新生儿缺氧缺血性脑病32例临床分析

新生儿缺氧缺血性脑病(HIE)是指围产期缺氧窒息,导致脑的缺氧缺血性损害,包括特征性的神经及病理生理改变,并在临床上出现一系列脑病的表现,部分病例可留有不同程度的神经系统后遗症[1] .新生儿缺氧缺血性脑病为围产期最常见的颅内病变,容易导致新生儿死亡或遗留不同程度的神经系统症状.     

TCD检测大动脉炎的脑血流动力学改变

目的 应用经颅多普勒超声(TCD)检测观察大动脉炎的血流动力学改变,分析其血流速度、搏动指数及频谱形态的变化,从而为临床诊断大动脉炎提供重要科学依据.方法 将11例大动脉炎患者与10例健康志愿者分成两组,分别采用BMS-9000型TCD仪,以2MHz,4MHz探头检测颅内血管及颈总动脉,分析各血管的收缩期血流速度(Vs)、舒张末期血流速度(Vd)、搏动指数(PI)与频谱形态等.结果 TCD检测发现,11例大动脉炎患者颅内各大动脉血流速度、搏动脉指数及频谱形态均有不同程度的血流动力学改变.结论 应用TCD结合临床资料及影像学检查对大动脉炎的诊断方法无创,科学,有效.     

糖尿病患者经颅多普勒超声检查结果分析

目的 探讨糖尿病患者的脑血管功能状态及血流动力学的变化.方法 应用经颅多普勒超声(TCD)检测糖尿病患者的颅内动脉,并就脑动脉收缩期血流速度、舒张期血流速度异常程度、血流频谱形态、搏动指数的结果进行分析.结果 糖尿病颅内动脉血流速度、频谱形态、搏动指数异常检出率明显高于非糖尿病患者,频谱形态多有改变.结论 TCD可对糖尿病患者血管状态提供客观的信息,在临床诊断、治疗、预防中起到重要作用.     

新生儿重度缺氧缺血性脑病的脑肾血流变化

目的 了解新生儿重度缺氧缺血性脑病时,脑、肾的实际灌流状态。方法 采用美国Acuson-128电脑声像仪测定颈内动脉和肾动脉血流速度,探头5MHz。新生儿重度缺氧缺血性脑病组12例,正常组14例。结果患儿颈内动脉和肾动脉血流的平均血流速度、最大流速较正常组均降低。结论 连续动态测定颈内动脉和肾动脉血流速度,对评价新生儿缺氧缺血性脑病的发生及预后有一定的参考意义。     

新生儿缺氧缺血性脑病76例分析

目的:探讨新生儿缺氧缺血性脑病(HIE)的病因，寻找预防措施，降低新生儿死亡率。方法:对76例新生儿缺氧缺血性脑病原因进行回顾分析。结果:新生儿缺氧缺血脑病的发生与脐带、早产、产程异常，胎膜早破，妊高征等因素有关。     

高压氧治疗新生儿缺氧缺血性脑病34例疗效观察

新生儿缺氧缺血性脑病(HIE)是在围产期窒息导致脑的缺氧缺血损害，是围产足月新生儿常见的颅内病变，其预后因病损程度及治疗而不同。我科于1999-11起对3-4例皿患儿在药物治疗基础上进行高压氧治疗，取得较好疗效，现报告如下。     

经颅彩超应用于新生儿缺血缺氧性脑病的检测

目的:运用经颅彩色多普勒超声(Transcranial Doppler,TCD)检测缺氧缺血性脑病(Hypoxic Ischemic encephalopathy,HIE)及正常新生儿脑血流动力学变化,评估及预测缺血缺氧性脑病患儿的病情及预后.方法:对2010年4月-2010年8月期间共45例临床诊断为缺血缺氧性脑病患儿及20例正常新生儿分组进行比较,对其TCD检查结果进行对比分析.结果:缺血缺氧性脑病患儿大脑动脉的收缩期峰值流速S可升高或降低,舒张末期峰值流速D降低明显,S/D升高,阻力指数RI明显增高,尤其以大脑中动脉和大脑前动脉较敏感.45例缺血缺氧性脑病患儿中大脑动脉的舒张末期峰值流速较高(D)10cm/s),S/D较低(<3.0),RI较低(<0.63)的患儿预后较好.结论:运用TCD检测新生儿大脑动脉的血流情况,分析血流速度,S/D比值,RI值,对评估及预测缺血缺氧性脑病患儿的病情及预后有重要的参考价值.     

彩色多普勒超声在新生儿颅脑疾病诊断中的应用

目的探讨运用经颅彩色多普勒超声(Transcranial Doppler,TCD)检测新生儿颅脑疾病在临床中的应用价值.方法 对临床怀疑为新生儿颅脑疾病的50例患儿进行彩色多普勒超声检查,对其结果进行回顾性分析.结果 50例患儿经过彩色多普勒超声检查发现:8例(占16%)仅有多普勒血流频谱异常者,42例患儿发现颅内有异常表现(占84%).结论 彩色多普勒超声简便、易行、无创、价廉、可反复,可作为早期诊断新生儿缺氧缺血性脑病的首选检查方法.     

新生儿缺氧缺血性脑病发病机制研究进展

新生儿缺氧缺血性脑病(HIE)是指围产期窒息导致的缺氧缺血损伤(HIBD),笔者现就HIE发生机制研究进展综述如下.     

新生儿缺氧缺血性脑病30例临床观察及护理

新生儿缺氧缺血性脑病(HIE)是指各种围产期窒息引起的部分或完全缺氧,脑血流减少或暂停而导致胎儿和新生儿脑损伤.新生儿缺氧缺血脑病(HIE)是引起新生儿急性脑病和慢性神经 系统损伤的主要原因之一.早期的诊断、治疗,减少或预防后遗症的发生,护理起到重要作用,现将我科2007年至今收治的30例新生儿HIE的病因,临床表现及护理总结如下:     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.