15%阿维菌素·嘧菌酯·咪鲜胺热雾剂的研制

通过对溶剂、表面活性剂等筛选,确定15%阿维菌素·嘧菌酯·咪鲜胺热雾剂最优配方:阿维菌素5%、嘧菌酯5%、咪鲜胺5%、三乙二醇47%、二甲基甲酰胺28%、表面活性剂600#6%、500#3%、700#1%。所制15%阿维菌素·嘧菌酯·咪鲜胺热雾剂外观透明,闪点高,黏度低,发烟量大,冷贮、热贮稳定性良好,达到热雾剂国家标准,可用来防治橡胶树白粉病以及螨类害虫。     

几种热雾剂对橡胶树炭疽病的大田防治效果

[目的]增加成龄橡胶树炭疽病防治有效剂型—热雾剂的种类。[方法]以10%百菌清油烟剂为对照,大田试验了配制的40.44 g/L苯醚甲环唑热雾剂、40.44 g/L丙环唑热雾剂和市售的16%百菌清.咪鲜胺.三唑酮热雾剂的防治效果。[结果]施药1次后4种药剂的防治效果依次为40.44 g/L苯醚甲环唑热雾剂>40.44 g/L丙环唑热雾剂>16%百菌清.咪鲜胺.三唑酮热雾剂>10%百菌清油烟剂,40.44 g/L苯醚甲环唑热雾剂药后30、60 d的防效分别为70.80%、76.73%,明显高于其他3种药剂,可在生产上应用。     

30%乙嘧酚磺酸酯·苯醚甲环唑水乳剂配方研发及应用

根据水乳剂形成的机理,选用合适的表面活性剂、助溶剂等,研究了30%乙嘧酚磺酸酯·苯醚甲环唑水乳剂的制备方法,并对其进行了性能测定和应用研究。试验表明,30%乙嘧酚磺酸酯·苯醚甲环唑水乳剂贮前、贮后的外观稳定,不结块、不析水、不析油,且有效成分乙嘧酚磺酸酯和苯醚甲环唑化学稳定性好,热贮分解率在5%以下。另外,30%乙嘧酚磺酸酯·苯醚甲环唑水乳剂防治黄瓜白粉病效果优异,同效果好于有效成分含量相同的乳油产品。     

阴离子、非离子表面活性剂的复配及在35%嘧菌酯悬浮剂中的应用研究

应用复配表面活性剂协同增效理论,对35%嘧菌酯悬浮剂的润湿分散剂进行筛选。结果表明:单十二烷基磷酸钾与NP-10间具有强烈的协同增效作用。使用单十二烷基磷酸钾与NP-10复配表面活性剂制备的35%嘧菌酯悬浮剂,热贮后在标准硬水中悬浮率达到96.5%,在3倍硬水中悬浮率达到90.1%,未出现析水分层现象,分解率仅为0.72%。较单一表面活性剂制备的35%嘧菌酯悬浮剂,产品性能有明显提高。复配表面活性剂的协同增效作用有利于提高35%嘧菌酯悬浮剂的稳定性。     

4%噻呋·嘧菌酯展膜油剂配制及田间防效研究

以噻呋酰胺和嘧菌酯为有效成分,通过对溶剂、表面活性剂的筛选,确定4%噻呋·嘧菌酯展膜油剂的最优配方为噻呋酰胺2%、嘧菌酯2%、癸酰胺10%、十二碳醇酯5%、601#2%、JP-95112%,助溶剂(油酸甲酯和溶剂油200#的质量比为2︰1)补至100%。田间防效试验结果显示,4%噻呋·嘧菌酯展膜油剂对水稻纹枯病防效较好,有效成分用药量为90 g/hm2、105 g/hm2时,药后10 d防效分别为68.77%、73.18%,药后30 d防效分别为82.39%、87.48%,均优于对照药剂240 g/L噻呋酰胺悬浮剂和250 g/L嘧菌酯悬浮剂。     

其它助剂

聚烯烃薄膜用去雾剂的研制;用作表面活性剂的化合物;透明、热稳定的抗静电聚碳酸酯的组成     

4.3%高氯·甲维盐微乳剂的研制

主要对4.3%高氯·甲维盐微乳剂的配方进行了研究,筛选出较优的表面活性剂、助表面活性剂,确定其最佳配方和制备方法,进而对4.3%高氯·甲维盐微乳剂质量指标和性能进行了测试,分析了不同水质对产品质量的影响。     

