硝酸甘油介入~(99)Tc~m-MIBISPECT心肌显像对PTCA决策的影响

目的　评价硝酸甘油 (NTG)介入99Tcm 甲氧基异丁基异腈 (MIBI)SPECT心肌显像对心肌梗死患者行经皮冠状动脉腔内成形术 (PTCA)决策的影响。方法　 5 1例心肌梗死患者PTCA前 1周内行99Tcm MIBI静息和NTG介入心肌显像 ,术后 2～ 3个月内复查静息心肌显像 ,并进行对比分析。结果　 5 1例患者共 14 1个心肌灌注异常节段 ,其中术后 74个节段心肌血流灌注改善 ,治疗有效率为5 2 4 8%。术前NTG介入显像表现为可逆性缺损 79个节段 ,术后 84 81% (6 7个 )节段心肌灌注改善 ,其中有明显填充的 5 8个节段 ,术后全部灌注改善。NTG介入显像表现为不可逆性缺损的 6 2个节段 ,有 11 2 9% (7个 )节段术后心肌灌注改善。NTG介入显像检测心肌存活的准确性为 86 5 2 %。结论NTG介入99Tcm MIBISPECT心肌显像对患者行PTCA起重要的决策作用。     

硝酸甘油介入99Tcm-MIBI SPECT心肌显像对PTCA决策的影响

目的评价硝酸甘油(NTG)介入99Tcm-甲氧基异丁基异腈(MIBI) SPECT心肌显像对心肌梗死患者行经皮冠状动脉腔内成形术(PTCA)决策的影响.方法 51例心肌梗死患者PTCA前1周内行99Tcm-MIBI静息和NTG介入心肌显像,术后2～3个月内复查静息心肌显像,并进行对比分析.结果 51例患者共141个心肌灌注异常节段,其中术后74个节段心肌血流灌注改善,治疗有效率为52.48%.术前NTG介入显像表现为可逆性缺损79个节段,术后84.81%(67个)节段心肌灌注改善,其中有明显填充的58个节段,术后全部灌注改善.NTG介入显像表现为不可逆性缺损的62个节段,有11.29 %(7个)节段术后心肌灌注改善.NTG介入显像检测心肌存活的准确性为86.52%.结论 NTG介入99Tcm-MIBI SPECT心肌显像对患者行PTCA起重要的决策作用.     

异舒吉~(99m)TcMIBI心肌断层显像评价直接PTCA术与溶栓治疗心肌梗死的效果

目的 :异舒吉99mTc MIBI心肌断层显像比较直接经皮冠状动脉腔内成形术 (PTCA)与溶栓治疗急性心肌梗死的效果。材料与方法 :对 47例经直接PTCA治疗 (A组 )、溶栓再灌注成功 (B组 )和失败 (C组 )的急性心肌梗死患者行异舒吉和静态99mTc MIBI心肌显像。 2 0例经介入性治疗患者 ,术后 3个月复查静态心肌显像。结果 :不论是静态 ,还是异舒吉99mTc MIBI心肌显像 ,A组心肌缺损面积小于B组 ,B组小于C组 ,三组之间差异有显著性。与静态心肌显像比较 ,A组和B组异舒吉心肌显像提示心肌灌注明显改善 ,在C组改善不明显 ,其中A组异舒吉心肌显像灌注改善大于B组 C组。 15例介入治疗异舒吉显像有心肌存活者 ,术后心肌缺损面积缩小 ,由术前 36 3%± 2 2 6 %降至 2 2 0 %± 19 3%。 5例无心肌存活者 ,术后心肌缺损面积与术前比较无差异。结论 :异舒吉99mTc MIBI心肌断层显像定量分析显示直接PTCA术可减少心肌缺损面积 ,挽救更多的濒死心肌 ,同时可准确识别心肌梗死后存活心肌。     

