Plasma alpha-tocopherol, beta-carotene, and lipid levels in semi-free-ranging Przewalski horses (Equus przewalskii)

To describe the features of railway-related deaths in Cape Town, South Africa, we reviewed demographic, autopsy, and accident report data on all such deaths between 1 April 1992 and 30 September 1994. Of the 379 railway-related deaths, 27 were among pedestrians or commuters who were hit by a train while crossing the track, 38 were among commuters who fell from moving trains, 32 were suicides, 43 were the result of criminal violence on trains or at railway stations, and 38 were due to other causes. Most railway fatalities were among men between the ages of 25 and 44 years. About half of all railway fatalities occurred at peak commuting times, with high levels of violence (often robbery related) recorded during the evening peak. A blood alcohol concentration > 0.1 g/100 ml was found in 35% of the people who died from crossing the track or falling from moving trains. Fatal railway injury is characterized by extensive disruption of more than one body region. The high levels of fatal railway injury make a strong case for a range of injury control interventions, including ticket control, surveillance, law enforcement, and safety engineering.     

Task-related arousal of Type A and Type B persons: Level of challenge and response specificity.

To determine whether different levels of challenge had differential effects on the arousal levels of Type A (coronary prone) and Type B (noncoronary prone) persons, 30 Type A and 30 Type B male undergraduates worked on an intelligence test task (digits backwards recall) that was easy, moderately difficult, or extremely difficult. Arousal was measured in terms of systolic blood pressure, diastolic blood pressure, pulse rate, pulse volume, skin resistance, and subjective arousal. Results indicate that, while working on the extremely difficult task, the Type A's evidenced reliably higher systolic blood pressure than did Type B's and that there were not reliable differences between Ss in systolic blood pressure at other levels of challenge or on other measures of arousal. (15 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Exposure to methyl tertiary-butyl ether from oxygenated gasoline in Stamford, Connecticut

In 1993, state health officials in Connecticut invited the Centers for Disease Control and Prevention (CDC) to assist in an investigation of exposure to methyl tertiary-butyl ether in oxygenated gasoline in Stamford, Connecticut. Venous blood samples were collected from 14 commuters and from 30 other persons who worked in the vicinity of traffic or automobiles, and the samples were analyzed for methyl tertiary-butyl ether, tertiary-butyl alcohol, benzene, m-/p-xylene, o-xylene, and toluene. The highest levels of methyl tertiary-butyl ether in blood were measured among gasoline service station attendants (median = 15 micrograms/l, range = 7.6-28.9 micrograms/l). Blood levels of methyl tertiary-butyl ether were highly variable among persons who worked in car-repair shops (median = 1.73 micrograms/l, range = 0.17-36.7 micrograms/l) and were generally lowest among commuters (median = 0.11 micrograms/l, range = < 0.05-2.60 micrograms/l). Blood levels of methyl tertiary-butyl ether were correlated strongly with personal-breathing-zone samples of methyl tertiary-butyl ether and blood levels of other volatile organic compounds. This exposure information should prove useful to a future risk analysis of this high-volume chemical.     

Effects of methyl ethyl ketone, acetone, or toluene coadministration on 2,5-hexanedione concentration in the sciatic nerve, serum, and urine of rats

PURPOSE: The aim of this study was to examine the associations among fasting insulin, adiposity, waist girth, and blood pressure among a nondiabetic multiethnic population. METHODS: A cross-sectional study was performed among 25-44-year-old African-Americans (n = 159), Cuban-Americans (n = 128), and non-Hispanic whites (n = 207) selected from Dade County, Florida. Fasting insulin levels were correlated with resting blood pressure level within each ethnic group. The separate effects of percentage body fat and waist girth on the association between blood pressure and insulin were analyzed in multiple linear regression and analysis of covariance. RESULTS: Fasting insulin was positively associated with systolic (r = 0.26-0.39; P < 0.01) and diastolic blood pressure (r = 0.19-0.30; P = 0.10 to P < 0.001) among women of all ethnic groups and among non-Hispanic white men (r = 0.27; P < 0.05). Stepwise linear regression analyses revealed statistically significant associations between systolic and diastolic blood pressure and fasting insulin level in non-Hispanic whites independent of other covariates, including sex and percentage body fat (P < 0.001). Fasting insulin was also independently and significantly related to systolic blood pressure among African-Americans (P = 0.02). Among Cuban-Americans, sex and percentage body fat were the main correlates of blood pressure level. Analysis of covariance revealed a relationship between insulin and blood pressure that was independent of waist girth among men and women. CONCLUSIONS: Fasting insulin level and blood pressure were positively associated among African-Americans and non-Hispanic whites. This association was not entirely due to the common association with percentage body fat or waist girth.     