高蜡原油化学清蜡减阻剂的组成及性能

通过对多种油基清蜡剂进行溶蜡、减阻性能研究,筛选、复配较优化清蜡剂组成,分析了温度、溶剂种类等因素对溶蜡效果的影响。结果发现石蜡的溶解量与溶剂的体积相关性不大,石蜡量应控制在溶剂的饱和溶蜡量以内,此外溶蜡的时间不宜过长,理想时间选择40～100 min之间。既在10 mL溶剂中溶解0.5 g石蜡比较符合实际情况,且加热状态的温度选择在35 ℃左右较为适宜。同时发现,表面活性剂对石蜡有增溶作用,只有选择HLB值在13～16范围内的表面活性剂才能有利于提高溶剂溶蜡的速度。采用差示扫描量热法（DSC）考察了石蜡的热性能和相变性质。结果表明,温度因素的影响特别显著,且石蜡熔点越高,其相变所需要的能量也越大,当石蜡的熔点44.30 ℃时,相变能为29.28 J/g。     

1984年《日用化学工业》总目录

期数页数(8)浆伏洗涤剂复配与凝胶性能探讨…………………………………2 17综述与专论(3)洗衣粉抑茵作用的再观察……………31。(‘)C12——C刁——”方串行可逆反穴体乙表面活性剂、合成洗涤剂 系的执力学分析一拄链下构烷烃SR(1)高分子表面活性剂——聚醚—·’·’…··”且ZS 劲V仇九7pg｝N……··,………………4 二(2)两性表面活性剂—一咪哇ot(5)洗衣粉喷 干燥过程自动yi制改进方衍生物…………………”………·”””…126 案的设计和运行··二……………··二……。1(S)烷烃磺氯化反应的宏观动力学··…     

1%米尔贝微乳剂的研制

对有效成分为40%的米尔贝霉素原药,通过不同溶剂、表面活性剂、助溶剂、防冻剂的配方筛选试验,且进行相关理化性质的检测,得到优化配方为米尔贝霉素原药2.5%、有机溶剂8%、表面活性剂16%、助溶剂2%、防冻剂5%、水余量的1%米尔贝微乳剂.并针对小菜蛾、红蜘蛛进行药效试验,证明1%米尔贝微乳剂对这2种田间害虫有较好的防治效果.     

10%丙硫磷热雾剂高效液相色谱分析

介绍了高效液相色谱法在Ｓｉｌｉｃ正相柱上，以石油醚＋乙醚作为流动相，紫外检测器对丙硫磷热雾剂进行定量检测。该方法的变异系数为１．８９％，平均回收率为９９．６８％。     

三唑酮热雾剂的研制

本文提出了三唑酮热雾剂的组成和技术指标，研究了影响热雾剂性能的各种因素，报道了三唑酮热雾剂的毒性及其对树白粉病的防效。     

聚乙烯防雾薄膜的研制Ⅱ.影响防雾性的若干因素探讨

探讨了影响聚乙烯防雾膜防雾性的各种因素。研究表明：增加膜厚能增强防雾的持久性；聚乙烯蜡作分散剂能很好地分散防雾滴剂，提高防雾性能；活性土缓释了防雾滴剂但影响了薄膜的外观；接枝聚乙烯和乙烯－醋酸乙烯共聚物作基料时，提高了防雾效果；氟表面活性剂的加入能同时增强持久防雾性和初期防雾性。     

Development of a new silicone‐base transdermal therapeutic system. II. Study of trifunctional ingredients

The effect of two trifunctional silicon compounds was investigated on the polarity behavior of silicone elastomers by investigating the swelling properties in solvents of various polarity. The properties of the silicone elastomer were also influenced by methyltrimethoxysilane (MTS) and N‐[(aminoethyl)aminopropyl]trimethoxysilane (GF‐91) if they were used together with the networking agent. The cooperative effect of the polar liquid ingredients [glycerol, ethylene glycol, propylene glycol, poly(ethylene glycol) 400] and GF‐91 as well as the dissolution of the liquid ingredients from the silicone elastomer were studied. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 82: 1187–1194, 2001     

阿维菌素微囊悬浮剂的制备及其田间药效试验

[目的]阿维菌素是一种具有极高杀虫活性的十六元大环内酯杀虫剂,目前主要应用剂型为乳油,乳油中的有机溶剂会造成环境污染和资源浪费;微囊悬浮剂可改善制剂的环境相容性,抑制有效成分因环境因素造成的分解,延长持效期。采用细乳液聚合法制备了1.8%阿维菌素/聚丙烯酸酯微囊悬浮剂。利用激光粒度分析仪、透射电镜和FT-IR对制备的阿维菌素/聚丙烯酸酯微囊悬浮剂粒子进行了表征,田间药效试验考察了其对橘全爪螨的防治效果。[结果]微囊悬浮剂粒子平均粒径为316 nm,具有核/壳结构,不含有毒有机溶剂;对橘全爪螨喷药后1、3、10、15 d的防效达99.83%、98.75%、97.49%、98.0%,与相同剂量的对照药剂阿维菌素乳油的防效基本相当,喷药后20、30 d防效为96.45%、88.17%,显著优于乳油(93.45%、76.04%)。[结论]细乳液聚合法制备的阿维菌素微囊悬浮剂环境友好,持效期明显延长,防效优于乳油。     

