脑卒中后癫痫发作的临床特点和视频脑电图分析

目的针对脑卒中后癫痫发作的临床特点和视频脑电图表现进行研究,为患者的治疗和预后提供参考依据。方法随机选择2012年12月至2015年12月收治的脑卒中后癫痫发作患者120例作为本次研究的对象,对患者的临床症状、特点,以及视频脑电图特征和表现进行观察分析。结果在本次研究中,脑梗死患者23例,占19.17%;脑出血患者38例,占31.67%;蛛网膜下腔出血患者59例,占49.17%。早发型癫痫发生率为65.00%,迟发型癫痫发生率为35.00%。脑梗死迟发型癫痫发生率(60.87%)明显高于早发型癫痫发生率(39.13%),差异有统计学意义(P0.05)。脑出血早发型癫痫发生率(65.79%)明显高于迟发型癫痫发生率(34.21%),差异有统计学意义(P0.05)。蛛网膜下腔出血早发型癫痫发生率(77.97%)明显高于迟发型癫痫发生率(22.03%),差异有统计学意义(P0.05)。部分性发作的早发型癫痫发生率(7.69%)与明显低于迟发型癫痫发生率(33.33%),差异有统计学意义(P0.05)。部分性发作继发全面性发作早发型癫痫发生率(48.72%)明显高于迟发型癫痫发生率(23.81%),差异有统计学意义(P0.05)。120例脑卒中后癫痫患者发作期间视频脑电图正常12例,边缘状态脑电图改变10例,视频脑电图异常患者98例。视频脑电图异常以癫痫样放电为主。结论脑卒中后癫痫发作的时间与类型存在相关性,不同类型的脑卒中患者的癫痫发生率不同,且视频脑电图以癫痫样放电为主。     

视频脑电图检测在卒中后癫痫的分型和诊断中的应用价值

目的:探讨视频脑电图(VEEG)检测在卒中后癫痫的分型和诊断中应用价值。方法:卒中后癫痫患者87例,均行VEEG和常规脑电图(REEG)监测,比较2种检测方法的检测效率、VEEG对癫痫分型作用以及不同类型卒中癫痫发作类型。结果:VEEG监测到癫样放电、临床发作的比例明显高于REEG监测(P<0.05);VEEG监测到的临床发作中,13例临床诊断癫痫分型与发作时临床表现不符;脑梗死癫痫部分性发作比例明显高于脑出血和蛛网膜下腔出血(P<0.05);蛛网膜下腔出血全身性发作比例明显高于脑梗死和脑出血(P<0.05)。结论:VEEG在卒中后癫痫诊断中有较好的应用价值,有助于卒中后癫痫分型判断,同时癫痫分型与脑卒中类型有一定关系。     

老年脑卒中后继发性癫痫的相关因素分析

背景老年卒中后继发癫痫是老年人癫痫的主要原因,对卒中的康复和预后有一定的影响.目的探讨卒中后癫痫发作与卒中类型、部位以及卒中面积的关系.设计病例分析.单位山东省千佛山医院神经内科.对象选择1999-01/2004-12山东省千佛山医院神经内科住院的脑卒中后继发癫痫患者68例,男42例,女26例;年龄60～83岁,平均(68±7)岁.患者均知情同意.方法[1]根据入组患者卒中后癫痫首发时间分为早发型癫痫(卒中后2周内发作);迟发性癫痫(卒中后2周后发作),分析癫痫发生时间与卒中类型的关系.[2]根据影像学结果将缺血性卒中(包括脑血栓形成和脑栓塞)按梗死面积分为＜一侧半球的1/4,1/4～1/2和＞1/2;按脑出血量分为小于20 mL,20～40 mL和大于40mL.分析癫痫发作与卒中部位和面积的关系.[3]对患者进行对症治疗,并采用复诊形式进行随访6个月～4年,平均21个月.[4]计数资料差异比较采用χ2检验.结果脑卒中后癫痫发作患者68例均进入结果分析.[1]癫痫发生时间与卒中类型的关系早发性癫痫患者脑出血、蛛网膜下腔出血患者数明显多于迟发性癫痫患者(10,2例;4,0例,P＜0.05),而脑血栓形成患者数明显少于迟发性癫痫患者(3,36例,P＜0.05).[2]癫痫发作与卒中部位和面积的关系脑梗死面积占一侧半球的1/4～1/2和＞1/2患者明显多于＜一侧半球的1/4(26,17,9例,P＜0.05);脑出血20～40和＞40 mL患者明显多于＜20 mL者(4,9,1例,P＜0.05).[3]癫痫发作的预后21例早发性癫痫患者中,6例以癫痫为首发症状,15例患者2周内未再发作.47例迟发性癫痫患者中,18例1年后完全控制;23例癫痫控制良好;6例发作较频繁.结论[1]早发性癫痫以脑出血、蛛网膜下腔出血和脑栓塞为主,迟发性癫痫以脑血栓形成为主.[2]脑梗死面积超过一侧半球面积的1/4,脑出血＞40mL者发生癫痫的危险性明显增高.[3]早发性癫痫的预后较好.     

