抗菌药物与其它药物合用时引发或加重的不良反应

抗菌药物与其它药物联合应用产生相互作用(Drug Interaction,DU),包括药代动力学,药效学和药剂学3个方面.由于药物相互作用,可能引发或加重不良反应.医师和药师在临床实践中应注意及时发现和解决不良的药物相互作用和因此引起的药物不良反应.     

Direct contact with bone marrow stromal cells promotes the invasions of SHI-1 leukemia cells

Background Interactions of tumor cells with the microenvironment were deemed to promote the tumor invasion and metastasis.CXC chemokine receptor 4 (CXCR4) and extracellular matrix metalloproteinase ind...     

贯彻指南,重视冠心病的药物治疗

新近在美国心脏病学院(ACC)学术会上公布, New England Journal of Medicine电子版同日全文发表,美国最畅销报纸US today的2007年3月27日头版报道了对比经皮冠状动脉血管重建和根据指南强化药物治疗改善稳定性冠心病患者的预后(Clinical Outcomes Utilizing Percutaneous Coronary Revascuarizaton and Aggressive Guideline-driven Drug Evaluation,COURAGE)试验的结果,引起医学界与社会的关注。研究入选2287例严重但稳定的冠     

国外心脏病治疗最新动态报道

1贯彻指南,重视冠心病的药物治疗 新近在ACC学术会上公布，新英格兰医学杂志电子版同日全发表，美国最畅销报纸US today的2007年3月27日头版报道了对比经皮冠状动脉血管重建和根据指南强化药物治疗改善稳定性冠心病患的预后（Clinical Outcomes Utilizing Percutaneous Coronary Revascuarizaton and Aggressive Guideline-driven Drug Evaluation，COURAGE）试验的结果，引起医学界与社会的关注。研究人选2287例严重但稳定的冠心病患，均有心绞痛症状和心肌缺血的客观证据，冠状动脉造影显示在冠状动脉近端至少70％狭窄。[第一段]     

FDA acknowledges TCM belonging to whole medical systems

Recently, 2007, the U.S. Food and Drug Administration (FDA) issued a draft guidance for the industry, titled "Complementary and Alternative Medicine Products and Their Regulation by the Food and Drug     

EDITORIAL

On Apr 15th, 2000, we successively managed thesymposium on the Clinical Application of An-tibiotic Mechanism of Bacterial Drug Resistanceand New Drugs, which is cooperated hy North-China Pharmaceutical Co Prof. Mingwu Zhao presidedat this meeting in which 40 doctors attended.     

关于医学科研中的伦理审查的思考

<正>随着世界经济的不断进步、科技水平的不断提高,人类对健康的需求也日益增长,也促使医务工作者不断探索新的诊疗技术,企业加大新药、医疗器械等的研发。国家食品药品监督管理局(State Foodand Drug Administration,SFDA)在2003年颁布了《药物临床试验质量管理规范》(Good Clinical Prac-     

维生素D与慢性鼻炎

国际医学杂志《变态反应与临床免疫学新见》(Current Opinion in Allergy and Clinical Immunology)2012年第1期刊载一篇题为《维生素D与慢性鼻炎》的综述文章,探讨维生素D与慢性鼻炎及慢性鼻窦炎之间的关系。维生素D作为一种重要的营养成分已经广为人知,它负责调节人体内环境中钙和磷。在过去20年中,维生     

《美国家庭医生》(American Family Physician)三月份目次选登

Reducing the Risk of Adverse Drug Events in Older Adults降低老年患者中的药物不良事件风险Diabetic Ketoacidosis:Evaluation and Treatment糖尿病酮症酸中毒:评估和治疗Identification and     

长效骨质疏松药物的探索

华盛顿特区——于3月份，食品与药品管理局（the Food and Drug Administration，FDA）批准了每月服用一次的ibandronate，这项工作显著改善病人坚持骨质疏松治疗的能力。在临床试验中，检验骨质疏松药物的药物公司需要减少用药频率的趋势，已成为4月份第六次国际骨质疏松专题讨论会的最重要的内容。     

