Parallel unstructured multigrid simulation of 3D unsteady flows and fluid-structure interaction in mechanical heart valve using immersed membrane method

In this work, a second-order accurate immersed membrane method (IMM) is adopted to simulate the fluid-structure interaction phenomena in the mechanical heart valves (MHVs). The leaflets of the MHV are immersed in the fluid flows and move on top of the fixed fluid mesh. The blood flow is computed by a 3D parallel unstructured multigrid implicit finite-volume Navier-Stokes solver for incompressible flows. The opening and closing phases of a St. Jude 29 mm MHV are computed under pulsatile inflow to investigate the blood-leaflet interactions. The results show that the moment generated by the fluid pressure is the major cause for the valve motions, while the moment due to the fluid shear stresses is almost negligible. It is also observed that near the end of the opening phase the valve opening speed decelerates, so the valve leaflets have a cushioning effect and avoid a sudden impact on the hinges. For closing phase, jet flows are formed in the central channel and squeeze flows occur in the side channels near the fully closed positions.     

Analysis and experiment of capillary valves for microfluidics on a rotating disk

This paper presents an analytical expression of the pressure barrier in a capillary-burst valve for flow regulation in centrifugal microfluidics. The analysis considers variations of the interfacial energies at the meniscus of three-dimensional (3D) configuration in a rectangular microchannel with a sudden expansion in cross-section. We derive a simple expression that predicts the critical burst pressure or rotational speed to overcome the capillary valve. Experiments were carried out for capillary valves that were integrated with microchannels on a rotating disk having various cross-sectional dimensions (300 and 400 μm in width and 80–600 μm in depth) and wedge angles (30°–100°) of sudden expansion. The flow visualization of the meniscus development across the capillary valve supports the assumptions made for the present analysis. The measurements of burst rotational speeds for the capillary valves are in good agreement with the predictions by the simple expression except that those with a larger channel width and wider wedge angles are nearly 10% lower than the predicted values.     

Modeling of fluid flow in a tube with a moving indentation

The time-dependent flow in a tube with a moving indentation is numerically simulated using a dynamic mesh model. The model was used to simulate the flow in a tube with an indentation moving at different frequencies. The model was validated for a two-dimensional channel with a moving indentation. The results exhibited good agreement with the available experimental results. The results show that a single vortex was formed at a wall frequency of 0.1 Hz and was swept out of the tube at the end of the period. At a higher frequency of 1 Hz, vortex doubling occurred with reverse flow dominating downstream of the indentation. The results also show that the wall shear stress was larger for the higher frequency case of the moving indentation.     

A Biohybrid Microfluidic Valve Based on Forisome Protein Complexes

Externally adjustable and reversibly switchable valves are key actuators in microchannels. A related function is required for full fluidic control over the flow in the vascular microchannels (phloem) of plants. Evolution fulfilled this in the Fabaceae family through using reversibly swellable protein aggregates (forisomes). The swelling behavior is regulated in the vessels by calcium but is also pH dependent. In order to utilize the natural forisome elements in a technical chip application, we integrated the protein complexes into the channel system of a microflow cell. In this artificial environment, the reversible conformation change of the forisomes could be induced by varying the calcium concentration or by an electrically generated pH shift. In consequence, the swelling of the forisome reversibly blocked a microparticle flow in various branched and unbranched channel geometries. The regulation of the flow was successfully verified by detecting the particle flux while switching the valve and by impedance spectroscopy. In conclusion, forisome plant protein bodies are a valve element that can readily be integrated into microfluidics and can also be externally controlled to selectively retain objects that pass the channel.$hfill$[2008-0040]      

Topology optimization of a no-moving-part valve incorporating Pareto frontier exploration

