调Q开关翠绿宝石激光治疗282例色素性皮肤病临床分析

目的观察调Q开关翠绿宝石激光在皮肤科色素性疾病治疗中的疗效及不良反应。方法用Q开关翠绿宝石激光治疗282例皮肤色素性疾病包括脂溢性角化症、斑痣、褐青色痣、黄褐斑、咖啡斑、口周黑子、雀斑、雀斑样痣、色素沉着斑、色素性毛痣、色素痣、太田痣、外伤粉尘沉着、文身、伊藤痣、遗传性对称性色素异常。观察就诊患者的疗效及不良反应。结果脂溢性角化症、雀斑3次治愈率100%。斑痣4次治疗有效率64.7%,治愈率17.6%。太田痣6次治疗有效率91.7%,治愈率达61.1%。咖啡斑3次治疗有效率达46.1%,治愈率达23.1%。文身3次治疗有效率达100%,治愈率达50.0%。雀斑样痣2次治疗有效率达66.7%。外伤粉尘沉着4次治疗有效率达86.7%,治愈率达46.7%。色素沉着、口周黑子1次治愈率可达50%。伊藤痣、褐青色痣、黄褐斑、遗传性对称性色素异常病例数较少,需进一步观察。色素痣和色素性毛痣效果差,不推荐使用。结论 Q开关翠绿宝石激光对太田痣、雀斑、脂溢性角化症、文身、外伤粉尘沉着、口周黑子、色素沉着治疗效果好。对于咖啡斑、雀斑样痣、斑痣等有一定疗效。     

IPL光子嫩肤技术治疗92例面部色素性皮肤病的效果分析

目的探讨对面部色素性皮肤病患者进行IPL光子嫩肤技术治疗后获得的临床治疗效果。方法选择我院2015年3月至2016年12月收治的92例面部色素性皮肤病患者作为实验对象;对所有面部色素性皮肤病患者进行光子嫩肤技术治疗,最终对面部色素性皮肤病疗效进行回顾性分析。结果对所有面部色素性皮肤病患者施以治疗后发现,雀斑及痤疮后色素沉着患者治疗总有效率分别为97.67%、86.36%,明显高于脂溢性角化、黄褐斑以及其他类型色素沉着症状患者的61.54%、42.86%,28.57%,P<0.05。结论对面部色素性皮肤病患者进行光子嫩肤技术治疗,可以获得一定疗效,尤其对雀斑及痤疮后色素沉着患者进行治疗后,获得的治疗效果更为明显,从而满足面部色素性皮肤病的治疗美观需求。     

高频电离子治疗仪配合CO2激光治疗脂溢性角化病

目的 探讨脂溢性角化病的最佳治疗方法.方法 采用高频电离子治疗仪配合CO2激光治疗脂溢性角化病.结果 87例均能治愈,巨大者分二到三次治疗,无一例感染和留有疤痕,色素沉着在3个月消退.结论 采用本法治疗脂溢性角化病是一种简便、安全、不出血、不留疤痕的最佳方法.     

合理应用维甲酸类药物 减轻不良反应

维甲酸类系列药物有较强的角质剥脱作用，可抑制皮肤滞留性角化过度，防止新的阻塞和炎症性损害的形成。主要用于治疗角化异常性皮肤病、色素性疾病、痤疮、脂溢性皮肤病。尤对治疗痤疮等有显著疗效。     

Q开关Nd-YAG激光治疗色素增加性皮肤病临床观察

目的：观察Q开关Nd-YAG激光治疗色素增加性皮肤病临床疗效、美容效果及治疗次数。方法：Q开关Nd-YAG激光（1064nm、532nm波长）治疗164例色素性疾病,观察、分析其疗效和美容效果。结果：Q开关Nd-YAG激光治疗色素性皮肤病的治疗效果好,其中对纹眉、雀斑、脂溢性角化、色素痣等治疗总有效率＆gt;90%,治疗次数为1～4次。常见的不良反应为轻微的皮肤发红或肿胀、疼痛、渗血等。结论：Q开关Nd-YAG激光治疗色素增加皮肤病效果好,是目前理想的治疗方法之一。     

