美沙拉嗪联合益生菌治疗溃疡性结肠炎疗效分析

目的探讨美沙拉嗪联合益生菌治疗溃疡性结肠炎的临床疗效。方法选取广东省英德市中医院收治的64例溃疡性结肠炎患者作为研究对象,按照随机数字法分成两组,对照组32例患者给予单独的美沙拉嗪进行治疗;研究组32例患者给予美沙拉嗪联合益生菌治疗,比较分析两组的临床疗效与复发情况。结果研究组患者的总有效率为93.75%,对照组患者的总有效率为71.88%,研究组的临床疗效明显好于对照组(P0.05):两组患者在治疗后的血清C-蛋白水平均有所下降,而研究组患者的下降程度明显高于对照组(P0.01);研究组中患者复发率为12.50%,对照组患者复发率为34.38%,两组的差异具有统计学意义(P0.05)。结论相比单纯使用美沙拉嗪,采用美沙拉嗪联合益生菌治疗溃疡性结肠炎的临床疗效更为显著,治疗后复发率低,具有临床推广使用价值。     

前列地尔注射液治疗老年糖尿病肾病34例的临床疗效观察

目的观察研究前列地尔注射液治疗老年糖尿病肾病患者的临床疗效。方法从揭阳市人民医院收治的老年糖尿病肾病患者中随机选择68例作为研究对象,并采用数字收取表法将患者分为两组,其中采用常规治疗方案的34例患者为对照组,另外34例患者则采用前列地尔注射液治疗为观察组,对两组患者的临床疗效、血脂及肾功能等进行比较。结果治疗后观察组的甘油三酯、血肌酐、尿素氮及24 h尿蛋白排泄率等指标显著低于对照组,数据比较差异具有统计学意义(P0.05);观察组患者的治疗总有效率为94.12%,对照组患者的治疗总有效率为76.47%,数据比较差异具有统计学意义(P0.05)。结论对老年糖尿病肾病患者采用前列地尔注射液治疗能够有效改善患者的临床症状,降低血脂及肾功能指标,值得推广应用。     

腹腔镜手术联合药物治疗子宫内膜异位症的临床疗效分析

目的评价腹腔镜手术联合药物治疗子宫内膜异位症的临床疗效。方法选取东莞市第三人民医院于2015年1月至2017年1月收治的150例子宫内膜异位症患者,按随机盲选法分为两组,对照组75例给予腹腔镜手术治疗,观察组75例给予腹腔镜手术联合药物治疗,对比两组临床治疗效果。结果在治疗总有效率方面,观察组为94.67%,明显要比对照组的70.67%高,两组数据差异有统计学意义(P<0.05)。在不良反应发生率方面,观察组为5.33%,明显要比对照组的22.67%低,两组数据差异有统计学意义(P<0.05)。结论对于子宫内膜异位症患者,采取腹腔镜手术联合药物进行治疗,具备显著疗效,能够降低不良反应发生率,因此,值得在临床中采纳及应用。     

高压氧治疗糖尿病足的疗效分析

为观察高压氧(HBO)治疗糖尿病并发糖尿病足的临床疗效,HBO组36例患者在使用抗生素及局部换药等治疗的同时,采用HBO治疗;对照组34例患者仅使用抗生素及局部换药等治疗。结果表明,HBO组患者总的有效率为91.7%,而对照组总有效率为67.5%,两组的疗效有显著性差异(P<0.05)。HBO对糖尿病足有显著的疗效,值得临床进一步研究和应用。     

通脉化浊汤对痰瘀互结型冠心病患者的临床疗效

目的观察通脉化浊汤对痰瘀互结型冠心病患者的临床疗效,以期为临床治疗提供一定的参考。方法选取2010年1月—2015年1月间入院收治的痰瘀互结型冠心病患者110例,随机分为实验组(55例)和对照组(55例)。对照组应用常规西药消心痛、阿司匹林治疗,实验组在此基础上应用通脉化浊汤。观察两组患者治疗8周的疗效。结果症状观察中,对照组显效19例,好转21例,总有效率为72.73%;实验组显效26例,好转26例,总有效率为94.54%。心电图疗效对比中,对照组显效18例,好转23例,总有效率为74.55%;实验组显效27例,好转26例,总有效率为96.36%。结论应用通脉化浊汤治疗痰瘀互结型冠心病患者疗效显著,可明显改善患者的临床症状与心电图表现。     