异舒吉^99Tc—MIBI心肌断层显像评价直接PTCA术与溶栓治疗心肌梗死的效果

目的：异舒吉^99mTc－MIBI心肌断层比较直接经皮冠状动脉内成形术（PTCA）与溶栓治疗急性心肌梗死的效果。材料与方法：对47例经直接PTCA治疗（A组）、溶栓再灌注成功（B组）和失败（C组）的急性心肌梗死患者异舒吉和静态^9mmTc－MIBI心肌显像。20例经介入性治疗患者,术后3个月复查静态心肌显像。结果：不论是静态,还是异舒吉^99mTc-MIBI心肌显像,A组心肌缺损面积小于B组,B组小于C组,三组之间差异有显著性。与静态心肌显像比较,A组和B组异舒吉心肌显像提示心肌灌注明显改善,在C组改善不明显,其中A组异舒吉心肌显像灌注改善大于B组＋C组。15例介入治疗异舒吉显像有心肌存活者,术后心肌缺损面积缩小,由术前36．3％±22．6％降至22．0％±19．3％。5例无心肌存活者,术后心肌缺损面积与术前比较无差异。结论：异舒吉^99mmTc－MIBI心肌断层显像定量分析显示直接PTCA术可减少心肌缺损面积,挽救更多的濒死心肌,同时可准确识别心肌梗死后存活心肌。     

分级组合方案~(99)Tc~m-MIBI心肌显像对冠心病围PTCA期的监测

目的　建立一种反映冠心病围经皮冠状动脉腔内成形术 (PTCA)期心肌病理生理信息的监测方法。方法　冠心病患者 87例 ,PTCA术前 1周内进行99Tcm 甲氧基异丁基异腈 (MIBI)运动、静息和硝酸甘油介入三级心肌显像 ,术后 1～ 2周内进行运动、静息二级显像 ,对照手术前后各项指标。结果　①术后 1～ 2周内显像的疗效评价与临床判断结果基本一致。②术前 1周内的三级显像缺损程度依次改善 ,介入显像与术后静息显像接近。③术前三级显像预测指标与疗效指标的相关性好 (r=0 947,P <0 0 0 1)。结论　分级组合方案99Tcm MIBISPECT心肌显像在冠心病围PTCA期的监测中有重要价值 ;术前三级显像能准确预测疗效 ;术后二级显像能准确评价疗效。     

门控心肌灌注显像筛选冠心病介入治疗及其疗效的评价

目的探讨腺苷负荷/静息99mTc-MIBI门控心肌灌注显像(G-MPI)联合硝酸甘油(NTG)介入心肌灌注显像,筛选冠心病患者进行经皮冠状动脉介入治疗(PCI),并且用腺苷负荷/静息99mTc-MIBI G-MPI评价治疗后的疗效。方法238例疑诊的冠心病患者均行腺苷负荷/静息G-MPI,间隔1～2天后对确诊为心肌梗死的68例患者继续行NTG介入心肌灌注显像,筛选出具有存活心肌的患者进行PCI治疗。治疗后6～12个月复查腺苷负荷/静息G-MPI,比较PCI术前及术后随访期G-MPI的定性与定量分析的结果。结果 68例心肌梗死患者NTG介入显像提示心肌存活患者51例,静息显像的524个异常灌注节段,NTG介入显像发现有242个节段灌注得到改善,改善率为46. 2%(242/524),NTG介入显像所获得的总评分SS低于静息显像SS(14. 62±5. 81 vs 18. 82±6. 37,P 0. 05)。51例心肌存活患者中33例患者行PCI术,术后腺苷负荷/静息G-MPI显示可逆性缺损区节段数、固定性缺损区节段数及负荷静息评分差值SDS均低于术前(204 vs 113,134 vs 92,5. 37±1. 96 vs 2. 49±1. 13,P值均0. 05)。患者PCI术后左室射血分数高于术前(55. 39±11. 71vs 48. 56±10. 27,P 0. 05),术后左室舒张末容积和左室收缩末容积低于术前(97. 98±29. 25 vs 112. 82±30. 38,45. 96±20. 77 vs 55. 64±21. 12,P值均0. 05)。结论负荷/静息G-MPI联合NTG介入显像能提高对心肌梗死患者存活心肌的检出,从而对PCI患者进行更为准确、合理的筛选,同时负荷/静息G-MPI对于术后患者预后及长期随访中也具有一定意义。     

硝酸甘油介入~(99m)Tc-MIBI心肌断层显像评估存活心肌

目的:探讨含服硝酸甘油介入99mTc-MIBI心肌断层显像在判断心肌存活中的价值.方法:12例心肌梗死患者先行静息99mTc-MIBI心肌断层显像,48小时后在静脉注射99mTc-MIBI前5分钟舌下含服硝酸甘油0.5mg,然后再行静息心肌断层显像.结果:12例心肌梗死患者静息心肌断层显像有68个节段放射性分布异常,服硝酸甘油介入后26个节段灌注改善;42个节段无变化或有异常加重.结论:含服硝酸甘油介入99mTc-MIBI心肌断层显像对判断心肌存活有一定的临床价值,且方法简便易行,安全可靠.     