溴化银内敏乳剂灰化中心形成过程的研究

制备铱内敏乳剂时,乳剂颗粒表面和内部都生成了灰化中心,并且灰化中心优先在颗粒内部生成。实验结果表明,灰化剂分子可能与乳剂颗粒表面的Ag~+作用生成单个的Ag原子,随后这些单个的Ag原子分解成Ag~+和电子,电子进入卤化银晶体的导带。因此,可以得出这样的结论:灰化剂分子提供的电子象光电子一样进入了卤化银晶体的导带,电子进入导带后,容易被敏化中心或晶体缺陷捕获而形成灰化中心。     

Solvent Screening for Solubility Enhancement of Theophylline in Neat,Binary and Ternary NADES Solvents: New Measurements and Ensemble Machine Learning

Theophylline, a typical representative of active pharmaceutical ingredients, was selected to study the characteristics of experimental and theoretical solubility measured at 25 °C in a broad range of solvents, including neat, binary mixtures and ternary natural deep eutectics (NADES) prepared with choline chloride, polyols and water. There was a strong synergistic effect of organic solvents mixed with water, and among the experimentally studied binary systems, the one containing DMSO with water in unimolar proportions was found to be the most effective in theophylline dissolution. Likewise, for NADES, the addition of water (0.2 molar fraction) resulted in increased solubility compared to pure eutectics, with the highest solubilisation potential offered by the composition of choline chloride with glycerol. The ensemble of Statistica Automated Neural Networks (SANNs) developed using intermolecular interactions in pure systems has been found to be a very accurate model for solubility computations. This machine learning protocol was also applied as an extensive screening for potential solvents with higher solubility of theophylline. Such solvents were identified in all three subgroups, including neat solvents, binary mixtures and ternary NADES systems. Some methodological considerations of SANNs applications for future modelling were also provided. Although the developed protocol is focused exclusively on theophylline solubility, it also has general importance and can be used for the development of predictive models adequate for solvent screening of other compounds in a variety of systems. Formulation of such a model offers rational guidance for the selection of proper candidates as solubilisers in the designed solvents screening.     

Determination and correlation solubility of m-phenylenediamine in (methanol,ethanol, acetonitrile and water) and their binary solvents from 278.15 K to 313.15 K

In this study, the solubility of m-phenylenediamine in four pure solvents(methanol, ethanol, acetonitrile and water) and three binary solvent(methanol + water),(ethanol + water) and(acetonitrile + water) systems were determined in the temperature ranging from 278.15 K to 313.15 K by using the gravimetric method under atmospheric pressure. In the temperature range of 278.15 K to 313.15 K, the mole fraction solubility values of m-phenylenediamine in water, methanol, ethanol, and acetonitrile are 0.0093–0.1533, 0.1668–0.5589,0.1072–0.5356, and 0.1717–0.6438, respectively. At constant temperature and solvent composition, the mole fraction solubility of o-phenylenediamine in four pure solvents was increased as the following order:water b ethanol b methanol b acetonitrile; and in the three binary solvent mixtures could be ranked as follows:(ethanol + water) b(methanol + water) b(acetonitrile + water). The relationship between the experimental temperature and the solubility of m-phenylenediamine was revealed as follows: the solubility of mphenylenediamine in pure and binary solvents could be increased with the increase of temperature. The experimental values were correlated with the Jouyban–Acree model, van't Hoff–Jouyban–Acree model, modified Apelblat–Jouyban–Acree model, Sun model and Ma model. The standard dissolution enthalpy, standard dissolution entropy and the Gibbs energy were calculated based on the experimental solubility data. In the binary solvent mixtures, the dissolution of m-phenylenediamine could be an endothermic process. The solubility data,correlation equations and thermodynamic property obtained from this study would be invoked as basic data and models regarding the purification and crystallization process of m-phenylenediamine.     

Characterization of unextractable organic matter associated with heavy minerals from oil sand

Considerable quantities of organic matter are associated with heavy metal minerals recovered from Suncor aqueous sludge. This organic matter is not extractable with common organic solvents. Attempts were made to concentrate this organic matter by dissolving the mineral matter in acids. Various soluble fractions were also obtained by extraction with methanol/benzene (1:4) after each dissolution step. All these fractions were analysed by elemental analysis, infrared, proton and ¹³C nuclear magnetic resonance spectroscopy.