合理应用维甲酸类药物减轻不良反应

维甲酸类系列药物有较强的角质剥脱作用 ,可抑制皮肤滞留性角化过度 ,防止新的阻塞和炎症性损害的形成。主要用于治疗角化异常性皮肤病、色素性疾病、痤疮、脂溢性皮肤病。尤对治疗痤疮等有显著疗效。痤疮是一种常见皮肤病 ,青少年人群发病率高达 80 % ,可持续数年 ,不及时治疗 ,可导致瘢痕 ,影响外貌而给患者带来苦恼 ,临床迫切需要满意的治疗药物。维甲酸类的发现被认为是药物发展史上的一个里程碑 ,但它的致胚胎毒性和致畸性一直受到关注。因为这类药物的所有活性化合物都是强致畸原 ,而且对人及所有实验动物都不例外 ;外用维甲酸类药物…     

高频电针治疗脂溢性角化病疗效观察

脂溢性角化病是临床上较常见的一种皮肤病，男性多见，影响美容。高频电针治疗脂溢性角化病是一种精确、术中不出血、术后创面修复快和并发症少的皮肤美容外科技术。我院自2003年6月～2005年6月以来对诊断为脂溢性角化病的患者70例采用高频电针治疗，效果满意，现报告如下：     

E光治疗痤疮的疗效观察

目的评价E光治疗痤疮的临床疗效和安全性。方法应用E光治疗仪治疗面部寻常痤疮患者32例,采用自身前后对照进行疗效观察。结果 32例患者均完成治疗,7例(21.88%)痊愈,14例(43.75%)显效,11例(34.38%)有效,0例无效,有效率65.63%。结论 E光治疗痤疮安全有效。     

面部脂溢性角化病联合治疗的临床观察

目的 观察CHR型多功能美容手术仪联合倍频Q开关掺钕钇铝石榴石激光治疗面部脂溢性角化病的临床疗效.方法 采用CHR型多功能美容手术仪联合Q开关Nd：YAG激光治疗脂溢性角化病72例,118处面部皮损.结果 72例患者,共计118个面部皮损,治疗4周后随访,104个皮损痊愈,治愈率88.1%,14个皮损显效,有效率100%,经1至2次治疗,有效率为100%.结论 CHR型多功能美容手术仪联合Q开关Nd：YAG激光治疗面部脂溢性角化病迅速、有效、安全.     

痤疮膏的制备方法及疗效观察

痤疮膏为我院常用的治疗痤疮的外用软膏制剂.临床使用多年,疗效显著,对于治疗痤疮、脂溢性皮炎、黄褐斑、雀斑有良好的治疗效果.本品为纯中药的外用软膏剂,具有质地细腻,色泽均匀,无过敏反应和副作用,疗效显著的特点.     

氨甲环酸在治疗黄褐斑领域中的应用进展

黄褐斑是一种常发于面部的难治性皮肤疾病,以不规则的色素沉着斑为特征。目前主要治疗药物有对苯二酚、维A酸等,但其副作用较大。氨甲环酸是一种人工合成的赖氨酸衍生物,属于抗纤维蛋白溶解剂,经FDA批准用于治疗月经过多和预防出血。另外,氨甲环酸具有治疗黄褐斑功效,它通过对纤溶酶原激活途径的抑制作用,从而减轻色素沉着症状。本文在PubMed、Web of Science、CNKI、ScienceDirect等数据库进行了广泛的文献检索,对氨甲环酸在治疗黄褐斑领域的制剂学研究和临床有效性研究进行了资料归纳与分析,为临床上应用氨甲环酸治疗黄褐斑提供参考。     

Comparison of different test models for the assessment of cytotoxicity of composite resins

