脑性瘫痪患儿运动疗法治疗体会

脑性瘫痪是出生前至出生后脑发育阶段各种原因所致的非进行性脑损伤综合征.主要表现为中枢性运动障碍与姿势异常,是造成小儿肢体残疾的主要疾病.在小儿脑性瘫痪治疗中,运动疗法占有非常重要的地位,运动疗法主要是抑制异常运动模式,促进正常运动模式的出现的一种训练方法.现将采用运动疗法治疗的2例中度痉挛手足徐动混合型患儿的治疗体会报道如下.     

70例小儿脑性瘫痪的康复护理

７０例小儿脑性瘫痪的康复护理泉州市儿童医院张平脑性瘫痪是指在出生前、出生时、出生后，由多种原因引起的脑部疾病，其特点是非进行性中枢性运动功能障碍。本病如不进行适当的治疗和护理将会严重影响患儿的正常生活。现将我科１９９２～１９９５年收治的７０例小儿脑性...     

小儿脑性瘫痪康复护理的临床体会

<正>脑瘫是以肢体运动功能障碍为主的由多种原因引起的非进行性脑损伤的致残性疾病,多伴有智力低下、癫痫、感觉障碍、言语行为障碍等临床表现~([1])。该病病程长、恢复慢,易留下后遗症,严重影响患儿身体正常生长发育和日常生活,给患儿家庭会带来严重的经济负担和精神压力。治疗小儿脑性瘫痪的方法多但效果不明显,且治疗时间长、费用高等~([2])。早期治疗及长久的坚持不懈的康复护理是小儿脑性瘫痪的有效治疗手段。现将我科收治脑性瘫痪患儿展开康复治疗护     

中西医结合治疗对小儿脑性瘫痪运动功能恢复的影响

本文通过中西医结合治疗,探讨对小儿脑性瘫痪患儿运动功能、日常生活活动能力恢复的影响. 1临床资料     

神经节苷脂治疗小儿脑性瘫痪的疗效观察(附110例报告)

小儿脑性瘫痪简称脑瘫,是指患儿出生前到生后1个月内因各种原因所致的非进行性脑损伤,主要表现为中枢性运动功能障碍及姿势异常,常伴有智力低下、语言障碍、癫痫等[1].     

家庭康复护理对小儿脑性瘫痪康复的作用研究

目的探讨家庭康复护理对小儿脑性瘫痪康复效果的影响。方法将我院收治的88例小儿脑性瘫痪患者随机分为家庭组和对照组(各44例),对照组患儿采用常规的康复治疗措施,家庭组在对照组基础上增加家庭康复护理,比较两组患儿的康复效果。结果治疗后,两组的GMFM评分均有明显提高,家庭组治疗后的GMFM评分显著高于对照组(P<0.05);两组患儿治疗前的运动功能分级比较无明显差异(P>0.05);家庭组治疗后运动功能Ⅴ级所占比例显著高于对照组(P<0.05)。结论在脑性瘫痪患儿的康复治疗中,增加家庭康复护理,有助于提高患儿的运动功能改善程度,增强康复效果,具有重要的临床应用价值。     

鼠神经生长因子治疗小儿脑性瘫痪的疗效分析

目的探索鼠神经生长因子在治疗小儿脑性瘫痪中的疗效。方法 99例脑性瘫痪住院患儿随机分为观察组（50例）和对照组（49例）。两组均采用常规的运动康复训练,观察组在此基础上再加用鼠神经生长因子,随访3年。采用Gesell发育量评价治疗前后小儿脑性瘫痪患者的发育商（DQ）。结果观察组治疗小儿脑性瘫痪的有效率为89.8%,较对照组治疗小儿脑性瘫痪有效率的64.0%效果明显,差异具有统计学意义（P〈0.05）。结论鼠神经生长因子对于治疗小儿脑性瘫痪具有较好的疗效,值得推广与普及。     

康复护理对小儿脑性瘫痪痉挛型偏瘫预后的影响评估

<正>小儿脑性瘫痪是临床儿科比较常见的一种疾病,临床上将其称之为非进行性脑损伤综合征,最主要的临床症状表现为语言障碍、智力低下、听力功能障碍以及中枢性运动功能障碍,又以痉挛型偏瘫最为常见,由于患儿大部分伸张处于反     