No-moving-part (NMP) valves, such as Tesla valves, are engineered fluid channels whose flow resistance depends on the flow direction. They have no moving parts and do not deform, but rely on inertial forces of the fluid to preferentially allow flow in one direction while strongly inhibiting flow in the reverse direction. NMP valves have significant advantages over active valves in terms of their reliability and easy manufacturability. Several previous studies have explored optimum designs of NMP valves, and the most widely used indicator of NMP valve performance is diodicity, defined as the ratio of the pressure drop of reverse flow to that of the forward flow. However, higher diodicity does not necessarily imply a lower pressure drop for the forward flow, and if this pressure drop is too high, significant pumping power is required, which makes the NMP valve inefficient for use in pumping applications. Therefore, for the design NMP valves, treating the forward and reverse flow pressure drops independently in a multiobjective formulation is preferable to optimization of the diodicity alone. In this paper, we propose a bi-objective topology optimization method for an optimum design of an NMP valve. One objective function is to minimize the pressure drop in the forward flow, and the other is to maximize the pressure drop in the reverse flow. A numerical example is provided to illustrate the effectiveness of the proposed method.     

Study of an innovative one-sided actuating piezoelectric valveless micropump with a secondary chamber

Previous studies have indicated that a one-sided actuating piezoelectric micropump (OAPMP) combined with two valves may enhance the liquid flow rate to 4.1 ml/s and make it possible to reach the maximum pump head of 9807 Pa in a limited space. In this study, an innovative one-sided actuating piezoelectric valveless micropump (OAPMP-valveless) has been developed to actuate fluid at a higher flow rate in one direction by adding a secondary chamber. The secondary chamber plays a key role in the application of the valveless micropump: the flow rate of the pump can reach 0.989 ml/s by adding a secondary chamber. The maximum pump head is 1522.5 Pa when using the 0.3 mm-thick secondary diaphragm and the 0.5 mm-thick primary diaphragm. In addition, if a nozzle/diffuser element is applied to the OAPMP-valveless with a secondary chamber, the flow rate can be further improved to 1.183 ml/s at a frequency of 150 Hz. A three-dimensional numerical model of the valveless micropump has been built to compare the measured results with the simulated results.     

Hydrodynamic trap-and-release of single particles using dual-function elastomeric valves: design, fabrication, and characterization

This paper introduces a simple method for trapping and releasing single particles, such as microbeads and living cells, using dual-function elastomeric valves. Our key technique is the utilization of the elastomeric valve as a dual-function removable trap instead of a fixed trap and a separate component for releasing trapped particles, thereby enabling a simple yet effective trap-and-release of particles. We designed, fabricated, and characterized a microfluidic-based device for trapping and releasing single beads by controlling elastomeric valves driven by pneumatic pressure and a fluid flow action. The fluid flow is controlled to ensure that beads flowing in a main stream enter into a branch channel. A bead is trapped by deflected elastomeric valves positioned at the entrance of a branch channel. The trapped bead is easily released by removing the applied pressure. The trapping and releasing of single beads of 21?μm in diameter were successfully performed under an optimized pressure and flow rate ratio. Moreover, we confirmed that continuous trapping and releasing of single beads by repeatedly switching elastomeric valves enables the collection of a controllable number of beads. Our simple method can be integrated into microfluidic systems that require single or multiple particle arrays for quantitative and high-throughput assays in applications within the fields of biology and chemistry.     

Large-eddy simulation of streamwise-rotating turbulent channel flow

In many engineering and industrial applications the investigation of rotating turbulent flow is of great interest. Whereas some research has been done concerning channel flows with a spanwise rotation axis, only few investigations have been performed on channel flows with a rotation about the streamwise axis. In the present study an LES of a turbulent streamwise-rotating channel flow at Re_τ = 180 is performed using a moving grid method. The three-dimensional structures and the details of the secondary flow distribution are analyzed and compared with experimental data. The numerical-experimental comparison shows a convincing agreement as to the overall flow features. The results confirm the development of a secondary flow in the spanwise direction, which has been found to be correlated to the rotational speed. Furthermore, the findings show the distortion of the main flow velocity profile, the slight decrease of the streamwise Reynolds stresses in the vicinity of the walls, and the pronounced increase of the spanwise Reynolds stresses at higher rotation rates near the walls and particularly in the symmetry region. As to the numerical set-up it is shown that periodic boundary conditions in the spanwise direction suffice if the spanwise extent of the computational domain is larger than 10 times the channel half width.     

