共查询到19条相似文献,搜索用时 296 毫秒
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微波辐射下5-(1-氧基)-2(5H)-呋喃酮的合成 总被引:1,自引:0,他引:1
研究在微波辐射条件下,以手性助剂天然薄荷醇与5-羟基-2(5H)-呋喃酮反应,合成5-(1-氧基)-2(5H)-呋喃酮.获得了微波的功率40%、反应时间100min、苯为溶剂,薄荷醇/5-羟基-2-(5H)呋喃酮为1/1.7,产率78.6%的好结果. 相似文献
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研究在微波辐射条件下 ,以手性助剂天然薄荷醇与 5 -羟基 -2 (5 H ) -呋喃酮反应 ,合成 5 -(1 -氧基 ) -2 (5 H ) -呋喃酮。获得了微波的功率 40 %、反应时间 1 0 0 min、苯为溶剂 ,薄荷醇 /5 -羟基 -2 -(5 H )呋喃酮为 1 /1 .7,产率 78.6%的好结果 相似文献
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以3,5二-羟基苯乙酮(4)为原料,经三步反应制得3,5二-乙酰氧基苯乙烯(1)。在硫酸催化下化合物(4)与乙酸酐反应,得到3,5二-乙酰氧基苯乙酮(3),收率92%,对于化合物(3)进行了1H NMR表征;化合物(3)经催化加氢,得到1-(1羟-基乙基)-3,5二-乙酰氧基苯(2),收率98%,对于化合物(2)进行了1H NMR表征;化合物(2)在固体酸催化下反应得到3,5二-乙酰氧基苯乙烯(1),制备化合物(1)的反应条件为:m[化合物(2)]∶m(固体酸)=5∶1,110℃回流5 h,收率95%,纯度98%,对化合物(1)进行了IR,1H NMR,MS表征,并对化合物(1)的1HNMR,MS表征结果进行了进一步分析。 相似文献
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对一类核苷类似物的关键中间体———(4R,5R) 4 (N 甲基羟氨基) 5 [(叔丁基二苯基硅烷基)氧甲基] 3,4 二氢 2(5H) 呋喃酮的合成进行了研究。以L 抗坏血酸为原料,经Pd/C催化加氢和缩酮保护,生成5,6 O 异亚丙基 L 古洛糖酸 1,4 内酯,产率74 3%。该内酯经NaIO4氧化、Wittig反应、水解成环和柱色谱分离,得(R) (+) 5 羟甲基 2 (5H) 呋喃酮,产率43 0%。最后该呋喃酮再经硅烷保护和羟胺Michael加成,即得到目标化合物。这7步反应的总产率27 9%。 相似文献
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4—羟基—2,5—二甲基—3(2H)呋喃酮的合成研究 总被引:2,自引:0,他引:2
本文研究了以 3 ,4 -二羟基 -2 ,5 -己二酮为原料制备 4 -羟基 -2 ,5 -二甲基 -3 (2H)呋喃酮的实验方法 ,讨论了主要因素对得率的影响 ,得到了制备的较佳条件 :pH值为 6.5 ,3 ,4 -二羟基 -2 ,5 -己二酮浓度为 1 0 % ,反应温度为1 0 0℃ ,反应时间为 1 6小时 ,哌啶浓度为 7.5 % ,此条件下 ,4 -羟基 -2 ,5 -二甲基 -3 (2H)呋喃酮得率为 5 5 %。 相似文献
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研究在微波辐射条件下,以手性助剂天然薄荷醇与5-羟基-2(5H)-呋喃酮反应,合成5-(1-Meng氧基)-2(5H)-呋喃酮。获得了微波的功率40%、反应时间100min、苯为溶剂,薄荷醇/5-羟基-2(5H)呋喃酮为1/1.7,产率78.6%的好结果。 相似文献
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以N-叔丁基-6-氯烟酰胺(化合物2)为原料,经1,4-加成与氧化、缩合、N-去烷基化、Hofmann重排反应,采用叠缩工艺合成了(6-(4-甲基哌嗪-1-基)-4-(邻甲苯)吡啶-3-基)氨基甲酸甲酯(化合物1)。化合物2与邻甲苯基氯化镁反应后,经I2氧化生成N-叔丁基-6-氯-4-邻甲苯基烟酰胺(化合物3)。化合物3与N-甲基哌嗪发生缩合反应得到N-叔丁基-6-(4-甲基哌嗪-1-基)-4-邻甲苯基烟酰胺(化合物4)。在MeSO3H作用下,化合物4发生去烷基化反应得到6-(4-甲基哌嗪-1-基)-4-(邻甲苯基)烟酰胺(化合物5)。在KOH/MeOH溶液中,化合物5与PhI(OAc)2发生Hofmann重排反应生成化合物1,总收率达到67.4%。 相似文献
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Chemistry of Mucohalic Acids. V. Reaction of 3,4,5-Trichloro-2(5H)-furanone and 3-Aroxy-4,5-dichloro-2(5H)-furanones with Azide 3,4,5-Trichloro-2(5H)-furanone 1 reacts with sodium azide to afford 4-azido-3,5-dichloro-2(5H)-furanone 2 , whereas 3-aroxy-4,5-dichloro-2(5H)-furanones 11 provides under the same conditions 3-aroxy-5-azido-4-chloro-2(5H)-furanones 12 . Reactions of 1 and 11 with two equivalents of azide lead to diazido derivatives 5 and 13 . β-Lactam 9 or pyrimidone 10 were synthesized from 5 and benzanilide. 相似文献
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胺类化合物作为亲核试剂,与手性5-(S)-5-(L-孟氧基)-3,4-二溴-2(5H)呋喃酮通过不对称Michael加成-消除反应得到4个含手性中心的胺类衍生物,产率80%~93%。所有化合物均经IR、1HNMR、13CNMR、HRMS得到确证,为室温下方便地制备含多手性中心的胺类衍生物提供了一条可能的新途径。 相似文献