中药药浴对痉挛型脑性瘫痪患儿康复疗效的影响

目的 探讨中药药浴对痉挛型脑性瘫痪患儿粗大运动功能康复疗效的影响.方法 将40例痉挛型脑性瘫痪患儿随机分为2组,A组20例给予中药药浴治疗配合运动疗法,B组20例给予普通运动疗法,2组治疗时间均为3个月,分别在治疗前后采用粗大运动功能测定表(GMFM)对患儿进行粗大运动功能测评.结果 2组患儿治疗后GMFM评分均升高(P＜0.05),且A组明显高于B组(P<0.05).结论 中药药浴康复治疗对提高痉挛型脑性瘫痪患儿童粗大动力功能的康复疗效具有影响作用,值得应用推广.     

小儿脑性瘫痪的康复护理

脑性瘫痪是指出生前至出生后1个月内,由各种原因引起的非进行性脑损伤,表现为中枢性运动障碍及姿势异常,多伴有智力低下、癫痫、行为异常等[1]。是继小儿麻痹症后,又一个以肢体运动功能障碍为主的致残性疾病。早期发现与治疗,综合性康复训练及全面的护理是小儿脑性瘫痪的有效治疗手段。我院儿童康复治疗中心自2010年6月-2012年11月收治85例脑瘫患儿,均采用综合康复治疗同时配合康复护理,     

多发性硬化和视神经脊髓炎患者血尿酸水平分析

类风湿关节炎(Rheumatoid Arthritis)是一种以慢性关节滑膜炎为主要特征的自身免疫性疾病,以形成侵袭性滑膜血管翳,破坏软骨、骨与周围组织为基本病理改变,发病2年内即可能出现全身性骨量减少及小关节的破坏,Wnt信号通路在在类风湿关节炎慢性炎症和骨质破坏的病理生理过程中起重要作用,研究Wnt信号通路作用,能为我们理解类风湿关节炎临床分型和预后提供理论依据,同时也能为类风湿关节炎的治疗提供新的研究方向。     

Wnt调控类风湿性关节炎研究进展

类风湿性关节炎(RA)是一种主要以持续关节组织滑膜增生、软骨侵蚀、关节损坏为主要特征的累及多关节的系统性疾病,发病机制不明。滑膜衬里层成纤维样滑膜细胞(FLS)在RA发病机制中起关键作用。Wnt通路广泛参与细胞癌变和肿瘤细胞的侵袭、转移等,在肿瘤的发病机制中发挥重要调控作用。Wnt通路同样调控了RA的发生发展,下调RA Wnt和Fz表达能够抑制FLS活化、增殖,提示Wnt通路Wnt蛋白可能是潜在的RA治疗靶点。     

A Role for WNT/β-Catenin Signaling in the Neural Mechanisms of Behavior

Wnt signaling pathways play a role in a variety of cellular processes including development, cell proliferation, cell fate, and motility. The Wnt/??-catenin pathway is among the most studied of the Wnt pathways and is highly conserved throughout evolution. Recent in vitro and slice physiology experiments have shown that this pathway also functions in synaptic transmission and activity-dependent synaptic plasticity. Since it has now been shown that many components of this signaling pathway are found in the adult brain, Wnt/??-catenin signaling may be important for maintaining and protecting neural connections throughout the lifespan. Here we summarize the role of Wnt/??-catenin signaling in the postnatal brain and discuss recent studies suggesting that deregulated Wnt signaling can result in altered behavior and cognitive disorders.     

Wnt/β-catenin信号通路调控Sp5机制的研究进展

摘要：Wnt/β-catenin信号通路是一条广泛存在于生物体内且在进化上具有高度保守特性的通路。该通路在细 胞生长、发育、迁移及凋亡过程中发挥着重要作用。特异性蛋白-5（Sp5）作为Wnt/β-catenin信号通路的下游靶点,在 发育过程中也有着重要的调控作用,包括细胞分化、组织形成及肿瘤的发生等。本文就Wnt/β-catenin信号通路对其 下游分子Sp5的作用进行综述,明确Wnt/β-catenin-Sp5在疾病发展中的作用。     

Wnt signaling as potential therapeutic target in lung cancer

Introduction: Wingless-type (Wnt) signaling is tightly regulated at multiple cellular levels and is dysregulated in lung cancer. Therefore, it offers therapeutic targets for developing novel agents for lung cancer treatment.

