腹主动脉瘤的治疗

目的 探讨腹主动脉瘤(AAA)的治疗方法。方法 回顾性分析26例AAA的临床资料。结果 26例中夹层动脉瘤3例，真性动脉瘤21例，动脉瘤破裂后再形成的假性动脉瘤1例，动脉瘤穿破十二指肠空肠曲形成腹主动脉肠瘘1例。病变累及肾动脉平面以上者3例，肾动脉平面以下者23例：病变仅累及腹主动脉者4例，病变除累及腹主动脉外，尚合并有单侧或双侧髂总动脉瘤者／2例，合并双侧髂总动脉瘤及一例或双侧髂内动脉瘤者5例，合并一侧髂总、髂内、髂外动脉瘤1例，合并有双侧髂总、髂内、髂外动脉瘤1例。施行紧急手术治疗3例，择期手术治疗14例，施行支架型人工血管腔内微创治疗7例，未手术2例。术后发生并发症3例，无瘫痪、下肢动脉栓塞等发生。术中及术后30d死亡率为3．8％(1例)。支架型人工血管治疗的7例无漏血、移位等并发症发生，均痊愈出院。22例随访3个月至4年，均存活良好。结论 AAA的腔内血管外科治疗具有创伤小，术石恢复快，并发症少等优点，有条件行支架型人工血管作腔内治疗的应优先考虑腔内治疗，传统手术方法在技巧等方面的改进有利于提高手术的成功率，并能为不具备腔内治疗条件的患者解除疾患。     

主动脉疾病现代治疗进展

腹主动脉瘤(AAA)治疗 一、AAA治疗的历史及近况 AAA的外科手术治疗已经有50余年的历史,AAA切除,人工血管替换术已经是成熟的治疗手段,远期效果良好.AAA的腔内修复( endovascular aortic repair,EVAR)是用支架型人工血管隔绝瘤体内血流,防止动脉瘤破裂,从而达到治疗的目的.1964 年Dotter 医生首先提出腔内治疗动脉瘤的概念,1991 年Parodi 用聚四氟乙烯人造血管材料,固定在Palmaz支架上,制成第一代人造血管内支架,成功完成了第一例AAA的腔内治疗,是血管外科史上的一个里程碑[1].     

腹主动脉瘤腔内治疗进展

腹主动脉瘤(abdominal aortic aneurysms,AAA)是指腹主动脉的局部或普遍扩张,主动脉直径较正常直径增大50％以上的病理改变.随着瘤体的不断增大,其破裂风险不断增高[1].1951年Dubost首次成功进行了AAA切除术,成为AAA外科治疗的里程碑.1991年阿根廷血管外科医生Parodi首次采用支架-人工血管复合体治疗AAA并取得成功[2];开创了AAA腔内治疗的新纪元.随后腔内技术治疗AAA在世界范围内迅速开展,使AAA的治疗发生了根本的变革.本文对AAA最新的腔内治疗热点及进展进行综述.     

腹主动脉瘤腔内修复术并发内漏的防治

腹主动脉瘤(abdominal aortic aneurysm,AAA)是指腹主动脉局限性扩张,直径为邻近正常动脉1.5倍以上的病理性改变,其致命的并发症是破裂.自1952年以来,动脉瘤切除和人工血管原位移植术曾是治疗AAA唯一有效的方法.1990年,阿根廷学者Parodi制成直型腔内移植物(stent-graft,SG),首次对AAA患者进行腔内治疗.1991年,俄罗斯医师Volodos报道了29例AAA腔内隔绝术获得成功.1994年Yusof等报道了分叉型覆膜支架治疗AAA.1997年,景在平教授成功实施了国内首例腹主动脉瘤的腔内修复术(endovascular aneurysm repair,EVAR).EVAR至今已有20年的历史,国内已广泛开展此项技术;由于其创伤小,恢复快的特点,已逐步取代了一部分AAA的传统开腹手术.但是,内漏(endoleak)仍是一个有待解决的难题.     