Control over stress, Type A behavior pattern, and response to stress.

Examined (a) differences in physiological response of Type A and Type B individuals to conditions that varied in both controllability and consistency of controllability over an aversive stimulus and (b) whether Type A relative to Type B individuals use more denial and/or projection in cognitively coping with arousing situations as well as whether they differ in being preoccupied in such situations. 96 male undergraduates were randomly assigned to 1 of 4 conditions: no control over shock, consistent control over shock, intermittent control over shock, and low stress. Type A and B behaviors were assessed with the Activity scale of the Thurstone Temperament Schedule. Results indicated that relative to Type B Ss, Type A's manifested (a) greater pulse rates and systolic and diastolic blood pressure in the consistent control condition, (b) greater systolic blood pressure in the no-control condition, and (c) greater diastolic blood pressure in the intermittent control condition. Type A's also used more denial and projection across the 3 high-stress conditions but did not differ in how preoccupied they were as compared to Type B's. (39 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Systematic analytic procedure for identification of unknown medicaments in biological material

Increase in blood pressure and its circadian alterations in Type 1 diabetes are usually associated with diabetic nephropathy. To evaluate if diabetes itself could be responsible for the observed increase in blood pressure levels, we studied a group of 17 normotensive, normoalbuminuric Type 1 diabetic patients with a disease duration more than 15 years, with no clinical evidence of autonomic neuropathy or ischaemic heart disease, and without any known determinant of hypertension, and a control group of 17 normal subjects, normotensive, each matched for sex, age, BMI, albumin excretion rate, and clinical blood pressure to a diabetic subject. In both groups an ambulatory blood pressure monitoring was performed through an oscillometric recorder. The mean systolic and diastolic ambulatory blood pressure values were significantly higher in diabetic patients (p < 0.001) in the 24-h analysis and during waking and sleeping periods. The night/day ratio of systolic and diastolic blood pressure were not significantly different in patients and controls, as well as heart rate values and heart rate variability. We conclude that mechanism(s) inherent to the diabetic condition other than diabetic nephropathy or autonomic neuropathy could be responsible for blood pressure evaluation in normotensive Type 1 diabetes with normoalbuminuria.     

Role ambiguity, Type A behavior, and job satisfaction: Moderating effects on cardiovascular and biochemical responses associated with coronary risk.

Studied 217 male managers (mean age 44 yrs), classified as Type A (coronary-prone) or Type B (non-coronary-prone), to examine the effects of job satisfaction as a moderator between a common job stressor (role ambiguity) and coronary risk indicators. For Type A's, the results support the hypotheses that changes in ambiguity are associated with changes in blood pressure and that intrinsic job satisfaction has both a direct and moderating effect on these changes. Few similar effects were found for extrinsic job satisfaction. For Type B's, the effects on systolic blood pressure were opposite to those for type A's. It is suggested that either Type A's and Type B's differ in autonomic and cardiovascular response or that ambiguity as a stressor may have differential effects for Type A's and Type B's, indicating that their "fit" with ambiguous environments may be opposite. (53 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Chronic stress as a factor in physiologic reactivity to challenge.

Examined the hypothesis that chronic stress contributes to heightened cardiovascular reactivity. 17 residents (mean age 35 yrs) of crowded neighborhoods and 24 residents (mean age 39 yrs) of uncrowded neighborhoods worked on a challenging task while blood pressure and heart rate were measured. Self-report and biochemical measures indicate that the 2 groups differed in level of chronic stress. Results also indicate that chronic stress contributed to cardiovascular reactivity. Crowded residents showed greater increases in systolic and diastolic blood pressure and heart rate and took longer to return to baseline than did uncrowded residents. The few differences found between Type A (coronary prone) and Type B (noncoronary prone) residents were found only in the low-stress group. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Protective effect of GTS-21, a novel nicotinic receptor agonist, on delayed neuronal death induced by ischemia in gerbils

