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1.
Burning candles and incense generate particulate matter (PM) that produces poor indoor air quality and may cause human pulmonary problems. This study physically characterised combustion particles collected in a church during services. In addition, the emissions from five types of candles and two types of incense were investigated using a combustion chamber. The plasmid scission assay was used to determine the oxidative capacities of these church particles. The corresponding risk factor (CRf) was derived from the emission factor (Ef) and the oxidative DNA damage, and used to evaluate the relative respiratory exposure risks. Real-time PM measurements in the church during candle–incense burning services showed that the levels (91.6 μg/m3 for PM10; 38.9 μg/m3 for PM2.5) exceeded the European Union (EU) air quality guidelines. The combustion chamber testing, using the same environmental conditions, showed that the incense Ef for both PM10 (490.6–587.9 mg/g) and PM2.5 (290.1–417.2 mg/g) exceeded that of candles; particularly the PM2.5 emissions. These CRf results suggested that the exposure to significant amounts of incense PM could result in a higher risk of oxidative DNA adducts (27.4–32.8 times) than tobacco PM. The generation and subsequent inhalation of PM during church activities may therefore pose significant risks in terms of respiratory health effects.  相似文献   

2.
Particulate and gaseous emissions from indoor combustion appliances and smoking can elevate the indoor concentrations of various pollutants. Indoor pollutant concentrations resulting from operating one of several combustion appliances, or from sidestream tobacco smoke, were measured in a 27-m3 environmental chamber under varying ventilation rates. The combustion appliances investigated were gas-fired cooking stoves, unvented kerosene-fired space heaters, and unvented natural-gas-fired space heaters. Results showed elevated levels of carbon dioxide, carbon monoxide, nitric oxide, nitrogen dioxide, formaldehyde, and suspended particles from one or more of the pollutant sources investigated. Our findings suggest that, of the sources examined in this study, nitrogen dioxide from combustion appliances and particles from sidestream cigarette smoke are the most serious contaminants of indoor air, if we use existing standards and guidelines as the criteria. An emission rate model was used to quantify the strengths of the pollutant sources, which are reported in terms of the mass of pollutant emitted per energy unit of fuel consumed (in the case of gas and kerosene appliances) and per mass of tobacco combusted (in the case of smoking).  相似文献   

3.
The use of indoor combustion appliances can cause an increase in the levels of many different pollutants. The work presented here shows the usefulness of a model for extrapolating environmental chamber results on pollutant emissions from combustion appliances to determine indoor pollutant concentrations in actual residences. In addition, the effects of infiltration, whole-house ventilation, and spot ventilation on pollutant levels are investigated. The results show that a range hood is the most effective means of removing pollutants emitted from a gas-fired range; removal rates varied from 60% to 87%.  相似文献   

4.
Formaldehyde, an economically important chemical, is classified as a human carcinogen that causes nasopharyngeal cancer and probably leukemia. As China is the largest producer and consumer of formaldehyde in the world, the Chinese population is potentially at increased risk for cancer and other associated health effects. In this paper we review formaldehyde production, consumption, exposure, and health effects in China. We collected and analyzed over 200 Chinese and English documents from scientific journals, selected newspapers, government publications, and websites pertaining to formaldehyde and its subsequent health effects.Over the last 20 years, China's formaldehyde industry has experienced unprecedented growth, and now produces and consumes one-third of the world's formaldehyde. More than 65% of the Chinese formaldehyde output is used to produce resins mainly found in wood products — the major source of indoor pollution in China. Although the Chinese government has issued a series of standards to regulate formaldehyde exposure, concentrations in homes, office buildings, workshops, public places, and food often exceed the national standards. In addition, there have been numerous reports of formaldehyde-induced health problems, including poisoning and cancer. The lack of quality epidemiological studies and basic data on exposed populations emphasizes the need for more extensive studies on formaldehyde and its related health effects in China.  相似文献   