This study compared the use of different test models to assess the cytotoxicity of a dental composite. The cytotoxicity of a composite polymerized using two halogen-based light-curing units (LCUs) (Max LC and Astralis) and two light-emitting diode LCUs (E-light and Freelight) served as the basis of comparison. Disk-shaped specimens (7 mm diameter, 2 mm high) were fabricated using the four different light sources. The specimens were used in several cytotoxicity test models: direct and indirect contact tests as well as an extract test with an established cell line L-929. The cells were stained with neutral red after cell-material contact for 48 h. Neutral red-stained areas (in mm2, for direct and indirect tests) and absorbance readings (for extract tests) were analysed statistically using ANOVA and the Tukey post hoc test, with P < 0.05 considered to be significantly different. Good correlation between direct and indirect contact tests (r = 0.903) was found. The extract test was the least correlated among the three tests. It was found that the E-light + Freelight-cured composite elicited cytotoxicity from the correlated studies. Uncured specimens were most detrimental to the cells in all tests. Our data demonstrated that composite cured with light-emitting diode LCUs were cytotoxic to L-929 cells. Different test models were found to give rise to different findings. Thus, a good cell-material contact method would replicate more closely the physiological situation in vivo. This in turn would give more clinically relevant results.     

Undifferentiated connective tissue disease with various pigmentary patterns: a study of three patients

Undifferentiated connective tissue disease (UCTD) is a condition characterized by the presence of clinical manifestations suggestive of a connective tissue disease and at least one non-organ specific autoantibody. In this report I am presenting three types of cutaneous pigmentary changes are presented in three patients which were the clue to the diagnosis of UCTD.     

Photorejuvenation of facial skin with topical 20% 5-aminolevulinic acid and intense pulsed light treatment: a split-face comparison study

BACKGROUND: Photorejuvenation of facial skin has been reported after intense pulsed light (IPL) therapy alone and in conjunction with topical 5-aminolevulinic acid (5-ALA), but no comparative studies between these regimens have been performed. OBJECTIVE: To evaluate the safety and effectiveness of combination topical 5-ALA and IPL compared to IPL treatment alone. METHODS: Ten patients with mild to moderate photodamage were randomly assigned treatment with 5-ALA + IPL on one facial half and IPL alone on the contralateral side. Two treatments were delivered at 4-week intervals. Clinical improvement scores were determined by masked evaluations of digital photographs obtained at baseline, prior to each treatment session, and at 1, 3, and 6 months after the final treatment. RESULTS: Higher clinical improvement scores were noted on the combination 5-ALA + IPL treated areas. Mild edema, erythema, and desquamation were observed on the facial halves where 5-ALA was applied. No scarring or unwanted pigmentary alteration was seen. CONCLUSIONS: Photodynamic therapy with combination topical 5-ALA + IPL is safe and more effective for facial rejuvenation than IPL treatment alone.     

迈之灵片治疗进行性色素性紫癜性皮病的疗效

目的评价迈之灵治疗进行性色素性紫癜性皮病的临床疗效。方法 90例患者按2∶1比例随机分为治疗组和对照组,治疗组口服迈之灵片,每次300mg,每天2次;对照组口服复方丹参片,每次855 mg,每天3次,每2周观察记录一次,均治疗4周。结果治疗组在2周后的总有效率分别为70.0%,4周为95.0%,对照组则分别为50.0%和76.6%,组间疗效比较差异有统计学意义(P<0.05)。结论迈之灵是进行性色素性紫癜性皮病治疗的良好选择。     

维生素对黑色素代谢的影响

黑色素是人及动物皮肤或者毛发中存在的一种黑褐色的生物色素,是皮肤为避免受紫外线等的伤害而自行产生的一种保护性色素。遗传易感性、过度暴露在阳光下以及其他来源的紫外线均会破坏皮肤的抗氧化能力,影响黑素细胞合成黑素颗粒,引起皮肤色素相关疾病。现有研究表明皮肤中的抗氧化因子能有效保护机体免受紫外线的危害,维生素作为抗氧化物质已广泛应用于临床,本文概述了维生素B、维生素E、维生素C和维生素D等抗氧化维生素通过不同的抗氧化机制影响着黑色素代谢而应用于皮肤色素相关疾病的治疗,以期为维生素治疗色素疾病提供理论依据。     