BACKGROUND: The difference between clinic and ambulatory average daytime blood pressures is frequently taken as a surrogate measure of the 'white-coat effect' (i.e. the pressor reaction triggered in the patient by the physician's visit). OBJECTIVE: To assess the reproducibility of this difference and its relationship with clinic and average ambulatory daytime blood pressure levels. DESIGN AND METHODS: These issues were addressed with two large groups of subjects in whom both clinic and ambulatory blood pressures were measured, namely 783 outpatients with systolic and diastolic essential hypertension [Group 1, aged 50.8+/-9.4 years (mean +/- SD)], participating in standardized Italian trials of antihypertensive drugs, and 506 elderly patients (group 2, age 71+/-7 years) with isolated systolic hypertension, participating in the European Syst-Eur trial. RESULTS: The clinic-daytime blood pressure difference for the essential systolic and diastolic hypertensive patients (group 1) was 13.6+/-14.3 mmHg for systolic and 9.1+/-8.6 mmHg for diastolic blood pressure (P always < 0.01). This difference for the elderly patients with isolated systolic hypertension (group 2) was 21.2+/-16.0 mmHg for systolic and only 1.3+/-10.2 mmHg for diastolic blood pressure (P < 0.01 and P < 0.05, respectively). In both studies little or no systematic clinic-daytime difference could be observed for heart rate. The reproducibility of the clinic-daytime blood pressure difference, tested for 108 essential systolic and diastolic hypertensive patients from group 1 and 128 isolated systolic hypertensives from group 2, was invariably lower than that both of daytime and of clinic blood pressure values. Finally, the clinic-daytime blood pressure difference was progressively higher for increasing levels of clinic blood pressure and progressively lower for higher levels of ambulatory daytime blood pressure. CONCLUSIONS: Thus, the clinic-daytime blood pressure difference has a limited reproducibility; depends not only on clinic but also on daytime average blood pressure, which means that its size is a function of the blood pressure criteria employed for selection of the patients in a trial; and is never associated with a systematic clinic-daytime difference in heart rate, which further questions its use as a reliable surrogate measure of the true pressor response induced in the patient by the doctor's visit.     

Type A behavior, family history of hypertension, and cardiovascular responsivity among Black women.

Determined the effects of Type A (coronary-prone) behavior and family history of hypertension on cardiovascular reactivity to mental stress in 50 26–63 yr old employed Black women. Results indicated that Type A behavior was associated with systolic and diastolic blood pressure hyperresponsivity during a structured interview (SI) but not during mental arithmetic. Certain speech components of the Type A pattern, as well as features of the potential-for-hostility component, were also related to cardiovascular responses during the SI. Family history of hypertension did not influence the cardiovascular parameters. Results suggest that many of the cardiovascular response characteristics of the Type A pattern that have been observed in predominately White samples also hold true for Blacks. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

AIDS related knowledge and behaviours among college students, Gondar, Ethiopia: a comparative study

The objective of this study was to estimate the prevalence of diabetes among people aged 40 or more and to compare selected factors such as systolic and diastolic blood pressure, body mass index and lipid profile in diabetic and non-diabetic subjects. This is a cross-sectional study of subjects aged over 40 in Isfahan. Selection of diabetic subjects were based on multi-stage random sampling. Diabetes status was defined by the World Health Organization criteria and was based on fasting plasma glucose and oral glucose tolerance test results. Data on age, body mass index, blood pressure and lipid profile were obtained. Results show that a total of 3910 eligible subjects were examined and classified into different diabetes status. The overall age-standardized prevalence of diabetes was 7.54% (95% CI: 6.24-8.84%) in males and 7.97% (95% CI: 6.75-9.19%) in females with no difference. Similarly, the overall age standardized prevalence was 7.76% (95% CI: 6.87-8.65%). The prevalence of diabetes was shown to increased in the older age groups. Multiple logistic regression analysis showed that age, systolic blood pressure, hypertriglyceridemia, being overweight and also obesity were independently associated with diabetes. A large number of newly-diagnosed diabetic subjects were identified, which necessitates powerful screening programs. High levels of blood pressure, body mass index and lipid profile should draw attention to probable presence of diabetes.     