腹主动脉瘤的腔内治疗现状

腹主动脉瘤(abdominal aortic aneurysm,AAA)是指腹主动脉局限性扩张超过正常直径的50%,常发生于老年人,破裂是其最常见、最凶险的并发症,在65岁以上男性的死亡原因中居第10位[1]。其经典的治疗方式是AAA(或加髂动脉)切除、人工血管置换术,但手术创伤大,不适合存在心、肺、肾等严重合并症的高危患者。自1991年Parodi等[2]报道了第一例人工血管支架腔内治疗成功至今,AAA腔内修复术(endovascul araortic repair,EVAR)在全世界范围内得到了广泛的重视及推广,本文就近年来     

如何做好腹主动脉瘤腔内修复术

腹主动脉瘤（abdominal aortic aneurysm,AAA）为血管外科临床重要疾病之一,随瘤体增大,其增长速度加快,破裂风险增加,破裂AAA的病死率高。多数AAA患者因高龄或伴有其他严重内科疾病而不适于行开放手术。1991年,阿根廷Parodi等首次报道用支架型人工血管（后简称“支架”）成功治愈AAA,开创了AAA腔内修复治疗（endovascular aneurysm repair,EVAR）的新时代。以下将就如何做好AAA的EVAR的相关问题作一探讨。     

腔内隔绝术微创治疗肾下腹主动脉瘤

我科2003年6月至12月应用微创人造血管腔内隔绝术（endovascular graft exclusion，EVGE）治疗肾下腹主动脉瘤（abdominal aortic aneurysms，AAA）4例，现报道如下。     

复杂瘤颈的近肾腹主动脉瘤腔内修复中烟囱技术的应用

目的探讨瘤颈解剖复杂的近肾腹主动脉瘤(juxtarenal aortic aneurysms,JAA)腔内修复(endovascular aneurysmrepair,EVAR)中应用烟囱技术的价值。方法 2007年1月～2011年10月,对7例瘤颈复杂的JAA采用EVAR治疗。由于瘤颈解剖结构不适于标准的腔内修复方案,术中自肱动脉穿刺预先于可能被覆膜支架主体覆盖的肾动脉置入导丝,置入修复腹主动脉瘤的覆膜支架主体后造影明确肾动脉覆盖情况,于相应肾动脉置入自膨支架或球囊扩张支架,以延长瘤颈长度使之符合EVAR要求,并有效保护肾动脉(即烟囱技术),然后再完成标准EVAR操作。结果 7例手术全部获成功。7例使用9枚肾动脉支架,其中5枚球扩支架,4枚自膨支架。腔内治疗最后的造影显示:腹主动脉瘤(abdominal aortic aneurysm,AAA)瘤腔隔绝良好,肾动脉血流良好。术中1例近端Ⅰ型内漏,近端增加Cuff后内漏消失;1例造影显示少量的Ⅱ型内漏,无须处理。7例随访1～52个月,平均11.6月:1例术后2个月因心功能衰竭死亡;1例Ⅱ型内漏术后3个月随访内漏消失;肾动脉烟囱支架均保持通畅。结论对于不适宜行开腹手术治疗的瘤颈解剖不佳的JAA,烟囱技术是传统EVAR技术的有效补充,远期效果及肾动脉支架长期通畅性尚需要进一步观察。     

腹主动脉瘤腔内治疗现状

1991年,Parodi等发明人工血管内支架（stent graft,SG）并用于临床成功治愈腹主动脉瘤（abdominal aortic aneurvsm,AAA）,此后腹主动脉瘤腔内治疗（endovascular abdominal aortic aneurysm repair,EVAR）取得迅速发展。由于EVAR避免了传统开腹手术创伤大和出血多的缺点,使高龄或伴有心、肺、肝、肾功能不全的患者获得积极治疗的机会。一般来讲,腔内治疗主要是指肾下型腹主动脉瘤。     

腹主动脉瘤的治疗方法与远期效果评价——腹主动脉瘤的治疗方法和中远期效果评价

随着人口老龄化，以及高血压、动脉硬化等高危因素的增加，腹主动脉瘤（abdominal aortic aneurysm．AAA）的发病率也随之增高。最新数据表明美国每年约有30，000人死于AAA破裂，一旦破裂死亡率高达90％，因此早期诊断，积极治疗，防止破裂意义重大。AAA治疗方法主要包括开放手术和腔内修复术（endovascular aortic repair，EVAR）。[第一段]     

