共查询到20条相似文献,搜索用时 31 毫秒
1.
Chuang Wei Zeyu Jiang Congcong Li Peifeng Li Qinrui Fu 《Advanced functional materials》2023,33(26):2214655
Cardiovascular disease (CVD) is the number one cause of death worldwide, which propels the development of advanced technologies for CVD diagnosis and treatment. Biomarker-responsive nanomaterials are appealing therapeutic platforms that provide new horizons for CVD theranostics. In this review, recent advances in nanomaterials with endogenous biomarkers as stimuli or targets for CVD theranostics is presented. First, the categories of biomarkers involved are comprehensively itemized based on pathological mechanisms including pH, reactive oxygen species, lipids, enzymes, macrophage receptors, subendothelium components, platelet receptors, inflammation, and osteopontin. The role of these biomarkers in bridge-building between nanomaterials and CVD is then presented. Next, the biomedical applications of nanomaterials responsive to endogenous biomarkers as stimuli or targets for the diagnosis and treatment of CVD are elaborated. Finally, the challenges and future research directions of biomarker-responsive nanomaterials in CVD are also discussed. This review will provide scientific guidance to facilitate clinical applications of biomarker-responsive nanomaterials. 相似文献
2.
Donglu Shi 《Advanced functional materials》2009,19(21):3356-3373
This article provides an overview on the development of integrated multifunctional nanosystems for medical diagnosis and treatment. In particular, a novel system is developed specifically for achieving simultaneous diagnosis and treatment of cancer. Critical issues are addressed on the architecture and assembly of nanocomponents based on medical requirements: targeted in vivo imaging, controlled drug release, localized hyperthermia, and toxicity. Nanotube‐based carriers are summarized with surface functionalized properties. Other types of nanocarriers are also included such as super paramagnetic composite nanospheres and biodegradable hydroxylapatite nanoparticles. In addition, polymeric‐based nanosystems are introduced with several novel features: they can be bio‐dissolved due to environmental pH and temperature fluctuations. The nanocarriers are surface tailored with key functionalities: surface antibodies for cell targeting, anti‐cancer drug loading, and magnetic nanoparticles for both hyperthermia and MRI. Future requirements, aims, and trends in the development of multifunctional nanosystems, particularly with intelligent functionalities for fundamental studies, are also provided. 相似文献
3.
Qinrui Fu Leilei Yu Yin Wang Peifeng Li Jibin Song 《Advanced functional materials》2023,33(2):2206300
Chronic diseases claim millions of lives every year, and it is of great significance to explore and develop advanced drugs to improve the cure rate of chronic diseases. Nanotheranostics are innovative strategies that enable the integration of diagnostic and therapeutic properties into a single nanosystem. Despite great success in nanotheranostics, their applications of nanotheranostics in nanomedicine are still in their infancy. This is because each disease has its corresponding characteristic pathological microenvironment, which motivates the development of endogenous biomarker-responsive nanosystems to meet the requirements of diagnosis and treatment. Herein, recent progress is presented in biomarker-responsive nanosystems and their biomedical applications. First, biomarker-responsive nanosystems are classified into eight subsections according to the type of chronic diseases, including tumors, cardiovascular diseases, neurological diseases, Wilson's diseases, chronic liver diseases, chronic kidney diseases, diabetes mellitus, and rheumatoid arthritis. In the following, a variety of intriguing applications of biomarkers-responsive nanosystems are briefly elaborated, such as biosensing, diagnosis, therapy, combined theranostics, and early evaluation of therapy effect, etc. Finally, the challenges and future directions from research to clinical translation of these responsive nanosystems are also presented. 相似文献
4.