Nocturnal blood pressure and relation to vasoactive hormones and renal function in hypertension and chronic renal failure

The purpose of this study was to assess the blood pressure profile and to measure vasoactive hormones in patients with essential hypertension (n=61), secondary hypertension (n=32) and chronic renal failure (n=32) matched with healthy control subjects (n=35), and to study the relationship between circadian changes in blood pressure and baseline levels of vasoactive hormones and renal function. Non-invasive, automatic blood pressure measurement was performed for 24 or 48 h. Venous plasma concentrations of renin, angiotensin II, aldosterone, arginine vasopressin, atrial natriuretic peptide and endothelin were measured. The mean 24-h blood pressure was higher in all groups of hypertensive patients than in control subjects. The nocturnal blood pressure fall was preserved in essential hypertension, in contrast to secondary hypertension in which it was attenuated. In the patients with chronic renal failure the 24-h mean blood pressure was the same as in the controls. Night-time blood pressure was higher among the chronic renal failure patients than in the control group, and the nightly blood pressure fall in both diastolic and systolic blood pressure was reduced. Plasma concentrations of renin activity, arginine vasopressin, atrial natriuretic peptide, aldosterone and endothelin were significantly increased in secondary hypertension and chronic renal failure, compared to essential hypertension and control subjects. Plasma angiotensin II was increased in chronic renal failure compared to essential hypertension and controls. Estimated creatinine clearance and nightly blood pressure dips were inversely correlated in essential and secondary hypertension, i.e. with a decreasing renal function both systolic and diastolic nightly blood pressure dips were gradually attenuated. In the whole group of patients the nightly systolic and diastolic blood pressure dips were negatively correlated to basal plasma renin activity, plasma aldosterone and atrial natriuretic peptide levels, i.e. the higher the basal plasma hormone level the lower the blood pressure dip. In conclusion, patients with essential hypertension have elevated but normally configured 24-h blood pressure profiles, and patients with different kinds of secondary hypertension have elevated 24-h blood pressure profiles and attenuated nightly systolic and diastolic blood pressure falls. The more the renal function is reduced and the more the plasma levels of renin and aldosterone are increased, the more the nocturnal fall in blood pressure is reduced. It is suggested that the attenuated or absent decrease in nocturnal blood pressure in secondary renal hypertension is caused by an abnormally increased secretion of vasoactive hormones and/or by so far unknown factors released from the diseased kidney.     

Trends in blood pressure levels and control of hypertension in Finland from 1982 to 1997

OBJECTIVE: To assess the trends in blood pressure levels and hypertension control in Finland from 1982 to 1997. DESIGN: Four independent cross-sectional population surveys conducted in 1982, 1987, 1992 and 1997. SETTING: From 1982 to 1997, the provinces of North Karelia and Kuopio in eastern Finland and the region of Turku-Loimaa in southwestern Finland were surveyed. From 1992 to 1997, the Helsinki-Vantaa region in southern Finland was surveyed. PARTICIPANTS: Men and women aged 25-64 years were selected randomly from the national population register. The total number of participants was 27 623. MAIN OUTCOME MEASURES: We assessed mean systolic and diastolic blood pressure, prevalence of hypertension (subjects with systolic blood pressure > or = 160 mmHg or diastolic blood pressure > or = 95 mmHg or current use of antihypertensive drug treatment) and antihypertensive drug treatment and quality of hypertension care among hypertensive persons. RESULTS: Mean systolic blood pressure and the prevalence of hypertension decreased significantly in all areas except among men in the Helsinki-Vantaa region. The fall in mean diastolic pressure was significant only in eastern Finland. The proportion of hypertensives who were unaware of their condition fell from 45.5 to 24.1% in men and from 27.2 to 15.7% in women. At the same time, the proportion of hypertensives with adequately controlled blood pressure (systolic pressure < 160 mmHg and diastolic pressure < 95 mmHg) increased from 9.4 to 23.5% in men and from 16.0 to 36.7% in women. CONCLUSION: Hypertension care in Finland has improved significantly during the last 15 years. However, the situation is still far from optimal. It is obvious that the biggest problem in hypertension care has shifted from detection to adequate treatment of high blood pressure.     

Age-related differences in cardiovascular reactions to mental stress tests in women.

Tested 84 healthy, sedentary women in the laboratory during performance of difficult and easy problem-solving tasks. Ss were divided into 3 equal age groups: 19–32 yrs, 33–43 yrs, and 44–60 yrs. Baseline systolic blood pressure (SBP) and diastolic blood pressure increased with age, whereas skin conductance level was lower in older Ss. Initial SBP reactions to tasks were positively related to age, even after controlling for baseline blood pressure, aerobic fitness, and Framingham Type A Scale (S. G. Haynes et al; see PA, Vol 68:10702) behavior scores. There were no differences in heart rate (HR) or additional HR reactions, so the anticipated decline in cardiac sympathetic response with age was not observed. Mechanisms underlying age-related reactions to mental stress are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of exercise, relaxation, and management skills training on physiological stress indicators: A field experiment.

