子痫前期和子痫孕妇胎盘血小板源性生长因子-B的表达及意义

目的 通过比较正常妊娠、子痫前期和子痫孕妇胎盘组织血小板源性生长因子(PDGF)-B mRNA与PDGF-BB蛋白的表达,探讨PDGF-B与子痫前期、子痫发病的关系.方法 在20例轻度子痫前期(轻度子痫前期组)、20例重度子病前期(重度子痫前期组)、3例子痫(子痫组)和20例正常妊娠(对照组)孕妇分娩后取胎盘母体面绒毛组织,采用RT-PCR法检测PDGF-B mRNA表达情况,采用免疫组织化学法结合计算机显微图像分析系统检测PDGF-BB蛋白表达情况.结果 轻度子痫前期组、重度子痫前期组和子痫组胎盘组织PDGF-B mRNA和PDGF-BB蛋白表达量(1.56±0.30和1.32±0.34、1.91±0.28和2.00±0.41、2.57±0.06和2.73±0.15)明显高于对照组(1.38±0.25和1.01±0.26),差异有统计学意义(P＜0.01),重度子痫前期组和子痫组明显高于轻度子痫前期组,差异有统计学意义(P＜0.01).相关分析表明,PDGF-B mRNA和PDGF-BB蛋白表达量均与疾病的严重程度呈正相关(r =0.691、0.797,P＜0.01).结论 子痫前期孕妇胎盘组织高度表达PDGF-B,其可促进动脉粥样硬化形成,可能在子痫前期孕妇的胎盘血管病变中起重要作用,并参与子痫前期的发生和发展.     

胎盘蛋白13在子痫前期孕妇血清中的表达和意义

目的探讨子痫前期孕妇血清中胎盘蛋白13的表达水平与妊娠孕周长短的关系。方法选取2012年1月~2013年12月间该院收治的子痫前期孕妇52例,根据病情严重程度分为轻度子痫前期组(20例)和重度子痫前期组(32例);选取同期来本院健康体检的健康孕妇33例为对照组。分别于妊娠中期(孕33~36周)和妊娠晚期(孕33~36周)收集3组孕妇的肘静脉血5ml,采用ELISA法检测血清样本中胎盘蛋白13的含量。结果轻度子痫前期组、重度子痫前期组血清胎盘蛋白13含量均明显高于对照组孕妇,差异有统计学意义(P0.05);重度子痫前期组血清胎盘蛋白13含量明显高于轻度子痫前期组,差异有统计学意义(P0.05)。3组孕妇妊娠晚期胎盘蛋白13含量均高于妊娠中期,其中对照组妊娠晚期胎盘蛋白13含量与妊娠中期之间差异无统计学意义(P0.05);轻度子痫前期组和重度子痫前期组妊娠晚期胎盘蛋白13含量均明显高于妊娠中期,差异有统计学意义(P0.05)。对照组胎盘蛋白13含量与孕周之间无明显相关性(P0.05);轻度子痫前期组和重度子痫前期组胎盘蛋白13含量与孕周之间有明显相关性(P0.05)。结论子痫前期孕妇外周血清中胎盘蛋白13含量明显增加,可能参与了子痫前期病情的进展;随着孕周的延长,子痫前期孕妇血清中胎盘蛋白13表达水平明显升高,与病情严重程度呈正相关,可作为预测病情进展的指标。     