Chiara Villa Marcello Campione Beatriz Santiago‐González Francesco Alessandrini Silvia Erratico Ileana Zucca Maria Grazia Bruzzone Laura Forzenigo Paolo Malatesta Michele Mauri Elena Trombetta Sergio Brovelli Yvan Torrente Francesco Meinardi Angelo Monguzzi 《Advanced functional materials》2018,28(19)
Fluoromagnetic systems are recognized as an emerging class of materials with great potential in the biomedical field. Here, it is shown how to fabricate fluoromagnetic nanotubes that can serve as multimodal probes for the imaging and targeting of brain cancer. An ionic self‐assembly strategy is used to functionalize the surface of synthetic chrysotile nanotubes with pH‐sensitive fluorescent chromophores and ferromagnetic nanoparticles. The acquired magnetic properties permit their use as contrast agent for magnetic resonance imaging, and enable the tracking of tumor cell migration and infiltration responsible for metastatic growth and disease recurrence. Their organic component, changing its fluorescence attitude as a function of local pH, targets the cancer distinctive acidity, and allows localizing and monitoring the tumor occurrence and progression by mapping the acidic spatial distribution within biopsy tissues. The fluoromagnetic properties of nanotubes are preserved from the in vitro to the in vivo condition and they show the ability to migrate across the blood brain barrier, thus spontaneously reaching the brain tumor after injection. The simplicity of the synthesis route of these geomimetic nanomaterials combined with their demonstrated affinity with the in vivo condition strongly highlights their potential for developing effective functional materials for multimodal theranostics of brain cancer. 相似文献
5.
Xiao‐Dong Zhang Jie Chen Yuho Min Gyeong Bae Park Xiu Shen Sha‐Sha Song Yuan‐Ming Sun Hao Wang Wei Long Jianping Xie Kai Gao Lianfeng Zhang Saijun Fan Feiyue Fan Unyong Jeong 《Advanced functional materials》2014,24(12):1718-1729
Bi, a high atomic number element, has a high photoelectric absorption coefficient, and Se has anticancer activity. Hence, their compound chalcogenide (Bi2Se3) deserves a thorough investigation for biomedical applications. This study reveals that Bi2Se3 nanoplates (54 nm wide) protected with poly(vinylpyrollidone) (PVP) could be presumed to have low toxicity even at a high dose of 20 mg/kg in mice. This conclusion is made through studies on the biodistribution and 90‐day long term in vivo clearance of the nanoplates. The liver and spleen are dominant organs for accumulation of the nanoplates, which is mainly due to RES absorption. 93% of the nanoplates are cleared after 90 days of treatment. Concentrations of Bi and Se in tumor tissue continuously increased until 72 h after intraperitoneal injection into mice. Such selective accumulation of Bi is utilized to enhance the contrast of X‐ray computerized tomography (CT) images. Bi element concentrated in a tumor leads to damage on the tumor cells when exposed to gamma radiation. Growth of the tumor is significantly delayed and stopped in 16 days after the tumor is treated by radiation with Bi2Se3 nanoplates. This work clearly shows that Bi2Se3 nanoplates may be used for cancer radiation therapy and CT imaging. The nanoplates deserve further study for biological and medical applications. 相似文献
6.
Nur Farhanah Rosli Nasuha Rohaizad Jiri Sturala Adrian C. Fisher Richard D. Webster Martin Pumera 《Advanced functional materials》2020,30(21)
2D monoelemental group 14 materials beyond graphene, such as silicene and germanene, have recently gained a lot of attention. Covalent functionalization of group 14 layered materials can lead to significant tuning of their properties. While optical and electronic properties of germanene, silicene, and their derivatives have been studied in detail previously, there is no information on their electrochemistry and toxicity. Herein, electrochemical applications of 2D siloxene, germanane, and methylgermanane, specifically for detection of an important biomarker, dopamine, as well as catalyzation of oxygen reduction and hydrogen evolution reactions, which are important in energy applications, are explored. Among the three materials, germanane portrays most superior properties for the electrochemical applications mentioned. All three materials possess fast heterogeneous electron transfer rates, relative to bare glassy carbon electrodes. In addition, toxicity studies of these materials are conducted to gain insights on their possible harmful effects toward human health. The results of this study show siloxene nontoxic while germanane and methylgermanane impose dose‐dependent toxicity. Interestingly, methylation successfully reduce the toxicity of methylgermanane at lower concentrations. These studies provide fundamental insights into electrochemical and toxic properties of functionalized group 14 layered materials for future electrochemical applications. 相似文献
7.