25例脑卒中后癫痫发作的临床特点及脑电图特征分析

分析脑卒中后癫痫发作的临床特点及脑电图特征。选取2015年2月~2016年1月就诊于我院的脑卒中后癫痫发作患者25例,分析脑卒中患者癫痫发作临床特点。记录患者癫痫发作的时间、类型和脑卒中后癫痫发作脑电图特征。迟发型癫痫发生率于脑梗死患者中较高,而早发型癫痫发生率于蛛网膜下腔出血和脑出血患者中较高,迟发型癫痫中部分性发作高于早发型癫痫,而早发型癫痫中部分性发作继发全面性发作高于迟发型癫痫(P0.05),迟发型癫痫中全面性发作早发型癫痫中无明显差异(P0.05)。脑卒中后癫痫患者发作期间3例脑电图正常、2例边缘状态脑电图改变;20例脑电图异常,脑电图异常患者中以癫痫样放电为主。脑卒中后癫痫发作的类型及时间具有密切联系,不同类型脑卒中导致癫痫的发生率有明显不同,而脑电图检查多以癫痫样放电为主。因此实施脑电图监测能有效为医师诊断、治疗脑卒中后癫痫发作提供重要的依据。     

老年脑卒中后继发性癫痫的相关因素分析

背景：老年卒中后继发癫痫是老年人癫痫的主要原因，对卒中的康复和预后有一定的影响。目的：探讨卒中后癫痫发作与卒中类型、部位以及卒中面积的关系。设计：病例分析。单位：山东省千佛山医院神经内科。对象：选择1999—01／2004-12山东省千佛山医院神经内科住院的脑卒中后继发癫痫患者68例，男42例，女26例；年龄60-83岁，平均（68&;#177;7）岁。患者均知情同意。方法：①根据入组患者卒中后癫痫首发时间分为早发型癫痫（卒中后2周内发作）；迟发性癫痫（卒中后2周后发作），分析癫痫发生时间与卒中类型的关系。②根据影像学结果将缺血性卒中（包括脑血栓形成和脑栓塞）按梗死面积分为：〈一侧半球的1／4，1／4～1／2和〉1／2；按脑出血量分为小于20mL，20—40mL和大于40mL。分析癫痫发作与卒中部位和面积的关系。③对患者进行对症治疗，并采用复诊形式进行随访6个月～4年，平均21个月。④计数资料差异比较采用x^2检验。结果：脑卒中后癫痫发作患者68例均进入结果分析。①癫痫发生时间与卒中类型的关系：早发性癫痫患者脑出血、蛛网膜下腔出血患者数明显多于迟发性癫痫患者（10，2例；4，0例，P〈0．05），而脑血栓形成患者数明显少于迟发性癫痫患者（3，36例，P〈0．05）。②癫痫发作与卒中部位和面积的关系：脑梗死面积占一侧半球的1／4～1／2和〉1／2患者明显多于〈一侧半球的1／4（26，17，9例，P〈0．05）；脑出血20～40和〉40mL患者明显多于〈20mL者（4，9，1例，P〈0．05）。③癫痫发作的预后：21例早发性癫痫患者中，6例以癫痫为首发症状，15例患者2周内未再发作。47例迟发性癫痫患者中，18例1年后完全控制；23例癫痫控制良好；6例发作较频繁。结论：①早发性癫痫以脑出血、蛛网膜下腔出血和脑栓塞为主，迟发性癫痫以脑血栓形成为主。②脑梗死面积超过一侧半球面积的1／4，脑出血〉40mL者发生癫痫的危险性明显增高。③早发性癫痫的预后较好。     

卒中后癫痫临床研究

目的：探讨脑卒中后癫痫发生率、发作类型、病变部位及其相互关系以及发作机制、预后。方法：回顾性分析经头颅CT或MRI、脑电图(EEG)证实的脑卒中后癫痫患者93例的临床资料。结果：卒中后癫痫的发生率占同期住院卒中患者的6．24％，癫痫发作可发生在卒中后任何时期，早期发作多在卒中发病48小时内。皮质病灶较皮质下病灶更易引发癫痫。结论：脑卒中后癫痫发作与病灶部位密切相关。脑电图检测对早期诊断有一定意义，早期发作与晚发癫痫的治疗、转归有所不同。     

