基于声表面波技术实现纸基微流开关研究

提出了采用声表面波技术实现纸基微流开关的方法。它由127.68°旋转Y切割X传播方向的LiNbO3压电基片和两个有一定间隙的纸微通道组成。压电基片上采用微电子工艺制作1个中心频率为27.5MHz的叉指换能器和1个反射栅,纸微流通道采用PDMS薄膜贴附于压电基片的声传播路径上,微流通道一侧微流体在没有声表面波作用时,微流...     

微通道导引下数字微流体快速混合

微流体混合是微流控芯片急需完善的重要操作单元,提出了在声表面波驱动下实现微通道内数字微流体快速混合方法.在1280YX-LiNbO3基片上设计相互垂直排列的两叉指换能器和反射栅,并在其声传播路径上制作微通道且进行疏水处理以防止微流体偏离运动方向,待混合的数字微流体移液于微通道中,分别在两叉指换能器上分时加RF电信号激发相互垂直声表面波,以驱动微通道中微流体输运、合并及快速混合.输运实验结果表明微流体在没有微通道时运动发生严重偏离声传播方向;混合实验表明:相比于自由扩散混合,声表面波作用极大地提高微通道中微流体混合速度且混合程度更高.     

一种新的纸基微流开关及其活跃方法

提出了一种新的、基于声表面波的纸基微流开关。通过软光刻技术制作内含两个微孔的聚二甲基硅氧烷(PDMS)微架,其上固定经折叠、长度可变的纸通道。PDMS微架贴附于压电基片之上,并在待连接的两微通道之下方,折叠纸通道最低端离压电基片间距为2 mm。压电基片上采用微电子工艺光刻一对叉指换能器和反射栅。当足够强度的电信号加到叉指换能器对时,激发两相向声表面波,使得压电基片上微流体输运到折叠纸通道,改变其长度,连接其上待连通的两纸基微通道,完成开关功能。对可编程微流器件提供了一种新的编程和开关控制方法。     

基于声表面波技术数字微流体基片间输运研究

复杂的生化分析系统往往很难集成于一个微流基片中,而按功能分别集成于两个或多个基片,为此,需要实现质荷在两基片间输运.提出了采用声表面波技术实现数字微流体在压电基片和玻璃基片间输运的新方法,它在128°YX-LiNbO3基片上光刻一个叉指换能器和一个反射栅,经功率放大器放大后频率为27.5 MHz的RF信号加到叉指换能器上,它激发的声表面波驱动其声路径上的数字微流体,使其按声传播方向快速运动,并到达与其相连接且经疏水处理的弧形聚合物表面,数字微流体由于自身重力克服表面张力作用沿弧形聚合物表面滑落到玻璃基片,实现两基片间输运.实验结果表明弧形聚合物曲率半径和微流体体积的大小影响其在两基片间输运.同时,提出了较小体积的微流体采用不相溶的油作为辅助微流体实现目标数字微流体在两基片间输运.     

声表面波为能量源的微通道关闭研究

为控制微通道内微流体流向,提出了一种声表面波关闭微通道方法。在128°旋转Y切割X传播方向的LiNbO3压电基片上制作中心频率为27.5 MHz的叉指换能器,其激发的声表面波熔融聚二甲基硅氧烷微槽内固体石蜡,熔融后的石蜡由于毛细作用力沿微通道输运。当移去激发声表面波的电信号后,熔融石蜡固化并阻塞微通道,实现微通道关闭。以红色染料溶液为实验对象,对微通道进行关闭操作。结果表明,声表面波可以成功地实现微通道关闭操作,当电信号功率为31.7 dBm时,微通道关断时间约为5 min。本文工作对声表面波为驱动源的微阀研究具有一定的借鉴意义。     

光纤型微流控电泳芯片的研制

介绍了一种光纤型微流控电泳芯片,该芯片主要由两部分组成:多模光纤,PDMS基片和盖片.利用二次曝光技术制作出芯片的模具;通过浇注的方法制成电泳芯片;实现了在PDMS上制作深度不同的微流控沟道和光纤沟道,使光纤与微流控沟道能够方便地对准;利用异硫氰酸酯荧光素考察了系统的性能,最小检测浓度达到1.3×10-7mol/L,信噪比S/N=5.     