冠状动脉介入治疗后缺血心肌恢复时间观察

目的：观察分析冠状动脉介入治疗（PCI）术后7～14天、3个月运动／静息99mTc-MIBI心肌灌注显像，评估PCI术后缺血心肌完全恢复时间。方法：将冠心病不稳定心绞痛42例PCI术后7～14天、3个月分别行运动／静息99mTc—MIBI心肌灌注显像，并进行比较分析。结果：PCI术后7～14天运动／静息99mTc—MIBI心肌灌注显像比较，差异显著（P〈0．01）；而术后3个月运动／静息99mTc—MIBI心肌灌注显像比较，差异不显著（P〉0．05）。结论：PCI术后7～14天仍有部分缺血心肌未完全恢复血流灌注，而3个月后缺血心肌完全恢复血流灌注。运动／静息99mTc—MIBI心肌灌注显像是评估心肌血流灌注的有效方法。     

~(99)Tc~m-MIBI心肌灌注断层显像在急诊治疗急性心肌梗死中的作用

目的　比较直接冠状动脉 (简称冠脉 )内支架置入和静脉溶栓疗法在急性心肌梗死(AMI)治疗中的效果。方法　 42例急诊入院AMI患者 ,随机分为冠脉内支架组 2 3例 ,静脉溶栓组 19例。两组患者均于梗塞相关动脉 (IRA)再通治疗前和后行99Tcm 甲氧基异丁基异晴 (MIBI)心肌SPECT显像。将左室心肌分为 2 0个节段 ,并对心肌摄取99Tcm MIBI的程度进行打分 ,分别计算治疗前心肌显像的总积分 (SBS)、治疗后心肌显像的总积分 (SAS)和两者相减的积分 (SDS)。结果　直接冠脉内支架组与溶栓组比较 :SBS为 41 3± 9 8和 39 4± 7 9(t=1 2 ,P >0 0 5 ) ,SAS为 17 8± 6 4和 2 7 3±6 7(t=5 8,P <0 0 1) ,SDS为 2 4 5± 4 2和 12 2± 2 3(t =7 3,P <0 0 1)。在冠脉内支架组的总共46 0个心肌节段中 ,IRA再通治疗前有 193个 3分和 4分节段 ,治疗后有 10 6个改善至 0分 (5 4 9% )。在溶栓组的总共 380个心肌节段中 ,溶栓前有 149个 3分和 4分节段 ,溶栓后有 6 1个节段改善至 0分(4 0 9% ) ,两组间的完全改善率差异有极显著性 (P =0 0 14)。结论　在AMI的急诊治疗中 ,直接冠脉内支架置入的疗效明显优于静脉溶栓疗法 ;99Tcm MIBI心肌SPECT显像可对AMI患者IRA再通治疗疗效进行可靠的无创性评价。     

分级组合方案^99Tc^m—MIBI心肌显像对冠心病围PTCA期的监测

目的建立一种反映冠心病围经皮冠状动脉腔内成形术(PTCA)期心肌病理生理信息的监测方法。方法冠心病患者87例，PTCA术前1周内进行99Tcm-甲氧基异丁基异腈(MIBI)运动、静息和硝酸甘油介入三级心肌显像，术后1～2周内进行运动、静息二级显像，对照手术前后各项指标。结果①术后1～2周内显像的疗效评价与临床判断结果基本一致。②术前1周内的三级显像缺损程度依次改善，介入显像与术后静息显像接近。③术前三级显像预测指标与疗效指标的相关性好(r=0.947，P＜0.001)。结论分级组合方案99Tcm-MIBISPECT心肌显像在冠心病围PlCA期的监测中有重要价值；术前三级显像能准确预测疗效；术后二级显像能准确评价疗效。     

运动静息介入三步^99mTc—MIBI心肌显像预测PTCA疗效

目的：探讨组合方案的ＳＰＥＣＴ ９９ｍＴｃＭＩＢＩ 心肌显像术前预测ＰＴＣＡ 疗效的价值。材料与方法：采用运动、静息、静滴硝酸甘油介入三步９９ｍＴｃＭＩＢＩ 心肌显像对１２２ 例拟行ＰＴＣＡ 治疗的患者进行监测,并以术后１ ～２ 周的运动、静息显像作为疗效指标进行比较。结果：术前心肌显像显示的缺损变化与ＰＴＣＡ 疗效有重要关系。以运动与ＮＴＧ 显像组合反映的缺损变化作为预测指标,则与疗效指标呈正相关（ｒ ＝ ０ ．９３６６） 。结论：运动、静息、静滴硝酸甘油介入三步９９ｍＴｃＭＩＢＩ 心肌显像能够在术前全面准确地预测ＰＴＣＡ 的疗效。     

