TREATMENT OF ACUTE PANCREATITIS WITH LIYI TANG -A Report of 50 Cases

Fifty cases of acute pancreatitis (AP) were treated with LIYI TANG (Decoction for AP) as the treatment group, and the other 50 cases of the disease with Western drugs as the control group. The results of one-week clinical observation showed that, in the treatment group, 43 cases were cured, 3 markedly effective, 2 improved and 2 ineffective; while in the control group, 32 cases were cured, 5 markedly effective, 4 improved, and 9 ineffective, showing a statistically significant difference in therapeutic effects between the two groups (P< 0.05).     

Clinical Observation on Cervical Spondylopathy of the Vertebroarterial Type Treated by Electro-acupuncture

Objective: To observe the clinical therapeutic effects of electro-acupuncture in the treatment of cervical spondylopathy of the vertebroarterial type. Methods: According to the consulting order, the patients were randomly divided into a treatment group (29 cases treated with electro-acupuncture), and a control group (28 cases treated with simple acupuncture). 20 treatments were given to patients in both groups. Results: The markedly effective rate of the treatment group was 75% and that of the control group was 61.54% (P<0.05). Conclusion: Electro-acupuncture has a better therapeutic effect than the simple acupuncture in the treatment of cervical spondylopathy of the vertebroarterial type.     

Seventy-two Cases of Antidiabetic-Induced Hepatopathy Treated by Huatan Yigan Decoction

In order to observe the therapeutic effects of Huatan Yigan Decoction (化痰益肝汤 Decoction for resolvingphlegm and replenishing the liver) on antidiabetic-induced hepatopathy,129 cases were divided into twogroups,72 cases in the treatment group were administrated with Huatan Yigan Decoction and 57 cases inthe control group with the liver-protecting drugs.Their liver function,plasma prothrombin time (PT),bloodurea nitrogen and symptoms of the patients before and after treatment were observed during the threetherapeutic courses.Results:The total effective rate and cured rate of the treatment group manifested anobvious difference in comparison with those of the control group (P<0.05 or P<0.01).Even though the liverfunction,blood urea nitrogen (BUN) and symptoms in both groups were improved markedly,theseindicators in the treatment group were improved more markedly than those in control group (P<0.01).Noadverse effect was found during the treatment.Conclusion:Huatan Yigan Decoction shows a repair actionon hepatic injury.     

Thirty Cases of Obsession Treated by Point-Stimulation and with Small Dose of Chlorimipramine

Objective: To investigate the clinical therapeutic effects of point-stimulation for obsession. Methods: Sixty cases of obsession were divided into two groups: a control group of 30 cases treated with chlorimipramine (Ch1), and a treatment group of 30 cases treated by point-stimulation (PS) plus chlorimipramine (PS Chl). The therapeutic effects and side-effect were evaluated according to the criteria set in Yale-Brown Obsession Scale (Y-BOCS), Hamilton's depression scale (HAMD), brief psychiatric rating scale (BPRS) and treatment emergent symptom scale (TESS). Results: The cure rate and markedly effective rate were respectively 26.7% and 56.6% in the control group, and 43.3% and 50% in the treatment group, suggesting that the therapeutic effect in the treatment group was better than that in the control group. The incidence of adverse side-effects was 73.33% in the control group and 46.67% in the treatment group, with a significant difference between the two groups (P<0.05). Conclusion: Point-stimulation plus small dose of chlorimipramine was superior to the simple chlorimipramine treatment, indicating that the combined method was more effective and safe for obsession with less side effects.     

Seventy-two Cases of Antidiabetic-Induced Hepatopathy Treated by Huatan Yigan Decoction

In order to observe the therapeutic effects of Huatan Yigan Decoction (化痰益肝汤 Decoction for resolving phlegm and replenishing the liver) on antidiabetic-induced hepatopathy, 129 cases were divided into two groups, 72 cases in the treatment group were administrated with Huatan Yigan Decoction and 57 cases in the control group with the liver-protecting drugs. Their liver function, plasma prothrombin time (PT), blood urea nitrogen and symptoms of the patients before and after treatment were observed during the three therapeutic courses. Results: The total effective rate and cured rate of the treatment group manifested an obvious difference in comparison with those of the control group (P＜0.05 or P＜0.01). Even though the liver function, blood urea nitrogen (BUN) and symptoms in both groups were improved markedly, these indicators in the treatment group were improved more markedly than those in control group (P＜0.01). No adverse effect was found during the treatment. Conclusion: Huatan Yigan Decoction shows a repair action on hepatic injury.     