Areas covered: In this article, we discuss the role of the Wnt signaling pathway in lung cancer, highlighting the aberrant activation of Wnt in lung cancer stem cells and its implication in resistance to radiotherapy, chemotherapy and targeted therapy. We also expound the regulatory roles of microRNAs in Wnt signaling, as well as the potential of the Wnt pathway to provide biomarkers and therapeutic targets in lung cancer. The potential use of small molecule and biological inhibitors targeting the Wnt pathway for lung cancer therapy and prevention is also discussed.

Expert opinion: Wnt signaling plays an important role in the development and metastasis of lung cancer; the pathway provides targets to develop agents towards for cancer prevention and therapy. A number of clinical trials have shown the effectiveness of Wnt pathway inhibitors in epithelial tumors. However, the side effects should be considered. Nevertheless, the results from clinical studies suggest that inhibitors targeting the Wnt signaling show promise against lung cancer.     

Developing drugs that target the Wnt pathway: recent approaches in cancer and neurodegenerative diseases

Introduction: Wnt/β-catenin signaling is an evolutionarily conserved pathway that has a crucial role in embryonic and adult life. Dysregulation of Wnt/β-catenin pathway has been associated with various diseases, including cancer and neurodegenerative disorders, including Parkinson’s disease (PD). Several molecular components of the signaling have been proposed as innovative targets for cancer therapy, and very recently, some of them have been also evaluated as potential therapeutic targets for PD.

Areas covered: This review focuses on the role of Wnt/β-catenin pathway in the pathogenensis of cancer and PD, examining some recent therapeutic approaches that are ongoing in preclinical and clinical studies. The possibilities that this signaling offers for diagnosis and prognosis of neoplastic diseases, and the concerns of targeting this pathway are also discussed.

Expert opinion: Despite the stimulating results obtained in preclinical studies on cancer and other disease models, the clinical experience with Wnt modulators is still in its infancy, and is mainly restricted to anticancer therapy. Even with concerns of the safety of drugs targeting Wnt signaling, the attention of researchers worldwide is increasing to this issue in terms of their therapeutic potential for diseases such as PD, for which no cure exists.     

Wnt信号通路途径调控细胞凋亡在肿瘤治疗中的作用

Wnt信号通路在生物体内参与调节了很多生命过程,其中包括各个组织的形成及器官的产生、免疫作用的发生、机体应激性的产生、细胞癌变和细胞凋亡与抗凋亡的过程等重要生命活动。越来越多的研究揭示了Wnt信号通路在细胞凋亡过程中的巨大作用,当然,Wnt信号通路通过很多已知的途径进行细胞凋亡过程的调节,其中包括通过调整细胞所处的外环境从而刺激细胞凋亡过程的加速或减缓等过程。本文将在Wnt细胞信号通路调控细胞凋亡从影响肿瘤细胞生长及生物体发育上对近期发表的研究成果作简要综述,并对Wnt信号通路中存在的关键基因、转录蛋白质做重点介绍并对其在细胞凋亡过程中所起的重要作用加以详细阐述。     

Wnt信号通路诱导肿瘤细胞上皮间质转化的研究进展

肿瘤细胞发生上皮间质转化(epithelial-mesenchymaltransition,EMT)从而具有侵袭转移的能力,是肿瘤发展的一个重要过程。既往研究发现Wnt信号通路调节控制着许多生命过程,也发现其是诱导EMT不可缺少的重要通路。通过对Wnt信号分子的调控,可以有效的阻断甚至逆转EMT。Wnt诱导EMT发生发展过程的研究,也为抗肿瘤新药开发提供了新思路,推动了药物的研发。该文旨在对近年Wnt信号通路诱导EMT的研究做一综述。