99m Tc－M IBI心肌灌注断层显像对实验性心肌梗塞的评价

目的：评价９９ｍ锝一甲氧基异丁基异腈（９９ｍＴｃ－ＭＩＢＩ）ＳＰＥＣＴ显像对心肌梗塞范围的估测及硝酸甘油介入后对存活心肌检测的价值。材料和方法：７条杂种犬通过结扎冠状动脉造成心肌梗塞模型，分别在实验第一天及实验第七天行９９ｍＴｃ－ＭＩＢＩＳＰＥＣＴ静息显像及硝酸甘油介入９９ｍＴｃ－ＭＩＢＩ心肌显像。用圆周剖面法定量分析短轴６个断面心肌缺损面积大小。结果：末次显像缺损面积与病理梗塞面积有良好相关性（ｒ＝０．８６和ｒ＝０．８７分别为硝酸甘油介入前后心肌缺损面积与病理梗塞面积的相关系数），末次显像与首次显像相比缺损面积明显缩小（Ｐ＜０．０５），硝酸甘油介入后心肌显像的平均缺损面积在首次和末次显像均明显减小（Ｐ＜０．０１），且缺损区的平均计数在硝酸甘油介入后均明显增高（Ｐ＜０．０５）。结论：９９ｍＴｃ－ＭＩＢＩ心肌断层显像是了解急性心肌梗塞范围的较好手段及硝酸甘油介入９９ｍＴｃ－ＭＩＢＩＳＰＥＣＴ显像可以提高检测低灌注区残存的存活心肌。     

门控~(18)F-FDG/~(99m)Tc-MIBI双核素显像评价冠脉搭桥术对心功能改善的作用

目的应用门控18F-FDG/99mTc-MIBI双核素显像评价陈旧性心肌梗死(MI)患者经冠脉搭桥(CABG)术对心功能改善的作用。方法31例陈旧性心肌梗死(MI)患者在冠脉搭桥术前及4个月后行18F-FDG及99mTc-MIBI DISA法显像。将左室心肌分为9个节段,根据术前显像结果分为灌注代谢匹配组(M)和不匹配组(MM),半定量法分别计算各节段99mTc-MIBI、18F-FDG摄取分数F值,评价局部心肌灌注、代谢情况,计算术前术后各种心功能参数包括EF、SV,观察整体心功能改善情况。结果31例患者,共分为279个节段;13例患者含有不匹配的节段108个,术前后99mTc-MIBI、18F-FDG摄取分数F值分别为1.71±0.44、1.22±0.31和2.33±0.72、1.50±0.50(P<0.01),术前后EF、SV值分别为(28.5±9.4)%、(47.1±17.0)ml和(34.2±9.7)%、(58.81±27.1)ml(P<0.05);18例患者含匹配的节段152个,术前后99mTc-MIBI、18F-FDG摄取分数F分别为1.51±0.44、1.23±0.31和1.60±0.50、1.34±0.22(P>0.05);术前后EF、SV值分别为(25.3±9.4)%、(45.6±17.0 ml)和(26.5±9.7)%、(46.81±27.1)ml(P>0.05)。结论冠脉搭桥术只能改善有存活心肌细胞的心室功能,而对无存活心肌细胞的心室功能无明显改善作用。     

^99mTc-MIBI心肌灌注断层显像假阴性与假阳性的临床分析

目的探讨^99mTc-MIBI（甲氧基异睛）心肌灌注断层显像与冠状动脉造影不一致的临床意义。方法136例临床诊断为冠心病患者,于冠状动脉造影术（CAG）前2周内行^99mTc-MIBI心肌灌注断层显像（运动或药物负荷及静息显像）。以CAG为金标准,分析^99mTc-MIBI心肌灌注断层显像假阳性与假阴性的临床意义。结果两者不相符合13例,^99mTc-MIBI心肌灌注断层显像阳性而冠状动脉正常者10例,^99mTc-MIBI心肌灌注断层显像阴性而冠状动脉造影阳性者3例。结论^99mTc-MIBI心肌灌注断层显像阴性而冠状动脉造影阳性提示冠脉临界病变,^99mTc-MIBI心肌灌注断层显像阳性而冠状动脉造影阴性提示冠脉微循环灌注不足。     