CLINICAL STUDY ON 118 CASES OF ULCERATIVE COLITIS TREATED BY INTEGRATION OF TRADITIONAL CHINESE AND WESTERN MEDICINE

118 cases of ulcerative colitis were treated by integration of traditional Chinese andWestern medicine. Another 86 cases of ulcerative colitis were treated by simple westerndrugs as controls. The therapeutic effects for both groups were observed and comparedafter two therapeutic courses of 40 consecutive days. As a result, 39 cases were cured, 60cases improved and 19 cases failed, with a total effective rate of 84% in the treatmentgroup; in the control group, 15 cases were cured, 37 cases improved and 34 cases failed,with a total effective rate of 60.5%. Statistically, the difference was very significant(P<0.01). It can be concluded that treatment of ulcerative colitis by the integrated methodis superior to that by simple western drugs.     

Clinical Observation on 930 Child Epilepsy Cases Treated with Anti-epilepsy Capsules

1090 cases of child epilepsy were divided randomly into two groups:the treatment group(930 cases treatedwith anti-epilepsy capsules)and the control group(160 cases treated with luminal).The results showed thatin the treatment group,534 cases were markedly effective,241 effective,96 improved,46 ineffective,and 13aggravated,with a total effective rate of 83.33%;while in the control group,64 cases were markedlyeffective,19 effective,38 improved,29 ineffective,and 10 aggravated,with a total effective rate of 51.88%.The treatment group showed an obviously higher total effective rate than that in the control group(P<0.01).After treatment,cases in the two groups all had lower frequency of epilepsy attacks and shorter duration ofeach attack as compared with that before treatment(P<0.01),but the situation was obviously better in thetreatment group.The anti-epilepsy capsules had very good effect on various types of epilepsy,especially onautonomic epilepsy and on epilepsies due to wind,phlegm,or terror as differentiated in TCM.Aftertreatment,the recovery rate shown by EEG examination was 54.3% in the treatment group,while 38.4% inthe control group,the former being obviously higher than the latter(P<0.01).     

Clinical Observation in 31 Cases of Chronic Bronchitis at Remission Stage Treated with Bufei Keli

To observe the therapeutic effects of a Chinese drug Bufei Keli (补肺颗粒 granules for invigorating thelung) in the treatment of chronic bronchitis at remission stage, 62 cases were randomly divided into atreatment group (treated with Bufei Keli) and a control group (treated with Yupingfeng Keli 玉屏风颗粒).The results turned out to be that the short-term clinically controlled and markedly effective rate was77.42% and the long-term relapse-resisting markedly effective rate was 74.2% in the treatment group,which were obviously higher than 45.16% and 38.71% respectively in the control group (P<0.05). And theincrease in contents of SOD and CD_3 and the decrease in LPO content in the treatment group were alsobigger than that in the control group (P<0.01). It is therefore concluded that Bufei Keli can improve qideficiency syndrome and raise the immunity of patients with chronic bronchitis, hence its effect ofresisting relapse of chronic bronchitis.     

Clinical Observation in 45 Cases of Hemorrhagic Apoplexy of the Acute Stage Treated by Promoting Blood Circulation and Removing Blood Stasis

To explore the therapeutic effects of the method of promoting blood circulation and removing blood stasison hemorrhagic apoplexy of acute stage,45 cases were treated by the method and observed for theirconscious state and motor function,which were compared with 40 cases treated with regular western drugs.The results showed that the effective rate in the treated group was 82.2% and that in control group 60% witha significant difference(P<0.05) between the two groups.In the treated group,the scores of the consciousstate and the motor function after treatment were elevated dramatically(P<0.01),indicating a much bettereffect in the treated group than in the control group.     

Clinical Observation on Acupuncture Treatment in 35 Cases of Diabetic Gastroparesis

In order to observe the therapeutic effects of acupuncture on diabetic gastroparesis, 80 cases were dividedrandomly into 3 groups. In addition to the routine treatment for diabetes, 35 cases in the treatment groupwere additionally treated with acupuncture, and 25 cases in the control group 1 with domperidone, while20 cases in the control group 2 with nothing. The three groups were all observed for 25 days. The resultsturned out to be that the total effective rate in the treatment group reached 94.2%, that in the control group1, 72%, and in the control group 2, 40%, the treatment group showing a better therapeutic effect than theother two control groups (P<0.05, P<0.01). It can be concluded that in addition to the routine treatment forcontrolling blood sugar, acupuncture can give quite good therapeutic effects on diabetic gastroparesis.     

