平阳霉素注射治疗口腔颌面部低回流型静脉畸形

目的探讨口腔颌面部低回流型静脉畸形的平阳霉素注射治疗并评价其疗效。方法应用平阳霉素细针局部注射治疗口腔颌面部低回流型静脉畸形36例,注射浓度2 mg/mL,隔周1次,连续4~6次为1疗程。治疗有效但病变尚未完全消退者,间隔1个月后进行第二疗程的治疗。观察病变消退、局部外形和功能保存情况,记录全身及局部不良反应。结果 31例患者完全治愈(Ⅳ级),4例基本治愈(Ⅲ级),1例因疗效不佳改行无水乙醇硬化治疗。所有病例均未见局部功能障碍和溃疡形成,无严重全身并发症。结论采用平阳霉素细针局部注射治疗口腔颌面部低回流型静脉畸形创伤微小,疗效明显,局部功能和外形保存良好,无明显不良反应,是较为理想的治疗方式。     

平阳霉素加碘油治疗颌面部海绵状血管畸形

目的:分析平阳霉素加碘油局部注射治疗口腔颌面部海绵状静脉畸形的优点。方法:31例口腔颌面部海绵状静脉畸形分为单纯平阳霉素瘤腔内局部注射组(13例)和平阳霉素加碘油注射治疗组(18例),均一次相同剂量注药后一个月随访,根据静脉畸形缩小程度来评判两种治疗方法的优劣。结果:平阳霉素加碘油注射组较单纯平阳霉素注射组静脉畸形退缩更明显(P<0.05),即平阳霉素加碘油局部注射治疗口腔颌面部海绵状静脉畸形疗效优于单纯注射平阳霉素。结论:碘油加平阳霉素治疗海绵状静脉畸形有协同作用。其机制可能是碘油的粘滞性可以延缓药物在静脉腔内的排空,从而延长药物局部作用时间。     

电化学疗法联合平阳霉素治疗高回流量静脉畸形的临床疗效分析

目的 观察电化学疗法联合平阳霉素注射治疗高回流量静脉畸形的临床疗效.方法 回顾分析中国医科大学口腔医学院口腔颌面外科收治的68例高回流量静脉畸形患者,其中32例单纯电化学疗法(A组),36例采用电化学联合平阳霉素治疗(B组),随访时间6～30个月.结果 A组有效率78％ (25/32),B组有效率97％ (35/36),B组有效率显著高于A组(P＜0.05),两组均未见严重不良反应.结论 电化学疗法联合平阳霉素注射是治疗高回流量静脉畸形有效的方法.     

婴幼儿腮腺咬肌区静脉畸形的平阳霉素局部硬化治疗

目的 探讨婴幼儿腮腺咬肌区静脉畸形的无创治疗方法 及其疗效.方法 采用平阳霉素局部注射治疗婴幼儿腮腺咬肌区静脉畸形19例,隔周1次,连续4次为1个疗程.1个疗程不能治愈者,间隔1周开始第2疗程治疗.记录病变转归和不良反应,追踪随访,评价疗效.结果 经过3 ～ 8次局部注射,16例患儿完全治愈,腮腺咬肌区病变消退,表面皮肤色泽正常.注射期间未见局部溃疡,无过敏病例.随访1 ～ 3年,未见复发,无瘢痕形成及面神经损伤症状.3例病变范围较大的患儿,注射1疗程后因疗效不显著,分别改行手术或翻瓣激光联合平阳霉素腔内注射治疗,随访可见手术瘢痕,腮腺咬肌区轻度凹陷畸形,手术治疗的1例出现面神经损伤症状,3例均无复发.结论 平阳霉素局部注射治疗婴幼儿腮腺咬肌区静脉畸形治愈率高,不遗留瘢痕,不损伤面神经,是值得推荐的治疗方式.但对大范围的静脉畸形疗效较差,需配合其它治疗.     

高浓度平阳霉素治疗口腔颌面部静脉畸形的疗效评价

目的:观察高浓度平阳霉素治疗不同部位静脉畸形的临床疗效.方法:2002-2008年共收治114例口腔颌面部静脉畸形患者,其中男50例,女64例,年龄最小12岁,最大76岁,病变最小2.0cm×1.5cm,最大15cm×10cm.对不同部位的静脉畸形均采用浓度为8mg/3mL的平阳霉素每1530d局部注射1次,注射15次.对治疗后0.5～5a的随访资料进行回顾分析,治疗效果分为治愈、基本治愈、有效及无效4级.结果:皮下静脉畸形有效率为92%,黏膜血管畸形有效率为96%.结论:采用高浓度的平阳霉素治疗口腔颌面部静脉畸形,可取得较好的治疗效果.     

