共查询到20条相似文献,搜索用时 62 毫秒
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《中国医学文摘:皮肤科学》1998,(2)
980954 晕痣和痣细胞痣OKT_6阳性细胞的免疫组化观察/普雄明(新疆维吾尔自治区人民医院皮肤科)…//中国皮肤性病学杂志.-1997,11(5).-272 着重对晕痣(8例)和痣细胞痣(8例)进行了3OKT_6标记的免疫组织化学的观察。结果表明痣细胞痣表皮内OKT_6阳性细胞较少,而且大多数细胞轮廓清楚,树状突明显,真皮浅层及痣细胞巢内未见到阳性细胞。晕痣表皮内OKT_6阳性细胞明显多于痣细胞痣。少数阳性细胞树突小而少,轮廓不清,特点是晕痣的真皮浅层及痣细胞巢内也可见到少数阳性细胞,晕痣绝大多数由痣细胞痣发展而来,认为其发生与自身免疫有关。LC晕痣损害内明显多于痣细胞痣,提示它可能 相似文献
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晕痣和痣细胞痣的免疫组化比较观察 总被引:1,自引:0,他引:1
应用IgG、IgD、IgM和C3c4种标记抗体对11例晕痣和13例痣细胞痣进行了平行免疫组化观察,结果显示晕痣与痣细胞痣具有明显不同的免疫病理特点,支持晕痣的发生与自身免疫有关的观点。 相似文献
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《临床皮肤科杂志》2015,(6)
目的:总结晕痣的临床特点,初步探讨晕痣与白癜风的临床相关性。方法:对277例晕痣患者的临床特点进行分析,并对部分患者进行随访。结果:277例行晕痣切除术的患者中,皮损单发219例(79.06%),多发58例(20.94%)。好发于面颈部(54.86%)与躯干(37.03%)。106例患者(38.27%)并发白癜风,其平均发病年龄小于未并发白癜风者(P=0.041)。随访110例未并发白癜风的晕痣患者术后转归,17例继发白癜风,其中11例于半年内发生。比较未并发白癜风的晕痣患者与继发白癜风的晕痣患者,后者多发晕痣的比例高于前者(P=0.003)。结论:晕痣皮损以单发多见,面颈部好发。晕痣发病年龄小、皮损多发是白癜风发病的危险因素。手术切除是治疗晕痣的一种有效方法,晕痣切除术后半年可能是白癜风发生的高风险期,应密切随访。 相似文献
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对晕痣和痣细胞痣进行了 OKT6阳性细胞的免疫组化观察 ,结果表明晕痣表皮内 OKT6阳性细胞数显著多于痣细胞痣 ,提示 OKT6阳性细胞可能在晕痣的自身免疫发病机制中起着一定作用 相似文献
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晕痣和痣细胞痣bcl-2蛋白的表达 总被引:1,自引:0,他引:1
为了研究细胞凋亡在晕痣发生中的作用,我们对8例晕痣和8例痣细胞痣患者皮损进行了bcl-2原癌基因产物(B-cell lymphoma/leukemia 2 gene product,以下简称bcl-2)的免疫组化观察.结果表明8例晕痣均见有bcl-2的阳性表达,8例痣细胞痣仅有3例表达bcl-2,而且染色明显较弱,大部分组织呈阴性表达.由于两种痣bcl-2表达明显不同,作者认为晕痣组织内bcl-2的过量表达与晕痣发生的自身免疫机制有关,可能是痣组织内对痣细胞的高凋亡率的一种自动平衡反应. 相似文献
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晕痣的免疫组化特点与自发性消退机制的研究 总被引:1,自引:1,他引:1
目的 研究晕痣自发性消退早期及晚期皮损区炎细胞表型、数目及其分布特点,探讨晕痣自发性消退的免疫机制。方法 应用免疫组化方法对晕痣皮损区、非皮损区及正常对照皮肤进行CD3、CD4、CD8、CD20、CD1a、CD56、CD68染色,用计算机图像分析系统(Image-pro PLUS 6.0)观察及定量分析。结果 晕痣早期及晚期皮损区CD4、CD8、CD20、CD1a阳性细胞数均明显高于非皮损区及正常对照皮肤(P < 0.01),皮损区CD1a、CD68阳性细胞直径明显大于非皮损区及正常对照皮肤(P < 0.01)。消退晚期CD8 与CD4阳性细胞数目比值(2.05 ∶ 1)高于消退早期(1.82 ∶ 1),CD8阳性细胞在痣细胞巢内大量浸润。结论 CD4、CD8、CD20、CD1a、CD56、CD68阳性细胞均参与晕痣自发性消退,CD8阳性T细胞在晕痣消退中起主要作用。 相似文献
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Smith KC 《Dermatologic therapy》2007,20(6):388-393
ABSTRACT: Two new collagen-based lidocaine-containing dermal fillers, ArteSense™/ArteFill™ (Artes Medical, San Diego, CA) and Evolence® (Colbar LifeScience Ltd., Herzliya, Israel), have proved to be of particular interest to men, many of whom seek a long-lasting or permanent correction. ArteFill™ has been available in the United States since 2006, and it is expected that Evolence® will reach the American market in 2008. The properties of the two products will be described, and experience based on the administration of many hundreds of syringes of both products by a Canadian dermatologist will be detailed here, with tips and precautions to optimize patient outcomes. 相似文献
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It is generally believed that ablative laser therapies result in prolonged healing and greater adverse events when compared with nonablative lasers for skin resurfacing. To evaluate the efficacy of ablative laser use for skin resurfacing and adverse events as a consequence of treatment in comparison to other modalities, a PRISMA‐compliant systematic review (Systematic Review Registration Number: 204016) of twelve electronic databases was conducted for the terms “ablative laser” and “skin resurfacing” from March 2002 until July 2020. Studies included meta‐analyses, randomized control trials, cohort studies, and case reports to facilitate evaluation of the data. All articles were evaluated for bias. The search strategy produced 34 studies. Of 1093 patients included in the studies of interest, adverse events were reported in a total of 106 patients (9.7%). Higher rates of adverse events were described in nonablative therapies (12.2% ± 2.19%, 31 events) when compared with ablative therapy (8.28% ± 2.46%, 81 events). 147 patients (13.4%) reported no side effects, 68 (6.22%) reported expected, transient self‐resolving events, and five (0.046%) presented with hypertrophic scarring. Excluding transient events, ablative lasers had fewer complications overall when compared with nonablative lasers (2.56% ± 2.19% vs 7.48% ± 3.29%). This systematic review suggests ablative laser use for skin resurfacing is a safe and effective modality to treat a range of pathologies from photodamage and acne scars to hidradenitis suppurativa and posttraumatic scarring from basal cell carcinoma excision. Further studies are needed, but these results suggest that ablative lasers are a superior, safe, and effective modality to treat damaged skin. 相似文献