脑卒中后癫痫的临床、影像学特点与预后分析

目的 探讨脑卒中后继发癫痫的临床表现、影像学特点与预后的关系。方法 对840例脑卒中后出现癫痫发作的患者78例进行临床资料回顾性分析。结果 脑卒中后癫痫的发生率为9.29%,其中早期发作癫痫(2周内)占61.54%,发作类型以部分发作及强直-阵挛发作为主,脑出血及病灶累及皮层者发病率高,对症治疗控制良好,但病死率比无癫痫发作者高(P<0.05)。结论 脑卒中后癫痫多并发于皮层病灶,脑出血比脑梗死多见,控制良好,但预后欠佳。     

缺血性脑卒中后癫痫相关因素分析

目的探讨缺血性脑卒中后癫痫发作相关因素及临床特点。方法选择2005年1月至2013年12月因缺血性脑卒中入院的患者112例,为癫痫组,并选取同期脑卒中无癫痫发作患者144例作为对照组,对脑卒中后癫痫患者的临床特点,包括病灶部位、癫痫发作时间、发作次数和神经功能缺损程度进行研究。结果缺血性脑卒中后癫痫病灶于皮层62例(55.36%),皮层下50例(44.64%);单次发作86例(76.79%),反复发作26例(23.21%);神经功能缺损程度轻度26例(23.21%)、中度59例(52.68%)、重度27例(24.11%),早发性癫痫49例(43.75%)、迟发性癫痫63例(56.25%)。卒中类型、病灶部位和神经功能缺损评分与缺血性脑卒中后癫痫发作相关(P<0.05),且多次发作者神经缺损程度更为严重(P<0.05)。结论脑栓塞、病灶部位位于皮质、神经功能缺损评分等因素是缺血性脑卒中患者易继发癫痫发作的高危因素,临床上应积极预防并发症,提高患者生存质量。     

脑卒中继发癫痫的临床研究

目的探讨脑卒中与其继发癫痫的关系。方法回顾性分析365例脑卒中患者并发癫痫的发病率，发病时间及预后。结果脑出血后癫痫占5．66％；脑梗死后癫痫占6．42％；蛛网膜下腔出血后的癫痫发生率最高占21．05％（4／19）。卒中后2周内发作占多数，为68％。发病后4周内死亡率为12％，明显高于非癫痫组的3．52％，P〈0．01。另外，继发癫痫与病变部位有关。结论脑卒中是老年人癫痫的重要原因，且卒中并发癫痫较非癫痫组预后差。     

脑卒中后癫痫的临床研究——附72例报告

目的探讨脑卒中后癫痫的临床特征。方法对852例脑卒中病人中72例继发癫痫患者的临床资料进行回顾性分析。结果卒中后癫痫的发生率为8．45％，男女性别无明显差异，发作类型以全身强直-阵挛发作为主，出血性与缺血性卒中的发生率无明显差异，皮质范围的较皮质下的发生率高。结论癫痫发作是脑卒中患者的常见症状，卒中后癫痫的发生率与病灶部位（皮质／皮质下）有明显相关性，其病变影响皮质是重要的致痫因素，而与性别及卒中类型无明显相关。卒中后癫痫多数药物控制效果良好，其癫痫发作机制，认为早期多由于脑水肿和脑代谢异常，晚期多由于癫痫灶所致。     

Predictors of seizure onset after intracerebral hemorrhage and the role of long-term antiepileptic therapy

Objective

Seizures are a common complication after hemorrhagic stroke that may slow recovery and decrease quality of life. Recent evidence suggests that early- and late-onset seizures have distinct etiologies, rendering the role of prophylactic long-term antiepileptic drugs controversial. We investigated predictors of early- and late-onset seizures after evacuation of intracerebral hemorrhage (ICH) in an attempt to guide antiepileptic drug management in this patient population.

Methods

We performed a retrospective analysis of 110 patients admitted to Columbia University Medical Center between 1999 and 2007 for ICH and subsequent clot evacuation. Patients were included if they had a head computed tomography indicating ICH, an operative note confirming surgical evacuation, and sufficient medical records to determine seizure status. Demographic, clinical, and radiographic findings were recorded. Univariate and multivariate logistic regression analyses were used to determine factors associated with early- and late-onset electrographic and clinical seizures.

Results

Seizures occurred in 41.8% of patients, 29.6% of which had clinical manifestations and 16.3% of which were recorded on continuous electroencephalogram (EEG). After controlling for demographic factors, multivariate analysis identified 3 factors that were predictive of early-onset seizures (volume of hemorrhage, presence of subarachnoid hemorrhage, and subdural hemorrhage) and 2 factors that were predictive of late onset seizures (subdural hemorrhage and increased admission international normalized ratio (INR)).