Clamp before you cut: Proximal control of ruptured abdominal aortic aneurysms using endovascular balloon occlusion--Case reports

While the mortality rate for elective abdominal aortic aneurysm (AAA) repair has declined over the last several decades, the rate for ruptured abdominal aortic aneurysm (RAAA) has unfortunately remained disturbingly high. Undiagnosed aneurysms may present with little warning until abdominal pain, syncope, and hypotension signify rupture. Fifty percent of patients with ruptured aneurysms die before reaching a medical facility, and their survival is highly dependent on hemodynamic stability at presentation. The degree of rupture containment and comorbid status of the patient determine hemodynamic stability. Endovascular stent grafting has significantly improved perioperative morbidity and mortality rates for elective AAA repair, and some of the same endovascular techniques can be used to obtain proximal control in patients presenting with RAAA. We describe 3 consecutive cases of RAAA where proximal control was obtained using a percutaneously placed, transfemoral aortic occlusion balloon before induction of anesthesia.     

主动脉病变的手术治疗与腔内血管外科治疗

目的 探讨主动脉病变的手术治疗和腔内血管外科治疗方法。方法 回顾性分析45例胸腹主动脉病变外科治疗的临床资料。结果 男37例，女8例。年龄2l～85(平均年龄64、7)岁。其中胸主动脉夹层ll例；降主动脉夹层破裂并假性动脉瘤形成伴椎骨破损2例；肾上，下型腹主动脉瘤各为3，23例；腹主动脉瘤破裂2例；腹主动脉瘤空肠瘘l例；腹主动脉外伤性破裂3例。45例患者中腔内治疗者l8例，25例行人工血管置换治疗，3例行腹主动脉修补。围手术期死亡率为6．7％(3／45)。随访36例，随访时间2个月～4年，均生存良好。结论 腔内血管外科治疗有着创伤小，术后恢复快，并发症少等优点，有条件行支架型人工血管腔内治疗的可优先考虑腔内治疗。传统手术方法在技巧等方面的改进有利于提高手术的成功率，并能为不具备腔内治疗条件的患者解除疾苦。     

Mortality,Morbidity, and Costs of Ruptured and Elective Abdominal Aortic Aneurysm Repairs in Nova Scotia,Canada

Ruptured abdominal aortic aneurysms (RAAA) have a 78-94% mortality rate. If cost-effectiveness of screening programs for abdominal aortic aneurysms (AAA) are to be assessed, direct costs for RAAA repairs and elective AAA (EAAA) repairs are required. This study reports mortality, morbidity, and direct costs for RAAA and EAAA repairs in Nova Scotia in 1997-1998 and also compares Nova Scotia and U.S. costs. We performed a retrospective study of 41 consecutive RAAA and 48 randomly selected EAAA patients. Average total costs for RAAA repair were significantly greater than those for EAAA repair (direct costs: $15,854 vs. $9673; direct plus overhead costs: $18,899 vs. $12,324 [pricing in 1998 Canadian dollars]). Intensive care unit length of stay and blood product usage were the most substantial direct cost differentials ($3593 and $2106). Direct cost for preoperative testing and surveillance was greater in the EAAA group ($839 vs. $33). Estimates of U.S. in-hospital RAAA and EAAA repair costs are more than 1.5 times Nova Scotia costs. Direct in-hospital RAAA repair costs are $6181 more than EAAA repair costs. These in-hospital cost data are key cost elements required to assess the cost-effectiveness of various screening strategies for earlier detection and monitoring of AAA within high-risk populations in Canada. Further studies are required to estimate cost per quality-adjusted-life-year gained for various AAA screening and monitoring strategies in Canada.     