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Philip R. Cohen 《The Journal of dermatology》1996,23(4):290-292
A black woman with the concurrent onset of two subcutaneous nodules located on the digits of her upper extremities is described. Initially, a single systemic disorder was considered; yet, the lesions differed in morphology and consistency. Microscopic examination of the nodules showed a giant cell tumor of tendon sheath and a lipoma. Although Occam's “razor” suggests that multiple lesions in the same person are more likely to represent variable manifestations of a single disorder than several different diseases in that individual, the simultaneously appearing lesions in this patient represented two different conditions. 相似文献
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Franziska Mayrshofer Michael Hertl Ronald Sinkgraven Michael Sticherling Christiane Pfeiffer Detlef Zillikens Gerald Messer Berthold Rzany für die deutscheBSD‐Studiengruppe 《Journal der Deutschen Dermatologischen Gesellschaft》2005,3(6):431-435
Background: Pemphigus vulgaris is a potentially life‐threatening autoimmune disorder of the skin and mucous membranes characterized by antibodies against epidermal adhesion molecules. Clinically characteristic are painful chronic blisters or erosions of mucous membranes and skin. There are no published studies on the impact o this disease on quality of life. Patients and methods: This registration was performed within the scope of the German BSD (Bullous Skin Disease) study group, from November 1997 until January 2002. A total of 36 patients with the first diagnosis of pemphigus vulgaris were registered at the university hospitals of Dresden, Erlangen, Kiel, Mannheim, München and Würzburg. Thirty of the 36 (83 %) patients participated in the quality of life questionnaire utilizing the German version of ‘Dermatology Life Quality Index’ (DLQI) provided by A. Y. Finlay. The DLQI varies from 0 to 30 with an increased DLQI score indicating a decrease in quality of quality. Results: The overall DLQI total score of 10 ± 6,7 in the investigated pemphigus patients was significantly increased in comparison to other skin diseases. Conclusions: These results suggest that the DLQI can be a very useful additional outcome criteria for clinical studies with pemphigus vulgaris and in the treatment of these patients. 相似文献
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Joan A. Puig‐Butillé Celia Badenas Zighereda Ogbah Cristina Carrera Paula Aguilera Josep Malvehy Susana Puig 《Experimental dermatology》2013,22(2):148-150
Studies integrating clinicopathological and genetic features have revealed distinct patterns of genomic aberrations in Melanoma. Distributions of BRAF or NRAS mutations and gains of several oncogenes differ among melanoma subgroups, while 9p21 deletions are found in all melanoma subtypes. In the study, status of genes involved in cell cycle progression and apoptosis was evaluated in a panel of 17 frozen primary acral melanomas. NRAS mutations were found in 17% of the tumors. In contrast, BRAF mutations were not found. Gains of AURKA gene (20q13.3) were detected in 37.5% of samples, gains of CCND1 gene (11q13) or TERT gene (5p15.33) in 31.2% and gains of NRAS gene (1p13.2) in 25%. Alterations in 9p21 were identified in 69% of tumors. Gains of 11q13 and 20q13 were mutually exclusive, and 1p13.2 gain was associated with 5p15.33. Our findings showed that alterations in RAS‐related pathways are present in 87.5% of acral lentiginous melanomas. 相似文献
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M.B. Madrid Álvarez G. Carretero Hernández A. González Quesada J.M. González Martín 《Actas dermo-sifiliográficas》2018,109(8):733-740