Hydraulic Conductivity Measurement from On-the-Fly uCPT Sounding and from VisCPT

Detailed profiles of hydraulic conductivity are recovered from the deployment of direct-push permeameters at the Geohydrologic Experimental and Monitoring Site, Kansas. Measurements with thin tapered tips, and with standard cone penetration test (uCPT) tips, show only minor differences, suggesting that tip-local disturbance effects are small, and that routine uCPT measurements are therefore representative of pristine conditions. Permeameter measurements are correlated against closely deployed uCPT measurements, estimates of hydraulic conductivity from uCPT sounding correlations, and from grain size correlations derived from both vision CPT (VisCPT) and from cone metrics. On-the-fly evaluations of hydraulic conductivity require that the tip-local pressure field is both steady and partially drained. Continuous penetration is shown to yield pore pressures sufficiently close to steady to enable conductivities to be directly determined. Cone metrics of cone resistance, sleeve friction, and pore pressure ratio are shown to be sufficient to discriminate between partially drained and undrained behavior, and therefore to define the permissible regime where conductivities may be determined from uCPT sounding data. Estimates of hydraulic conductivities from uCPT sounding data are shown to correlate with independently measured magnitudes of hydraulic conductivity recovered using the permeameter tests. However, most of hydraulic conductivities from the permeameter tests (4.5?cm length screen) are underpredicted, suggesting that storage effects, the inability to reach a steady state, or the effects of dilation may influence the response. Profiles of hydraulic conductivities evaluated from the on-the-fly method also correlate well with the permeameter measurements. Predictions from soil classification and from VisCPT methods are also capable of estimating conductivities, with soil classifications giving the closest correlations of these two for this particular suite of data.     

Radiation sensitivity of lymphocytes from human blood and from the thoracic duct

Rats were cerebellectomized 72-96 hr prior to evaluation (1) during maximum electroshock seizures and (2) for their capacity to respond to pentylenetetrazol-induced clonic seizures. Cerebellectomized rats failed to exhibit tonic hindlimb extension, an endpoint characteristic of maximal electroshock seizures. The dose of pentylenetetrazol required to produce clonic seizures or death was not different in cerebellectomized and sham-operated controls. The anticonvulsant efficacy of diazepam, when assessed as a pentylenetetrazol antagonist, was not influenced by removal of the cerebellum. These data indicate that whereas cerebellar influences may suppress seizure activity which is largely focal, seizures of more diffuse origin are not markedly influenced by cerebellar activity. It is, therefore, essential that the role of the cerebellum in suppressing seizures be characterized for each kind of experimentally induced seizure process.     

Molecular cloning and sequence analysis of interleukin 16 from nonhuman primates and from the mouse

We analysed the occurrence of anti-neutrophil cytoplasmic antibodies (ANCA) in sera of 191 patients with glomerulonephritis (76 females and 115 males) by the standard indirect immunofluorescence method (IIF). The presence of ANCA was demonstrated in sera of 4.4% (8/181) patients with idiopathic glomerulonephritis (GN) and in 30% (3/10) of patients with rapidly progressive glomerulonephritis (RPGN), as a form of renal limited vasculitis. In the experimental part of our study we analysed the influence of GN ANCA-negative sera on the neutrophil function in vitro and compared with the effect of ANCA-positive sera (titre > or = 4:40) from systemic vasculitis (SV) patients with renal involvement. The activation of neutrophils was established by reactive oxygen species (ROS) production and the ability of superoxide anion to reduce ferrocytochrome c. Among 30 ANCA-negative GN sera 20% (6/30) revealed the ability to activate neutrophils isolated from healthy donor. Remaining ANCA-negative GN sera and all sera from normal healthy individuals (negative control group) did not affect the neutrophil function and did not induce the superoxide anion production. Their effect was similar to the second negative reference system without serum. Only 33% (3/9) of high titre ANCA-positive sera (> or = 1:40) from SV patients were able to activate neutrophils and to produce the superoxide anion with following ferrocytochrome c reduction, but the effect of activation was most powerfully expressed (three times greater than by GN ANCA-negative sera). The remaining ANCA-positive sera and all SV ANCA-negative sera did not affect the neutrophil function in vitro. These experimental data indicate that the presence of ANCA in GN sera is not necessary to induce neutrophil activation in vitro. On the other hand the influence of the SV ANCA-positive sera was most powerful expressed, although only 33% of sera were able to activate neutrophils in vitro. Our results indicate that not always ANCA presence in serum was connected with the ability to neutrophil activation in vitro. It is possible that in ANCA-negative sera other factors were able to activate neutrophils in vitro, but the effect of activation was markedly lower.     

