强脉冲光与HGM激光联合非侵入性治疗面部皮肤光老化

目的观察强脉冲光治疗仪与HGM激光器联合应用非侵入性治疗面部皮肤光老化的效果。方法对460例FitzpatrickⅢ、Ⅳ型皮肤光老化患者,采用560nm强脉冲光与532nm HGM激光联合治疗4次,治疗分两步进行,首先使用560nm强脉冲光,能量密度30~40J/cm2的光子嫩肤治疗,然后使用532nm HGM激光器,能量密度35~60J/cm2,施行局部针对治疗。治疗间隔均为2周。分别于最后一次治疗的4、8周后,随访治疗效果和并发症情况。结果经4次治疗8周后,随访90%患者毛细血管扩张、毛孔粗大、色素沉着和细小皱纹改善的程度均达到了75%以上。主要并发症为短暂红斑和水疱。结论560nm强脉冲光治疗仪与532nm HGM激光器联合应用治疗面部皮肤光老化性毛细血管扩张、毛孔粗大、色素沉着和细小皱纹,疗效可靠,并发症少,是一种理想的非侵入性治疗亚洲人FitzpatrickⅢ、Ⅳ型皮肤光老化的方法。     

强脉冲光与HGM激光联合非侵入性治疗面部皮肤光老化

目的观察强脉冲光治疗仪与HGM激光器联合应用非侵入性治疗面部皮肤光老化的效果.方法对460例Fitzpatrick Ⅲ、Ⅳ型皮肤光老化患者,采用560 nm强脉冲光与532 nm HGM激光联合治疗4次,治疗分两步进行,首先使用560 nm强脉冲光,能量密度30～40 J/cm2的光子嫩肤治疗,然后使用532 nm HGM激光器,能量密度35～60 J/cm2,施行局部针对治疗.治疗间隔均为2周.分别于最后一次治疗的4、8周后,随访治疗效果和并发症情况.结果经4次治疗8周后,随访90%患者毛细血管扩张、毛孔粗大、色素沉着和细小皱纹改善的程度均达到了75%以上.主要并发症为短暂红斑和水疱.结论 560 nm强脉冲光治疗仪与532 nm HGM激光器联合应用治疗面部皮肤光老化性毛细血管扩张、毛孔粗大、色素沉着和细小皱纹,疗效可靠,并发症少,是一种理想的非侵入性治疗亚洲人Fitzpatrick Ⅲ、Ⅳ型皮肤光老化的方法.     

强脉冲光联合Q开关532nm激光治疗面部皮肤光老化疗效观察

目的：探讨强脉冲光联合Q开关532nm激光治疗面部皮肤光老化的临床疗效。方法：将128例患者根据光老化皮肤损害的不同选择不同的波长及模式进行1个疗程（4～6次）的强脉冲光治疗,2周后使用Q开关532nm激光对疗效欠佳的皮损进行局部治疗,4周后进行疗效评价。结果：经过强脉冲光和激光联合治疗后,128例患者的光老化皮肤损害均有不同程度的改善,其中以毛细血管扩张、色素沉着、皮肤质地的改善最为明显,治疗的总有效率均达到90%以上,细小皱纹及毛孔粗大的总有效率也达到了73.81%、71.15%。结论：强脉冲光联合Q开关532nm激光治疗面部光老化,疗效可靠,并发症少,是一种理想的非侵入性治疗面部皮肤光老化的方法。     

强脉冲光治疗面部皮肤光老化65例

目的:探讨强脉冲光(IPL)治疗面部皮肤光老化的临床疗效。方法:采用波长为400~1200nm的GP666B型光子嫩肤仪治疗65例面部皮肤光老化患者,5次为一个疗程,每次治疗间隔时间10天,每位患者治疗前后对比拍照、记录参数并进行临床疗效评估。结果:65例患者中各种病变的有效率分别为:色素沉着斑76.36%,微细皱纹93.02%,毛细血管扩张94.67%。结论:IPL治疗面部光老化有良好疗效。     

Ellipse Flex强脉冲光对某些面部皮肤疾病的治疗效果

目的探讨Ellipse Flex强脉冲光对黄种人某些面部皮肤疾病的治疗效果。方法采用丹麦DDD公司生产的第2代强脉冲光子嫩肤仪对色斑、细小皱纹、毛孔粗大、毛细血管扩张等良性皮肤疾病进行强脉冲光治疗,每5次为1个疗程,每次治疗间隔4周。结果349例中148例(42.4%)痊愈,118例(33.8%)显效,52例(14.9%)有效,总有效率91.17%;5例出现色素沉着,2例出现表皮灼伤,均未做特殊处理自然恢复。结论Ellipse Flex强脉冲光子嫩肤仪用于面部皮肤美容,效果明显、安全,是一种无创、非剥脱性的治疗方法。     

