基于柔性衬底的三维生物刺激微电极阵列研究

设计了一种基于聚酰亚胺薄膜的三维生物刺激微电极阵列,用于植入式人造视网膜应用.采用非硅MEMS技术,在柔性衬底上制备出具有生物相容性和化学稳定性,电极高度为80 μm的生物刺激电极阵列,通过PDMS牺牲层实现器件从基底的完整释放.实验中器件以聚酰亚胺和PDMS封装,电极柱和焊盘均镀金,从而提高电极的生物相容性.采用三电极法对微电极进行了电化学性能测试,在10-1～105Hz频率范围内,其阻抗为1.5～0.3 kΩ.制造出的器件尺寸小,质量轻,可靠性高,机械柔性好,符合生物电刺激要求.     

基于Parylene的柔性神经微电极的研制和表征

衬底集成的微电极是植入式微系统中的重要部件,起着对神经进行电刺激并记录神经信号的关键作用。采用微细加工技术在新型柔性基底——聚对二甲苯(Parylene)上制作微电极阵列。阐述了Parylene基微电极阵列的加工工艺,并利用光学显微镜和电化学表征技术对微电极的表面形貌和电学性能进行了研究。结果表明:在工作频率范围内(104~105Hz),柔性神经微电极的阻抗值低(400~1000Ω),相位延迟小(-20°),适于用作视网膜修复。     

用于视觉假体的柔性生物微电极阵列的设计和制作

提出了一种用于视网膜假体的基于Parylene的柔性微电极阵列的设计和制作.微电极阵列为5×5,通过光刻胶热熔回流技术形成的电极点为半球形凸起,底部直径为60 μm,高度大约为24 μm.整个电极具有很好的柔韧性,能够更好的适应视网膜表面轮廓,提高刺激效果.同时,电极具有很好的透明性,便于手术时电极的植入和手术后对生物组织的观察.     

基于柔性微电极的高灵敏度MEMS电化学地震检波器

为了进一步降低微机电系统(MEMS)电化学地震检波器敏感电极的加工成本,提升传感器的灵敏度,推动其在地球物理勘探等领域的发展,提出了一种基于柔性微电极结构的新型MEMS电化学地震检波器.与基于硅衬底制作敏感电极相比,敏感电极的制作方法可以通过有效减小电极间距,大幅度提升传感器的灵敏度,大幅降低工艺成本.介绍了柔性微电极的加工工艺流程,并对传感器的性能进行了测试.结果表明:提出的地震检波器较基于硅衬底微电极器件灵敏度提高了一个数量级.     

利用喷墨打印技术制备的类神经气体传感器

利用喷墨打印技术沉积生物高分子溶液的方法,打印出金的梳状微电极的阵列图形,并采用NaX型沸石分子筛作为敏感膜,研制了探测神经类毒气沙林的相似物DMMP气体的阻抗型传感器。电极图形使用简单的绘图软件autoCAD画出,通过简单改进过的办公用喷墨打印机在金衬底上打印一层自组装膜的阻挡层,经过湿法刻蚀后得到了梳状微电极阵列。将制得的传感器对1ppm(即1×10-6)DMMP气体进行检测,测得在0.01Hz处,其电阻的相对变化值为10.7%。与传统MEMS工艺相比较,喷墨打印方法制备传感器具有工艺步骤简化,成本低,可在柔性等不同材料上制作等优点,有着广泛的应用前景。     

中国微米纳米-微纳结构对电容式柔性压力传感器性能影响的研究

设计制备出三明治结构的电容式柔性压力传感器,并对其性能进行研究.该传感器以银纳米线为电极材料,聚二甲基硅氧烷(PDMS)为柔性衬底,同时采用毛面玻璃和光面玻璃分别作为柔性衬底的制备模板,制备出微纳结构和平面结构的PDMS薄膜.然后采用喷涂法制备AgNWs/PDMS复合电极,以另外一层PDMS为介电层,将两电极面对面封装,得到电容式柔性压力传感器,最后系统研究了传感器的电极微纳结构对器件性能的影响.本文研究表明,具有微纳结构的AgNWs/PDMS复合薄膜传感器的灵敏度为1.0 kPa-1,而平面结构的AgNWs/PDMS复合薄膜传感器的灵敏度为0.6 kPa-1,由此可知具有微纳结构的柔性衬底能够显著提高器件的灵敏度.     

