共查询到20条相似文献,搜索用时 15 毫秒
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目的:探讨慢性乙肝患者CD25、CD25 mRNA表达水平及其临床意义。方法:选择249例典型慢性乙肝患者,用生物素-链霉亲和素(BSA)法和Real—time PCR法分别检测PHA诱导前后患者PBMCCD25和CD25 mRNA表达水平;用PCR法检测患者HBV—DNA载量。结果:慢性乙肝患者静息态和诱导态CD25、CD25 mRNA表达水平与正常对照组相比均降低,差异有显著性(P〈0.05或P〈0.01)。慢性乙肝、肝硬化患者CD25和CD25 mRNA的表达水平不完全相同,但差异无显著性(P〉0.05)。结论:乙肝患者存在一定程度的免疫功能低下,CD25、CD25 mRNA表达水平降低,其表达水平与病情活跃程度、病毒复制水平相关。 相似文献
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以下25条是世界权威健康专家的最新研究成果:1.观看电视预告。美国加州大学的研究人员发现,你若能期望未来几天内有自己感兴趣的电视节目,心中的忧虑、愤懑、疲劳和紧张就会降低50%。2.按摩面部。当疲倦劳累时,可按摩或摩擦面部,从太阳穴经鼻梁一直到下唇。美国乔治城心理学家伯特·斯托勒认为,经常进行面部压力按摩有助于均衡周身能量,减轻焦虑,降低疲劳感,增强兴奋感。3.在鸡蛋和面食中加入适量蘑菇。根据洛杉矶城市癌症研究中心权威专家的说法,蘑菇的化学成分能降低食物中的雌激素,从而降低患乳腺癌的可能性。4.正确刷牙。每天刷牙时,牙… 相似文献
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25丙型肝炎流行病学研究进展 总被引:1,自引:1,他引:0
丙型肝炎(丙肝)是由丙肝病毒(HCV)引起的,以肝脏损害为主的一组全身性传染病。其急性感染期症状不明显,易慢性化,比例可达50.0%~85.0%[1];10.0%~20.0%的HCV感染者在感染20年后发展为肝硬化,但在某些国家高达50.0%,1.0%~3.0%的人在感染30年后发展为肝癌[2]。 相似文献
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Hutchinson MS Figenschau Y Almås B Njølstad I Jorde R 《International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ern?hrungsforschung. Journal international de vitaminologie et de nutrition》2011,81(5):317-327
The relationships between vitamin D concentrations, hyperglycemia, and insulin resistance remain uncertain. During 2008 - 2010, an oral glucose tolerance test was performed in 3520 subjects from Troms?, Norway. Serum 25-hydroxyvitamin D [25(OH)D] was measured in 1193 subjects with normal glucose tolerance, in 304 with isolated impaired fasting glucose, in 254 with isolated impaired glucose tolerance, in 139 with a combination of the two, and in 194 subjects with type 2 diabetes. Serum 25(OH)D did not differ between subjects with isolated impaired fasting glucose or impaired glucose tolerance, but was lower in all groups of deranged glucose metabolism as compared with normal subjects. These differences could not be explained by differences in intakes of vitamin D from cod liver oil or other supplements and remained statistically significant after adjustment for gender, age, body mass index, physical activity score, and month of examination. When the cohort was divided according to serum 25(OH)D quartiles, there was an improvement in all measures of glucose metabolism (fasting and 2-hour plasma glucose, serum insulin, HbA(1c)) and estimates of insulin resistance (QUICKI , HOMA-IR, ISI(0.120)) with increasing serum 25(OH)D quartile. However, interventional studies are needed to prove a causal relationship between vitamin D and glucose metabolism. 相似文献
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[目的]探讨正常医学生外周血单个核细胞(PBMC)中CD25、CD25 mRNA表达水平,为了解机体生理状态下细胞免疫功能提供实验依据。[方法]用生物素-链霉亲和素(BSA)法检测150名(男91人,女59人)在校医学生外周血单个核细胞植物血凝素(PHA)诱导前后CD25水平,Real-PCR法法检CD25 mRNA含量。[结果]男生PHA诱导前后CD25水平分别为(4.66±1.23)%、(33.12±7.02)%,CD25 mRNA含量分别为1.516 5±0.275 0、1.6050±0.2502;女生PHA诱导前后CD25水平分别为(4.59±1.34)%、(34.78±7.75)%,CD25 mRNA含量分别为1.4420±0.2428、1.7103±0.2755,两者相比,诱导期女生CD25 mRNA水平偏高,差异有统计学意义(P﹤0.05)。[结论]医学生PBMC中CD25、CD25 mRNA表达正常,女生PBMC对PHA具有更高的反应性。 相似文献
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Nakamura K Nashimoto M Yamamoto M 《International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ern?hrungsforschung. Journal international de vitaminologie et de nutrition》2001,71(1):25-29