5.
A sample of 58 occupied homes in Rochester, NY, most of which incorporated special builder-designed weatherization components, were studied to assess (1) the effectiveness of construction techniques designed to reduce air leakage; (2) the indoor air quality and air-exchange rates in selected airtight houses, and (3) the impact on indoor air quality of mechanical ventilation systems employing air-to-air heat exchangers. The “specific leakage area” was measured in each house using the fan pressurization technique. Houses built with polyethylene vapor barriers and joint-sealing were as a group 50% tighter than a similar group of houses without such components. Mechanical ventilation systems with air-to-air heat exchangers were installed in nine relatively airtight houses, some of which had gas stoves and/or tobacco smoking occupants. Air-exchange rates and indoor concentrations of radon (Rn), formaldehyde (HCHO), nitrogen dioxide (NO2), and humidity were measured in each house for 1-week periods with and without mechanical ventilation. More detailed measurements, including concentrations of carbon monoxide and inhalable particulates, were made in two of these houses by a mobile laboratory. In all nine houses, air-exchange rates were relatively low (0.2–0.5 ach) without mechanical ventilation, and yet indoor concentrations of Rn, HCHO, and NO2 were below existing guidelines. Mechanical ventilation systems were effective in further reducing indoor contaminant concentrations. We conclude that when contaminant source strengths are low, acceptable indoor air quality can be compatible with low air-exchange rates.  相似文献   

6.
This paper summarizes recent data on the occurrence of major organic compounds (benzene, toluene, xylenes, styrene, acetaldehyde, formaldehyde, naphthalene, limonene, α-pinene and ammonia, classified by the European Commission's INDEX strategy report as the priority pollutants to be regulated) and evaluates accordingly cancer and non-cancer risks posed by indoor exposure in dwellings and public buildings in European Union (EU) countries. The review process indicated that significant differences in indoor air quality exist within and among the countries where data were available, indicating corresponding differences in sources and emission strength of airborne chemicals, identified or not. Conservative exposure limits were not exceeded for non-carcinogenic effects, except for formaldehyde; for carcinogenic agents the estimated risks were up to three orders of magnitude higher than the one (10(-6)) proposed as acceptable by risk management bodies. However, the risk assessment evaluation process faces crucial difficulties, either due to the relative paucity of indoor air quality measurements in many EU countries, or by the lack of sampling consistency in the already existing studies, indicating the need for additional measurements of indoor air quality following a harmonized sampling and analytical protocol. Additionally, uncertainties embodied in the cancer potency factors and exposure limit values impose further difficulties in substance prioritization and risk management.  相似文献   

7.
This study aims to investigate incidence of allergic rhinitis, bronchitis and asthma, in children living near a petrochemical complex with SO2 pollution obtained by air monitoring stations. A total of 587 children aged 11 to 14 were recruited and classified into high and low exposure groups based on a radius of 10 km from the complex. To study the influence of health on children since the operation of complex in 1999 and observe the difference of these diseases' short-term and long-term impact, we obtained the incidence rates of allergic rhinitis (ICD-9: 477), bronchitis (490–491) and asthma (493) from the Taiwan Health Insurance Database for three periods: 1999–2002, 1999–2006, and 1999–2010. Since 2001, the mean and 99th percentile of SO2 concentrations in the high exposure area have been significantly higher than those in low exposure area. There were significant differences between the high and low exposure groups in the percentage of smoking, alcohol consumption, passive smoking exposure and incense burning habits. The incidence rates of three intervals were 26.9%, 35.7%, 41.7%; 8.3%, 8.8%, 10.2%; 18.5%, 25.0%, 26.9% for allergic rhinitis, bronchitis and asthma in high exposure group. Significant differences were found between groups for allergic rhinitis in all periods, bronchitis in the first two periods, and asthma in the first period using Student's t-test. After we adjusted age, gender, group, living near roads, incense burning and passive smoking exposure, the hazard ratios between exposure groups were 3.05, 2.74, and 1.93 for allergic rhinitis with significant difference in three periods, and 2.53, 1.92 and 1.72 for bronchitis with significant difference in first period and 1.60, 1.28 and 1.29 for asthma with significant difference in first period by Cox regression. The higher incidence of allergic rhinitis was related to boys and living near roads and the higher incidence of asthma was also related to younger children, boys, and passive smoking exposure.  相似文献   

8.
Efforts to reduce the energy needs to heat or cool dwellings have the potential to create new health hazards. Increases in indoor levels of radon and its progeny from the reduction in air exchange rates add a substantial radioactive burden to the general population. Other indoor pollutants reaching critical concentrations in homes with low air exchange rates are CO and NO2 from unvented combustion in gas stoves and heaters, tobacco smoke, and asbestos fibers. In addition, insulation materials and certain types of furniture may contribute the toxicant formaldehyde diffusing from foam injected walls or chipboard. Risk estimations using linear dose-response relationships show risk factors per kWh saved which are orders of magnitude greater than for a kWh produced by large power plants using coal, oil, gas, or uranium.  相似文献   