Yukun Duan Min Wu Dehong Hu Yutong Pan Fang Hu Xingang Liu Nitish Thakor Wai Hoe Ng Xin Liu Zonghai Sheng Hairong Zheng Bin Liu 《Advanced functional materials》2020,30(38)
Brain tumor targeted delivery of diagnostic contrast agents has been an elusive goal due to the presence of the blood brain barrier (BBB) and the complex brain tumor microenvironment. Herein, an ingenious design of nanoscale contrast agents coated by bioorthogonally labeled brain tumor cell membrane for targeted diagnosis of glioblastoma through multiple complementary imaging modalities is presented. Taking advantage of bioorthogonal click reactions, an endothelial integrin receptor‐targeting peptide cRGD is decorated onto the nanocomposite surface to act in synergy with brain tumor cell membrane to offer BBB‐penetrating and homotypic targeting effect in the brain tumor microenvironment. Cellular and animal experimental results validate the superior targeting outcomes achieved by cRGD‐labeled brain tumor cell membrane coating. This study offers an example of a surface modified cell membrane as a potential theranostic strategy to overcome the delivery barriers in brain tumors. 相似文献
8.
视频光谱成像技术是目前遥感探测发展的一个重要方向,可以实现4维信息获取(两维空间+光谱+时间),对于动态目标探测等应用场景有十分重要的意义。目前的技术手段是以滤光片方式为主,不具备光栅作为分光元件时的高光谱分辨率优势。基于此,提出了非耦合狭缝阵列扫描光谱成像(uSASHI)和编码狭缝阵列扫描光谱成像(cSASHI)系统,通过增加狭缝数目的方式,实现同一时刻多个视场信息的获取,极大地提升信息获取效率。uSASHI的每个狭缝获取信息之间不会耦合,n条狭缝可以实现n倍的信息获取效率的提升,cSASHI的狭缝按照压缩感知理论排列,可以实现欠采样条件下(采样率α≤1)视频光谱成像,信息获取效率可以提升n/α倍。本文设计的系统最终实现了1024*496*30的光谱数据立方体10 Hz视频光谱成像方式,cSASH实现了更高帧频。所提系统为视频光谱成像技术提供了新的方向,为未来动态目标探测等应用打下了基础。 相似文献
9.
Zachary T. Rosenkrans Jessica C. Hsu Eduardo Aluicio-Sarduy Todd E. Barnhart Jonathan W. Engle Weibo Cai 《Advanced functional materials》2023,33(33):2302777
The therapeutic efficacy of photodynamic therapy is limited by the ability of light to penetrate tissues. Due to this limitation, Cerenkov luminescence (CL) from radionuclides has recently been proposed as an alternative light source in a strategy referred to as Cerenkov radiation-induced therapy (CRIT). Semiconducting polymer nanoparticles (SPNs) have ideal optical properties, such as large absorption cross-sections and broad absorbance, which can be utilized to harness the relatively weak CL produced by radionuclides. SPNs can be doped with photosensitizers and have ≈100% energy transfer efficiency by multiple energy transfer mechanisms. Herein, an optimized photosensitizer-doped SPN is investigated as a nanosystem to harness and amplify CL for cancer theranostics. It is found that semiconducting polymers significantly amplify CL energy transfer efficiency. Bimodal positron emission tomography (PET) and optical imaging studies show high tumor uptake and retention of the optimized SPNs when administered intravenously or intratumorally. Lastly, it is found that photosensitizer-doped SPNs have excellent potential as a cancer theranostics nanosystem in an in vivo tumor therapy study. This study shows that SPNs are ideally suited to harness and amplify CL for cancer theranostics, which may provide a significant advancement for CRIT that are unabated by tissue penetration limits. 相似文献
10.
实时太赫兹探测与成像技术新进展 总被引:3,自引:2,他引:3
图像获取速率和空间分辨率一直是面向应用型太赫兹成像所要解决的关键问题。针对这一问题,学者们基于合成孔径雷达(SAR)成像技术、电磁干涉与压缩感知(CS)等理论,提出了太赫兹合成孔径成像、太赫兹干涉成像和太赫兹压缩感知成像技术,它们在成像速度和空间分辨率等方面具有良好的发展潜力。综述了上述三种方法,总结概括其各自的技术优势以及新近的研究进展。展望了太赫兹成像技术在军事、公共安全领域以及无损探伤等领域的应用前景。 相似文献
11.
12.