口腔颌面部静脉畸形1412例临床报告

目的 :评价鱼肝油酸钠和平阳霉素单独或联合瘤体内注射治疗口腔颌面部静脉畸形的疗效和安全性。方法 :对 764例患者应用 5 %鱼肝油酸钠 ,2 98例患者应用平阳霉素 ,3 5 0例患者联合应用鱼肝油酸钠和平阳霉素进行瘤体内注射。通过随访和临床观察 ,分析其疗效和安全性。结果 :随访 1～ 14年 ,鱼肝油酸钠组有效率 89.3 % ,平阳霉素组 88.2 % ,联合用药组 95 .4%。鱼肝油酸钠组与平阳霉素组比较 ,有效率无显著性差异 (P >0 .0 5 ) ,联合用药组有效率明显高于鱼肝油酸钠组和平阳霉素组 (P <0 .0 5 )。鱼肝油酸钠组注射局部均有不同程度的肿胀 ,治疗有效的 5 97例中有 48例 ( 8% )复发 ;平阳霉素组有 9例 ( 3 % )出现发热反应。结论 :鱼肝油酸钠或平阳霉素瘤内注射治疗口腔颌面部静脉畸形均有良好的疗效 ,两者联合应用疗效更好、副作用小     

平阳霉素与鱼肝油酸钠局部注射治疗颌面部静脉畸形的临床疗效比较

目的比较平阳霉素与鱼肝油酸钠分别注射治疗口腔颌面部静脉畸形的临床疗效。方法颌面部静脉畸形40例，20例小剂量平阳霉素局部注射治疗，20例5％鱼肝油酸钠局部瘤体注射治疗。结果平阳霉素有效19例（19／20），鱼肝油酸钠有效12例（12／20）。不良反应：平阳霉素10例（10／20），鱼肝油酸钠14例（14／20），前者主要为轻度全身反应，后者为局部严重反应。经x^2检验，差异有统计学意义（P〈0．05）。结论平阳霉素治疗颌面部静脉畸形疗效好，疗程短，是一种简便、有效的方法，平阳霉素疗效优于鱼肝油酸钠。     

平阳霉素和泼尼松龙及鱼肝油酸钠联合注射治疗颌面部静脉畸形60例报道

目的：评价平阳霉素和泼尼松龙及鱼肝油酸钠联合注射治疗颌面部静脉畸形的疗效。方法：采用平阳霉素和泼尼松龙及鱼肝油酸钠联合病变内注射治疗60例颌面部静脉畸形患者。1周注射1次，3-5次为1个疗程，治疗结束后对疗效进行评价。结果：60例患者平均疗程3周，治疗完成后随访0．5～2a，治愈和显效率达94％，有效率为100％。结论：平阳霉素和泼尼松龙及鱼肝油酸钠联合注射治疗颌面部静脉畸形安全、廉价、高效、简便，疗程适中。     

电化学联合平阳霉素局部注射治疗舌血管畸形

目的 :探讨电化学联合平阳霉素局部注射治疗舌血管畸形的临床疗效。方法 :回顾2013-01—2018-05期间,在我院接受电化学联合平阳霉素局部注射治疗的舌血管畸形患者54例,病变大小为2 cm×3 cm^7 cm×9 cm,其中高流速血管畸形16例。根据病变大小给予电化学治疗量为5~10 C/cm2,平阳霉素注射量为3~5mL。术后给予抗生素和激素治疗。结果:随访1~5年,54例患者均有不同程度的改善,有效率达100%。患者术后常发生局部疼痛、肿胀等症状,症状一般于5~7 d后消失。所有患者术后主观感觉及舌体运动正常。结论:电化学联合平阳霉素局部注射治疗舌血管畸形安全有效,并发症少,值得临床推广。     

褥式环扎联合电化学及平阳霉素注射治疗颌面部大范围静脉畸形的临床观察

目的:观察褥式环扎联合电化学及平阳霉素注射治疗颌面部大范围静脉畸形的临床疗效。方法 :回顾2007-01—2012-12期间,采用褥式环扎联合电化学及平阳霉素注射治疗的23例颌面部大范围静脉畸形患者的临床资料,分析其临床治疗效果及不良反应发生情况,根据疗效评价标准,将治疗结果分为治愈、显效、无效。结果:全组随访6个月³年,有效率100%,临床治愈率78.3%(18/23)。术后不良反应主要是肿胀、疼痛、发热等,未见严重不良反应。结论:褥式环扎联合电化学及平阳霉素注射治疗颌面部大范围静脉畸形具有创伤小、无瘢痕、安全可靠等优点,外形和功能恢复良好,是一种有效的治疗方法。     