The physiological effects of three stress intervention strategies (management skills training, exercise, and meditation) were examined in a longitudinal field experiment. Sixty-two subjects were randomly assigned to four groups (three experimental groups and a control group). Pulse rate, diastolic blood pressure, systolic blood pressure, and galvanic skin response were used as physiological stress indicators. Analysis of covariance and multiple comparison tests indicated that each of the strategies led to decreases in pulse rate and systolic blood pressure. Dual combination strategies also showed significant decreases in pulse rate. However, no reliable results were found for combination strategies when examined for ordered effects. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Definition of a responder: analysis of behavioral, cardiovascular, and endocrine responses to varied workload in air traffic controllers

Individual differences in behavioral, cardiovascular, and endocrine responses to varying workload among 381 air traffic controllers were assessed using random regression modeling. Although most men showed significant increases in behavioral arousal associated with increasing planes, there were major individual differences in response in systolic and diastolic blood pressure, heart rate, and cortisol. Approximately 20% to 25% of those studied had large increases in each of these domains, along with a smaller group showing inverse responses in heart rate and cortisol. There was also evidence of a smaller number of enhanced responders within the highest groups, who tended to have more missing values at higher levels of workload. There was convergence in the definition of responders using three statistical strategies: random regression, correlational analyses, and ANOVA. Response in one physiological/behavioral domain was essentially independent of response in another, supporting the conclusion of specificity, rather than a global tendency to respond to increasing work load.     

A botanical compound, Padma 28, increases walking distance in stable intermittent claudication

Thirty-six patients with a median age of sixty-seven years and a median duration of intermittent claudication of five years were randomized to either active treatment with Padma 28 or placebo. The effect of treatment was quantified by measurements of systemic and peripheral systolic blood pressures and by measurements of the pain-free and the maximal walking distance on a treadmill. The ankle pressure index (ankle systolic pressure/arm systolic pressure) was calculated. The group randomized to active treatment received two tablets bid containing 340 mg of a dried herbal mixture composed according to an ancient lamaistic preparation (Padma 28). After active treatments, administered over a period of four months in a double-blinded, randomized design, the patients allocated to this group attained a significant increase in the pain-free walking distance from 52 m (20-106) to 86 m (24-164; P < 0.05) and in the maximal walking distance from 115 m (72-218) to 227 m (73- > 1,000; P < 0.05). The patient-group receiving placebo treatments did not show any significant changes in either the painfree or the maximal walking distance. The authors could not demonstrate any significant changes in the ankle pressure index either during active or during placebo treatment. In conclusion, this study has shown that treatment with Padma 28 over a period of four months significantly increased the walking distance in patients with stable, intermittent claudication of long duration.     

Blood pressure and twenty-year mortality in the city of Bergen, Norway

A blood pressure survey was carried out in 1963 in the city of Bergen, Norway. The relation between 20-year mortality and blood pressure in 52,064 participants aged 30-89 years at examination was analyzed. Increased blood pressure was related to increased mortality from coronary heart disease, stroke, and all causes in all age groups except the oldest, where a more irregular pattern was present. The relative risks decreased with age at screening, while the absolute increase in mortality with increasing blood pressure was greatest in persons aged 60-69 or 70-79 years at screening. A log-linear relation between systolic blood pressure and coronary heart disease and stroke mortality was seen in both men and women. An upturn in total mortality at low systolic blood pressures was suggested in the groups aged 60 years or more at screening. An upturn, or leveling off, was also seen at low diastolic blood pressures for total deaths and stroke deaths in both men and women.     

Protestant ethic endorsement and attitudes toward commuting to work among mass transit riders.

273 suburban adult commuters completed a survey assessing attitudes toward commuting to and from work by train, behavior while commuting, and endorsement of the Protestant work ethic. It was found that Protestant ethic endorsement was positively correlated with perceiving the commute as being part of the work day, engaging in work-related behavior while in transit, and a stronger preference for working than for commuting. However, endorsement of the Protestant ethic was uncorrelated with the frequency with which respondents' jobs provided them with differential opportunities to actually do work while commuting. Findings suggest that work values can account for behavior and attitudes that extend beyond the work place. (13 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)