强脉冲光治疗皮肤色素性疾病的临床观察

目的 光子嫩肤技术是用强脉冲光改善皮肤光老化的非剥脱治疗；对皮肤色素病有较好疗效。观察强脉冲光对颜面常见色素性皮肤病的短期疗效。方法 应用强脉冲光对患者面部照射，治疗波长为560nm，治疗脉宽为2．4～6ms，每个光斑2～3脉冲，能量密度24～36J／cm^2。每隔3周治疗一次，5～6次为一个疗程。每次治疗前采集皮损图像。按痊愈、显效、有效及无效4级做出评价。结果 受治患者综合疗效有不同程度改善。色素性疾病中，雀斑和脂溢角化病的疗效最明显。毛细血管扩张也有显著疗效。其他色素病有不同程度消退。经半年以上随访未见复发。结论 强脉冲光可治疗毛细血管扩张以及多种色素性皮肤损害，改善皮肤外观。其优势为无创伤。痛苦小，不影响工作。     

光子嫩肤个体化参数方案的临床应用

目的：总结光子嫩肤个体化参数方案在面部皮肤美容中的应用经验，探索适合中国人皮肤的光子嫩肤治疗参数。方法：采用560～1200nm强脉冲光、个体化参数方案，治疗面部皮肤色素性病变、毛细血管性病变、真皮和表皮结构的改变。结果：582-g4患者，经过4～6次治疗，痊愈125例(21．5％)，显效256例(44．0％)，有效149例(25．6％)，无效52例(8．9％)；共治疗2956例次，发生皮肤红斑、小水疱、色素沉着等不良反应109例次(3．7％)。结论：强脉冲光子嫩肤技术是皮肤美容的无创伤性、安全有效的方法；根据病变情况，灵活选择个体化参数方案可显著提高疗效，预防不良反应的发生。     

强脉冲光照射兔皮肤后的组织学观察

目的：观察强脉冲光照射兔皮肤后的组织学变化，为临床提供参考信息。方法：用34J／cm^2的强脉冲光对10只兔四个部位分别进行1．2、3、4次照射，术后第1、7、15、30、60、90天行切片观察。结果：一定能量的IPL能治疗光老化，并不引起严重炎症反应；IPL可使表皮层增厚，引起的胶原纤维增生可持续3个月以上。结论：光子嫩肤术可安全有效的治疗光老化，其效果可超过3个月，但它也是一种创伤性刺激。     

强脉冲光治疗烧伤后面部色素沉着疗效观察

目的：探讨强脉冲光治疗烧伤后面部色素沉着的疗效。方法：采用意大利GP公司的光子嫩肤仪对37例面部烧伤后色素沉着患者实施治疗,波长590～1200nm,治疗5～8次,每次治疗间隔20天,治疗过程中不采用任何麻醉,治疗完成后面部无需包扎。结果：所有患者均能耐受,经治疗后面部色素基本恢复正常。其中3例治疗区皮肤出现红斑和疼痛,均自行缓解,1例出现水疱,给予清创换药后愈合,后期继续行强脉冲光治疗,无色素沉着及瘢痕形成。随访3～6个月,面部皮肤色泽如常,患者比较满意。结论：采用强脉冲光治疗面部烧伤后色素沉着疗效可靠、操作简单、治疗耗时短,不影响日常工作和生活,无严重并发症发生,是一种较理想的治疗烧伤后色素沉着的方法,而且应在伤口愈合后早期应用。     

光子嫩肤技术治疗面部皮肤光老化200例临床疗效分析

目的:探讨光子嫩肤技术治疗面部皮肤光老化的临床疗效。方法:将200例皮肤光老化患者分为三组。第一、二组采用Lumenis One强脉冲光子嫩肤仪560nm波长,双脉冲,脉宽为3.0~5.0nm,脉冲延迟时间为20~30ms,能量密度为15~25J/cm2;第三组采用640nm波长,三脉冲,脉宽为3.0~6.0nm,脉冲延迟时间为25~35ms,能量密度为18~25J/cm2进行治疗,经过6次治疗后判定疗效。结果:三组患者在合适的波长、脉冲宽度、延迟时间、能量密度下经过6次治疗,有效率分别88.75%、80.0%、81.8%,在6个月内随访显示4例皮损加重,但皮损加重程度均较轻且面积不超过原皮损面积的1/3。结论:光子嫩肤技术对皮肤光老化具有良好的效果,不良反应小,复发率低,是一种安全、可靠的治疗方法,值得临床推广应用。     

Intense Pulsed Light as a Nonablative Approach to Photoaging

Background and Objective. To describe the introduction and use of intense pulsed light (IPL) to treat vascular and pigmented lesions comprising photorejuvenation and its use in photodynamic therapy.
Methods. Review of the medical literature and the authors' experience with IPL.
Results and Conclusions. IPL is an excellent treatment modality for vascular and pigmented manifestations of photoaging and can be combined with photodynamic therapy for the treatment of early forms of skin cancer.     