9.
According to the World Health Organization (WHO), indoor air pollution (IAP) from the use of solid fuels in households in the developing world is responsible for more than 1.6 million premature deaths each year, whereof 0.42 million occur in China alone. We argue that the methodology applied by WHO--the so-called fuel-based approach--underestimates the health effects, and suggest an alternative method. Combining exposure-response functions and current mortality and morbidity rates, we estimate the burden of disease of IAP in China and the impacts of three abatement scenarios. Using linear exposure-response functions, we find that 3.5 [0.8-14.7 95% CI] million people die prematurely due to IAP in China each year. The central estimate constitutes 47% of all deaths in China. We find that modest changes in the use of cooking fuels in rural households might have a large health impact, reducing annual mortality by 0.63 [0.1-3. 2 95% CI] million. If the indoor air quality (IAQ) standard set by the Chinese government (150 microg PM(10)/m(3)) was met in all households, we estimate that 0.9 [0.2-4.8] million premature deaths would be avoided in urban areas and 2.8 [0.7-12.4] million in rural areas. However, in urban areas this would require improvements to the outdoor air quality in addition to a complete fuel switch to clean fuels in households. We estimate that a fuel switch in urban China could prevent 0.7 [0.2-4.8] million premature deaths. The methodology for exposure assessment applied here is probably more realistic than the fuel-based approach; however, the use of linear exposure-response relationships most likely tends to overestimate the effects. The discrepancies between our results and the WHO estimates is probably also explained by our use of "all-cause mortality" which includes important causes of death like cardiovascular diseases, conditions known to be closely associated with exposure to particulate pollution, whereas the WHO estimate is limited to respiratory diseases.  相似文献   

10.
This report presents results of a review of available methods for control of environmental hazards applied to indoor air pollutants. Indoor air pollution originates from transport of ambient outdoor air contaminants into occupied spaces by natural infiltration ventilation, or by mechanical ventilation using outdoor makeup air, plus contributions from indoor emission sources. When air exchange with the external ambient environment is reduced to conserve energy, contributions from indoor emission sources may dominate indoor air pollutant levels. This paper identifies alternative methods available to control indoor air pollutant exposures. The performance characteristics of ventilation systems and of air cleaning devices used in mixed modes for ventilation of occupied spaces are described. Models for predicting effectiveness of several alternative modes are reviewed, with field trial validation results cited where available. Results of previous confined-space studies are briefly reviewed as points of departure for consideration of necessary air quality, ventilation, and air cleaning. Understanding of indoor air contaminant generation and controls is aided by examination of earlier studies of indoor air quality, using modern perspectives on occupational environmental health and hygiene.  相似文献   

11.
The airway irritation of a reaction mixture of R-(+)-limonene and ozone was evaluated by a mouse bioassay in which sensory irritation, bronchoconstriction and pulmonary irritation were measured. Significant sensory irritation (33% reduction of mean respiratory rate) was observed by dynamic exposure of the mice, during 30 min, to a ca. 16 s old reaction mixture of ozone and limonene. The initial concentrations were nominally 4 ppm O3 and 48 ppm limonene. After reaction, the residual O3 was <0.03 ppm. Conventional analytical chemical methods were used to measure the formation of readily identified and stable products. Besides the expected products, 1-methyl-4-acetylcyclohexene (AMCH), 3-isopropenyl-6-oxoheptanal (IPOH), formaldehyde and formic acid, autooxidation products of limonene and a series of compounds including acetone, acrolein and acetic acid, which may or may not be artefacts, were identified. Addition of the sensory irritation effects of the residual reactants and all the identified compounds could not explain the observed sensory irritation effect. This suggests that one or more strong airway irritants were formed. Since limonene is common in the indoor air, and ozone is infiltrated from outdoors and/or produced indoors (e.g., by photocopiers), such oxidation reactions may be relevant for indoor air quality.  相似文献   