热休克蛋白70在妊娠期高血压疾病孕妇血清、脐血及胎盘组织中的表达及其意义

目的探讨热休克蛋白70在妊娠期高血压疾病孕妇血清、脐血及胎盘组织中的表达及其在发病中的作用。方法选取2013年1月-2014年4月间在西安医学院第二附属医院分娩的妊娠期高血压疾病孕妇105例,分为妊娠期高血压组、轻度子痫前期组,重度子痫前期组,每组各35例。选取同期在该院分娩的35例健康孕妇为对照组。采用ELISA法检测4组孕妇血清、脐血中的热休克蛋白70水平;采用免疫组织化SP法检测胎盘组织中热休克蛋白70蛋白表达水平;采用RT-PCR技术检测胎盘组织中热休克蛋白70 mRNA表达水平。结果轻度和重度子痫前期组孕妇血清和脐血中的热休克蛋白70水平均明显高于妊娠期高血压组和对照组,差异有统计学意义(均P0.05);重度子痫前期组孕妇血清和脐血中热休克蛋白70水平明显高于轻度子痫前期组,差异有统计学意义(P0.05);妊娠期高血压组与对照组孕妇之间差异无统计学意义(P0.05)。妊娠期高血压组、轻度和重度子痫前期组胎盘组织中热休克蛋白70蛋白阳性率均明显高于对照组,差异有统计学意义(P0.05);重度子痫前期组热休克蛋白70蛋白阳性率明显高于轻度子痫前期组和妊娠期高血压组,差异均有统计学意义(均P0.05);轻度子痫前期组与妊娠期高血压组孕妇之间差异无统计学意义(P0.05)。妊娠期高血压组、轻度和重度子痫前期组孕妇胎盘组织中热休克蛋白70 mRNA表达明显高于对照组,差异均有统计学意义(均P0.05)。重度子痫前期组孕妇胎盘组织中热休克蛋白70 mRNA表达明显高于妊娠期高血压组和轻度子痫前期组,差异均有统计学意义(P0.05)。结论妊娠期高血压疾病孕妇血清、脐血及胎盘组织中热休克蛋白70表达水平明显提升,且随病情严重程度加重而增加,提示热休克蛋白70在妊娠期高血压疾病病程中可能起到一定作用。     

胎盘组织中IL-37的表达及其与子痫前期发病的关系

目的探讨胎盘组织白细胞介素-37(IL-37)的表达及与子痫前期发病的关系。方法选取2015年1月-2016年1月在该院治疗的子痫前期患者81例,其中轻度子痫前期患者47例(轻度组),重度子痫前期患者34例(重度组);同时选取正常妊娠孕妇50例作为对照组,采用免疫组化染色和Western Blot检测各组IL-37蛋白表达,采用RT-PCR检测各组IL-37 mRNA表达。结果重度组胎盘组织IL-37蛋白表达为(0.561±0.123),明显低于轻度组和对照组(P0.05);轻度组胎盘组织IL-37蛋白表达为(0.658±0.116),明显低于对照组(P0.05);重度组胎盘组织IL-37 mRNA表达为(0.540±0.103),明显低于轻度组和对照组(P0.05);轻度组胎盘组织IL-37 mRNA表达为(0.834±0.156),明显低于对照组(P0.05);子痫前期患者IL-37 mRNA和蛋白表达与分娩孕周无相关性(P0.05)。结论子痫前期和正常妊娠孕妇胎盘组织均有IL-37表达,其中子痫前期患者IL-37蛋白和mRNA表达明显降低,可能参与了子痫前期的发病过程。     

子痫前期患者胎盘组织IL-4 mRNA和IFN-γ mRNA的表达水平

目的:探讨子痫前期的病因及发病机制。方法:用原位杂交法测定子痫前期患者胎盘组织中IFN-γmRNA和IL-4mRNA的基因表达。结果:①IL-4mRNA在正常妊娠组、子痫前期轻度组和子痫前期重度组的表达随病情的加重表达减弱,但3组间两两比较无统计学意义(P>0.05);②IFN-γmRNA的表达随病情的加重表达增强,子痫前期重度组与正常妊娠组、子痫前期轻度组相比差异有统计学意义(P<0.05),且与正常妊娠组相比差异显著(P<0.001);子痫前期轻度组的表达也高于正常妊娠组,但差异无统计学意义(P>0.05);③IFN-γmRNA/IL-4mRNA比值结果显示,随病情的加重比值增大,且子痫前期轻度组、重度组与正常妊娠组两两相比差异均有统计学意义(P<0.05),重度组与正常妊娠组相比差异显著(P<0.001)。结论:子痫前期孕妇胎盘中表现为免疫杀伤的Th1型细胞因子IFN-γmRNA表达增强,表现为免疫保护或免疫营养的Th2型细胞因子IL-4mRNA表达无差异,提示子痫前期患者母胎界面中IFN-γmRNA的高表达与其发病有关,IL-4mRNA在子痫前期的发生、发展中的作用不明显;IFN-γmRNA/IL-4mRNA比值随病情的加重而增大,提示母胎界面的Th1/Th2细胞因子的平衡偏离可能是导致子痫前期发病的病因之一。     