Enhanced detection of reversible myocardial hypoperfusion by technetium 99m-tetrofosmin imaging and first-pass radionuclide angiography after nitroglycerin administration

Background  Reversal of ischemia after myocardial infarction by revascularization is worth-while only if viability exists in a sufficiently large portion of the left ventricle. Methods and Results  To determine myocardial hypoperfusion reversibility and its influence on segmental and global function, we studied 50 patients after myocardial infarction. Three technetium 99m-tetrofosmin scintigraphies were performed: 1 at rest, 1 after 0.6 mg sublingual nitroglycerin (NTG), and 1 after injection at peak stress. First-pass multigated radionuclide angiography was obtained at rest and after NTG. Each patient also underwent a stress redistribution-reinjection thallium-201 scintigraphy. During stress ^99mTc-tetrofosmin, 104 segments had normal uptake, 51 showed moderately reduced uptake, and 186 had severely reduced uptake. Of these 186 segments, 33 (18%) improved at rest, and 41 (22%) improved only after NTG. Fifty-nine (79%) of these segments with improved uptake were also found to have reversible defects on ²⁰¹Tl imaging. In the 26 patients with ventricular dysfunction, a 73% agreement was found between the functional and ^99mTc-tetrofosmin uptake post-NTG improvement, whereas a 69% agreement was found with thallium reinjection. No significant differences were seen between ^99mTc-tetrofosmin and ²⁰¹Tl imaging. Conclusion  Nitroglycerin administration during ^99mTc-tetrofosmin scintigraphy improves the detection of myocardium with reversible hypoperfusion in patients with a previous myocardial infarction.     

Improved detection of myocardial perfusion reversibility by rest-nitroglycerin Tc-99m-MIBI: Comparison with Tl-201 reinjection

BACKGROUND: The role of nitroglycerin (NTG) in Tc-99m-methoxyisobutil isonitrile (MIBI) studies to improve the assessment of myocardial viability in patients with coronary artery disease and its comparison with TI-201 reinjection has not yet been clarified. This study aimed to test whether sublingual administration of NTG could improve the capability of Tc-99m-MIBI to detect reversibility in exercise-induced perfusion defects and to compare it with the TI-201 stress-redistribution-reinjection protocol. METHODS AND RESULTS: Thirty-eight patients (33 men, 5 women; mean age 49.3 +/- 8.2 years with previous myocardial infarction [mean evolution 7.1 +/- 3.9 months]) underwent exercise, redistribution, and reinjection TI-201 imaging, as well as exercise, rest, and NTG MIBI myocardial scintigraphy (3-day protocol). A total of 494 myocardial segments were assessed by quantitative analysis. Of the 136 myocardial segments with fixed defects on exercise-rest sestamibi imaging, 109 (80%) did not change after NTG MIBI study, and 27 (20%) demonstrated enhanced uptake. In the 140 myocardial segments with fixed defects on exercise-redistribution thallium imaging, 112 (80%) did not improve after TI-201 reinjection study, and 28 (20%) showed increased activity. The observed agreement on reversibility detection between NTG MIBI and TI-201 reinjection, with the 210 segments with perfusion defects used for this analysis on both studies, was 78%, with a significant kappa = .56 +/- .07 SE. CONCLUSION: Our data suggest that the use of an NTG MIBI protocol results in an incremental improvement for detecting exercise-induced perfusion defect reversibility and achieves results similar to those from a TI-201 reinjection protocol.     

^99Tc^m-MIBI运动负荷-静息心肌灌注显像对冠心病患者经皮腔内冠状动脉血管成形术的疗效评价

目的 用^99Tc^m-甲氧基异丁基异腈（^99Tc^m-MIBI）运动-静息心肌灌注显像评价经皮腔内冠状动脉成形术（PTCA）的疗效。方法20例冠心病患者在PTCA术前和术后应用^99Tc^m-MIBI行运动负荷．静息心肌灌注显像,并对图像进行半定量分析。其中8例患者于术后6个月再次心肌灌注显像。结果对20例患者的27支冠状动脉呈狭窄病变进行PTCA,术前血管的平均狭窄为（84．3±9．2）％,术后平均残留狭窄减为（31．2±9．1）％。运动负荷-静息显像显示可逆性缺损（心肌缺血）的心肌节段数由术前的55个（30．6％）减为术后的10个（5．6％）,差异有显著性（x^2=38．02,P〈0．005）。术后心肌灌注的改善率为81．8％,8例患者术后6个月心肌显像显示3例出现缺血节段,冠状血管造影证实为再狭窄。结论^99Tc^m-MIBI运动负荷-静息心肌灌注显像是一种有效的无创性的判断PTCA术后疗效及再狭窄的方法。     