A randomized controlled single-blind clinical trial on 84 outpatients with psoriasis vulgaris by auricular therapy combined with optimized Yinxieling Formula (银屑灵优化方)

Objective:To explore the therapeutic effect of auricular therapy combined with optimized Yinxieling Formula(银屑灵优化方) on psoriasis vulgaris.Methods:A randomized controlled single-blind clinical trial on 84 outpatients with psoriasis vulgaris was conducted.The patients were randomized to a treatment group(43 cases treated by auricular therapy combined with optimized Yinxieling Formula) and a control group (41 cases treated by optimized Yinxieling Formula alone) according to a random number generated by SPSS 17.0 software.The treatment duration for both groups was 8 weeks.The therapeutic effect was comprehensively measured by the primary outcome measure[Psoriasis Area and Severity Index(PASI) reduction rate]and the secondary outcome measure[PASI,Visual Analogue Scale(VAS),Dermatology Life Quality Index(DLQI), Self-rating Depression Scale(SDS),and Self-rating Anxiety Scale(SAS)].The outcomes of both groups were obtained and compared before and after the intervention.Results:The PASI reduction rate in the treatment group was 74.4%(32/43),which was higher than that in the control group(36.6%,15/41,P<0.01).The PASI scores decreased in both groups after treatment and was lower in the treatment group compared with the control group (P<0.01).With stratified analysis,there were significant differences between the PASI scores in the following subgroups:age 18-30,baseline PASI>10 and stable stage(P<0.05).DLQI decreased in both groups on some categories after treatment,but there were no significant differences between the two groups in SDS,SAS and VAS(P>0.05).No obvious adverse reactions were found in either group.Conclusion:The therapeutic effect of auricular therapy combined with Optimized Yinxieling Formula was superior to Optimized Yinxieling Formula alone with no obvious adverse reaction.     

Forty-six Cases of Acute Cerebral Infarction Treated with the Combined Use of Acupuncture and Drugs

Objective: To observe the clinical therapeutic effects of treatment for acute cerebral infarction with the combined use of acupuncture and drugs, and study the therapeutic mechanism. Methods: 88 cases of acute cerebral infarction were divided randomly into two groups, a treatment group of 46 cases treated with acupuncture, Danshen Zhushe Ye (丹参注射液 Saliva Injection) and routine western drugs and a control group of 42 cases treated simply with drugs. The therapeutic effects were evaluated based on the evaluation criteria for damage of the nerve function. Observation was also made on changes in the skull CT images, and in the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-px), and nitric oxide synthase (NOS) in serums, and levels of malondialdehyde (MDA) and nitric oxide (NO) in serums. Results: After treatment for 15 days, the total effective rate of the treatment group reached 80.43%, while that of the control group was 61.90%, showing significant differences. The effective rate shown by the skull CT images of the treatment group was 51.61%, while that of the control group was 45.16%, showing no significant differences. But as compared with the control group, the activities of SOD and GSH-px in serums were significantly enhanced, and the levels of MDA and NO, and activity of NOS in serums were significantly decreased in the treatment group. Conclusion: The prompt acupuncture treatment of acute cerebral infarction can markedly raise the clinical therapeutic effects, improve the activity of SOD and GSH-px in serums, lower down the level of MDA in serum, and markedly decrease NO level and NOS activity in serums.     

External Application of Chinese Drugs on Acupoint Shenque Combined with Salpingostomy for Treatment of Sterility Caused by Obstruction of the Fallopian Tube——A Clinical Report of 45 Cases

Objective： To observe the therapeutic effect of external application of Chinese drugs on acupoint Shenque （CV 8） combined with salpingostomy for treatment of sterility caused by obstruction of the fallopian tube. Method： 75 cases were randomly divided into the following 2 groups. Forty-five patients in the treatment group were treated with external application of Chinese drugs on acupoint Sbenque （CV 8） combined with salpingostomy, while 30 patients in the control group were treated with salpingostomy only. Results： The results showed that in the treatment group, 26 cases were cured, 11 cases improved, and 8 cases failed, with a total effective rate of 82.22%; while in the control group, 14 cases were cured, 7 cases improved, and 9 cases failed, with a total effective rate of 70.00%. There is a significant difference in the total effective rate between the two groups （P〈0.05）. Conclusion： The therapeutic effect of external application of Chinese drugs on acupoint Shenque combined with salpingostomy is better than that of salpingostomy only.     

