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Background

Since May 2022, increasing numbers of monkeypox virus (MPXV) infections have been reported from across Europe and North America. Studies, mainly from Africa, have suggested a higher risk for severe MPXV cases in people living with HIV.

Methods

This was a retrospective study of all confirmed MPXV infections observed in the participating centres since 19 May 2022. We conducted a chart review to evaluate clinical characteristics, comorbidities, and coinfections, including HIV, viral hepatitis, and sexually transmitted infections (STIs).

Results

By 30 June 2022, a total of 546 MPXV infections were reported from 42 German centres. All patients were men who have sex with men (MSM), of whom 256 (46.9%) were living with HIV, mostly with a preserved immune system and with viral suppression. In total, 232 (42.5%) MSM were also taking HIV pre-exposure prophylaxis (PrEP) and 58 (10.6%) MSM had no known HIV infection or PrEP use. The median age was 39 years (range 20–67), and comorbidities were rare. However, 52.4% and 29.4% of all patients had been diagnosed with at least one STI within the last 6 months or within the last 4 weeks, respectively. The most frequent localizations of MPXV infection were genital (49.9%) and anal (47.9%), whereas fever (53.2%) and lymphadenopathy (42.6%) were the most frequent general symptoms. The hospitalization rate was low (4.0%), and no fatal course was observed. The clinical picture showed no apparent differences between MSM with or without HIV.

Conclusions

In this preliminary cohort analysis from a current large outbreak among MSM in Germany, the clinical picture of MPXV infection did not differ between MSM with and without HIV infection. Severe courses were rare and hospitalization rates were low. However, most patients were relatively healthy, and only a few people living with HIV were viremic or severely immunosuppressed.  相似文献   

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The Royal Prince Alfred Hospital Mpox Vaccination Clinic opened in response to the 2022 multicountry mpox outbreak. A total of 9500 vaccinations were administered intradermally and subcutaneously during the first 16 weeks of clinic operation. The rate of adverse events was 0.1%. Compared to people who received the vaccine intradermally, those who received it subcutaneously were more likely to be aged 30–39 years (P = 0.047), sexual partners of gay and bisexual men (P < 0.001), eligible for Medicare (P < 0.001) and born in the Philippines (P = 0.01) or Malaysia (P = 0.04).  相似文献   

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Aim: To analyse changes in the quantity and quality of media reporting about dementia in Australian media between two time periods. Methods: A media retrieval service collected all news items related to dementia. Quality ratings based on previously developed criteria were made for a stratified random sample of items – 1129 items for 2000/2001 and 1606 for 2006/2007. Nine items of quality were assessed. A summary score for quality was constructed. The content of the sampled media items was also coded. Results: Overall, the mean total quality score for dementia‐related items significantly improved over the study period. There were very large improvements in quality of reporting of ‘sensationalism’, ‘language’ and ‘provision of information about help services’ and some small deterioration in quality for ‘medical terminology’ and ‘illness versus person’. Conclusions: A very positive finding here is that generally the quality of reporting dementia has improved over the period studied.  相似文献   

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Up to 22 June 2022, 508 confirmed cases of monkeypox (MPX) have been reported in the Madrid region of Spain, 99% are men (n = 503) with a median age of 35 years (range: 18–67). In this ongoing outbreak, 427 cases (84.1%) reported condomless sex or sex with multiple partners within the 21 days before onset of symptoms, who were predominantly men who have sex with men (MSM) (n = 397; 93%). Both the location of the rash, mainly in the anogenital and perineal area, as well as the presence of inguinal lymphadenopathy suggest that close physical contact during sexual activity played a key role in transmission. Several cases reported being at a sauna in the city of Madrid (n = 34) or a mass event held on the Spanish island of Gran Canaria (n = 27), activities which may represent a conducive environment for MPX virus spread, with many private parties also playing an important role. Because of the rapid implementation of MPX surveillance in Madrid, one of the largest outbreaks reported outside Africa was identified. To minimise transmission, we continue to actively work with LGBTIQ+ groups and associations, with the aim of raising awareness among people at risk and encouraging them to adopt preventive measures.  相似文献   

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AIM: To evaluate public awareness following a nationwide educational campaign on hypertension. METHODS AND RESULTS: In 1978 the Austrian Heart Foundation conducted a nationwide educational campaign to increase the awareness of the population regarding the importance of recognizing and treating high blood pressure. Following this campaign, five opinion polls of random and representative samples were conducted to measure the awareness and knowledge of the population relating to issues of high blood pressure. The poll results indicated that during the period immediately following the awareness campaign, knowledge and perception of the dangers of high blood pressure increased. However, this effect dissipated during subsequent years. In 1978, 14% of the population were reported to be hypertensive and 10% had no relevant information about their blood pressure status. In 1998, those who labelled themselves as hypertensive dropped to 12%, while those who did not know their blood pressure values, increased to 14%. The percentage of the population who recalled having their blood pressure measured during the last 3 months dropped from 49% in 1978, to 34% in 1993, and remained at 34% in 1998. CONCLUSION: We conclude that the intensive blood pressure education campaign had only a temporary effect on improving blood pressure awareness. Improved strategies are needed to achieve better community control of hypertension.  相似文献   

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HIV testing was offered to 2,185 people receiving mpox (formerly monkeypox) vaccination, who reported not being HIV positive. Among them 390 were current PrEP users, and 131 had taken PrEP in the past. Of 958 individuals consenting testing, six were newly diagnosed with HIV. Two patients had symptomatic primary HIV infection. None of the six patients had ever taken PrEP. Mpox vaccination represents an important opportunity for HIV testing and counselling about risk reduction and PrEP.  相似文献   

