Choosing the parameter for a 2 x 2 table or a 2 x 2 x 2 table analysis.

Fourteen 2 x 2 table measures of association are compared and six 2 x 2 x 2 table measures of synergism are compared. The presentation is based on a conceptual population model for the true association between the disease and the risk factor(s). Each measure is judged as to potential use and identified with the study designs under which it can be estimated. It is shown that prior information about the correct population model is required to adequately measure synergism.     

Sensory irritation due to methyl-2-cyanoacrylate,ethyl-2-cyanoacrylate,isopropyl-2-cyanoacrylate and 2-methoxyethyl-2-cyanoacrylate in mice

The expiratory bradypnoea indicative of upper airway irritation in mice was evaluated during a period of 60 min of nasal exposure to methyl-2-cyanoacrylate, ethyl-2-cyanoacrylate, isopropyl-2-cyanoacrylate and 2-methoxyethyl-2-cyanoacrylate vapors using nose only exposure. Irritation of the upper respiratory tract caused a concentration-dependent decrease in the respiratory rate. The maximum effect occurred within the first 10 min of exposure and was followed by a drop-off in the response during the remainder of the exposure period. The airborne concentration resulting in a 50% decrease in the respiratory rate of mice (RD(50)) was calculated for each chemical. The results show that the four chemicals had similar irritant potencies. The RD(50) values of methyl-2-cyanoacrylate, ethyl-2-cyanoacrylate, isopropyl-2-cyanoacrylate and 2-methoxyethyl-2-cyanoacrylate were 1.4, 0.7, 0.6 and 1.0 p.p.m. Tentative estimates of threshold limit values showed that 0.1 RD(50) was closer to the values recommended by the American Conference of Governmental Industrial Hygienists for methyl- and ethyl-2-cyanoacrylate than 0.03 RD(50). On the basis of a threshold limit value for short-term exposure limit (TLV STEL) equal to 0.1 RD(50), the TLV STELs for the four cyanoacrylates should not exceed 0.1 or 0.2 p.p.m.     

Selective cyclooxygenase 2 inhibitors (COX-2)

Cyclooxygenase is key enzyme in the prostaglandin synthesis. It exists in two isoforms, which have distinct functions in the organism. Cyclooxygenase-2 (COX-2) participates in the pathophysiology of inflammation. Differences in the molecular structure of cyclooxygenases allowed to develop drug that selectively inhibit that isoform. Recently, selective inhibitors of COX-2 were introduced into therapy, providing new opportunities to the treatment of inflammation.     

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第五届侯祥川奖励基金获奖名单(经中国营养学会奖励基金管理委员会评选)一等奖ZhuoqinJiang(蒋卓勤),QinYan(阎勤),YixiangSu(苏宜香),KevinJAcheson,Acheson,AnneliesThelin,ChristellePiguet-Welsch,PatrickRitzandZhi-chienHo(何志谦):EnergyexpenditureofChineseinfantsinGuangdongProvince,southChina,determinedwithuseofthedoubledwatermethod.AmJClinNutr　1998,67(6):1256-1264.二等奖刘佃辛,张符光,马清钧,顾景范:重组人胸腺α原对衰老和缺锌时免疫功能的影响.营养学报1999,21(2):152-158.三等奖颜崇超,赵熙和,金大勋…