3 (with short or long dendrites) was seen in 71% of subjects. There was a significant association between Langerhans cell frequency and density with male gender (rho and p-values: -0.669, 0.001 and -0.441,0.045) and between Langerhans cell density and nerve fibre tortuosity (0.479,0.028). No significant association observed with age, contact lens wear or ocular symptoms.Conclusion
Langerhans cells were present in a significant number of subjects suggesting the possibility of inflammation in keratoconus. Based on the association of Langerhans cells with nerve parameters, we propose inflammation as the underlying cause for corneal nerve changes in keratoconus. 相似文献20.