不同剂型玻璃离子水门汀溶解性比较研究

目的:研究、比较不同剂型玻璃离子水门汀的溶解性和表面微观形态改变,为临床使用提供依据.方法:将3M树脂加强型玻璃离子水门汀(水粉剂型)、GC玻璃离子水门汀(水粉剂型)及GC玻璃离子水门汀(双糊剂型)分别在人工唾液中浸泡30 d,冷热循环15000次,烘干测重,比较前后质量变化,计算溶解率,并用扫描电镜观察表面微观改变.结果:不同剂型的玻璃离子水门汀溶解率由高到低分别为3M树脂加强型玻璃离子水门汀(水粉剂型)、GC玻璃离子水门汀(水粉剂型)、GC玻璃离子水门汀(双糊剂型).3种玻璃离子水门汀经浸泡溶解后,SEM扫描表面微观形态可观察到GE玻璃离子水门汀(双糊剂型)表面形态改变较少,其他2组玻璃离子水门汀表面微观改变较多.结论:双糊剂型玻璃离子水门汀理化性能及溶解率均低于传统水粉剂型,是未来临床修复治疗的的良好选择.     

Evidence of the validity of a model of determinants of quality of restorative dental care

A model describing the relationship between self-reported quality of restorative dentistry and dentist characteristics for 119 Montana general dentists is presented. The best predictors formed a significant model explaining 22% of the variance of the quality measure. Results are contrasted with a previous estimation of the model for 102 Washington general practitioners. Evidence for the external validity of the model is presented.     

Design of clinical trials of traditional therapies of periodontitis

The present paper on the design of clinical trials of periodontal therapy first addresses the issue of the etiology of periodontal disease. It is suggested that most if not all forms of destructive periodontal disease are caused by microorganisms and that there are different forms of disease with different microbial etiologies. The progressive nature of destructive periodontal disease is subsequently discussed and it is emphasized that, in a given patient, periodontal sites which show signs of inflammation and attachment loss may not over a period of several months and years show further sign of attachment loss. The present methods of assessing periodontal disease do not allow us to discriminate between potentially active and inactive sites in untreated patients. The significance and variability of indicators of periodontal disease such as bleeding on probing, probing pocket depth and probing attachment level measurements are discussed. The errors inherent in the various measurements are analyzed and suggestions are presented describing how alterations in any of the above parameters could be identified and presented in a clinical trial. Of concern for the statistical analysis of clinical data of periodontal disease is the definition of the "experimental unit". For a number of years, the "experimental unit" in periodontal trials was the patient. It is clear, however, that different sites within the same individual show different patterns of disease progression and lesion morphology and often respond differently to periodontal therapy. Statistical analyses must consequently be designed which recognize differences in site-to-site infection and lesion morphology within a common host. Until such analyses are available, the investigator should be wary of pooling data within the same individual, since such pooling may obscure meaningful alternatives which may take place in individual periodontal sites. Some goals of periodontal therapy are subsequently identified. 4 goals are discussed more in detail, namely: to establish conditions which will allow the patient to maintain a dentition without further breakdown of the periodontium; to reduce pocket depth to establish an anatomy in the dentogingival region which with proper maintainance care will prevent the re-establishment of the subgingival infection; to gain attachment as a result of treatment; to assess the effect of a certain chemotherapeutic agent on periodontal disease.     

Experimental evidence of formation of imines in the course of reduction of hydrazones

The reduction of hydrazones is generally suggested to proceed through a reductive cleavage of the nitrogen–nitrogen bond followed by a reduction of the carbon–nitrogen bond. This sequence of reduction processes is here supported for fluorenone (V) and benzophenone (VI) hydrazones as well as by a comparison of the reduction of fluorenone and benzophenone hydrazonium ions (I,III) with corresponding imines (II,IV). Another proof of the presence of imines as intermediates is the splitting of four-electron waves of hydrazones V and VI and hydrazonium ions I and VIII into two waves at pH < 2. This has been interpreted as due to differences in slopes dE_1/2/dpH and pK_a-values of protonated hydrazine derivatives on one side and corresponding imines on the other. In this pH-range imines formed in reductions of VI and VIII are reduced in a single two-electron wave, those of I and V in two one-electron steps. Fluorenone imine (II) is sufficiently stable to allow recording of time-independent current–voltage curves between pH 6 and 11. In this pH-range the imine (II) is reduced in two one-electron steps. Benzophenone imine (IV) has been found stable between pH 4.6 and 12. At pH 4.6–8 the reduction of the imine IV takes place in a single two-electron step, at pH 8–12 in two one-electron steps. Final proof of the initial cleavage of the N–N bond is presented by comparison with the reduction of nitrones.     