寒冷气候对正常妊娠及子痫前期孕妇循环肾素和血管紧张素Ⅱ的影响及意义

目的:探讨寒冷季节正常妊娠和子痫前期孕妇循环肾素(PRA)和血管紧张素Ⅱ(AngⅡ)的水平的变化.方法:采用放射免疫分析方法检测孕妇血浆PRA和AngⅡ的水平.结果:与同季节型正常妊娠相比,冬季及过渡季型子痫前期组血浆PRA水平降低,过渡季型子痫前期组血浆AngⅡ水平降低,冬季型子痫前期组血浆AngⅡ水平升高(P均＜0.05);与过渡季型正常妊娠相比,冬季型正常妊娠AngⅡ水平升高(P＜0.05);与过渡季型子痫前期组相比,冬季型子痫前期组血浆AngⅡ水平升高(P＜0.01);各组血浆PRA水平均无统计学差异(P＞0.05).结论:寒冷刺激时,子痫前期患者循环肾素-血管紧张素系统(RAS)显著激活,血浆AngⅡ升高,导致血管收缩增强,血管痉挛、组织缺血,可能是寒冷季节子痫前期发病率增高的原因之一.     

胎盘辅助性T细胞因子IL-4、IL-6和IFN-γ与子痫前期关系的研究

目的:通过研究辅助性T细胞因子IL-4、IL-6及IFN-γ在子痫前期患者及血压正常的晚期妊娠妇女(NLP)胎盘母体面与胎儿面中的表达规律,探讨其在子痫前期发病过程中的病理生理机制。方法:选取子痫前期和正常妊娠孕妇作为研究组和对照组,应用免疫组化方法对两组胎盘的母体面与胎儿面Th1型细胞因子(IFN-γ)和Th2型细胞因子(IL-4、IL-6)进行标记并通过彩色病理图像分析系统对染色结果进行定量检测并作比较。结果:①胎盘母体面滋养细胞IFN-γ表达的平均光密度在子痫前期轻度组、重度组及正常妊娠组分别为0.2034±0.0148、0.2688±0.0278、0.2075±0.0154,子痫前期重度组与正常妊娠组差异有统计学意义(P0.001);IL-6表达的平均光密度在子痫前期轻度组、重度组及正常妊娠组分别为0.1864±0.0009、0.1579±0.0070、0.1862±0.0127,子痫前期重度组与正常妊娠组差异有统计学意义(P0.001);IL-4表达的平均光密度在子痫前期轻度组、重度组及正常妊娠组分别为0.2026±0.0163、0.1994±0.0163、0.2011±0.0124,3组比较差异均无统计学意义(P0.05)。②胎盘胎儿面滋养细胞IFN-γ、IL-6、IL-4在子痫前期轻度组、重度组及正常妊娠组表达的平均光密度均无统计学差异。③子痫前期重度组滋养细胞IFN-γ、IL-6表达的平均光密度在胎盘母体面与胎儿面比较差异有统计学意义(P0.05);IL-4表达的平均光密度在胎盘母体面与胎儿面比较,无统计学差异(P0.05)。结论:在重度子痫前期孕妇胎盘母体面中表现为免疫杀伤的Th1型细胞因子表达增强,表现为免疫保护的Th2型细胞因子则表达减弱,而在胎盘胎儿面则无上述表现,提示胎盘母体面的Th1/Th2细胞因子失衡可能是导致子痫前期发病的病因之一。     

神经病靶酯酶与妊娠期高血压疾病发病的相关性研究

目的探讨正常妊娠妇女和妊娠期高血压疾病患者胎盘中神经病靶酯酶(NTE)的表达模式,以及NTE的表达与妊娠期高血压疾病患者的孕产儿体质量的关系。方法收集2017年1月1日-2018年12月31日在嘉兴学院附属妇儿医院定期产检并分娩的重度子痫前期30例、轻度子痫前期10例、妊娠期高血压疾病30例、妊娠合并慢性高血压疾病10例以及随机选择同期住院分娩无其他妊娠合并症的正常妊娠妇女(对照组) 30例为研究对象,比较各组基本资料差异情况。采用定量PCR和Western蛋白定量检测正常妊娠妇女和妊娠期高血压疾病患者胎盘的NTE表达水平。结果重度子痫前期较其余4组分娩孕周小,差异有统计学意义(P<0. 05);轻度子痫前期、妊娠期高血压疾病患者与对照组和妊娠合并慢性高血压疾病患者比较,差异有统计学意义(P<0. 05)。重度子痫前期、轻度子痫前期的孕期体质指数(BMI)与妊娠期高血压疾病、对照组及妊娠合并慢性高血压疾病患者比较,差异有统计学意义(P<0. 05);新儿体质量在重度和轻度子痫前期与妊娠期高血压疾病、对照组及妊娠合并慢性高血压疾病比较,差异有统计学意义(P<0. 05);重度子痫前期患者胎盘中NTE mRNA和蛋白表达水平均显著低于正常对照组、妊娠期高血压疾病患者、轻度子痫前期患者以及妊娠合并慢性高血压疾病患者。轻度子痫前期胎盘中NTE mRNA和蛋白表达水平显著低于正常对照组、妊娠期高血压疾病组以及妊娠合并慢性高血压组。妊娠期高血压组患者胎盘中NTE mRNA和蛋白表达水平显著低于正常对照组以及妊娠合并慢性高血压组。妊娠期高血压疾病患者胎盘中NTE mRNA和蛋白表达水平与胎儿体质量呈现正相关。结论胎盘中NTE可能参与子痫前期的发生和发展以及预后。未来需要进一步的基础研究来证实。     