基于氧化石墨烯/聚吡咯-铟锡氧化物微电极的细胞阻抗生物传感器构建及细胞粘附增殖行为检测

构建一种基于氧化石墨烯/聚吡咯-铟锡氧化物GO/PPy-ITO（Graphene Oxide/Polypyrrole-Indium Tin Oxide）微电极的细胞阻抗生物传感器并用于细胞粘附增殖行为学检测。ITO微电极采用光刻技术对感光干膜绝缘层蚀刻而成,通过一步法电聚合技术在ITO微电极表面沉积GO/PPy纳米复合膜制备GO/PPy-ITO微电极;形状测量激光显微镜和扫描电子显微镜分别对GO/PPy表面粗糙度和拓扑形貌进行表征;电化学循环伏安法及阻抗谱表征GO/PPy-ITO微电极的电化学性质;人肺癌细胞株A549粘附、铺展和增殖实验考察GO/PPy界面的生物相容性;以GO/PPy-ITO微电极作为传感电极,利用电化学阻抗谱技术对A549细胞的粘附增殖行为进行检测。结果显示,ITO微电极表面上电沉积的GO/PPy纳米复合物表面平整,分布大量的微孔结构;电化————————————学实验结果显示GO/PPy-ITO微电极比裸ITO微电极具有更低的阻抗特征和更高的电化学活性;GO/PPy比纯PPy膜更能促进A549细胞粘附、铺展和增殖;GO/PPy-ITO微电极表面A549细胞的粘附增殖行为改变电极系统的阻抗谱特征,通过对阻抗谱数据进行等效电路拟合分析获得细胞粘附增殖行为学信息。本文发展的GO/PPy-ITO微电极兼具优良的电化学性质和细胞生物相容性,基于该电极系统构建的细胞阻抗生物传感器可用于细胞病理生理学行为、药物筛选等研究领域。     

植入式柔性神经刺激微电极研究进展

柔性微电极为电子系统与生物组织间提供一个信息交换界面。主要详述了不同设计的神经微电极,比如筛状电极、卡夫电极、螺旋电极及剑状和针形电极等,并且比较和讨论了它们的分类、结构以及特点。     

基于单壁碳纳米管的压阻式柔性传感器

一维纳米材料与微结构结合的纳器件制造过程,实现了微纳加工工艺上的创新升级,有可能突破微米级器件的性能极限。首先利用传统的硅微加工技术,在综合性能优异的聚酰亚胺PI(Polyimide)薄膜上制作金(Au)微电极,形成排列有序的平行电极对;然后通过交流介电电泳的方法在微电极对间实现单壁碳纳米管SWNTs(Single-Walled Carbon Nanotubes)一维定向排布;接着采用区域选择性电沉积技术定域沉积Au压覆SWNTs,改善SWNTs与电极的接触特性。最后,针对基于SWNTs的柔性微纳传感器进行了力电特性测试。结果表明:在环境温度为(23±5)℃,湿度为65±15%RH,0.1 V工作电压下,压阻因子约为443,精度约为5.16%。上述研究结果在柔性微纳器件的制作方面显示了一定的应用前景,为实现超微型化和高功能密度化的柔性器件铺平道路。     

多参数血液分析型生物传感器的研究

研制了一种基于叉指阵列(interdigital array ;IDA)薄膜电极的血液分析型医用多参量测量的生物传感器.利用光刻等微加工技术在玻璃基底上制备四个IDA微金电极,电极薄膜以铬为粘附层,金膜厚250nm,finger电极宽和间距均为10μm.工作区中的微电极上分别固定上不同的酶,通过检测"发生-收集"模式下的IDA微电极上生化反应所产生的微电流分别测试血液中血糖,胆固醇,酮体和乳酸浓度.     

Only connect: teaching, technology and telesis

Abstract This paper describes an approach to the design of interactive multimedia materials being developed in a European Community project. The developmental process is seen as a dialogue between technologists and teachers. This dialogue is often problematic because of the differences in training, experience and culture between them. Conditions needed for fruitful dialogue are described and the generic model for learning design used in the project is explained.     

European Community policy and the market

Abstract This paper starts with some reflections on the policy considerations and priorities which are shaping European Commission (EC) research programmes. Then it attempts to position the current projects which seek to capitalise on information and communications technologies for learning in relation to these priorities and the apparent realities of the marketplace. It concludes that while there are grounds to be optimistic about the contribution EC programmes can make to the efficiency and standard of education and training, they are still too technology driven.     

