共查询到19条相似文献,搜索用时 84 毫秒
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吸烟对男性精液质量的影响 总被引:1,自引:0,他引:1
目的 探讨吸烟对男性精液质量的影响.方法 应用伟力彩色精子质量分析系统对180例不育男性(96例不育吸烟组和84例不育非吸烟者)和112例正常生育男性精液从精液量、液化时间、精子总数、精子密度、精子活力、精子活率等参数方面进行分析.结果 (1)不育吸烟组、不育非吸烟组与正常对照组比较,精子活力、精子活率等参数显著降低(P<0.05或P<0.01),液化时间延长(P<0.05),而精液量、精子密度和精子总数之间无显著性差异(P>0.05);(2)不育吸烟组与不育非吸烟组相比,精子活力、精子活率显著降低(P<0.05或P<O.01);(3)小烟量组和短烟龄组与不育非吸烟组相比,精液各参数之间差异无显著性(P>O.05).大烟量组和长烟龄组与不育非吸烟组相比,精子总数、精子密度、精子活力和精子活率都显著降低(P<O.05或P<0.01),液化时间显著延长(P<0.01);(4)小烟量组和短烟龄组分别与大烟量组和长烟龄组相比,精子密度、液化时间、精子活力和精子活率等均有显著性差异(P<0.0 1).结论 (1)吸烟对男性精液质量的不良影响存在量效和时效关系.(2)大量吸烟(日吸烟量>20支)和长期吸烟者(烟龄>10年)可能是引起男性不育的重要原因之一. 相似文献
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《生殖医学杂志》2015,(12)
目的探讨吸烟对男性精液质量、精子DNA完整性Chk1基因表达的影响。方法将1 128例研究对象分为不吸烟组及吸烟组,且依据每日吸烟支数将吸烟组划分为轻度吸烟组、中度吸烟组、重度吸烟组,依据吸烟年限将吸烟组划分为:短烟龄组、中烟龄组、长烟龄组。对各组患者行精液常规参数、精子形态、精子DNA完整性及精子Chk1基因mRNA相对表达量检测。同时就精子DNA完整性及精子Chk1基因mRNA相对表达量与精液常规参数的相关性进行分析。结果(1)吸烟组与不吸烟组总体比较:吸烟组前向运动精子率及DNA双链精子百分率较不吸烟组显著下降(P0.05)。(2)不同烟量的影响:轻度、中度及重度吸烟组与不吸烟组相比,前向运动精子均显著下降(P0.05),且重度吸烟组头部精子缺陷率较不吸烟组显著增高(P0.05)。(3)不同烟龄的影响:长烟龄组精液量、浓度、总数及前向运动精子率较不吸烟组均下降显著(P0.05),中烟龄组较不吸烟组,仅前向运动精子率显著下降(P0.05)。长烟龄组头部精子缺陷率较不吸烟组显著增高(P0.05)。(4)相关性分析:精子DNA损伤程度与男性精液浓度及前向运动精子率间存在相关性(P0.05)。吸烟组患者较不吸烟组患者Chk1基因mRNA相对表达量降低(P0.05),且精子Chk1基因mRNA表达水平与男性精液浓度及前向运动精子率间存在相关性(P0.05)。结论吸烟可引起男性精液质量下降,且随着吸烟时间的延长及日吸烟量的增加,精液质量下降更为显著。而且,吸烟引发的精液质量下降不仅与精子DNA完整性存在一定的相关性,同时与DNA损伤修复相关基因Chk1下调相关。 相似文献
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吸烟对精液质量的影响 总被引:4,自引:0,他引:4
吸烟对精液质量的影响李丹滨,李长春随着人们对吸烟危害认识的不断深入,吸烟者不再认为吸烟仅有害于自己,而且还危害妇女和未出世的胎儿.近年来,国外学者对吸烟者生殖能力,尤其是男性精液质量的影响做了大量工作,但国内文献报告甚少.现就吸烟对精液质量的影响综述... 相似文献
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吸烟对男性精液参数、精子功能及睾酮影响的研究 总被引:12,自引:1,他引:12
为探讨吸烟对精液参数、精子功能及血睾酮的影响,本文对有生育史的吸烟男子进行了比较研究。结果显示:B组(51例,吸烟≤20支/日,吸烟时间≤10年)与A组(38例,不吸烟),精液各参数无明显变化(P〉0.05),但A组与C组(55例,吸烟〉20支/日,吸烟时间〉10年)比较,则有显著差异(P〈0.05)。A、B、C三组间HOS、HOP比较无显著性差异,而ESC和T值则存在显著性差异(P〈0.005)。提示长期大量吸烟可能对精液参数、精子头部DNA双螺旋结构及睾丸间质细胞有不良影响,且起始年龄越小,量越大,时间越长,影响越大。 相似文献
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目的:探讨吸烟对重庆市主城区健康成年男性精子凋亡和精液质量的影响。方法:235例健康成年男性根据吸烟习惯分为吸烟组和不吸烟组。不吸烟组89例,吸烟组146例。采用计算机辅助精液分析系统检测精液常规参数;流式细胞术结合Annexin V-FITC/PI荧光染色检测精子凋亡(AN-/PI-、AN+/PI-、AN+/PI+、AN-/PI+精子比率),并对吸烟组和不吸烟组的各项参数进行比较研究。结果:与不吸烟组比较,吸烟组的早期凋亡精子(AN+/PI-)率高于不吸烟组[(8.1±5.1)%vs(6.8±3.8)%,P=0.039],而晚期凋亡精子(AN+/PI+)率两组间差异无显著性[(5.6±5.2)%vs(5.5±5.1)%,P=0.87];两组间精液量、精子密度、精子活动率、活力和正常形态精子率等精液常规指标的差异均无显著性(P=0.30;0.82;0.37;0.81;0.84)。结论:吸烟者早期精子凋亡率较不吸烟者高,提示吸烟可能诱导精子出现早期的细胞损害。精子凋亡可作为较精液常规指标更为敏感的生物标志物反映吸烟对男性精子造成的损伤。 相似文献
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目的:调查在医院门诊和在家中通过自慰法收集的精液质量之间的差异。方法:对342例男性患者在医院门诊和在家中通过手淫法收集的精液样本,按WHO第5版操作标准常规分析精液,并测量反映附睾、前列腺和精囊腺功能状态的精浆标志物,即精浆中性α-葡糖苷酶(NAG)、锌(Zn)和果糖(FRU)含量。按照取精地点分成两组:在医院门诊和在家中,软件分析取精地点与精液参数的关系。结果:在家中收集的精液在精液量、精子浓度、精子总数和前向运动精子百分率(PR)方面均明显优于在医院门诊收集的精液;而精子形态、NAG、Zn和FRU在两组之间无显著性差异。精子浓度异常(20×106/ml)和精子活动率异常[PR32%]的精液样本,在家中获得的样本率[18%(62/342);64%(219/342)]均明显低于在医院门诊取精室获得的样本率[30%(103/342);75%(256/342)],两组之间均有显著差异。结论:与在医院门诊取精液相比,在家中手淫法取精液能获得更好的精液质量。在不孕症评估过程中,应该考虑取精液的环境因素。 相似文献