RANKL在子痫前期胎盘中的表达及意义

目的探讨胎盘中RANKL的表达及与子痫前期的关系。方法选择2008年11月~2009年7月在四川大学华西第二医院产科住院分娩的正常妊娠妇女30例和子痫前期妇女60例(轻度和重度各30例)。采用免疫组织化学法检测胎盘组织中RANKL蛋白的表达强度。结果 (1)3组研究对象绒毛细胞滋养细胞及合体滋养细胞胞浆内均有RANKL蛋白的阳性表达;(2)各组胎盘母面与子面RANKL蛋白表达水平比较,差异均无统计学意义(P﹥0.05);(3)重度子痫前期组胎盘RANKL蛋白表达水平高于轻度子痫前期组及正常妊娠组,差异有统计学意义(P﹤0.001);而轻度子痫前期组RANKL蛋白表达水平也高于正常妊娠组,差异有统计学意义(P﹤0.001)。(4)子痫前期患者胎盘RANKL的蛋白表达与分娩前收缩压、舒张压及24h尿蛋白呈正相关。结论 RANKL在胎盘组织中的异常表达与其病情的严重程度密切相关。     

胆碱能抗炎通路在子痫前期患者母胎界面的表达及意义

目的探讨胆碱能抗炎通路在子痫前期患者母胎界面的表达及意义。方法 2015年1月—2016年1月本院正常妊娠孕妇、轻度子痫前期患者和重度子痫前期患者各30例。采用qRT-PCR法和Western-blot法分别测定胎盘组织α7烟碱型乙酰胆碱受体(alpha-7 nicotinic acetylcholine receptor,α7nAChR)的mRNA和蛋白表达,免疫组化法检测胎盘组织核因子-κB(nuclear factor-kB,NF-κB)蛋白表达,ELISA法测定胎盘组织白介素6(interleukin6,IL-6)和肿瘤坏死因子(tumor necrosis factorα,TNF-α)蛋白水平。结果 (1)轻度子痫前期组胎盘组织中α7nAChR mRNA的表达水平明显高于对照组和重度组(P 0. 01),而重度组明显低于对照组,差异有统计学意义(P 0. 05)。α7nAChR蛋白表达结果与mRNA结果基本一致。(2)子痫前期组胎盘NF-κB蛋白表达均较对照组显著增强,差异有统计学意义(P 0. 05),且重度组显著高于轻度组(P 0. 05)。(3)子痫前期组胎盘IL-6和TNF-α蛋白表达明显高于对照组,差异有统计学意义(P 0. 05),且重度组显著高于轻度组(P 0. 05)。结论胎盘组织中α7nAChR和NF-κB表达异常及炎症介质的增多可能与子痫前期发病有关,胆碱能抗炎通路可能参与子痫前期的发生、发展的病理生理过程。     

孕妇对孕妇学校教育模式及课程内容需求

目的:探讨孕妇对孕妇学校授课模式及课程内容需求情况。方法:对在汕头市妇幼保健院孕妇学校听课的200名孕妇进行问卷调查。结果:①对孕妇学校授课的模式需求是多样化的,需求最高的为听讲座,其他依次为观看录像、与医护人员一对一交流、现场示范、模仿操作、参观产房、角色扮演等。②对孕妇学校课程内容需求最高的是新生儿喂养及新生儿的护理方面,其次是分娩知识及产褥期保健知识、胎儿发育过程及自我监护知识、孕产期营养、孕期常见问题应对知识方面。结论:顺应孕妇的需求,多安排孕妇最迫切需求的课程内容,设置多元化的授课方式,更有效地为孕产妇服务。     

Children and pregnant women.