Characterisation of granulocyte stimulation by thionins from European mistletoe and from wheat

Thionins are small basic peptides found in different plant species, which are known to exert cytotoxic properties. In addition, previous data indicated an activation of human granulocytes by thionins from European mistletoe (viscotoxins, VT). To extend these latter findings, we investigated the influence of VT and from thionins from wheat flour (purothionin) on human granulocytes by flow cytometry and tried to characterise the involved molecular structures and mechanisms. Phagocytosis was determined by incorporation of FITC-labelled Escherichia coli and respiratory burst by oxidation of dihydrorhodamine 123 to rhodamine 123. VT and purothionin significantly enhanced E. coli-stimulated phagocytosis and respiratory burst at 25 and 250 microgram/ml. Phagocytosis of damaged lymphocytes by granulocytes was detected by electron microscopy in the VT-stimulated (100 microgram/ml) but not in the control cultures. The poly-cationic structure of the intact molecule seems to be crucial, as evidenced by comparison of the burst and phagocytosis-enhancing effects induced by other poly-cationic (protamine sulphate, histone, poly-l-arginine, poly-l-lysine) and poly-anionic (poly-l-glutamic acid) peptides, while pore forming due to amphipathic properties seems to be less important. Ca2+ and Mg2+ could not inhibit VT-enhanced phagocytosis and, thus, could not inhibit binding of VT to granulocytes. In addition, verapamil at low concentrations inhibited VT activity, suggesting the involvement of Ca2+ channels for granulocyte activation by the VT. Similarly, thionins and histones in contrast to protamine sulphate induced cell death of granulocytes at 250 microgram/ml as demonstrated by an enhanced release of reactive oxygen intermediates in unstimulated granulocytes. From these data one may suggest that activity of VT is induced by strong unspecific ionic binding, probably followed by specific receptor binding, and thionins exhibit stimulatory and cytotoxic effects on immune cells, which have to be further characterised.     

Pressure from above and pressure from below as determinants of teachers' motivation and teaching behaviors.

When teachers are more supportive of autonomy and less controlling, students demonstrate higher levels of intrinsic motivation and self-determination. The purpose of this study was to examine social-contextual conditions that led teachers (N=254) who taught classes from Grades 1 to 12 to be more autonomy supportive versus controlling with their students. Using structural equation modeling, the authors observed that the more teachers perceive pressure from above (they have to comply with a curriculum, with colleagues, and with performance standards) and pressure from below (they perceived their students to be nonself-determined), the less they are self-determined toward teaching. In turn, the less they are self-determined toward teaching, the more they become controlling with students. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Triterpenes and saponins from Rudgea viburnioides

A novel triterpene, viburgenin (1), has been isolated from an extract of the ripe fruit rinds of Rudgea viburnioides, together with the known saponins, arjunglucoside I and trachelosperosides B-1 and E-1, and the triterpenes trachelosperogenin B (2) and arjungenin. Compound 2 was previously obtained as a product from enzymatic hydrolysis, and it is reported for the first time as a natural product. The structure of compound 1 was determined as 2alpha,3beta, 19alpha,23,24-pentahydroxyurs-12-ene by extensive use of 1D and 2D NMR spectroscopic methods. Compound 1 exhibited moderate antifungal activity against Cladosporium cladosporioides.     

Reply from Sommer and Sommer.

Responds to comments by H. L. Garber (see record 1985-24145-001), E. Furchtgott (see record 1985-24143-001), G. S. Bernstein (see record 1985-24133-001), K. Heskin (see record 1985-24148-001), and K. B. Carsrud (see record 1985-24136-001) on issues raised by the authors (see record 1984-10654-001) on the validity of research findings reported in textbooks. The hazards of unquestioning acceptance of appealing preliminary results and the need to exercise professional judgment in interpreting results are stressed. It is argued that textbooks in such core areas as developmental and abnormal psychology should be conservative in the facts they publish. The use of replication as a means of establishing validity is advocated. (7 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Serotonin syndrome from fluvoxamine and buspirone

From January 1991 to 1994, 99 aneurysms in 91 patients were clipped in the Neurosurgy Department of Beijing Tiantan Hospital. Six residual aneurysms were found by postoperative angiography. We analyzed these patients and concluded that the occurrence of residual aneurysms depends mainly on the location, size, type, neck width of the aneurysms, and their rupture during operation. According to this, we give opinions on how to prevent residual aneurysms and how to deal with them.     

Obesity and protection from risk.