Full-face photorejuvenation of photodamaged skin by intense pulsed light with integrated contact cooling: initial experiences in Asian patients

BACKGROUND AND OBJECTIVES: For Asian skin, recent "non-ablative" skin rejuvenation techniques have become the focus of attention for darker complected patients. In our earlier research, we have shown that intense pulsed light (IPL) technology can be applied to Asian skin with a high degree of safety and efficacy. In this study, we performed full-face photorejuvenation using a new IPL device incorporating a 560 nm filter and integrated contact cooling system for the improvement of various symptoms associated with photoaging in Asian patients. STUDY DESIGN/MATERIALS AND METHODS: A total of 73 patients were treated with a series of five or more full-face treatments at 3-4 week intervals using IPL with integrated contact cooling. One month after the third and fifth treatments, the patient and the treating physicians subjectively evaluated improvement in five areas-in pigmentation, telangiectasia, fine wrinkles, skin texture, and over-all improvement. In addition, histological changes were evaluated. RESULTS: Pigmentation improvement, telangiectasia reduction, fine wrinkle reduction, smoother skin texture, and over-all improvement were evaluated according to five grades of percentage improvement. In addition, the subjective rating by the patients and the physicians was averaged, and the combined results were evaluated. After the fifth treatment, a combined rating of greater than 60% improvement was given to more than 80% of patients for pigmentation improvement, telangiectasia reduction or removal, smoother skin texture, and overall improvement. Histological evaluations showed strong staining of Type I and Type III collagen. Complications were minor and transitory, with burning sensations and erythema in only two patients. CONCLUSION: Full-face photorejuvenation for Asian patients using this device is not only effective but is also associated with fewer post-treatment complications than other more invasive modalities. We conclude that IPL photorejuvenation can be the basis for safe and effective skin rejuvenation in Asian patients.     

强脉冲光联合调Q激光治疗色素增生性皮肤病

目的探讨强脉冲光联合调Q激光疗法对面部色素增生性皮肤病的疗效及安全性。方法根据患者面部色素性疾病的特点,对225例FitzpatrickⅢ、Ⅳ型皮肤的色素细胞增生性皮肤病患者,采用560nm强脉冲光联合调Q532nm激光治疗,首先使用560nm强脉冲光,能量密度30～40J／cm2的光子嫩肤治疗,每月1次,3个月后观察疗效。对于改善不品著的脂溢性角化斑、咖啡斑及眼睑、口唇周围残留的雀斑等,再使用调Q532nm激光,施行局部针对性治疗,能量密度70J／cm2。于激光治疗后2个月,对皮损的改善和满意度进行评估并记录不良反应。结果90％患者的雀斑、咖啡斑、脂溢性角化斑的色素均有50％～70％不同程度的消退,同时毛细血管扩张、毛孔粗大、细小皱纹均达到了60％以上的程度的改善。主要并发症为暂时性红斑和水疱。结论560nm强脉冲光联合调Q激光治疗面部色素增生性皮肤病安全有效,同时能有效改善肤质。     

Photodynamic Photorejuvenation

BACKGROUND: The visible signs of photodamage are characterized by wrinkling, coarse skin texture, pigmentation alterations, telangiectases, and in some case actinic keratosis (AKs). Intense pulsed light (IPL) photorejuvenation has been shown to improve each of the different components of photodamaged skin except AKs. OBJECTIVE: To present photodynamic therapy with topical 5-aminolevulinic acid (ALA-PDT) using IPL as a light source for treatment of AK in patients having IPL photorejuvenation. METHODS: Seventeen patients with varying degrees of photodamage and AKs (total of 38 AKs) were treated with two treatments with a 1-month interval of ALA-PDT using IPL as a light source. RESULTS: Thirty-three of 38 AKs disappeared with two ALA-PDT treatments using IPL. The follow-up period was 3 months. The technique was very well tolerated. Erythema and crusting took 1 week to resolve in the AK area. The cosmetic results were excellent in all patients without pigmentary alterations or scarring. CONCLUSION: This study describes a new application of IPL technology. Patients who are candidates for photorejuvenation procedures presenting with AKs can now have AKs treated as part of the photorejuvenation process rather than necessitating separate topical therapy with 5-fluorouracil (5-FU) or cryotherapy. In addition, many patients with AKs may benefit from the combination treatment with 5-ALA and IPL.     

