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1.
Linda Hermer-Vazquez 《Journal of Combinatorial Optimization》2008,15(3):242-256
Primary objective: To determine the relative uses of neural action potential (‘spike’) data versus local field potentials (LFPs) for modeling
information flow through complex brain networks. Hypothesis: The common use of LFP data, which are continuous and therefore more mathematically suited for spectral information-flow
modeling techniques such as Granger causality analysis, can lead to spurious inferences about whether a given brain area ‘drives’
the spiking in a downstream area. Experiment: We recorded spikes and LFPs from the forelimb motor cortex (M1) and the magnocellular red nucleus (mRN), which receives
axon collaterals from M1 projection cells onto its distal dendrites, but not onto its perisomatic regions, as rats performed
a skilled reaching task. Results and implications: As predicted, Granger causality analysis on the LFPs—which are mainly composed of vector-summed dendritic currents—produced
results that if conventionally interpreted would suggest that the M1 cells drove spike firing in the mRN, whereas analyses
of spiking in the two recorded regions revealed no significant correlations. These results suggest that mathematical models
of information flow should treat the sampled dendritic activity as more likely to reflect intrinsic dendritic and input-related
processing in neural networks, whereas spikes are more likely to provide information about the output of neural network processing. 相似文献
2.
This article aims to understand the role played by resource utilization levels as a driver of alliance portfolio evolution over time. Based on our theoretical framework and on a case study of Qatar Airways (199.3–2010), we develop insights into the micro-dynamics of resource structuring in firms that possess an alliance portfolio. Our research shows that firms can create either their own or network resources with different deployment modes according to their resource utilization levels to remain profitable. We also emphasize that optimized resource utilization is a key driver of resource-structuring efforts in firms. Finally, we show that based on the focal firm's life cycle phase, the level of resource utilization changes and leads to various resource-structuring mechanisms that can be observed at the alliance portfolio level. 相似文献