Frequent Ventricular Extrasystole Treated by Needling Neiguan （PC 6） plus Oral Administration of Mexiletine——A Report of 30 Cases

Purpose:To observe the therapeutic effect of needling at Neiguan(PC 6)plus oral administration ofmexiletine.Methods:60 cases of frequent ventricular extrasystole were randomly divided into two groups:a treatment group,and a control group.In the control group,mexiletine was orally administered,and in thetreatment group needling at bilateral Neiguan(PC 6)plus oral administration of mexiletine were given.2weeks of treatments constituted a therapeutic course.Results:Of the 30 cases in the treatment group,23cases were markedly effective,5 cases improved,and 2 cases failed;while in the control group 16 caseswere markedly effective,8 cases improved,4 cases failed,and 2 cases aggravated.The total effective ratesof 90.3% and 80.0%,respectively in the treatment and control groups showed a very significant differencebetween the two groups(P<0.01).Conclusion:Needling at bilateral Neiguan(PC 6)may enhance thetherapeutic effect for frequent ventricular extrasystole.     

A Clinical Study on the Effects and Mechanism of Xuebijing Injection(血必净注射液)in Severe Pneumonia Patients

Objective: To observe the effects of Xuebijing Injection (血必净注射液) in patients with severe pneumonia, and to explore the mechanism. Methods: Eighty cases of severe pneumonia are randomly assigned to the Xuebijing treatment (forty cases) and the control group (forty cases), with the same routine therapy provided in both groups. Clinical effective rates, inflammatory factors and organ function were observed in both groups. Results: The effective rate was higher in Xuebijing group than that of the control group (80.0% vs. 67.5%, P<0.05). As compared with the control group, the LDH, α1-AG, α1-AT levels and the peak body temperature decreased markedly with the Xuebijing treatment going, and the secretion of TNF-α, IL-6, IL-8 was suppressed in Xuebijing group; but no significant difference was found in leptin level. Conclusion: Xuebijing Injection may show a protective effect in patients with severe pneumonia. The mechanism is possibly with the decreased secretion of TNF-α, IL-6, and IL-8.     

A Multicentral Randomized Control Study on Clinical Acupuncture Treatment of Bell's Palsy

To confirm the clinical therapeutic effects of acupuncture and moxibustion on Bell's palsy.Methods:480 cases from 4 hospitals were enrolled for this study,among whom 439 cases completed thewhole course of the study.The patients were randomly divided into the following 3 groups,a controlgroup(treated with prednisone,vitamin Bl,vitamin B_(12)and dibazol),an acu-moxibustion group(treatedwith filiform needle plus moxibustion),and a basic treatment plus acu-moxibustion group(treated withoral medicine like those in the control group plus acupuncture,and with moxibustion like in theacu-moxibustion group).The whole treatment course lasted 4 weeks.The therapeutic effects wereevaluated according to the symptoms and signs,House-Brackmann grading scale and facial disabilityindexes(FDI).Results:All the 4 centers(hospitals)completed this study well,with no statisticallysignificant difference found among the 4 centers in therapeutic effects.The patients with differentconditions were well distributed in the 3 groups,thus the basic general,data were comparable(P>0.05).The therapeutic effects of the two treatment groups were better than the control group(respectivelyP<0.05 and P<0.01),and it was the best in the acu-moxibustion group(P<0.01).Conclusion:Acupuncture and moxibustion may exert definite therapeutic effects on Bell's palsy,better than that ofthe basic treatment group or the basic treatment plus acu-moxibustion group.     