DNA ligation using a disposable microfluidic device combined with a micromixer and microchannel reactor

A novel PDMS and glass-based microfluidic device consisting of a micromixer and microreactor for DNA ligation is described in this article. The new passive type planar micromixer is 10.33 mm long and composed of a straight channel integrated with nozzles and pillars, and the microreactor is composed of a serpentine channel. Mixing was enhanced by convective diffusion facilitated by the nozzles and pillars. The performance of the micromixer was analytically simulated and experimentally evaluated. The micromixer showed a good mixing efficiency of 87.7% at a 500 μL/min flow rate (Re = 66.5). DNA ligation was successfully performed using the new microfluidic device, and ligation time was shortened from 4 h to 5 min. When used for on-chip ligation, this new micromixer offers advantages of disposability and portability.     

Proportional directional valve based automatic steering system for tractors

Most automatic steering systems for large tractors are designed with hydraulic systems that run on either constant flow or constant pressure. Such designs are limited in adaptability and applicability. Moreover, their control valves can unload in the neutral position and eventually lead to serious hydraulic leakage over long operation periods. In response to the problems noted above, a multifunctional automatic hydraulic steering circuit is presented. The system design is composed of a 5-way-3- position proportional directional valve, two pilot-controlled check valves, a pressure-compensated directional valve, a pressurecompensated flow regulator valve, a load shuttle valve, and a check valve, among other components. It is adaptable to most open-center systems with constant flow supply and closed-center systems with load feedback. The design maintains the lowest pressure under load feedback and stays at the neutral position during unloading, thus meeting the requirements for steering. The steering controller is based on proportional-integral-derivative (PID) running on a 51-microcontroller-unit master control chip. An experimental platform is developed to establish the basic characteristics of the system subject to stepwise inputs and sinusoidal tracking. Test results show that the system design demonstrates excellent control accuracy, fast response, and negligible leak during long operation periods.     

Surface-Micromachined Parylene Dual Valves for On-Chip Unpowered Microflow Regulation

This paper presents the world's first surface-micromachined parylene dual-valved microfluidic system for on-chip unpowered microflow regulation. Incorporating a normally closed and a normally open passive check valve in a back-to-back configuration inside a microchannel, the dual-valved system has successfully regulated the pressure/flow rate of air and liquid without power consumption or electronic/magnetic/thermal transduction. By exclusively using parylene C (poly-para-xylylene C) as the structural material, the fabricated valves have higher flexibility to shunt flows in comparison to other conventional thin-film valves. A state-of-the-art multilayer polymer surface-micromachining technology is applied here to fabricate parylene microvalves of various designs. The parylene-based devices are completely biocompatible/implantable and provide an economical paradigm for fluidic control in integrated lab-on-a-chip systems. Design, fabrication, and characterization of the parylene dual valves are discussed in this paper. Testing results have successfully demonstrated that the microflow regulation of the on-chip dual-valved system can achieve a bandpass profile in which the pressure control range is 0-50 mmHg with corresponding flow rates up to 2 mL/min for air flow and 1 muL/min flow rate for water flow. This regulation range is suitable for controlling biological conditions in human health care, with potential applications including drug delivery and regulation of elevated intraocular pressure (IOP) in glaucoma patients     

Valves for autonomous capillary systems

Autonomous capillary systems (CSs) are microfluidic systems inside which liquids move owing to capillary forces. CSs can in principle bring the high-performances of microfluidic-based analytical devices to near patient and environmental testing applications. In this paper, we show how wettable capillary valves can enhance CSs with novel functionalities, such as delaying and stopping liquids in microchannels. The valves employ an abruptly changing geometry of the flow path to delay a moving liquid filling front in a wettable microchannel. We show how to combine delay valves with capillary pumps, prevent shortcuts of liquid along the corners of microfluidic channels, stop liquids filling microchannels from a few seconds to over 30 min, trigger valves using two liquid fronts merging, and time a liquid using parallel microfluidic paths converging to a trigger valve. All together, these concepts should add functionality to passive microfluidic systems without departing from their initial simplicity of use. Electronic supplementary material  The online version of this article (doi:) contains supplementary material, which is available to authorized users.     