The objective of this study was to investigate whether the serum 25-hydroxyvitamin D (25[OH]D) concentrations in winter are associated with the BMD in elderly Japanese women. The subjects were 117 healthy elderly Japanese women. Serum 25(OH)D concentrations were determined by high-performance liquid chromatography. Forearm BMD in the non-dominant arm was measured by dual-energy X-ray absorptiometry (DXA) using a DTX-200 Osteometer. The mean age of the subjects was 66.1 (SD 6.5) years (range: 46-80). The average 25(OH)D concentration was 59.1 nmol/L (SD 16.1), and five of the subjects had low 25(OH)D concentrations (< 30 nmol/L). Forearm BMD decreased linearly with age (r2 = 0.275). There was no linear association between the serum 25(OH)D concentrations and the forearm BMD (p = 0.9483). Multiple regression analysis did not reveal any association between the two (p = 0.5318) when age (p < 0.0001, r2 = 0.271) and weight (p < 0.0001, r2 = 0.153) were taken into account. Our cross-sectional study failed to reveal any association between the serum 25(OH)D concentrations and the forearm BMD in elderly Japanese women, suggesting that 25(OH)D does not play an important role in the determination of BMD. A follow-up study should be conducted to confirm the results of our cross-sectional study. 相似文献
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Kenneth Tang Dorcas E. Beaton Benjamin C. Amick III Sheilah Hogg-Johnson Pierre Côté Patrick Loisel 《Journal of occupational rehabilitation》2013,23(2):228-238
Purpose: To examine the factorial validity of the Work Limitations Questionnaire (WLQ-25) among workers’ compensation claimants with chronic upper-limb disorders. Methods: Attendees of the WSIB Shoulder and Elbow Specialty clinic in Toronto, Ontario, Canada, completed a survey that includes the WLQ-25 [4 subscales: time-management (TM), physical demands (PD), mental-interpersonal (MI), and output demands (OD)]. Confirmatory factor analyses (n = 2262) were conducted to evaluate and compare alternative 4- and 5-factor WLQ-25 structures [MI subscale intact vs. separated into mental demands (MD) and interpersonal demands (IP) subscales]. Model fit indices, saliency of factor loadings, and convergent/divergent validity of latent factors (r = 0.4 ? 0.85 expected) were concurrently assessed. Results: The 4-factor WLQ-25 showed acceptable model fit after allowing the residuals of a pair of PD items to correlate (CFI = 0.924, TLI = 0.915, RMSEA = 0.057, SRMR = 0.054); however, significantly lower-than-expected correlations between the PD factor and all other factors (r = ?0.11 – ?0.03) were also observed. Model fit for the 5-factor WLQ-25 was even more optimal (CFI = 0.934, TLI = 0.925, RMSEA = 0.053, SRMR = 0.051), with MD and IP factors correlating at r = 0.83. Conclusions: Evidence of factorial validity was demonstrated by the WLQ-25; however, users should be attentive of an instrumentation issue that could be directly related to the psychometric performance of its PD subscale. 相似文献
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膀胱损伤约占泌尿系损伤的15 %~3 0 %。外伤性膀胱破裂多合并其它脏器损伤或休克造成诊断困难。1994-0 1~2 0 0 2-0 9我院收治外伤性膀胱破裂2 5例报告如下。1 资料与方法1·1 一般资料 本组2 5例。男2 0例,女5例。年龄10~68岁,平均2 8岁。伤后到入院时间15min~2 0h。损伤类型:腹膜外型10例,腹膜内型11例,混合型4例。2 0例合并其它部位的损伤,合并骨盆骨折16例,后尿道断裂12例,肠破裂6例,脑外伤2例,肝、肾、脾破裂各2例,四肢骨折3例,出现创伤性休克16例。12例膀胱注水试验阳性。9例行膀胱造影其中8例阳性,1例阴性。2例行亚甲蓝液灌洗… 相似文献
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25例水泥尘肺分析报告 总被引:2,自引:0,他引:2
25例水泥尘肺分析报告广东湛江市职业病防治所(霞山录塘路,524018)李尚朝水泥尘肺已被列为法定职业病(1986)。为进一步了解水泥尘肺的特征,作者对本地区25例水泥尘肺作了调查分析。内容与方法发病工种、工龄、晋期情况及X线胸片、肺功能等资料来源于... 相似文献
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晨练5分钟1起床后锻炼5分钟,不仅为身体充电,而且能加倍燃烧卡路里。很多人误认为晨练必须5点钟爬起来跑上几公里,其实是不必要,也不太现实的。你只消花5分钟,做做俯卧撑和跳跃运动,使心率加快,就能达到理想的效果;要么对着镜子冲拳100下,感受那种能量积蓄的过程。 相似文献
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我院于2000年3月~2002年5月共收治艾滋病病人25例,现将临床情况分析如下。1 临床资料1.1 一般资料 男性16例,女性9例;年龄5岁1例,20~29岁7例,30~39岁10例,40~49岁4例,50岁以上3例。职业:工人9例,农民7例,商人1例,无职业5例,在押犯2例。传播途径;因其他疾病输血11例(其中产后输血5例),职业献血8例(其中单采3例),静脉吸毒2例,母婴垂直传播1例,原因不明2例。潜伏期3~4 a 12例,5~6 a 10例,7 a 3例。发病1-4个月5例,5~7个月9例,8-12个月11例。 相似文献