大动脉病变的外科手术治疗

目的　探讨大动脉病变的手术治疗方法。方法　回顾性分析 86例大动脉病变外科手术治疗的临床资料。其中胸腹主动脉瘤 3例 ;降主动脉夹层破裂并巨大假性动脉瘤形成椎骨破损 2例 ;腹主动脉局限性夹层破裂并假性动脉瘤形成 2例 ;腹主动脉瘤十二指肠空肠曲瘘并消化道大出血 1例 ;腹主动脉瘤破裂并休克 5例 ,腹主动脉外伤后破裂 3例 ;腹主动脉瘤和 /或并单或双侧髂动脉瘤2 1例 ;髂动脉瘤 6例 ;股动脉瘤 9例 ;髂或股动脉假性动脉瘤 2 1例 ;右锁骨下动脉和椎动脉起始部破裂并巨大假性动脉瘤形成 1例 ;左或右锁骨下动脉破裂并假性动脉瘤形成 3例 ;颈动脉瘤 2例 ,颈动脉假性动脉瘤 7例。行人工血管置换治疗 71例 ,自体静脉修补 3例 ,动脉破口修补术 12例。结果　术中及术后 3 0d死亡率为 3 .5 % ( 3 /86)。随访 73例 ,随访时间 1个月至 5年 ,除 1例腹主动脉瘤十二指肠瘘患者已死亡外 ,余均生存良好。结论　大动脉病变的外科手术治疗仍然是一种十分有效和经济实用的方法 ,在技巧等方面的改进有利于提高手术的成功率     

Rupture of abdominal aortic aneurysm (RAAA)--predictors of the early postoperative mortality

PURPOSE: To evaluate the main factors of the 30 days mortality rate of patients operated on for abdominal aortic aneurysm rupture (RAAA. PATIENTS AND METHOD: Univariate and multivariate analysis of various factors associated with RAAA was performed in a group of 73 patients operated on for RAAA between 1996-2001. RESULTS: The 30 days mortality rate was 35.6 %. The main factors of mortality were: misdiagnosis, cardio- pulmonary-cerebral resuscitation (CPCR) on admission, configuration of RAAA, number of blood transfusions, hypotension on admission (p < 0.0001) and duration of operation, type of reconstruction and hypertension in anamnesis (p < 0.01). Important factors (p < 0.05) of postoperative mortality were also low haemoglobin level on admission, abdominal aortic aneurysm (AAA) diameter and ischaemic heart disease in anamnesis. The probability of patient's death is the highest (p < 0.003), if factors like CPCR, number of blood transfusions and aneurysm diameter are combined (multivariate analysis, stepwise method). CONCLUSION: The early detection and surgical or endovascular elective treatment of AAA, the regular dispensation of patients with small AAA especially in hypertonics, the correct diagnosis of RAAA without time delay are the best tools for patients survival. The patient's chance for survival increases with highly trained prehospital resuscitation system and experienced team of vascular surgeons and anesthesiologists.     

Results of endoluminal grafting of abdominal aortic aneurysms are dependent on aneurysm morphology

The aim of this prospective study was to analyze the outcome of elective endoluminal grafting in patients with various morphologies of abdominal aortic aneurysms (AAA). Between May 1992 and May 1994, endoluminal repair of AAA was undertaken in 40 patients. After detailed imaging by means of CT scanning and arteriography, aneurysms were classified into one of two types according to the following criteria: type I (suitable for transfemoral implantation of a straight tube graft), AAA with a proximal neck (2 cm or longer), a distal neck (1.5 cm or longer), and an iliac artery diameter of 8 mm or greater (N=19); or type II (requiring tapered aortoiliac or bifurcated grafts or access through an iliac approach), AAA that did not fit the type I criteria (N=21). Radiographic guidance was used to pass the aortic endografts (38 Dacron and 2 PTFE) via a delivery sheath introduced through the femoral or iliac arteries into the aorta. The configuration of the aortic endografts was tubular in 26 patients, tapered aortoiliac in 11, and bifurcated in three. Successful endoluminal repair was achieved in 17 (89%) of 19 patients with type I AAA and in 15 (71%) of 21 patients with type II AAA. All failed endoluminal repairs proceeded to successful open repair, and there were no deaths during the period of hospitalization for the operation. The mean operative time and mean hospital stay were shorter in patients with type I AAA compared to patients with type II AAA. The incidence of postoperative complications was 37% in type I endoluminal repairs compared to 71% in type II endoluminal repairs. There was one cardiac death (procedure related) within 30 days, and there were three late deaths (one cardiac, one from liver failure in a type II AAA repair, and one from a ruptured esophagus in a type I repair). These preliminary results suggest that there is a better outcome in transfemoral endoluminal tube graft repair of aneurysms conforming to type I criteria compared to endoluminal repair of the more complex type II AAA.Presented at the Society for Vascular Surgery/International Society for Cardiovascular Surgery North American Chapter Meeting, Seattle, Wash., June 6–8, 1994.     