A review of the literature of the 1980s reveals that women living in rural American are at risk for receiving inadequate prenatal and maternal care. Documented risk factors include poverty and concomitant lack of medical insurance, residence in the most restrictive Medicaid states, and loss of local services including the closure of obstetric units of rural hospitals and the decision by local physicians to discontinue obstetrics. A prominent factor in a physician's decision to stop providing maternity care is the escalating cost of medical liability insurance; however, other forces are also at work, including interference with personal and family activities, disruption of other aspects of professional life (e.g., office schedule), inadequate reimbursement, and an inability to keep up with advancing technology. A research agenda for the 1990s should be consistent with previous recommendations and must stimulate the development of new programs that will induce the maximum number of providers to again offer high quality perinatal care to rural women. Other items on the 1990s research agenda include: (1) the clarification of the impact of lost perinatal services in rural areas, (2) the effects of travel time and distance on perinatal outcomes and cost of care, (3) the effect of loss of obstetric services on other health care services for women and children, and (4) comparisons of regionalized versus centralized systems for the provision of perinatal services.     

Pandemic influenza and pregnant women

Planning for a future influenza pandemic should include considerations specific to pregnant women. First, pregnant women are at increased risk for influenza-associated illness and death. The effects on the fetus of maternal influenza infection, associated fever, and agents used for prophylaxis and treatment should be taken into account. Pregnant women might be reluctant to comply with public health recommendations during a pandemic because of concerns regarding effects of vaccines or medications on the fetus. Guidelines regarding nonpharmaceutical interventions (e.g., voluntary quarantine) also might present special challenges because of conflicting recommendations about routine prenatal care and delivery. Finally, healthcare facilities need to develop plans to minimize exposure of pregnant women to ill persons, while ensuring that women receive necessary care.     

Sexuality of pregnant and breastfeeding women

The effect of pregnancy and lactation on the sexual behavior of women was studied, using a retrospective questionnaire answered by a nonrandom sample of 33 women. Sexual functioning was operationally defined by four categories: desire, frequency, enjoyment, and orgasm. Five time periods were studied: the three trimesters of pregnancy, the period of breastfeeding and the period after weaning. Most of the mothers reported that their sexual behavior was about the same during pregnancy as before except for the third trimester, where desire, frequency, and enjoyment decreased. Eighty-two percent of the mothers felt that sex relations should continue throughout all of the pregnancy. Sexual functioning during breastfeeding was reported to be about the same as before pregnancy by 75% of the women. Desire returned for most women by 4 weeks after childbirth, earlier than many of them felt it safe to resume sex relations. Women who had been married longer, with more children and more breastfeeding time, reported an earlier return of sexual interest and felt it safe to resume sex relations earlier. Most women reported their sexual interest after weaning was about the same. No one reported a decrease in sexual interest after weaning. All of the women reported breastfeeding to be enjoyable. Younger marrieds were apt to rate breastfeeding even higher than older marrieds. Also, younger marrieds felt freer about breastfeeding in public. Sexual relations continue when procreatively unfruitful and even when difficult in humans. This underscores the importance of the bonding value of sex.     

孕妇学校对孕妇牙周病治疗依从性的影响

目的了解孕妇学校的宣教对牙周病孕妇治疗依从性的影响。方法回顾性统计2013和2014年度在深圳市福田妇幼保健院门诊产前检查的孕妇数量,统计其中牙周病患病率及诊断为牙周病后到口腔科接受治疗情况。并将2个年度孕妇牙周病患者接受治疗的情况进行比较分析。结果 2013、2014年度门诊建卡产检的孕妇分别为7 260例和8 928例,其中牙周病患者分别为2 824例(38.9%)和3 348例(37.5%),诊断为牙周病后到口腔科接受治疗者分别为1 440例(51.0%)和3 298例(98.5%)。与2013年相比,2014年的牙周病发病率稍低,经比较差异均无统计学意义(均P>0.05),而接受治疗者较2013年明显增多,经比较差异有统计学意义(x^2=565.90,P<0.01)。结论孕妇学校牙周病宣教可明显提高牙周病孕妇治疗的依从性,治疗后可降低流产、早产儿及低出生体重儿的发生率,改善了妊娠结局。     