低功率电信号激发的不连续声表面波破裂压电基片上液滴

提出了一种新的微流器件上液滴破裂的方法。采用微电子工艺在128°yx-LiNbO3 基片上制作一对中心频率为27.5MHz叉指换能器和反射栅。瞬间下降电信号激发不连续声表面波辐射入待破裂液滴,在其内产生不连续声流。当电信号突然消失,部分微流体由于惯性力从液滴中飞逸。采用红色染料溶液进行液滴破裂实验,结果表明：当电信号功率从12.3dBm突然降低到-3.98dBm,压电基片上液滴能产生破裂,并且其均匀性受液滴体积影响。所提出的液滴破裂方法为微流系统进行微流分析提供了一种新的样品前处理技术,具有一定的学术价值。     

聚二甲基硅氧烷微流控芯片的制备

采用印刷电路板技术加工出芯片模具,以聚二甲基硅氧烷(PDMS)为材料制作出微流控芯片。该芯片由基片和盖片组成,微流控沟道位于基片上,深度和宽度分别为75μm和100μm,由盖片对其进行密封。考察了有绝缘漆模具和无绝缘漆模具制作的芯片的电泳分离情况。在该PDMS微流控芯片上对用异硫氰酸酯荧光素标记的氨基酸进行了电泳分离,当信噪比S/N=3时,最小检测浓度达到0.8×10-11mol/L。     

基于声表面波微液滴并行加热研究

提出了一种并行加热微液滴的方法。在128°旋转Y切割X传播方向的LiNbO3压电基片上采用微电子工艺制作叉指换能器和反射栅,在其声路径上贴合环形聚二甲基硅氧烷(PDMS)微槽,其内充满石蜡油微流体。设计有多个受热区的图案,经过激光切割转移到导热性良好的、厚度为0.3 mm的铜金属传热片上,并放置于PDMS微槽上。射频电信号加到叉指换能器上激发声表面波,辐射入微槽中的石蜡油微流体,并将能量通过传热片传递到受热区,进而加热受热区上的微液滴。以纯净水微液滴为实验对象,进行了多个微液滴并行加热实验。结果表明,在单个叉指换能器上加电信号激发的声表面波可同时加热多个微液滴,且其温度变化值随射频电信号功率增加而增加,同时,微液滴体积和受热区中并行加热的微液滴数影响其温度变化。     

细胞计数分析传感器芯片的研究

细胞计数分析在医疗和科学研究方面有着广泛的应用,本论文叙述了一种有效结合了微流控分析和细胞传感器技术,并能够进行细胞计数分析的传感器芯片.通过微加工技术制备的聚二甲基硅氧烷(polydimethylsiloxane,PDMS)微通道,并将PDMS芯片键合在光寻址电位传感器(light-addressable potentiometric sensor,LAPS)的芯片表面,使其在硅基底上形成十字形、100 μm宽、30μm深的微流控通道,通过LAPS光生电流的传感测量,对重力驱动的大鼠血细胞进行了计数分析.该研究将微流控技术引入细胞传感器的研究,有利于后续通过细胞芯片实现细胞计数分析仪器的微型化和多功能化.     

Power consumption analysis of surface acoustic wave sensor systems using ANSYS and PSPICE

The power consumption of a surface acoustic wave (SAW) sensor system was investigated using ANSYS and PSPICE. Simulation results show that several design parameters of the surface acoustic wave sensor, such as the center distance between two interdigital transducers (IDT), the thickness of the piezoelectric substrate, the finger space of the IDT, etc., can greatly affect the power consumption of the whole system. The results of this study will be helpful to optimum design and fabricate the SAW sensor systems with very low-power consumption.     

E-beam lithography of nano-interdigital transducers on insulating and semiconducting substrates

This work describes the micro-fabrication process developed to manufacture nano-interdigital transducers (nano-IDTs) to be used in surface acoustic wave applications. The combination of electron-beam (e-beam) lithography and lift-off process is shown to be effective in fabricating IDT finger patterns with a line width below 100 nm and good yield. It is also shown how a very thin organic anti-static layer can be used to avoid charge accumulation on the resist layer during e-beam lithography, which is easy to occur on insulating piezoelectric substrates and results in e-beam deflection. However, it is also shown how the use of this anti-static layer is not required with the insulating piezoelectric layer resting on a semiconducting substrate such as highly doped silicon. The effect of the e-beam dose on insulating and semiconducting layers is also discussed.     