《Chinese Journal of Integrative Medicine》CONTENTS OF VOLUME 14,2008

Editorial Clinical Service of Chinese Medicine CHEN Ke-ji……14(3):163 Short Remark West Meets East-Observations on Integrative Medicine in Rheumatology from the USA H.Ralph Schumacher……14(3):165 How to Connect the Gap between Clinical Trials and Clinical Practice SHANG Hong-cai,et al……14(4):309     

高龄离休老干部多重用药现状及影响因素分析

目的 探讨高龄离休老干部多重用药现状及其影响因素。方法 回顾性收集并分析2019年12月至2021年12月空军第九八六医院保障的226例军队高龄老干部相关资料,根据其使用药物的数量分组：非多重用药（2~4种药物）组、多重用药（5种药物及以上）组。收集研究对象临床资料,采用logistic回归模型分析离退休老干部多重用药的影响因素,采用Excel软件建立数据库,筛选出使用排名靠前的十大常用药物类别;采用Lexicomp Drug Interactions数据库对药物-药物相互作用（DDIs）进行分析和评价。结果 logistic回归模型结果显示,文化程度（OR=1.783,P=0.012）、慢性病共病（OR=7.546,P<0.001）、用药依从性差（OR=6.430,P< 0.001）、有用药不良反应（OR=1.904,P=0.003）是离退休老干部多重用药的危险因素。高龄离休老干部DDIs发生频次最高的依次为降压药、心血管系统用药、抗凝药物和抗骨质疏松药物。结论 高龄离休老干部多重用药比例较高,文化程度、慢性病共病、用药依从性、用药不良反应是其多重用药的影响因素,临床应指导其有效地进行个体化用药。     

The relationship of CyclinD1 and estrogen receptor expression in the process of proliferation and metastasis in breast neoplasm

Cylin D1 play a very importantrole in the prolifi-ration of tumor cells.The purpose of this study wasto investigate the role of Cylin D1 and estrogen recep-tor ( ER) expression in breast carcinomas and theirrelationship.1　MATERIALSAND METHODS1 .1　 Clinical DataAll the 1 46cases of breast neoplasm were fe-males with age ranging from 1 8to 65 years ( average45 .34± 1 0 .39) .The enrolled in this study were5 6cases of benign breast mass including 44cases ofbreastfibroadenoma,1 2 case…     

DISEASE CAUSED BY CHEMICAL AND PHYSICAL AGENTS

930027 Clinical and chest radiological studieson 15 cases of acute phosgene poisoning.ZHUHanzhou(朱汉洲),et al.Jingjiang CountyPeople's Hosp,Jiangsu,214500.Chin J Tuberc& respir Dis 1992;15(4):231—232.A clinical and chest radiological observation     

治疗药物监测与个体化治疗方案

药物对人体的作用即药效动力学表现为治疗作用与毒副作用;药代动力学效应则表现为人体对药物的吸收、转运、分布、代谢及排出。对药物与人体之间的上述相互作用进行精确的定量,方可确保用药的安全、有效、适时、简便、经济,即合理用药。治疗药物监测(Therapeutic Drug     

成人和儿童非酒精性脂肪性肝病纤维化的无创性诊断

2017年6月Clinical Liver Disease发表了克利夫兰小儿胃肠病学分会Naim Alkhouri M.D的综述《成人和儿童非酒精性脂肪性肝病纤维化的无创性诊断》(Naim Alkhouri,M.D.Putting it all together:noninvasive diagnosis of fibrosis in nonalcoholic fatty liver disease in adults and children.Clinical Liver Disease,2017,9:134-137).非酒精性脂肪性肝病(NAFLD)是肥胖和代谢综合征的肝脏表现.因儿童和成人NAFLD的患病率高,迫切需要安全和经济的活检替代物来确定肝纤维化的分期.该文简要讨论了成人肝纤维化的无创性诊断,并详细介绍儿童和青少年无创性检测的现状.     

Prognostic value of clinical characteristics and immunophenotypic biomarkers in 115 patients with primary central nervous system lymphoma

Background  Clinical outcome in patients with primary central nervous lymphoma (PCNSL) is variable and poorly predictable. This study investigated the association of clinical features and immune markers with prognosis of patients with PCNSL.