某型连续式跨声速风洞阀门控制系统设计

针对某型风洞阀门数目较多,位置分散,空间较少等问题,为避免"硬接线"集中控制方式带来的诸多问题,采用一套PLC系统完成对各类阀门的控制,并由上位机通过PROFINET网络进行调度与指挥,实现远程控制;对阀门阀芯定位精度与流量调节精度的关系进行了推算,并据此选定了阀门电动执行机构型号;在已调试完成的某风洞的吹风试验表明,通过该方法所设计的阀门控制系统流量调节精度可达到0.1%。     

Electrical characteristics of amorphous In–Ga–Zn–O thin-film transistors prepared by radio frequency magnetron sputtering with varying oxygen flows

This study investigates impacts of oxygen flow during the deposition of amorphous indium–gallium–zinc oxide (a-IGZO) channel layer with a radio frequency (r.f.) magnetron sputter on the electrical characteristics of the fabricated thin-film transistors (TFTs). Results indicate that as the film was deposited with a higher oxygen flow, the transfer curves are positively shifted while the field-effect mobility (μ_FE) is significantly decreased. To get more insight about the effects, channel resistance (R_CH) and the parasitic source-to-drain resistance (R_SD) of the fabricated devices are extracted using the total resistance method. The extracted a-IGZO channel resistance per unit length (r_ch) and R_SD are found to increase while the extracted effective mobility (μ_E) is decreased with increasing oxygen flow during sputtering. These observations are postulated to be related the decrease in the In/(In + Ga + Zn) ratio and the increase in the Zn/(In + Ga + Zn) ratio of the a-IGZO films with increasing the oxygen flow rate which lead to higher resistivity and lower carrier concentration. The extracted R_SD can be comparable with R_CH for the devices prepared with high oxygen flow, resulting in the roll-off of μ_FE as the channel length is shorter than 20 μm.     

Numerical simulation of patient-specific left ventricular model with both mitral and aortic valves by FSI approach

Intraventricular flow is important in understanding left ventricular function; however, relevant numerical simulations are limited, especially when heart valve function is taken into account. In this study, intraventricular flow in a patient-specific left ventricle has been modelled in two-dimension (2D) with both mitral and aortic valves integrated. The arbitrary Lagrangian–Eulerian (ALE) approach was employed to handle the large mesh deformation induced by the beating ventricular wall and moving leaflets. Ventricular wall deformation was predefined based on MRI data, while leaflet dynamics were predicted numerically by fluid–structure interaction (FSI). Comparisons of simulation results with in vitro and in vivo measurements reported in the literature demonstrated that numerical method in combination with MRI was able to predict qualitatively the patient-specific intraventricular flow. To the best of our knowledge, we are the first to simulate patient-specific ventricular flow taking into account both mitral and aortic valves.     

Automating fluid delivery in a capillary microfluidic device using low-voltage electrowetting valves

A multilayer capillary polymeric microfluidic device integrated with three normally closed electrowetting valves for timed fluidic delivery was developed. The microfluidic channel consisted two flexible layers of poly (ethylene terephthalate) bonded by a pressure-sensitive adhesive spacer tape. Channels were patterned in the spacer tape using laser ablation. Each valve contained two inkjet-printed silver electrodes in series. Capillary flow within the microchannel was stopped at the second electrode which was modified with a hydrophobic monolayer (valve closed). When a potential was applied across the electrodes, the hydrophobic monolayer became hydrophilic and allowed flow to continue (valve opened). The relationship between the actuation voltage, the actuation time, and the distance between two electrodes was performed using a microfluidic chip containing a single microchannel design. The results showed that a low voltage (4.5 V) was able to open the valve within 1 s when the distance between two electrodes was 1 mm. Increased voltages were needed to open the valves when the distance between two electrodes was increased. Additionally, the actuation time required to open the valve increased when voltage was decreased. A multichannel device was fabricated to demonstrate timed fluid delivery between three solutions. Our electrowetting valve system was fabricated using low-cost materials and techniques, can be actuated by a battery, and can be integrated into portable microfluidic devices suitable for point-of-care analysis in resource-limited settings.     