Pica practices of pregnant women

This report summarizes current knowledge about pica practices during pregnancy through a systematic review of the literature for the period 1950 through 1990. Pica behavior was considered in terms of its prevalence, risk factors, clinical profile, and effect on pregnancy outcome. Data on pica practices by pregnant women are limited and inconclusive but reveal several interesting relationships. The prevalence of pica among pregnant women in high-risk groups declined between the 1950s and the 1970s but now remains steady, affecting about one fifth of high-risk women. Women at high risk of pica are more likely to be black, to live in rural areas, and to have a positive childhood and family history of pica. The clinical picture of the disorder during pregnancy is not well described. The evidence suggests that pica during pregnancy results in anemia, but it is not definitive. Pica also has been associated with maternal and perinatal mortality. We conclude that the behavior is more prevalent than commonly believed, shows no sign of further decline, and may have serious effects, particularly anemia, on mother and infant. Dietetic practitioners who counsel pregnant women should ask questions about pica when they conduct nutrition assessments of their clients.     

乙肝孕产妇与正常孕产妇心理变化及比较

目的 分析乙肝孕产妇与正常孕产妇的心理应激的差异.方法 随机抽取69名门诊或住院就诊的HbsAg(+)孕产妇(病例组),随机抽取同期具有可比性的正常妊娠妇女123例(对照组).采用汉密尔顿抑郁量表、汉密尔顿焦虑量表及症状自评量表评定HbsAg(+)孕产妇与正常妊娠妇女的心理状况.结果 病例组抑郁和焦虑的发生率均较对照组高,经比较有显著性差异(χ2抑郁=13.487,P<0.01;χ2焦虑=53.756,P<0.01);病例组与对照组除敌对症状外(t=-2.513,P<0.05),其它各项及整体身心健康水平无显著性差异(均P>0.05).结论 HbsAg(+)孕产妇的心理应激水平比正常孕妇更高,以中度、重度抑郁、焦虑最为显著;其主要心理情绪反应及阶段与正常孕妇基本一致.     

Salmonella screening of pregnant women

Over a 9-year period all maternity patients were screened by rectal swab for salmonella excretion at the time of delivery. 30,471 mothers were screened and 60 (0.2%) yielded salmonellas, 43 (72%) of whom were symptomless excretors. Seven of the 60 babies (12%) excreted salmonellas, all of which were the same organism as in the mothers. Five had uncomplicated gastroenteritis in the neonatal period, but no mother or child suffered invasive disease and no incidents of hospital cross-infection occurred. These results show that screening is unjustified unless there are problems of cross-infection.     

天津市《职业病防治法》宣传周实施情况以及问题探究

<正>职业卫生健康教育和健康促进工作是从源头上控制和预防职业病的重要措施之一,可显著提升作业工人的职业卫生知识水平~([1])。每年一度的《职业病防治法》宣传周对于进一步落实《职业病防治法》,倡导和动员全体人民共同关注劳动者,督导用人单位认真履行职业病防治的主体责任,广泛宣传职业病防治知识和健康工作方式理念,增强劳动者自我保     

孕妇与非孕妇受血者不规则抗体筛查结果的报告

目的分析在临床安全输血中孕妇与非孕妇受血者不规则抗体筛查的临床价值。方法2017年3月-2019年3月收入深圳市福田区妇幼保健院的120例申请输血女性患者,依据是否怀孕将其分为非孕妇组(n=70例)和孕妇组(n=50例),开展受血者不规则抗体筛查、不规则抗体筛查特异性分布情况,并分析孕妇与非孕妇受血者不规则抗体筛查阳性率。结果120例受血者不规则抗体总筛查率是29.16%,其中抗-M占5.83%,抗-D占5.00%,抗-E占4.16%,抗-C占3.33%,抗-PI占2.50%,抗-Leb占1.67%,抗-Lea占1.67%,抗-H占0.83%,抗-H占0.83%,抗-Fyb占0.83%,抗-N占0.83%,抗-JKa占0.83%;非特异性抗体占1.67%。非孕妇组受血者不规则抗体筛查阳性率21.42%,低于孕妇组阳性率(40.00%),差异有统计学意义(P<0.05)。结论在对女性患者,尤其是孕妇,在输血前有必要实施受血者不规则抗体筛查,明确不规则抗体筛查特异性分布情况,有利于确保输血的整体安全性。