基于两相向声表面波快速富集悬液中微粒

为提高生化分析灵敏度,提出了一种快速富集悬液中微粒的新方法.它在127.68°旋转Y切割X传播方向的LiNbO3基片上采用微电子工艺制作了2×2叉指换能器阵列,在该叉指换能器阵列的一对对角叉指换能器上同时加经功率放大器放大后的RF信号,以激发两相向声表面波,采用微量进样器将待富集的微流体(微液滴)进样到两相向传播的声路径上,微液滴中的微粒在该两相向的声表面波作用下快速向心富集.淀粉溶液微液滴富集实验结果表明,两相向声表面波作用下,10秒内实现微液滴中淀粉微粒的快速富集.     

SAW nanopump for handling droplets in view of biological applications

This paper reports on the fabrication and development of a surface acoustic waves (SAW) platform dedicated to digital micro fluidics for biological applications. SAW at about 20 MHz are generated by InterDigital Transducers (IDT) laid on a LiNbO₃ piezoelectric substrate. An electrical characterization of the IDT is reported and first results related to droplet handling with the SAW platform are given. We show that accurate droplet displacement is the result of both a radio frequency (RF) pulsed excitation and a chemical pre-treatment of the platform surface. For biological applications the droplet carrying the biomaterial is squeezed between the platform and a cover to increase the surface exchange between the droplet and hydrophilic functionalized areas. Out of such areas the free displacement is significantly improved by a surface hydrophobic pre-treatment. Moreover, the fabrication of additional hydrophilic micro tracks is shown to be a solution for crossing these areas without droplet splitting. This result is a key point to validate the structure of the novel micro fluidic platform proposed in this paper.     

Design, simulation and fabrication of piezoelectric micro generators for aero acoustic applications

Energy harvesters based on acoustic vibration sources can generate electrical power through piezoelectric transduction. Significant miniaturization of electro mechanical devices using MEMS fabrication technology has encouraged the creation of portable, miniature energy harvesters. A niche application is aero acoustics, where wasted, high dB and high frequency sound generated by aircrafts are transformed into useful energy. Having self-powered, miniature acoustic sensors allows noise detection monitoring systems to be self-sustaining. This paper illustrates an Aluminium doped Zinc Oxide (AZO) cantilever beam on stainless steel substrate with a top copper electrode. Design and finite element modelling of the design was conducted using Coventorware™. The AZO piezoelectric thin film was RF-sputtered on the stainless steel substrate. Characterizations were performed using X-ray diffraction (XRD) and scanning electron microscopy (SEM) to evaluate the piezoelectric qualities and surface morphology, respectively. Experimental measurements indicate approximately 345.4 mV AC output voltage (open circuit voltage) is produced at vibration frequencies of 30 kHz. This is in accordance with the Coventorware™ simulation results. This measured power level is sufficient to power a miniature wireless acoustic sensor nodes to monitor noise generated by aircrafts.     

基于柔性基底的压电能量收集器的设计

以PDMS为柔性基底设计的PVDF压电薄膜新型压电能量收集器压电性能良好,柔韧性强,可适应复杂的振动环境,具有广阔的应用前景.首先设计了具有柔性基底的压电能量收集器的结构;其次,用PVDF颗粒采用静电纺丝法制备了PVDF压电薄膜;最后,实验表明设计的压电能量收集器在振动频率为25 Hz,振动幅度为2 mm的激励下,开路输出峰值电压为8.38 V,输出功率密度为6.32 μW/cm2;经Ansys有限元分析,发现增大激励源的振动幅度,可以提高压电能量收集器的开路输出电压和输出功率.     

An improved bulk acoustic waves chip based on a PDMS bonding layer for high-efficient particle enrichment

In this work, we developed a feasible way to package bulk acoustic waves chip with sandwich structure by inserting a polydimethylsiloxane (PDMS) layer as the adhesive between cover glass and silicon substrate. After spin-coating and curing process, a PDMS layer was formed on one side of the cover glass and then bonded to the silicon substrate with microchannels by oxygen plasma treating. Both simulation and experiment showed that the chip was not leaking and the acoustic waves produced by the piezoelectric transducer could be propagated through the PDMS layer. Finally, a standing wave field was formed in the microchannels. Compared with traditional chip bonded by anodic bonding, simulation results showed that this packaging method did decrease the acoustic pressure in the channel, but the reduction was acceptable. After optimizing the experimental parameters, we successfully aggregated 15-μm silica spheres under a very low input power (21 dBm) at a flow velocity of 1 ml/h, and the enrichment efficiency of silica spheres was greater than 97%.