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Diphtheria is an acute, highly infectious, vaccine‐preventable and previously endemic disease whose etiologic agent is Corynebacterium diphtheriae. Diphtheria may manifest as an upper respiratory tract infection, a cutaneous infection or as an asymptomatic carrier state. The most common sites of infection are the pharynx and the tonsils, with common clinical manifestations that include sore throat, malaise, cervical lymphadenopathy and low‐grade fever. Absorption and dissemination of C. diphtheriae from the respiratory tract can cause disseminated infection and may lead to cardiac or neurological toxicity. The cornerstone of treatment for diphtheria is diphtheria antitoxin. Early treatment is critical as the degree of protection is inversely proportional to the duration of the illness before its administration. Routine childhood vaccination virtually eliminated diphtheria in most industrialised countries. However, in the pre‐vaccination era, diphtheria was the most common infectious cause of death in Australia. A case of diphtheria in Brisbane in April 2011 and two recent positive cultures in regional Victoria underscore the need for heightened awareness of C. diphtheriae as an important pathogen. In order to prevent the re‐emergence of diphtheria in Australia, public health measures are required to increase immunity in early school leavers and the adult population, and to ensure that travellers to endemic regions are fully immunised. Health policy‐makers and clinicians alike should not underestimate the importance of primary vaccination and booster vaccination against diphtheria among healthy adults and travellers.  相似文献   

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Cultural interpretations of contagion   总被引:5,自引:0,他引:5  
Anthropological research in recent years has examined how single diseases such as Aids, tuberculosis, measles, malaria and leprosy are conceptualized by laypersons in non-Western societies. But how is disease transmission itself interpreted in other cultures? Data from ethnographical studies in Côte d'Ivoire and the Afro-Brazilian culture in Bahia, Brazil show that the interpretations of contagion and preventive practices cut across society involving five main relationships: empirical and analogical thinking, symbolic factors and social organization, the concept of person and body elements, natural and supernatural powers and individual and contextual factors. There is not a general theory, such as Pasteur's theory of germs. Instead,contagion presents itself as a transversal, multidimensional concept crossing and interconnecting society and culture. Public health programmes aimed at controlling infectious diseases need first to understand how contagion is conceptualized by laypersons, the extent to which diseases are considered infectious and the relation between perceptions and preventive practices. This would help in implementing infectious disease control programmes within local contexts based on meaningful community participation.  相似文献   

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Social media has become an integral part of daily life and its use is becoming increasingly intertwined with the healthcare sector. Instagram is a free photo and video sharing social media application that has been utilised extensively in visually rich fields within medicine. Herein, we discuss the advantages and disadvantages of its use in modern medicine.  相似文献   

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利霞  刘真  罗丽娟 《内科》2014,(4):486-490
目的观察实施绩效考核在城市社区公共卫生服务管理中的效果。方法以辖区内7个社区卫生服务中心为研究对象,把健康档案、预防接种、儿童保健、妇女保健、老年保健、高血压、糖尿病、重性精神病患者管理等作为观察指标,通过查阅资料和现场调查,对比实施绩效考核办法前及实施3年后基本公共卫生服务项目组织管理、资金筹集、服务实施等方面的差异。结果上述社区卫生服务中心实施绩效考核办法3年后基本公共卫生服务组织管理项目健全,监督指导进一步加强;在资金筹集情况、健康档案建立率和电子建档率、高血压和糖尿病管理率、重性精神病患者管理率等方面与实施绩效考核办法前比较,管理水平和效果有了显著的提高。结论城市实施基本公共卫生服务项目绩效考核,应用于公共卫生项目的管理可取得较大的成效。  相似文献   

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ABSTRACT A nationwide survey of the incidence of clinical thyrotoxicosis in Iceland was made during the three-year period 1980–1982. An annual incidence of 23.6 per 100 000 inhabitants was found, females outnumbering males by 4.2: 1; 72% of all patients were aged 20–49. Graves' disease was considered the cause in 83.3% of the patients.  相似文献   

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Up to 27 May 2022, Portugal has detected 96 confirmed cases of monkeypox. We describe 27 confirmed cases (median age: 33 years (range: 22–51); all males), with an earliest symptom onset date of 29 April. Almost all cases (n = 25) live in the Lisbon and Tagus Valley health region. Most cases were neither part of identified transmission chains, nor linked to travel or had contact with symptomatic persons or with animals, suggesting the possible previously undetected spread of monkeypox.  相似文献   

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Although HIV testing is critical to the treatment and prevention of HIV/AIDS, utilization rate of HIV testing services among married women and men remains low in Ghana. Mass media, as a tool to increase overall HIV testing turnouts, has been considered one of the important strategies in promoting and enhancing behavioural changes related to HIV/AIDS prevention. Using the 2014 Ghana Demographic and Health Survey, the current study examines the relationship between levels of exposure to print media, radio, and television and the uptake of HIV testing among married women and men in Ghana. Results show that HIV testing is more prevalent among married women than their male counterparts. We also find that higher levels of exposure to radio is associated with HIV testing among women, while higher levels of exposure to print media and television are associated with HIV testing among men. Implications of these findings are discussed for Ghana's HIV/AIDS strategic framework, which aims to expanding efforts at dealing with the HIV/AIDS epidemic. Specifically, it is important for health educators and programme planners to deliver HIV-related messages through television, radio, and print media to increase the uptake of HIV testing particularly among married women and men in Ghana.  相似文献   

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