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Jean-Pierre Farine Jean-Luc Le Quere Jérôme Duffy Claude Everaerts Rémy Brossut 《Journal of chemical ecology》1994,20(9):2291-2306
InEurycotis floridana, the male calling behavior is associated with the exposition of epidermal glands located under tergites 2, 7, and 8. 4-Hydroxy-5-methyl-3(2H)-furanone and 4-hydroxy-2,5-dimethyl-3(2H)-furanone were recently identified as the specific components of tergite 7 secretion. Methylene chloride extracts of tergite 7 and its major compound 4-hydroxy-5-methyl-3(2H)-furanone attract the conspecific females at a distance. Methylene chloride extracts of tergite 8 are also attractive at a distance to the females, whereas extracts of tergite 2 had no effect on males and females. Our GC investigations showed the absence of specific compounds in tergite 2 secretions. The GC-MS analyses revealed that the male secretion of the gland under tergite 8 is mainly a mixture of (2R*, 3R*)-butanediol, 1-dodecanol and benzyl 2-hydroxybenzoate. These compounds were tested at different concentrations on their own, or as a mixture. Only (2R*, 3R*)-butanediol and 1-dodecanol were attractive for the females. Their functions, as components of the male sex pheromone, in addition with the two derivatives of the furanone are discussed. 相似文献
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S. Y. Fung W. M. Herrebout R. Verpoorte F. C. Fischer 《Journal of chemical ecology》1988,14(4):1099-1111
A new butenolide, isosiphonodin [3-hydroxymethyl-2(5H)-furanone], along with a trace of siphonodin [4-hydroxymethyl-2(5H)-furanone], was isolated from fifth-instar larvae of the small ermine mothYponomeuta cagnagellus. Leaves of its host plant spindle-tree,Euonymus europaeus, were found to contain the same two butenolides with siphonodin being present as the major compound. TLC showed that isosiphonodin was also present in larvae or pupae of six other small ermine moths which did not feed on spindle-tree. InY. cagnagellus butenolides might be plant derived, while isosiphonodin in the other investigated small ermine moths is probably synthesized by the insect. The possible role of butenolides in the chemical defense of small ermine moths is discussed. 相似文献
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Susanne Karlsson Anders Hallberg Salo Gronowitz 《Journal of the American Oil Chemists' Society》1989,66(12):1815-1821
Hydrozirconation of oleyl alcohol gave a mixture of the ω-and γ-zirconium-stearyl alcohols. The zirconium alkyl bonds were
cleaved by reaction with D2O, Br2 or CO-Br2-2-methoxyethanol. 18-Bromo-stearyl alcohol (X) and 3-bromo-stearyl alcohol (IX) were isolated after bromination and 2-methoxyethyl
19-hydroxynonadecanoate (XII) and dihydro-3-pentadecyl-2(3H)-furanone (XIII) after carbonylation. 相似文献