一种自适应子融合集成多分类器方法

融合集成方法已经广泛应用在模式识别领域,然而一些基分类器实时性能稳定性较差,导致多分类器融合性能差,针对上述问题本文提出了一种新的基于多分类器的子融合集成分类器系统。该方法考虑在度量层融合层次之上通过对各类基多分类器进行动态选择,票数最多的类别作为融合系统中对特征向量识别的类别,构成一种新的自适应子融合集成分类器方法。实验表明,该方法比传统的分类器以及分类融合方法识别准确率明显更高,具有更好的鲁棒性。     

煤矿井下安全监控分站的设计及其仿真实现

为了设计一种具有低成本、低功耗、易操作、功能强且可靠性高的煤矿井下安全分站,针对煤矿安全生产实际,文章提出了采用MCS-51系列单片机为核心、具有CAN总线通信接口的煤矿井下安全监控分站的设计方案;首先给出煤矿井下安全监控分站的整体构架设计,然后着重阐述模拟量输入信号处理系统的设计过程,最后说明单片机最小系统及其键盘、显示、报警、通信等各个组成部分的设计;为验证设计方案的可行性与有效性,使用Proteus软件对设计内容进行仿真验证,设计的煤矿井下安全监控分站具有瓦斯、温度等模拟量参数超标报警功能和电机开停、风门开闭等开关量指示功能;仿真结果表明:设计的煤矿井下安全监控分站具有一定的实际应用价值.     

Avoiding semantic and temporal gaps in developing software intensive systems

Development of software intensive systems (systems) in practice involves a series of self-contained phases for the lifecycle of a system. Semantic and temporal gaps, which occur among phases and among developer disciplines within and across phases, hinder the ongoing development of a system because of the interdependencies among phases and among disciplines. Such gaps are magnified among systems that are developed at different times by different development teams, which may limit reuse of artifacts of systems development and interoperability among the systems. This article discusses such gaps and a systems development process for avoiding them.     

基于QTE的蒙古文显示机制研究与实现

蒙古语言是中国蒙古族使用的通用语言,由于蒙古文区别于其他文字的书写方式和其自身变形机制等特点,在很多通用的文字处理引擎中都不被支持。在嵌入式产品开发与应用领域中Linux加QTE已经成为流行方式。该文给出了一种在QTE环境上实现基于标准Unicode的蒙古文点阵显示和变形算法, 并自定义了支持蒙古文的QTE组件,扩展了QTE功能,为在Linux加QTE方式的嵌入式体系结构中处理蒙古文提供了一种解决方法。     

Designing economic np control charts: A programmed simulation approach

This paper presents control charts models and the necessary simulation software for the location of economic values of the control parameters. The simulation program is written in FORTRAN, requires only 10K of main storage, and can run on most mini and micro computers. Two models are presented - one describes the process when it is operating at full capacity and the other when the process is operating under capacity. The models allow the product quality to deteriorate to a further level before an existing out-of-control state is detected, and they can also be used in situations where no prior knowledge exists of the out-of-control causes and the resulting proportion defectives.     

基于AD9626的模拟信号采集存储卡设计

自然界的绝大部分信号都是以模拟的形式存在,因此模拟信号的采集转换存储在数字时代十分关键。文章讨论了在雷达信号处理领域基于AD9626的AD采集存储卡的设计原理、硬件结构和程序设计与芯片配置等问题,为今后相关领域的研究提供了可参考的方案。     

The development of robot art

Going through a few examples of robot artists who are recognized worldwide, we try to analyze the deepest meaning of what is called “robot art” and the related art field definition. We also try to highlight its well-marked borders, such as kinetic sculptures, kinetic art, cyber art, and cyberpunk. A brief excursion into the importance of the context, the message, and its semiotics is also provided, case by case, together with a few hints on the history of this discipline in the light of an artistic perspective. Therefore, the aim of this article is to try to summarize the main characteristics that might classify robot art as a unique and innovative discipline, and to track down some of the principles by which a robotic artifact can or cannot be considered an art piece in terms of social, cultural, and strictly artistic interest. This work was presented in part at the 13th International Symposium on Artificial Life and Robotics, Oita, Japan, January 31–February 2, 2008     

A human-computer interface for non-computer specialists

The COM teleconferencing system was designed to be easy to use for both beginners and people with much computer experience. A number of design choices in organizing the human-computer interface were considered very carefully. These design problems are not unique for teleconferencing applications, but will appear in many other developments of human-computer interfaces for non-computer specialists. This report discusses naming conventions, menu format, user commands, help facility and the treatment of ‘type ahead’ from the users.