Methods  One hundred and fifteen newly diagnosed PCNSL patients at the study institution were considered eligible for this study. Clinical characteristics and biochemical assay data were collected. Immunohistochemical staining of Cyclin D3, Cyclin E, Foxp1, and LMO2 were performed. All cases were followed-up regularly.

Results  The common sites of involvement were frontal lobe (54.8%) and thalamus (16.5%). Diffuse large B-cell lymphoma composed of 96.5% of the cases. The median overall survival was 22 (4–41) months, and the 5-year survival rate was 22.8%. Age >65 years, serum globulin >40 g/L, large size of tumor, lymphocyte count ³1´10⁹/L, and expression of Cyclin D3 and Cyclin E were associated with poor prognosis of PCNSL. Expressions of Foxp1, LMO2, and CD44 were not related to the survival. Expression of Cyclin E, large tumor size, and high serum globulin were independent prognostic factors for PCNSL.

Conclusions  PCNSL prognosis is relatively poor. Age, high tumor burden, higher lymphocyte count, expression of Cyclin D3, and Cyclin E are inferior prognostic factors for PCNSL.

     

攻击子宫颈癌

美国食品与药物管理局（US Food and Drug Administration，FDA）已批准了第1个保护妇女免于子宫颈癌的疫苗以及改善晚期子宫颈癌妇女存活率的联合用药方案。     

In Silico Screening of Potential Spike Glycoprotein Inhibitors of SARS-CoV-2 with Drug Repurposing Strategy

Objective: To select potential molecules that can target viral spike proteins, which may potentially interrupt the interaction between the human angiotension-converting enzyme 2(ACE2) receptor and viral spike protein by virtual screening. Methods: The three-dimensional(3 D)-coordinate file of the receptor-binding domain(RBD)-ACE2 complex for searching a suitable docking pocket was firstly downloaded and prepared. Secondly, approximately 15,000 molecular candidates were prepared, including US Food and Drug Administration(FDA)-approved drugs from Drug Bank and natural compounds from Traditional Chinese Medicine Systems Pharmacology(TCMSP), for the docking process. Then, virtual screening was performed and the binding energy in Autodock Vina was calculated. Finally, the top 20 molecules with high binding energy and their Chinese medicine(CM) herb sources were listed in this paper. Results: It was found that digitoxin, a cardiac glycoside in Drug Bank and bisindigotin in TCMSP had the highest docking scores. Interestingly, two of the CM herbs containing the natural compounds that had relatively high binding scores, Forsythiae fructus and Isatidis radix, are components of Lianhua Qingwen(莲花清瘟), a CM formula reportedly exerting activity against severe acute respiratory syndrome(SARS)-Cov-2. Moreover, raltegravir, an HIV integrase inhibitor, was found to have a relatively high binding score. Conclusions: A class of compounds, which are from FDA-approved drugs and CM natural compounds, that had high binding energy with RBD of the viral spike protein. Our work provides potential candidates for other researchers to identify inhibitors to prevent SARS-Co V-2 infection, and highlights the importance of CM and integrative application of CM and Western medicine on treating COVID-19.     

本院一九八四年院庆学术报告会题录

1。p一内酞胺抗生素的构效关系李明华2。维生素D3的立体选择性合成吴晓明3。集合论在药物设计中的成功应用—新强心药ARL一115BS的发展 陶德胜*周红介4。毗喃烯胺—一种有效的新抗过敏化合物芦金荣*黄树敏*红玮*蒋素梅份5。ALFREO BURGER and(( A Guide to the Chemieal Basis of Drug Design》 顾东蕾*6.新保肝药Malotilate的合成(综述)金育岐介7。抗皮肤病新药Crotamiton的合成(综述)蒋亚媛*5.抗组胺药Cle二astine的合成(综述)华文*9。中枢兴奋药Dopram的合成(综述)高志宏*10。华东地区药用植物化学会议介绍刘卫国等11.中、日…