12.
Fine particle (aerodynamic diameter <2.5 microm) samples were collected during six intensive measurement periods from November 2001 to August 2003 at Gosan, Jeju Island, Korea, which is one of the representative background sites in East Asia. Chemical composition of these aerosol samples including major ion components, trace elements, organic and elemental carbon (OC and EC), and particulate polycyclic aromatic hydrocarbons (PAHs) were analyzed to study the impact of long-range transport of anthropogenic aerosol. Aerosol chemical composition data were then analyzed using the positive matrix factorization (PMF) technique in order to identify the possible sources and estimate their contribution to particulate matter mass. Fourteen sources were then resolved including soil dust, fresh sea salt, transformed natural source, ammonium sulfate, ammonium nitrate, secondary organic carbon, diesel vehicle, gasoline vehicle, fuel oil combustion, biomass burning, coal combustion, municipal incineration, metallurgical emission source, and volcanic emission. The PMF analysis results of source contributions showed that the natural sources including soil dust, fresh and aged sea salt, and volcanic emission contributed to about 20% of the measured PM(2.5) mass. Other primary anthropogenic sources such as diesel and gasoline vehicle, coal and fuel oil combustion, biomass burning, municipal incineration, metallurgical source contributed about 34% of PM(2.5) mass. Especially, the secondary aerosol mainly involved with sulfate, nitrate, ammonium, and organic carbon contributed to about 39% of the PM(2.5) mass.  相似文献   

13.
The records of 708 nonsmoking white adult residents of Washington County, MD, who had participated in two of respiratory symptoms were analyzed to evaluate the effects of exposure at home to two potential sources of indoor air pollution: cigarette smoking by other household members, and use of gas as a cooking fuel. After adjustment for the effects of age, sex, socioeconomic level, occupational exposure to dust, and years of residence in household, the presence of one or more smokers in the household was only suggestively associated with a higher frequency of chronic phlegm and impaired ventilatory function defined as FEV1 < 80% predicted. The use for cooking was associated with a significantly increased frequency of chronic cough and a significantly greater percentage with impaired ventilatory function as measured both by FEV1 < 80% predicted and by FEV1/FVC < 70%.  相似文献   

14.
Due to energy crisis and shortage of fossil fuel, there is a growing interest in alternative fuel for internal combustion engine. Producer gas presents a very promising alternative fuel to diesel since it is a renewable and clean burning fuel having properties similar to that of diesel. In this study, a twin cylinder dual fuel diesel engine is experimentally optimized for maximum diesel saving and lower emissions, without any undue vibration of engine using woody biomass producer gas. The test is carried out to study the performance and emission parameters of the engine in diesel mode and dual fuel mode at different gas flow rates under different load conditions. The study reveals that maximum diesel savings is found to be 83% at optimum gas flow rate and 8 kW load. Carbon monoxide, hydrocarbon and carbon dioxide emissions in dual fuel mode were higher compared with diesel mode at all test ranges. However, the main pollutants, such as nitrogen oxide and smoke, decrease substantially in the dual fuel mode compared with the diesel mode. Lower brake thermal efficiency and higher brake-specific energy consumption as well as exhaust gas temperature are observed in dual fuel mode compared with diesel mode.  相似文献   

15.
Sixteen existing multi-family buildings (94 apartments) in Finland and 20 (96 apartments) in Lithuania were investigated prior to their renovation in order to develop and test out a common protocol for the indoor environmental quality (IEQ) assessment, and to assess the potential for improving IEQ along with energy efficiency. Baseline data on buildings, as well as data on temperature (T), relative humidity (RH), carbon dioxide (CO2), carbon monoxide (CO), particulate matter (PM), nitrogen dioxide (NO2), formaldehyde, volatile organic compounds (VOCs), radon, and microbial content in settled dust were collected from each apartment. In addition, questionnaire data regarding housing quality and health were collected from the occupants. The results indicated that most measured IEQ parameters were within recommended limits. However, different baselines in each country were observed especially for parameters related to thermal conditions and ventilation. Different baselines were also observed for the respondents' satisfaction with their residence and indoor air quality, as well as their behavior related to indoor environment. In this paper, we present some evidence for the potential in improving IEQ along with energy efficiency in the current building stock, followed by discussion of possible IEQ indicators and development of the assessment protocol.  相似文献   