超声激发联合小剂量尿激酶治疗老年脑梗死建立侧支循环的疗效分析

目的分析超声激发联合小剂量尿激酶治疗老年脑梗死建立侧支循环的疗效。方法回顾性分析佛山市第一人民医院2013年2月—2015年6月收治的150例老年脑梗死患者,根据不同治疗方案分为两组(各75例),对照组予以小剂量尿激酶治疗,研究组联合超声激发治疗,对比两组治疗前后NIHSS评分变化情况及临床疗效。结果治疗后两组NIHSS评分均有所降低,但研究组降低幅度比对照组大(P0.05);研究组治疗总有效率93.33%比对照组80.00%高(P0.05)。结论联合治疗老年脑梗死建立侧支循环可取得显著效果,值得临床推广应用。     

宫颈环形电切术联合纳米银凝胶应用于慢性宫颈炎的临床探讨

目的分析宫颈环形电切术联合纳米银凝胶应用于慢性宫颈炎的临床疗效。方法选择2014年10月至2015年10月在上栗县长平卫生院接受治疗的122例慢性宫颈炎患者作为研究对象。将122例患者随机分为常规组和实验组。常规组使用宫颈环形电切术进行治疗;实验组使用宫颈环形电切术联合纳米银凝胶进行治疗。对比两组患者的治疗效果以及阴道感染率及出血率。结果两组患者经过不同的治疗之后实验组患者的治疗总有效率(100.0%)显著高于常规组治疗总有效率(80.3%),数据差异显著,具备统计学意义(P0.05);实验组患者的阴道感染率(1.64%)及出血率(3.28%)分别明显低于常规组的阴道感染率(13.11%)与出血率(18.03%),两组数据差异显著,具备统计学意义(P0.05)。结论宫颈环形电切术联合纳米银凝胶应用于慢性宫颈炎的临床疗效显著,纳米银凝胶能够极大程度地帮助患者减少阴道出血、阴道感染的情况发生,能够很好地弥补宫颈环形电切术的不足,能够极大程度提升患者治疗效果,是慢性宫颈炎的理想治疗方式,值得临床推广。     

急诊内科治疗老年重症心力衰竭的临床疗效观察

目的探析老年重症心力衰竭在急诊内科治疗的临床效果。方法选取佛山市第一人民医院2014年1月—2015年6月收治的98例老年重症心力衰竭患者,将其随机分为治疗组和对照组,各为49例,对照组给予利尿剂、强心剂等常规治疗,治疗组在对照组的基础上给予厄贝尔沙坦氢氯噻嗪与美托洛尔联合治疗,对比分析两组患者的治疗疗效及临床指标改善情况。结果治疗组33例显效,15例有效,1例无效,总有效率为97.96%,对照组20例显效,16例有效,13例无效,总有效率为73.47%,两组比较差异显著,P0.05;治疗前两组患者的临床指标差异不显著,P0.05,治疗后,治疗组在LVFE(左室射血分数)、NYHA(心功能分级)及BNP(B型利钠肽)上较对照组比较差异显著,P0.05。结论老年重症心力衰竭在急诊内科治疗中加以厄贝尔沙坦氢氯噻嗪与美托洛尔,临床疗效更加显著,患者的临床指标改善更明显,值得应用。     

复方甲硝唑阴道栓治疗阴道炎的临床效果

目的探讨复方甲硝唑阴道栓治疗阴道炎的临床效果。方法从天津市武清区中医医院2014.年1月至2015年1月收治的除真菌以外的阴道炎患者中随机抽取100例作为研究对象,并将其分为研究组和对照组,每组各50例。研究组患者给予复方甲硝唑阴道栓治疗,对照组给予制霉菌素治疗,比较两组患者治疗后的效果。结果研究组治疗后,痊愈33例,占66%,总有效率为100%,对照组痊愈24例,占48%,治疗总有效率为88%,研究组治疗痊愈率和总有效率均显著高于对照组(P0.05)。结论复方甲硝唑阴道栓治疗在阴道炎患者中疗效显著,值得临床推广和应用。     

针灸治疗面瘫临床疗效观察

目的分析研究针灸治疗面瘫的临床效果。方法将40例面瘫患者随机分成对照组和实验组各20例,对照组患者采用常规西医疗法治疗,实验组患者采用中医针灸方法治疗,两组均治疗3个疗程后统计疗效。结果治疗组总有效率为95%,对照组总有效率为80%,治疗组疗效优于对照组,具有非常显著性差异(P0.05)。结论在治疗过程中,较常规针刺疗法,针灸疗法使面神经恢复正常功能;治疗时病人痛苦小,疗程短,疗效显著,为治疗面瘫首选方法。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.     

Facile synthesis of bicyclic 1-arylpyrazol-5-ones

In this Letter, we described a facile method for constructing fused bicyclic 1-arylpyrazol-5-one ring system. We employed various methylene-containing carboxylic acids as the substrates and proved that the pyrazolone ring closure requires activated methylene group in intermediate II. Accordingly, a series of structurally diversified, fused bicyclic 1-arylpyrazol-5-ones was prepared in moderate to high yields using the requisite substrates.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.     

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.