Evaluation of efficacy of chemiluminescence for diagnosis of leukoplakia

ObjectiveLeukoplakia is the most common potentially malignant disorder preceding oral cancer. Chemiluminescence has been developed as an adjunct to conventional examination for the diagnosis of these potentially malignant disorders. This study was conducted to assess the efficacy of chemiluminescence in the diagnosis of leukoplakia and to compare the results with histopathological examination.Study designA total of 50 patients with leukoplakia were included from the outpatients attending the Department of Oral Medicine and Radiology, Dental Hospital, Bengaluru, Karnataka, India. These patients were subjected to conventional oral examination followed by chemiluminescent examination with Vizilite (Zila, Fort Collins, CO, USA) and biopsy for histopathological confirmation.ResultsThe sensitivity, specificity, positive predictive value, and negative predictive value of chemiluminescence were 93.75%, 55.56%, 78.95%, and 83.3%, respectively. The overall accuracy of chemiluminescence was 80%. A statistically significant association was observed between histopathology results and chemiluminescence results.ConclusionAlthough it is an easy, safe, minimal time consuming, and noninvasive technique, it has only adjunctive utility and it does not replace biopsy for the diagnosis of leukoplakia.     

正常青年Monson球面半径的测量研究

目的测量正常青年Monson球面半径。方法选择60名(男30名,女30名)正常青年制取全口印模,应用立体摄影成像的原理与方法对Monson球面半径进行测量和统计学处理。结果Monson球面的半径平均为10.173 cm,大于理论值10.160 cm,差异有显著性(P<0.01);男、女性球面半径差异无显著性。结论本实验所得到的数据可作为全口义齿修复中记录颌位关系的一个参量。     

Electrodeposition of bilayers of dithiols

We report an electrochemical method to form a bilayer of dithiol. The cyclic voltammogram of the oxidative deposition of an aromatic dithiol on gold from an alkaline aqueous solution reveals two current peaks separated by more than 400 mV. The integrated charge of the oxidative current peak (B) at the most positive potential is twice that of the other oxidative current peak (A). These two oxidative current peaks were characterized by differential capacitance and electrochemical quartz crystal microbalance (EQCM) measurements. A decrease of the capacity by a factor of two, and an increase of the EQCM frequency change by a factor of two were observed when the potential was scanned from a value where only the first oxidative peak (A) is obtained, to a potential where both oxidative current peaks (A and B) are obtained. Infrared spectra show that the aromatic dithiols adsorb vertically at potentials corresponding to the current peak A and they become tilted for potentials corresponding to the current peak B. The simple relationships between the properties of the two oxidative current peaks are found to be compatible with a step-wise oxidative deposition of a bilayer of dithiol.     

正畸患者切牙影像失真发生情况分析

目的研究正畸患者曲面体层片上的切牙影像失真发生情况，并分析其原因。 方法从中山大学附属口腔医院放射科影像数据库中选取500例正畸患者的曲面体层片和头影测量侧位片，所有曲面体层片均采用咬合杆投照，分别从切牙牙体影像放大、缩小、牙根变短、根尖模糊等评价指标分析上下颌切牙影像失真的发生情况，在头影测量侧位片上测量中切牙根尖-对颌切牙切缘的距离，探讨切牙影像失真发生的原因。采用SPSS 19.0统计软件对所得数据进行统计学检验。 结果500例患者中，切牙牙体影像正常者共417例，切牙牙体影像失真者共83例，影像失真发生率16.6%，其中切牙牙体影像放大17例、牙体影像缩小0例、牙根变短30例，牙根影像变短伴模糊36例。影像失真患者的根尖-切缘距离大于影像正常的患者，差异有统计学意义（F = 5 187.18，P = 0）；影像失真患者的覆盖值大于影像正常的患者，差异有统计学意义（F>477，P = 0）。 结论严重牙颌面畸形如反 、深覆盖是导致曲面体层片的切牙影像失真的主要原因之一。     

颌骨动静脉畸形的栓塞治疗

目的：总结直接穿刺结合经血管内介入栓塞治疗颌骨动静脉静脉畸形的经验。方法：收治凳骨动静脉畸形患者6例,均进行了介入栓塞治疗。采用的栓塞材料为附凝血棉纤毛的螺圈,聚乙烯醇泡沫微粒和二氰基丙烯酸对丁酯。数字减影颈动脉造影在PHILIPSV300下完成。结果6例颌骨动静脉畸形患者中4,例急性出血得到了快速、有效控制,1例慢性渗血的右下 骨动静脉畸形患者,介入栓塞治疗,拔除松动的右下凳第一磨牙,有效地控制了出血,另1例伴局部软组织搏动性膨隆的上凳骨动静脉畸形患者,介入治疗后膨隆的搏动性得到明显改善,栓塞治疗后分别随访3－24个月,均未发现有口腔内渗血或出血。随访的X线片上,病灶区可见新骨形成。结论：局部穿刺结合经血管内介入栓塞治疗颌骨动静畸形是一种安全、有效的治疗方法。