16.
IntroductionFuel poverty affects 2.4 million UK homes leading to poor hygrothermal conditions and risk of mould and house dust mite contaminations, which in turn increases risk of asthma exacerbation. For the first time we assess how fuel poverty, occupants' risk perception and use of mechanical ventilation mediate the risk of mould contamination in social housing.MethodsPostal questionnaires were sent to 3867 social housing properties to collect adult risk perception, and demographic and environmental information on occupants. Participant details were linked to data pertaining to the individual properties. Multiple logistic regression was used to calculate odds ratios and confidence intervals while allowing for clustering of individuals coming from the same housing estate. We used Structured Equation Modelling and Goodness of Fit analysis in mediation analyses to examine the role of fuel poverty, risk perception, use of ventilation and energy efficiency.ResultsEighteen percent of our target social housing populations (671 households) were included into our study. High risk perception (score of 8–10) was associated with reduced risk of mould contamination in the bedrooms of children (OR 0.5 95% CI; 0.3–0.9) and adults (OR 0.4 95% CI; 0.3–0.7). High risk perception of living with inadequate heating and ventilation reduced the risk of mould contamination (OR 0.5 95% CI; 0.3–0.8 and OR 0.5 95% CI; 0.3–0.7, respectively). Participants living with inadequate heating and not heating due to the cost of fuel had an increased risk of mould contamination (OR 3.4 95% CI; 2.0–5.8 and OR 2.2 95% CI; 1.5–3.2, respectively). Increased risk perception and use of extractor fans did not mediate the association between fuel poverty behaviours and increased risk of mould contamination.DiscussionFuel poverty behaviours increased the risk of mould contamination, which corresponds with existing literature. For the first time we used mediation analysis to assess how this association maybe modified by occupant behaviours. Increased risk perception and use of extractor fans did not modify the association between fuel poverty and mould contamination. This suggests that fuel poor populations may not benefit from energy efficiency interventions due to ineffective heating and ventilation practices of those occupants residing participating households. Our findings may be modified by a complex interaction between occupant behaviours and the built environment. We found that participant age, occupancy, SES, pets, drying washing indoors, geographic location, architectural design/age of the property, levels of insulation and type of heating regulated risk of mould contamination.ConclusionFuel poverty behaviours affected around a third of participating households and represent a risk factor for increased exposures to damp and mouldy conditions, regardless of adult risk perception, heating and ventilation practices. This requires multidisciplinary approach to assess the complex interaction between occupant behaviours, risk perception, the built environment and the effective use of heating and ventilation practices.Study implicationsOur findings have implications for housing policies and future housing interventions. Effective communication strategies focusing on awareness and perception of risk may help address indoor air quality issues. This must be supported by improved household energy efficiency with the provision of more effective heating and ventilation strategies, specifically to help alleviate those suffering from fuel poverty.  相似文献   

17.
The airway irritation of a reaction mixture of R-(+)-limonene and ozone was evaluated by a mouse bioassay in which sensory irritation, bronchoconstriction and pulmonary irritation were measured. Significant sensory irritation (33% reduction of mean respiratory rate) was observed by dynamic exposure of the mice, during 30 min, to a ca. 16 s old reaction mixture of ozone and limonene. The initial concentrations were nominally 4 ppm O3 and 48 ppm limonene. After reaction, the residual O3 was <0.03 ppm. Conventional analytical chemical methods were used to measure the formation of readily identified and stable products. Besides the expected products, 1-methyl-4-acetylcyclohexene (AMCH), 3-isopropenyl-6-oxoheptanal (IPOH), formaldehyde and formic acid, autooxidation products of limonene and a series of compounds (i.e., acetone, acrolein and acetic acid), which may or may not be artefacts, were identified. Addition of the sensory irritation effects of the residual reactants and all the identified compounds could not explain the observed sensory irritation effect. This suggests that one or more strong airway irritants were formed. Since limonene is common in the indoor air, and ozone is infiltrated from outdoors and/or produced indoors (e.g., by photocopiers), such oxidation reactions may be relevant for indoor air quality.  相似文献   