^99mTc—MIBI提前显像在心肌梗塞诊断中的应用

目的：探讨99mTc-MIBI心肌显像能否成为急性心肌梗塞的快速诊断手段。资料和方法：选择临床确诊的心肌梗塞患者35例，于注射99mTc－MIBI后10min与60min以相同条件分别进行SPECT显像，并以相同条件分析处理图像，记录心肝肺的放射性计数率，比较两次显像结果的差异。结果；10min像阳性率31.2％，60min像为308％，符合率95.2％。有22个节段（4．8％）两次显像缺损程度有差异，以下后壁居多（13／22.59.1％）。图像质量以60min像为佳，心脏计数率随时间延长而降低，而心肝比、心肺比升高。结论：10min显像与60min显像在本组病例中具有很好的诊断一致性，至少可为急性心梗提前50min提供诊断，可望成为急性心梗的一种快速诊断手段。     

Evaluation of the clinical value of combination of 99mTc-MIBI myocardial SPECT and 18F-FDG PET in assessing myocardial viability.

PURPOSE: To evaluate the value of 18F-FDG PET metabolic imaging and 99mTc-MIBI SPECT in the identification of myocardial viability in patients with previous myocardial infarction and left ventricular dysfunction. METHODS: 18F-FDG PET (made in China) and 99mTc-MIBI SPECT were performed in 60 patients (pts) (age 54+/-9 yr) with myocardial infarction before revascularization. Before and after revascularization, LVEF and wall motion were measured with echocardiography in 36 pts (Group A), and myocardial perfusion was evaluated in 24 pts (Group B). RESULTS: According to the interpretation of perfusion and metabolic images, myocardial segments were classified into mismatch (MM): reduced myocardial perfusion and normal FDG uptake or match (M): reduced perfusion and FDG uptake. Out of 264 segments with hypoperfusion, 145 (54.9%) were MM, suggesting viable myocardium (G-A1 and G-B1), 119 (45.1%) were M, suggesting necrosis (G-A2 and G-B2). After revascularization, LVEF was increased in G-A1 (49+/-15% vs. 59+/-7%, p<0.05), and in G-B1 (50+/-8% vs. 59+/-12%, p<0.05), but was not improved in G-A2 and G-B2. LVEDD was decreased in G-A1 and G-B1 (p<0.05) and was unchanged in G-A2 and G-B2. The positive predictive value (PPV) of FDG PET for improvement of regional wall motion after revascularization was 88%, and the negative predictive value (NPV) was 72.6%. The PPV for improvement of perfusion was 84.1%, NPV was 85%, and accuracy was 84.4%. CONCLUSION: 18F-FDG imaging with Chinese PET has clinical value for assessing myocardial viability and identifying patients who will benefit from revascularization.     

99Tcm-MIBI运动负荷-静息心肌灌注显像对冠心病患者经皮腔内冠状动脉血管成形术的疗效评价

Objective To evaluate the outcomes of stress-rest 99Tcm-MIBI peffusion imaging in patients with percutaneous transluminal coronary angioplasty (PTCA). Methods Twenty patients with coronary heart disease underwent repeated 99Tcm-MIBI stress-rest perfusion imaging before and after PICA, and semi-quantitative analysis, 8 cases of them repeated coronary angiography after 6 monthes. Results Twenty patients with total of 27 coronary artery stenosis were distended, the average vascular stenosis were (84.3±9.2)% before PTCA, and were reduced to(31.2±9.1)% after PTCA. Stress-rest perfusion imaging showed myocardial segments were reversible defect (myocardial ischemia) from 55 (30.6%) befor PTCA to 10 (5.6%) after PTCA, there were significant difference (X2=38.02, P<0.005). The improved rate was 81.8%, 8 patients underwent repeated stress-rest SPECT imaging after 6 monthes, 3 cases appears ischemia segment, and coronary angiography confirmed was restenosis. Conclusion 99Tcm-MIBI stress-rest perfusion imaging is a useful noninvasive method for evaluating the effect of PTCA and for restenosis.