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Cigarette Smoking and Semen Quality in Men of Reproductive Age 总被引:4,自引:0,他引:4
The effect of cigarette smoking on conventional semen parameters was studied in voluntary men of reproductive age (n = 190). Special attention was focused on sperm motility and its quantitative and qualitative change in vitro during the observation period. The sperm output war normal in both smokers (n = 54) and non-smokers (n = 110), but semen volume was smaller (p less than 0.03) in heavy smokers (greater than 16 cigarettes/day) than non-smokers. In sperm morphology there was no difference between study groups. The only clear difference between men with different smoking habits was in the percentual change in the sperm motility during 24 hours. At the time of first examination, the sperm motility was better (p less than 0.02) in heavy smokers than those who smoked less than 16 cigarettes per day and the motility decreased more rapidly (p less than 0.007) in heavy smokers than non-smokers. The objectively measured initial mean velocities of the whole sperm population and of the progressive spermatozoa were slightly higher in subgroup of smokers than in non-smokers. The rapid decrease in the survival spermatozoa in smokers may be uneconomical and harmful in respect of fertility. 相似文献
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Chiung-Wen Kuo Tung-Hao Chang Wei-Lain Chi Tieh-Chi Chu 《Journal of clinical densitometry》2008,11(4):1241-524
The effect of cigarette smoking in relation to bone mineral density (BMD) remains inconclusive, especially in middle-aged men. This cross-sectional study was conducted to examine the effect of smoking on BMD in 837 healthy Taiwanese males (532 never-smokers, 258 current smokers, 47 former smokers; aged 46–64 yr), recruited at their routine health examination. Subjects with suspected conditions affecting bone metabolism or receiving any medications affecting bone metabolism were excluded. BMD of the lumbar spine (LSBMD) and femoral neck (FNBMD) was measured with dual-energy X-ray absorptiometry. After adjustment for confounding variables (age, weight, physical activity, alcohol consumption, and caffeine intake), we found that the mean value of LSBMD was significantly (2.9%) lower in current smoker compared with never-smokers (p = 0.024), but no significant difference was observed in FNBMD. No statistically significant association was observed between former smokers and never-smokers in any of the BMD sites, indicating that quitting smoking