Responds to W. B. Webb's (see record 1987-26955-001) and H. E. Yuker's (see record 1987-26956-001) comments on the present authors and J. Plotkin's (see record 1986-12806-001) study of human Ss review board decisions by affirming the need for human Ss review boards and by defending the study's distinction between sensitive and nonsensitive forms of discrimination. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Judging interevent relations: from cause to effect and from effect to cause

Stimulus competition was studied in college students' correlational judgments in a medical decision-making setting. In accord with prior findings, subjects making cause-to-effect (predictive) judgments discounted a stimulus event that was moderately correlated with a target event when rival stimuli were more highly correlated with the effect. However, subjects making effect-to-cause (diagnostic) judgments were not at all disposed to discount a stimulus event which was moderately correlated with a target event when rival stimuli were more highly correlated with the cause. The theoretical implications of these results are considered in connection with associative and mentalistic models of causal attribution.     

Iron uptake from ferrioxamine and from ferrirhizoferrin by germinating spores of Rhizopus microsporus

Mucormycosis caused by the fungus Rhizopus has been documented in iron overloaded patients and more particularly in dialysis patients, both when treated with desferrioxamine B (DFO). This iron and aluminium chelator is thought to play a role in the pathogenesis of this infection. We therefore investigated in vitro the cellular pharmacology of iron chelated by DFO in the fungus Rhizopus. In a medium, designed for fungal cultivation, Rhizopus microsporus var. rhizopodiformis takes up iron from ferric-DFO complex (55Fe.DFO) and from 55Fe.rhizoferrin, the siderophore synthesized and secreted by Rhizopus [Drechsel et al., Biol. Metals 4: 238-243, 1991]. In both cases, iron accumulation is partially saturable with the duration of exposure and the chelator concentration. Fe.DFO binds to Rhizopus; iron becomes trapped and remains associated with the fungus, whereas the iron-depleted siderophore is released in the extracellular medium. In a medium designed for mammalian cell cultivation and in the absence of human serum, the fungal iron accumulation both from 55Fe.DFO and from 55Fe.rhizoferrin is proportional to the chelator concentration. Human serum at 40% does not influence the iron accumulation from Fe.DFO but it significantly affects that from Fe.rhizoferrin which, in the presence of serum, only occurs at concentration > 5 microM. This difference finds its explanation in the iron transfer observed between Fe.rhizoferrin and seric apotransferrin, the latter making the metal unavailable to Rhizopus. By contrast, no iron transfer takes place between Fe.DFO and apotransferrin, allowing fungal iron utilization from this complex, even at very low concentrations. The iron uptake, being inhibited by NaN3 and KCN, is energy-dependent; being inhibited by bipyridyl, it requires prior reduction of ferric iron; being unaffected by the covalent linkage of Fe.DFO to albumin, it does not require the entry of Fe.DFO within the fungus. These in vitro results strongly suggest that, upon administration of DFO to iron overloaded or dialysis patients, the formed Fe.DFO is efficiently used as an iron source by Rhizopus, even in the presence of serum apotransferrin or rhizoferrin. The consequent promotion of the growth of Rhizopus helps explain the increased risk of mucormycosis in DFO-treated patients.     

管理出效益——广钢集团董事长袁今昔在集团公司第二届科技论坛上的总结讲话

同志们: 以管理出效益为主题的广钢集团第二届科技论坛召开了,现已取得圆满成功。 这次论坛,围绕管理出效益这一主题,共收到51篇论文,其中,有25位同志在大会上宣读了论文。以论坛这种形式,有这么多人参与,专门围绕管理出效益这个主题进行探索和研究,这在广钢集团管理发展史上是第一次,也是一次对管理进步具有创造性的探索和实践。     

Lessons from Roman Cement and Concrete

Although masonry and lime mortars had been used for centuries by earlier civilizations, the Romans were the first to extensively use naturally occurring volcanic earth to make hydraulic cement. The volcanic powder named “pulvis puteolanis,” found near the town of Puteoli near Naples (now Pozzouli), was used to build magnificent structures. The use of this hydraulic cement in masonry and concrete greatly expanded civil engineering possibilities. The Roman engineer Vitruvius, writing in The Ten Books on Architecture, described the careful materials selection, proportioning, and workmanship that was critical to the performance of Roman concrete. Masonry and coarse and fine aggregates were carefully selected for durability. Hydraulic cement concrete was used extensively for constructing bridge piers and harbor jetties. One of the greatest examples of Roman concrete construction was the dome of the Pantheon, with its 43.4-m span. The vast system of aqueducts also made extensive use of hydraulic cement. This paper summarizes the materials and construction methods used in Roman concrete construction, as well as structures and infrastructure built with concrete.