强脉冲光联合射频治疗面部皮肤光老化的临床体会

目的：探讨强脉冲光（IPL）联合射频（RF）治疗面部皮肤光老化的临床应用及其与单一使用IPL或RF方法的效果比较。方法：451例患者,其中134例行单一IPL治疗,138例行单一RF治疗,179例行IPL联合RF治疗。比较治疗前后患者面部毛细血管血管扩张、色素沉着、皮肤质地的改善情况,评估各方法的有效率及患者的满意程度。结果：单一行IPL组,单一行RF组以及IPL联合RF治疗组治疗毛细血管扩张有效率分别为84.33%、14.49%、88.27%,治疗色素沉着有效率分别为57.46%,12.32%,62.01%,改善皮肤质地有效率分别为57.71%、83.82%、85.29%,三种方法患者的满意度分别为73.13%,68.12%,88.27%。结论：IPL治疗面部毛细血管扩张、祛除色斑效果较好,RF治疗皮肤干纹,改善皮肤松弛效果明显,两者联合使用可相互促进达到优于两者单独治疗的效果。     

Photorejuvenation for Asian Skin by Intense Pulsed Light

BACKGROUND: Dermabrasion and deep chemical peeling are used in the treatment of photoaged skin. These ablative procedures are effective enough to produce a certain improvement but have often caused postinflammatory hyperpigmentation among Asian patients. To avoid such adverse effects, a new, nonablative procedure has been sought. OBJECTIVE: To determine the effectiveness of photorejuvenation for Asian skin using intense pulsed light (IPL). The specific parameters used, improvement ratios, side-effects, and downtime required are also discussed. METHODS: Ninety-seven patients were treated for photoaging using IPL. The cutoff filters of 550 nm and 570 nm were utilized for three to six treatments at intervals of 2 to 3 weeks. RESULTS: Treatment results were evaluated and rated by both patients and physicians at the end of the third treatment based on improvement in pigmentation, telangiectasia, and skin texture. A combined rating of "good" or "excellent" was given to more than 90% of the patients for pigmentation, more than 83% for telangiectasia, and more than 65% for skin texture. There were some minor complications in four cases: one had erythema that continued to the next day and three had minor blisters leaving no marks. CONCLUSION: Photorejuvenation using IPL is a completely safe and effective procedure even for Asian skin. It will be increasingly used for skin rejuvenation in the future.     

强脉冲光治疗面部植皮术后色素沉着和毛发过多

目的：观察强脉冲光（Intensepulsedlight,IPL）治疗植皮术后色素沉着和毛发过多的临床应用效果。方法：应用IPL治疗植皮术后色素沉着9例,全厚皮片移植术后色素沉着合并毛发过多2例,共11例。患者接受1～3次IPL去色素治疗,毛发过多者另接受3次IPL脱毛治疗。结果：11例患者治疗后色素沉着均出现不同程度好转,其中7例显效,4例有效,副反应轻微。2例毛发过多者治疗后毛发显著减少。结论：IPL是一种安全有效的治疗植皮术后色素沉着和毛发过多的方法。     

Non-ablative facial skin photorejuvenation with an intense pulsed light system and adjunctive epidermal care

Laser skin resurfacing is popular, but the appearance of the face during healing is unpleasant. Non-ablative photorejuvenation with intense pulsed light (IPL) has been reported as being successful but with varied results. In this study we sought the possibility of enhancing the clinical effects with adjunctive epidermal care. Twenty-five women aged from 32 to 68, skin types I–IV, with a variety of wrinkle types and other conditions associated with photoaged skin, were treated with IPL according to our parameters over six sessions coupled with an adjunctive pretreatment micropeel and applications of nutritive and antipigmenting creams. Macroscopic and histological assessments were performed. At weeks 4 and 8 fair to good satisfaction was noted in 17 and 19 patients, and poor satisfaction in 8 and 6 patients, respectively. The histology showed good dermal collagen remodelling in all cases, with a reduction in elastosis. The results of IPL photorejuvenation can be enhanced, as our trials showed. The good patient satisfaction obtained was clearly demonstrated in the histologies and evaluations throughout the study.     

强脉冲光治疗面部光老化的疗效评估

目的:评价强脉冲光(intense pulsed light,IPL)治疗面部光老化的疗效。方法:应用皮肤测试仪检测IPL治疗前后皮肤水分含量、弹性及色素值。结果:面部光老化经IPL治疗后,皮肤水分含量略增加(P0.05),皮肤弹性增加(P0.01),黑色素值下降(P0.01),血红素值下降(P0.01)。结论:应用皮肤测试仪检测IPL治疗前后皮肤水分含量、弹性及色素的改变,使评价IPL的治疗效果更为科学、准确、客观。