A randomized controlled trial comparing total glucosides of paeony capsule and compound glycyrrhizin tablet for alopecia areata

Objective:To observe the efficacy and safety of total glucosides of paeony capsule(TGPC)in patients with mild and moderate alopecia areata.Methods:A total of 86 outpatients were randomly allocated into two groups of TGPC(treatment,44 cases)and compound glycyrrhizin tablet(control,42 cases).The treatment group was given oral TGPC,three times daily and 600 mg per time;the control group was given oral compound glycyrrhizin tablets,three times daily and 50 mg per time.In addition,both groups were given 10 mg of vitamin B2 and tapped the bold patches with massage.The treatment course was three months for both groups.Peripheral blood T-cell subsets(CD3~+CD4~+,CD3~+CD8~+,Th,Ts,Th/Ts)of 10 patients randomly selected from each group respectively were tested before and after three months of treatment.The effectiveness and adverse reaction of all cases were observed each month.The safety was evaluated according to the incidence rate of adverse reaction. Results:In the treatment group,the cured and markedly effective rate was 36.36%(16/44),50.00%(22/44)and 68.18%(30/44)at the end of first,second and third month of treatment,respectively,and the incidence rate of adverse reaction was 13.64%(6/44).In the control group,the cured and markedly effective rate was 38.10% (16/42),57.14%(24/42)and 71.43%(30/42),respectively,and the incidence rate of adverse reaction was 16.67%(7/42).The cured and markedly effective rate and the incidence rate of adverse reaction were similar in both groups(P>0.05).TGPC and compound glycyrrhizin tablet can inhibit CD3~+CD4~+ and CD3~+CD8~+,and decrease the ratio of Th/Ts(P<0.05).Conclusion:TGPC is effective and safe in the treatment of alopecia areata.     

Clinical observation on the treatment of childhood refractory idiopathic thrombocytopenic purpura with Dihuang Zhixue Capsule (地黄止血胶囊)

Objective： To observe the clinical effect of Dihuang Zhixue Capsule （地黄止血胶囊, DZC, a Chinese preparation for cooling blood and dispelling toxic substances） in the treatment of childhood refractory idiopathic thrombocytopenic purpura （RITP）, with cyclosporin A （CsA） used as the control. Methods： Forty-one children of RITP were randomized into the treated group and the control group. The 21 patients in the treated group were orally given 2 to 3 DZC capsules each time, thrice a day and the 20 in the control group were given 3 mg/kg CsA per day, with 3 months as one therapeutic course. The therapeutic efficacy, platelet count and adverse reaction in the two groups were compared at the end of the course. Results： （1） In the treated group, 1 （4.8%） patient was evaluated as cured, 3 （14.3%） as markedly effective, 5 （23.8%） as effective, 5 （23.8%） as improved, 7 （33.3%） as ineffective, with the total effective rate being 66.7%; while in the control group, the corresponding numbers were 0. 2 （10.0%）, 2 （10.0%）, 3 （15.0%）, 13 （65.0%） and 35.0%, respectively, showing statistical significance in difference between the total effective rates of the two groups （ Х^2=4.11, P=0.0426）. （2） As compared with the baseline, the platelet count increased in both groups after 2 months＇ treatment （P〈0.05）. After 3 months＇ treatment, the platelet count was higher in the treated group than in the control group （P〈0.05）. （3） The improvement of hemorrhage in the treated group after 8 weeks＇ treatment was better than that in the control group （P〈0.05）. （4） No apparent adverse reaction was observed in the treated group, while in the control group, hirsutism was shown in 15 cases; gingival hyperplasia in 10; digestive reaction in 5, liver function impairment in 5, hypertension in 2 and renal impairment in 2. Conclusion： The therapeutic efficacy of DZC is better than that of CsA, and DZC shows good compliance but brings no obvious adver     

Clinical Observation on Treatment of Acute Gouty Arthritis byTongfengkang(痛风康)

Objective To objectively evaluate the clinical therapeutic effect of Tongfengkang (TFK) in treating acute gouty arthritis. Methods: Adopting randomized single blinded controlled trial, the 40 patients were equally divided into two groups. The tested group was treated with TFK, the control group was treated with indomethacin and allopurinol, the therapeutic course for both groups was 10 days. Results: The clinical cure rate in the tested group and the control group was 30% and 35% respectively, and the total effective rate 90% and 95% respectively, with no significant difference between the two groups (P>0.05).The scores of blood uric acid and symptom significantly lowered in both groups after treatment (P <0.01), but showed no significant difference between them (P>0.05). Adverse reaction to the treatment was shown in 3 patients in the control group. Conclusion: The therapeutic effect of TFK is similar to that of indomethacin plus allopurinol but with less adverse reaction, it is an effective and safe re