did have a positive effect on bone density. Compared with never-smokers, current heavy smokers who consumed at least 20 cigarettes/d (n = 94) had 3.8% lower LSBMD (p = 0.04), but no significant difference was observed in FNBMD. In the correlation analysis, the duration of smoking was negatively associated with LSBMD (r = −0.166, p = 0.004), but no association was shown in FNBMD. Our results suggested that both smoking status and duration of smoking were deleterious factors on the bone density of the lumbar spine, and the effect was cumulative with duration and quantity. 相似文献
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The levels of eight enzymes have been measured in the semen of 15 azoospermic subjects. The results indicate that the values of the enzymes Creatine kinase, and Alanine aminotransferase, just as the Aspartate aminotransferase/Alanine aminotransferase ratio are significantly different between excretory and secretory azoospermics. The enzymes Aspartate aminotransferase, Lactate dehydrogenase, alpha-Hydroxybutyrate dehydrogenase, Gammaglutamyl transferase, Acid phosphatase, and Alkaline phosphatase and the alpha-Hydroxybutyrate dehydrogenase/Lactate dehydrogenase ratio have values which do not differ significantly between the two groups of azoospermic men. 相似文献
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目的:探究显微镜与经腹膜后精索静脉高位结扎术对于精液质量的影响。方法:89例左侧精索静脉曲张患者,分别接受经腹膜后高位结扎术(开放组)和显微镜下精索静脉结扎术(显微镜组)治疗,随访时间为3个月。观察两组术前术后精液浓度、前向运动及血清抑制素B水平等指标。结果:患者平均年龄为(28±6)岁;平均病程为(14.3±16.7)月。两组术后精子浓度与前向运动均无统计学差异(P=0.839,0.169),显微镜组血清抑制素B水平显著高于开放手术组(P=0.021)。结论:两种术式均能有效改善精液质量;对于血清抑制素B水平的改善,显微镜下精索静脉结扎术优于经腹膜后高位结扎术。 相似文献
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Summary: A microbiological examination has been carried out in 116 patients with unexplained infertility and with asymptomatic bacteriospermia. Organisms more frequently isolated were Staphylococcus epidermidis (81.9%), non hemolytic streptococci (23.3%), diphtheroids (25%) and alpha-hemolytic streptococci (18.1%). None of the 103 patients were positive for C. trachomatis. Mycoplasmas were isolated in 56 (48.3%) of the 116 examined samples, U. urealyticum was present in 49 (42.2%), M. hominis in 3 (2.6%) and both species in 4 (3.5%) samples of examined fluids. Forty-one of the 56 mycoplasmas-positive patients have been treated with doxycycline therapy. The treatment improved motility and caused decrease of coiled tails in 12 cases. Conception occurred in 5 (26.3%) of the 19 treated patients whose cultures were negative for mycoplasmas. These 5 pregnancies occurred in the patients that had high titers (> 105 c.c.u./ml) of ureaplasmas and in which the antibiotic therapy was successful. No pregnancy was seen in the other 22 patients where treatment failed to eradicate