Single-step replicable microfluidic check valve for rectifying and sensing low Reynolds number flow

This paper presents a new microfluidic check valve well suited for low Reynolds number flow rate sensing, micropump flow rectification, and flow control in lab-on-a-chip devices. The valve uses coupling between fluid movement in a channel and an elastomeric column (flap) suspended in the fluid path to generate a strong anisotropic flow resistance. Soft lithography-based molding techniques were used to fabricate the valve, allowing for a low-cost, single-step fabrication process. Three valves—having heights of 25, 50, and 75 μm, respectively—were fabricated and experimentally evaluated; the best of them demonstrated a maximum fluidic diodicity of 4.6 at a Reynolds number of 12.6 and a significant diodicity of 1.6 at the low Reynolds number of 0.7. The valve’s notable low Reynolds number response was realized by adopting a design methodology that balances the stiffness of the elastomer flap and adhesion forces between the flap and its seat. A pair of elastomer check valves integrated with a miniature membrane actuator demonstrated a flow rectification efficiency of 29.8%. The valve’s other notable features include a wide bandwidth response, the ability to admit particles without becoming jammed, and flow rate sensing capability based on optical flap displacement measurements.     

Modeling and experimental validation of a piezoelectric micropump with novel no-moving-part valves

No-moving-part (NMP) valves are microconduits able to partially rectify an oscillating fluid moving through them. The modeling of such valves is not at all trivial. Even greater difficulties arise when the behavior of the whole micropump equipped with those NMP valves is investigated, because of the complex fluid-dynamic phenomena interacting with deformable structures. This paper proposes a generalization of the efficiency modeling, nowadays used for single valves, to whole micropump equipped with them. Such modeling has been applied to design a novel, high efficiency NMP valve to be used in a piezoelectric micropump. The main feature of the new valve is the presence of some properly shaped vortex area along its fluid-dynamic pattern, allowing to improve micropump performance. For comparison purposes, the same modeling has been applied to a standard nozzle-diffuser NMP valve to be used with the same piezoelectric actuator. The experimental comparison of micropump performance (maximum flow rate and pressure head) shows that the proposed modeling technique is able to discriminate between better and worse performer. The effects of unsteady dynamic effects have been evaluated a posteriori, confirming their important weight on the actual performance of the micropumps equipped with NMP valves.     

Direct numerical simulation of turbulent channel flows using a stabilized finite element method

Direct numerical simulations (DNS) of incompressible turbulent channel flows at Re_τ = 180 and 395 (i.e., Reynolds number, based on the friction velocity and channel half-width) were performed using a stabilized finite element method (FEM). These simulations have been motivated by the fact that the use of stabilized finite element methods for DNS and LES is fairly recent and thus the question of how accurately these methods capture the wide range of scales in a turbulent flow remains open. To help address this question, we present converged results of turbulent channel flows under statistical equilibrium in terms of mean velocity, mean shear stresses, root mean square velocity fluctuations, autocorrelation coefficients, one-dimensional energy spectra and balances of the transport equation for turbulent kinetic energy. These results are consistent with previously published DNS results based on a pseudo-spectral method, thereby demonstrating the accuracy of the stabilized FEM for turbulence simulations.     

Seasonal water storage on the Amazon floodplain measured from satellites

The amount of water stored and moving through the Amazon floodplain is not known, yet is necessary for understanding the role of the wetland in the regional carbon balance and the sediment and nutrient exchanged with the main river channel. Here, we separate the Amazon floodplain into six 330 km × 330 km areas and use gravimetric and imaging satellite methods (i.e., GRACE, SRTM, GPCP and JERS-1) to estimate the amounts of water filling and draining from the mainstem Amazon floodplain. We show that the amount of water stored on and subsequently drained from the mainstem Amazon floodplain each year represents about 5% of the total volume of water discharged from the Amazon River into the Atlantic Ocean. Despite a five-fold increase in mainstem discharge from upstream to downstream, the floodplain water volume exchanged with the river only doubles (based on all six 330 km reach lengths). Rates of exchange along the 330 km reach lengths vary from 5500 m³/s during floodplain infilling to −7500 m³/s during drainage. The contribution to the floodplain from local upland runoff represents less than 20% of the floodplain water volume for any given time.