Agrin in the CNS: a protein in search of a function?

The extracellular matrix molecule agrin mediates the motor neuron induced accumulation of acetylcholine receptors (AChR) at the neuromuscular junction. Agrin is also present in the CNS. However, while its spatiotemporal pattern of expression is consistent with a function in neuron-neuron synapse formation, it also suggests a role for agrin in other aspects of neural tissue morphogenesis. Here we review the data supporting these synaptic and non-synaptic functions of agrin in the CNS. The results of studies aimed at identifying a neuronal receptor for agrin (NRA) and its associated signal transduction pathways are examined. Possible roles for agrin in the etiology of diseases affecting the brain are also discussed.     

Distinct cytokine profile in SIDS brain: a common denominator in a multifactorial syndrome?

Cytokines modify neuronal function. Dysfunction in vital centers is reported in sudden infant death syndrome (SIDS). The authors detected high neuronal interleukin (IL)-1beta immunoreactivity in the arcuate and dorsal vagal nuclei in SIDS. This IL-1 overexpression might contribute to molecular interactions in brainstem neurovegetative centers, causing disturbed homeostatic control of cardiorespiratory and arousal responses, possibly leading to SIDS.     

Are parental gender role beliefs a predictor of change in sexual communication in a prevention program?

This study examined if pre-intervention maternal gender role beliefs predict change in sexual communication in a sexual risk behavior prevention program designed to increase parent-pre-adolescent communication about sex. A sample of 281 African American fourth and fifth graders and their mothers participated in the five-session program and completed computerized questionnaires at baseline, postintervention, and 6-month follow-up. Based on mother report, more egalitarian maternal gender role beliefs predicted greater increases in parent-pre-adolescent communication about sex at postintervention. Based on pre-adolescent report, similar findings emerged at the 6-month follow-up, but only for boys. The relationship of maternal gender role beliefs to changes in sexual communication was not accounted for by maternal comfort with sexual communication with their pre-adolescents. The implications of maternal gender role beliefs in a prevention program designed to increase communication about sexual topics are considered.