Skin rejuvenation in Asian skin: the analysis of clinical effects and basic mechanisms of intense pulsed light

BACKGROUND: Skin aging consists of photoaging and intrinsic aging. It is characterized clinically not only by rhytides, but also by pigmentary alterations and facial telangiectasias. There continues to be a growing interest in the efficacy of intense pulsed light (IPL) devices in the treatment of skin aging, as well as further defining its mechanism of action. OBJECTIVES: The objective of this clinical trial was to evaluate the effects and the mechanism of action of an IPL by comparing clinical photographs and biopsy results before and after treatment. METHODS: A total of 58 patients were treated using a new IPL device. Clinical photographs were taken before treatment and compared to those taken 3 weeks after the treatment. Also, 4 cases had pathological analyses of tissues that were stained by haematoxylin-eosin and Uana orcein. Immunohistology of human collagen of types 1 and 3 and quantitative analyses of elastin and collagen were performed by a poly-functional digital image light microscope; a transmission electron microscope was used for 2 of the cases to look for additional changes. RESULTS: After 3 treatments, 62.1% of the patients showed improvement in wrinkles and skin texture. Pigmentation improved in 84.6% of the patients, and a reduction in telangiectasis was seen in 81.25% of the patients. Pathological examination showed that both type 1 and type 3 collagens increased following treatment, but elastin content decreased; however, the elastin fibers were arranged more neatly. In the transmission electron microscope study, the amount of fibroblast activity increased, the fibroblasts were more active, and there were more collagen fibers neatly rearranged within the stroma. CONCLUSION: Clinical and pathological studies demonstrated that the IPL was effective in improving wrinkles and skin texture. The mechanism of action may be through the increasing activity of the fibroblasts, hyperplasia of the fibroblasts, and rearrangement of both collagen and elastin within the stroma.     

Episcleritis associated with pigmentary retinal degeneration in an HTLV-I carrier.

Human T-cell lymphotropic virus type I (HTLV-I) has been reported as the cause of a kind of endogenous uveitis (HTLV-I associated uveitis; HAU). We observed a case of episcleritis in a HTLV-I carrier with pigmentary retinal degeneration. HTLV-I infection might be associated with the development of episcleritis and pigmentary retinal degeneration. Patients with episcleritis or pigmentary retinal degeneration should be examined for HTLV-I infection.     

Fillers in the skin of color population

The skin of color population in the United States is rapidly growing and the cosmetic industry is responding to the demand for skin of color targeted treatments. The aging face in skin of color patients has a unique pattern that can be successfully augmented by dermal fillers. Though many subjects with skin of color were not included in the pre-market dermal filler clinical trials, some post-market studies have examined the safety and risks of adverse events in this population. The safety data from a selection of these studies was examined. Though pigmentary changes occurred, there have been no reports of keloid development. Developing a patient-specific care plan and instituting close follow up is emphasized.     

Case reports: clearance of lentigines in Japanese men with the long-pulsed alexandrite laser

Benign pigmented lesions can be effectively treated with multiple modalities including lasers. The treatment of pigmented lesions in phototype IV skin is more complicated and challenging given the risk of pigmentation changes and scarring. We present the novel use of the long-pulsed Alexandrite 755 nm laser for the treatment of solar lentigines in sun-reactive phototype IV skin of patients of Japanese decent. Our Japanese patients cleared with one treatment with no pigmentary changes or scarring. No recurrences were noted to date. The long-pulsed Alexandrite 755-nm laser is a novel, safe, and effective treatment of solar lentigines in Japanese patients.