Ningqiang Gong Yuxuan Zhang Zhen Zhang Xianlei Li Xing‐Jie Liang 《Advanced functional materials》2019,29(3)
Advances in cancer immunology have revealed that immunological tolerance, which is characterized by low immunogenicity, insufficient antigen presentation, and low T lymphocyte infiltration, increases the expression of inhibitory receptors and cytokines in tumors. These features make it possible for tumor cells to easily escape attack by immune cells. Nanomaterials, with unique properties such as ultrasmall size, unique surface characteristics, and multivalent effects, have attracted an increasing amount of attention in the regulation of the immunological microenvironment of tumors. In this review, the use of functional nanomaterials to reverse immunological tolerance in tumors is examined, including the use of nanomaterials for efficient cancer vaccines, checkpoint blockade delivery, cytokine delivery, artificial antigen presentation cells, and adoptive cell therapy. The benefits and challenges of using nanomaterials to circumvent the immunological tolerance of tumors are also discussed. 相似文献
13.
军用红外成像系统新概念新体制的发展 总被引:2,自引:9,他引:2
近年来,新的军事需求对军用红外成像系统提出了持久性监视、大范围覆盖、对目标区高分辨率成像、快速检测出目标事件等多项挑战,为了满足这些要求,军用红外成像系统的新概念、新体制研究成为热点.重点介绍了近年来在军用红外成像系统的新概念、新体制研究方面的新进展,并概述了压缩感知理论在新概念红外成像系统领域的应用情况,及用于新概念红外成像系统的微光机电系统和智能化红外焦平面阵列的发展. 相似文献
14.
The integration of triboelectric nanogenerators (TENGs) and 2D nanomaterials brings about 2D-nanomaterial-based TENGs (2D-TENGs) that promote the rapid development of self-powered sensing systems and wearable electronics. Extraordinary physical, electronic, chemical, and optical properties of 2D nanomaterials endow 2D-TENGs with improved output performance. This review presents the state of the art of 2D-TENGs with respect to basic classifications, enhancement mechanisms, special advantages, output performances, and applications in energy harvesting and self-powered sensing. Furthermore, several challenges that can impede applications of 2D-TENGs are discussed. 相似文献
15.
Kochurani K. Johnson Pramod Koshy Jia-Lin Yang Charles C. Sorrell 《Advanced functional materials》2021,31(43):2104199
Nanomaterials with cancer-imaging and therapeutic properties have emerged as the principal focus of nanotheranostics. The past decade has experienced a significant increase in research in the design, formulation, and preclinical and clinical trials of theranostic nanosystems. However, current theranostic nanoformulations have yet to be approved by the FDA for clinical use. Consequently, the present review focuses on the importance of the careful examination of the in vivo preclinical status of specific nanotheranostic materials as a prerequisite for their clinical translation. The scope of coverage is structured according to all of the major organic, inorganic, 2D, and hybrid nanotheranostic materials and their in vivo preclinical status. The therapeutic advantages and limitations of these materials in animal models are considered and the various strategies to enhance the biocompatibility of theranostic nanoparticles are summarized. 相似文献
16.
Hongxin Lin Lijiao Yang Xuan Zhang Guoming Liu Shuangmu Zhuo Jianxin Chen Jibin Song 《Advanced functional materials》2020,30(40)
Nanomaterials with unique physical and biological properties have attracted increased attention for bio‐microimaging applications. Among them, low‐dimensional nanomaterials have quantum confinement effect in zero, one, or two dimensions, which have high specific surface area for cargo (such as dye) loading, anisotropic optical properties for polarization, and enhanced infrared absorption for efficient photoluminescence. In this review, recent efforts on bio‐microimaging of low‐dimensional nanomaterials, including confocal imaging, multiphoton imaging, Raman imaging, and super‐resolution imaging, will be highlighted. Bio‐microimaging principle, respective advantages and bottlenecks, and applications of low‐dimensional materials in various imaging technologies will be discussed. Furthermore, the review will shed light on the common synthetic methods of low‐dimensional nanomaterials. Finally, the classification and comparison of various nanomaterials, including carbon, black phosphorus, gold, metal composites, and 2D graphene analogues will also be elaborated. 相似文献
17.