mycoplasmas. Zusammenfassung: Die mikrobiologische Flora im Sperma asymptomatischer infertiler Männer Eine mikrobiologische Untersuchung wurde bei 116 Patienten mit nicht erklärbarer Infertilität und asymptomatischer Bakteriospermie durchgeführt. Die meistisolierten Keime waren Staphylococcus epidermidis (81,9%), nicht-hämolysierende Streptococcen (23,3%), Diphtheroides (25%) und alpha-hämolysierende Streptococcen (18,1%). Bei keinem der 103 Patienten wurde C. trachomatis gefunden. Mykoplasmen wurden bei 56 (48,3%) der untersuchten Proben isoliert, U. urealyticum war bei 49 (42,2%), M. hominis in 3 (2,6%) und beide Arten bei 4 (3,5%) der Proben vorhanden. 41 der 56 Mykoplasma-positiven Patienten wurden mit Doxycyclin therapiert. Die Behandlung verbesserte die Beweglichkeit und bewirkte eine Abnahme der Spermatozoen mit eingerollten Schwänzen bei 12 Fällen. Zur Konzeption kam es bei 5 (26,3%) der 19 behandelten Patienten, deren Kulturen keine Mykoplasmen aufwiesen. Die 5 Schwangerschaften traten bei den Patienten ein, die hohe Titer (> 105 c.c.u./ml) an Ureaplasmen aufwiesen und bei denen die antibiotische Therapie erfolgreich war. Bei den 22 anderen Patienten wurde keine Schwangerschaft beobachtet, wenn die Behandlung des Mykoplasmabefalls versagte. 相似文献
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The effects of long term administration of the prostaglandin inhibitor, Indomethacin, on semen, in 22 infertile men with severe oligozoospermia and/or asthenozoospermia have been studied. Quantitative assessment of semen in the whole group showed improved sperm motility ( P < 0.05), normal morphology ( P < 0.05) and concentration ( P < 0.002) after treatment. Individual qualitative evaluation of semen parameters showed improvement in sperm count in one third and improved motility and morphology in 18 per cent of the patients. It would seem that Indomethacin has a beneficial effect on semen in some men with idiopathic oligoasthenozoospermia. It remains to be elucidated whether these effects are related to changes in prostaglandin levels. 相似文献
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司机职业不育男性的精液分析 总被引:11,自引:0,他引:11
目的 :探讨司机职业与男性精液质量有无相关性。 方法 :对 12 2 3例不育男性 (司机 78例、非司机 114 5例 )和 10 0例生育男性精液从液化、精子密度、精子活力、精子活率、精子形态等方面进行全面分析。 结果 :从事司机职业的不育男性精液质量异常率显著高于非司机职业不育男性 (P <0 .0 5 )和生育男性 (P <0 .0 1) ,且开车 8年以上组精液质量异常率显著高于开车 8年以下组 (P <0 .0 5 )。 结论 :司机职业可引起男性精液质量异常。 相似文献
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Luca Boeri Paolo Capogrosso Walter Cazzaniga Eugenio Ventimiglia Edoardo Pozzi Federico Belladelli Nicolò Schifano Luigi Candela Massimo Alfano Filippo Pederzoli Costantino Abbate Emanuele Montanari Luca Valsecchi Enrico Papaleo Paola Viganò Patrizia Rovere-Querini Francesco Montorsi Andrea Salonia 《European urology》2021,79(2):234-240