18.
Determinants of outdoor, indoor and personal concentrations of nitrogen dioxide (NO2) were assessed in a subset of pregnant women of the Spanish INMA (Environment and Childhood) Study. Home indoor and outdoor NO2 concentrations were measured during 48 h with passive samplers for 50 and 58 women from the INMA cohorts of Valencia and Sabadell, respectively. Women from Sabadell also carried personal NO2 samplers during the same period. Data on time–activity patterns, socio-economic characteristics, and environmental exposures were obtained through questionnaires. Multiple linear regression models were developed to predict NO2 levels.In Valencia, median outdoor NO2 levels (42 µg/m3) were higher than median indoor levels (36 µg/m3). In Sabadell, personal NO2 showed the highest median levels (40 µg/m3), followed by indoor (32 µg/m3) and outdoor (29 µg/m3) levels. Personal exposure to NO2 correlated best with the indoor NO2 levels. Temporal and traffic-related variables were significant predictors for outdoor NO2 levels. Thirty-two percent of the indoor NO2 variability in the two cohorts was explained by outdoor NO2 levels and the use of the gas appliances. The model for personal exposure accounted for 59% of the variance in NO2 levels in Sabadell with four predictor variables (outdoor and indoor NO2 levels, time spent in outdoor environments and time exposed to a gas cooker). No significant association was found between personal or indoor NO2 levels and exposure to environmental tobacco smoke (ETS) at home.Personal NO2 levels were found to be strongly influenced by indoor NO2 concentrations. The study supports the use of time–activity patterns along with indoor measurements to predict personal exposure to traffic-related air pollution.  相似文献   

19.
Cooking and heating with coal and biomass is the main source of household air pollution in China and a leading contributor to disease burden. As part of a baseline assessment for a household energy intervention program, we enrolled 205 adult women cooking with biomass fuels in Sichuan, China and measured their 48-h personal exposure to fine particulate matter (PM2.5) and carbon monoxide (CO) in winter and summer. We also measured the indoor 48-h PM2.5 concentrations in their homes and conducted outdoor PM2.5 measurements during 101 (74) days in summer (winter). Indoor concentrations of CO and nitrogen oxides (NO, NO2) were measured over 48-h in a subset of ~ 80 homes. Women's geometric mean 48-h exposure to PM2.5 was 80 μg/m3 (95% CI: 74, 87) in summer and twice as high in winter (169 μg/m3 (95% CI: 150, 190), with similar seasonal trends for indoor PM2.5 concentrations (winter: 252 μg/m3; 95% CI: 215, 295; summer: 101 μg/m3; 95% CI: 91, 112). We found a moderately strong relationship between indoor PM2.5 and CO (r = 0.60, 95% CI: 0.46, 0.72), and a weak correlation between personal PM2.5 and CO (r = 0.41, 95% CI: − 0.02, 0.71). NO2/NO ratios were higher in summer (range: 0.01 to 0.68) than in winter (range: 0 to 0.11), suggesting outdoor formation of NO2 via reaction of NO with ozone is a more important source of NO2 than biomass combustion indoors. The predictors of women's personal exposure to PM2.5 differed by season. In winter, our results show that primary heating with a low-polluting fuel (i.e., electric stove or wood-charcoal) and more frequent kitchen ventilation could reduce personal PM2.5 exposures. In summer, primary use of a gaseous fuel or electricity for cooking and reducing exposure to outdoor PM2.5 would likely have the greatest impacts on personal PM2.5 exposure.  相似文献   

20.
Formaldehyde, a highly reactive gas with a pungent odor, is released from a variety of sources including urea-formaldehyde foam insulation, particle board, and plywood, as well as various combustion processes. Concentrations of formaldehyde associated with the presence of these products are higher indoors than outdoors. Under controlled conditions, formaldehyde causes eye and nasal irritation at air concentrations of 0.24 mg/m3 and above. Exposure, residential or occupational, has been associated with eye, nose, and throat irritation, coughing, wheezing, skin rashes, nausea, and other symptoms. Formaldehyde is also a sensitizer; Individuals who are allergic to formaldehyde, or who suffer from respiratory diseases, are likely to suffer the effects of formaldehyde at even lower concentrations. Based on its known metabolism, reactivity with DNA and other marcomolecules, as well as its mutagenic effects in many test systems, formaldehyde is thought to be genotoxic. Recent studies have indicated that formaldehyde is also a carcinogen in rats and probably in mice. Epidemiological studies to date have been inadequate to determine whether or not formaldehyde is a human carcinogen. Formaldehyde seems to be a direct acting carcinogen and it is likely to pose a carcinogenic risk to humans.  相似文献   

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