计算光学成像是一种通过联合优化光学系统和信号处理以实现特定成像功能与特性的新兴研究领域。它并不是光学成像和数字图像处理的简单补充,而是前端(物理域)的光学调控与后端(数字域)信息处理的有机结合,通过对照明、成像系统进行光学编码与数学建模,以计算重构的方式获取图像与信息。这种新型的成像方式将有望突破传统光学成像技术对光学系统以及探测器制造工艺、工作条件、功耗成本等因素的限制,使其在功能(相位、光谱、偏振、光场、相干度、折射率、三维形貌、景深延拓、模糊复原、数字重聚焦,改变观测视角)、性能(空间分辨、时间分辨、光谱分辨、信息维度与探测灵敏度)、可靠性、可维护性等方面获得显著提高。现阶段,计算光学成像已发展为一门集几何光学、信息光学、计算光学、现代信号处理等理论于一体的新兴交叉技术研究领域,成为光学成像领域的国际研究重点和热点,代表了先进光学成像技术的未来发展方向。国内外众多高校与科研院所投身其中,使该领域全面进入了“百花齐放,百家争鸣”的繁荣发展局面。作为本期《红外与激光工程》——南京理工大学专刊“计算光学成像技术”专栏的首篇论文,本文概括性地综述了计算光学成像领域的历史沿革、发展现状、并展望其未来发展方向与所依赖的核心赋能技术,以求抛砖引玉。 相似文献
18.
基于超阈值时间技术的激光关联成像 总被引:1,自引:0,他引:1
针对现有基于全波形采样的激光关联成像回波采集数据量大且测距精度和测距分辨率受限于采样率的问题,研究了一种基于超阈值时间(TOT)技术的激光关联成像方法。利用基于TOT技术的时间宽度或峰值反推方法获取回波信号的强度信息,分析了TOT响应阈值选取、激光脉冲宽度、TOT测量误差对激光关联成像重构结果的影响。结果表明:基于TOT技术的回波信号获取方法可以实现激光关联成像;TOT响应阈值选为回波信号峰值的35%、激光脉宽不小于30个采样间隔、TOT测量误差的均方根误差小于1个采样间隔,能够保证较好的重构质量。此外,基于峰值反推获取目标回波信号强度信息的方法比基于TOT的时间宽度表征方法更准确。 相似文献
19.
Juan Wang Zhongmin Li Zhongtang Wang Yonghua Yu Di Li Baosheng Li Jianxun Ding 《Advanced functional materials》2020,30(30)
Radiotherapy, a clinically used local treatment modality of cancers, is regarded as a promising candidate to promote current immunotherapy through initiating an in situ vaccination effect and reprogramming the immunosuppressive microenvironment. The combination of radiotherapy and immunotherapy, referred to as combinational radio–immuno oncotherapy (CRIOT), elicits a synergistic antitumor effect based on the immunomodulatory properties of radiation. Unfortunately, current CRIOT accompanies low response rate and severe toxicity in clinical trials, thus limiting its application. To this end, various nanomaterials are being developed to sensitize radiotherapy or deliver immune agents, or both, to improve the unsatisfactory outcomes of CRIOT. Herein, enhanced antitumor efficacy of CRIOT with nanomaterials through the possible mechanisms of rejuvenation and activation of T cells, increased presentation of tumor‐related antigens, and inhibition of suppressive macrophages is presented, and the prospect of CRIOT in clinical practice is proposed. 相似文献
20.
在利用偏振遥感对地表目标或大气进行研究时,由于大气散射光相对地表反射具有更强的偏振特性,故常认为经地气系统反射回空间的太阳辐射偏振信息主要来源于大气,而在遥感反演时常忽略地表的偏振反射作用.这个结论是基于地面目标为漫反射体的假定,但事实上,在绝大多数情况下,地表并非朗伯体,在某些时候这种非朗伯体的地表偏振作用甚至超过大气的影响.本文从推导地表的偏振反射作用机理及偏振光谱解译模型出发,首次利用偏振成像光谱实验,证明了地表的偏振度在某些情况下甚至达到50%以上,说明地表的偏振作用对传感器的信号有时会有很大影响.该作用是进行定量遥感研究时不容忽视的一个重要因素. 相似文献