Long-term survival and late complications after repair of ruptured abdominal aortic aneurysms

Purpose:Long-term survival and late vascular complications in patients who survived repair of ruptured abdominal aortic aneurysms (RAAA) is not well known. The current study compared late outcome after repair of RAAA with those observed in patients who survived elective repair of abdominal aortic aneurysms (AAA). Methods:The records of 116 patients, 102 men and 14 women (mean age: 72.5 (8.3 years), who survived repair of RAAA (group I) between 1980 to 1989 were reviewed. Late vascular complications and survival were compared with an equal number of survivors of elective AAA repair matched for sex, age, surgeon, and date of operation (group II). Survival was also compared with the age and sex-matched white population of west-north central United States. Results:Late vascular complications occurred in 17% (20/116) of patients in group I and in 8% (9/116) in group II. Paraanastomotic aneurysms occurred more frequently in group I than in group II (17 vs. 8,p = 0.004). At follow-up, 32 patients (28%) were alive in group I (median survival: 9.4 years) and 53 patients (46%) were alive in group II (median survival: 8.7 years). Cumulative survival rates after successful RAAA repair at 1, 5, and 10 years were 86%, 64%, and 33%, respectively. These were significantly lower than survival rates at the same intervals after elective repair (97%, 74%, and 43%, respectively, p = 0.02) or survival of the general population (95%, 75%, and 52%, respectively,p < 0.001). Coronary artery disease was the most frequent cause of late death in both groups. Vascular and graft-related complications caused death in 3% (3/116) in group I and 1% (1/116) in group II. Cox proportional hazards modeling identified age p = 0.0001), cerebrovascular disease p = 0.009), and number of days on mechanical ventilation p = 0.01) to be independent prognostic determinants of late survival in group I. Conclusions:Late vascular complications after repair of RAAA were higher and late survival rates lower than after elective repair. These data support elective repair of AAA. As two-thirds of the patients discharged after repair of RAAA are alive at 5 years, aggressive management of RAAA remains justified. (J Vasc Surg 1998;27:813-20.)     

The true incidence of ruptured abdominal aortic aneurysms

The number of ruptured abdominal aortic aneurysms (RAAA) was documented over an 8-year-period in a known population age group. Patient figures were collected from the operative and post-mortem registers in the Worthing Health District. The overall mean incidence of RAAA was 13.9/100,000 patient years, although the incidence was noted to increase from 9.2 to 17.5/100,000 patient years during this period. The incidence in the male population rose from 4.7/100,000 for those in the fifth decade to 184.8/100,000 for those above 80. For patients undergoing operation, the peri-operative survival was 38%, however the overall survival was 11% as 64% of patients died at home. These figures demonstrate an increasing incidence of ruptured AAA. They also add support to the need for screening of asymptomatic abdominal aortic aneurysms and elective repair if the incidence and hence mortality is to be reduced.     

Simultaneous endovascular exclusion of thoracic aortic aneurysm with open abdominal aortic aneurysm repair.

BACKGROUND: The treatment of aneurysms at multiple sites within the aorta is problematic. METHODS: Between March 2002 and June 2003 in the Department of General, Vascular and Transplant Surgery, Medical University of Warsaw six patients with coexisting abdominal and descending thoracic aortic aneurysms underwent simultaneous open abdominal aortic aneurysm (AAA) repair and endoluminal thoracic aortic aneurysm (TAA) repair. The indication for a combined procedure was a diagnosed descending TAA and AAA with no significant risk factors for open aortic surgery or technical contraindications for endovascular treatment of TAA. RESULTS: One patient died in the peri-operative period while the other five patients all recovered well after surgery and were discharged with both aneurysms excluded. CONCLUSION: Endovascular treatment of TAA combined with a simultaneous open AAA repair is an efficient and relatively safe treatment modality in patients with TAA and AAA disqualified from endovascular repair. The fact that thoracotomy is not a necessity significantly lowers the complication rate in these patients.