Conclusions

The presence of subdural hematoma and increased INR is predictive of late-onset seizures in patients undergoing clot evacuation after ICH. The use of long-term antiepileptic therapy should be further studied in patients with these radiographic and clinical characteristics.     

Headache in cerebral hemorrhage is associated with inflammatory markers and higher residual cavity

BACKGROUND AND PURPOSE: The mechanisms responsible for headache in patients with intracerebral hemorrhage (ICH) are not completely understood. The present study was undertaken to analyze the headache-associated factors, the possible related biochemical mechanisms, and the headache potential predictors of outcome in spontaneous ICH. METHODS: We prospectively studied 189 patients from a large cohort of 266 consecutive patients with supratentorial ICH admitted within the first 12 hours of symptoms onset. The presence of headache at stroke onset was evaluated in these patients. The volumes of the initial ICH, peripheral edema at 48 hours, and the residual cavity at 3 months were measured on CT scan. Glutamate, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha levels were measured in blood samples obtained on admission. The Canadian Stroke Scale (CSS) and the modified Rankin Scale were used to evaluate stroke severity and neurological outcome, respectively. RESULTS: Headache at onset of stroke was observed in 65 patients (34.4%). Patients who experienced headache had a significantly higher frequency of history of infection (P= .009) or inflammation (P= .045), as well as higher body temperature (P= .021), leukocyte count (P= .038), ESR (P= .011), and mass effect (P= .017) on admission. Plasma concentrations of IL-6 and TNF-alpha were significantly higher in patients with headache than in those without. Headache was an independent predictor of the residual cavity volume in patients with spontaneous ICH (odds ratio 6.49; 95% CI 2.51 to 16.78; P= .0001). CONCLUSIONS: Headache at ICH onset is associated with clinical and biochemical markers of inflammation and is an independent predictor of higher residual cavity volume after spontaneous ICH.     

Intracerebral Hemorrhage: A Common yet Disproportionately Deadly Stroke Subtype

Spontaneous intracerebral hemorrhage (ICH) is a medical emergency and is disproportionately associated with higher mortality and long-term disability compared with ischemic stroke. The phrase “time is brain” was derived for patients with large vessel occlusion ischemic stroke in which approximately 1.9 million neurons are lost every minute. Similarly, this statement holds true for ICH patients due to a high volume of neurons that are damaged at initial onset and during hematoma expansion. Most cases of spontaneous ICH pathophysiologically stem from chronic hypertension and rupture of small perforating vessels off of larger cerebral arteries supplying deep brain structures, with cerebral amyloid angiopathy being another cause for lobar hemorrhages in older patients. Optimal ICH medical management strategies include timely diagnosis, aggressive blood pressure control, correction of underlying coagulopathy defects if present, treatment of cerebral edema, and continuous assessment for possible surgical intervention. Current strategies in the surgical management of ICH include newly developed minimally invasive techniques for hematoma evacuation, with the goal of mitigating injury to fiber tracts while accessing the clot. We review evidence-based medical and surgical management of spontaneous ICH with the overall goal of reducing neurologic injury and optimizing functional outcome.     

Effects of simultaneous application of ultrasound and microbubbles on intracerebral hemorrhage in an animal model

Microbubble-enhanced sonothrombolysis (MEST) may be an alternative therapeutic option in ischemic stroke. Clinical study of the efficacy of MEST as an adjunct stroke therapy, before imaging with CT or MRI, requires experimental data on the safety of this approach in the presence of hemorrhagic stroke. We, therefore, investigated the effect of diagnostic transcranial ultrasound combined with microbubbles (US + MB) in an experimental animal model of intracerebral hemorrhage (ICH). ICH was induced in anesthetized rats by intracerebral collagenase injection. Transcranial ultrasound (2 MHz, mechanical index 1.3, 1051 kPa) was applied 3 h after ICH induction to rat brains for 30 min during a continuous IV infusion of sulfur hexafluoride microbubbles (SonoVue). The size of cerebral hemorrhage, the extent of brain edema, and the amount of apoptosis were compared with those from control rats with ICH but without US + MB. Results showed no significant effect of US + MB on hemorrhage size (control 23.3 +/- 10.7 mm(3), US + MB 20.3 +/- 5.8 mm(3)), on the extent of brain edema (control 3.3 +/- 2.0%, US +MB 3.5 +/- 1.9%), or on the rate of apoptosis (control 5.2 +/- 1.5%, US + MB 5.2 +/- 1.0%). We conclude that diagnostic ultrasound in combination with microbubbles does not cause additional damage to the rat brain during ICH in our experimental set-up. This finding provides support for the use of MEST as an early stroke therapy.     

Third ventricle midline shift due to spontaneous supratentorial intracerebral hemorrhage evaluated by transcranial color-coded sonography.

OBJECTIVE: We aimed to assess the clinical usefulness of the third ventricle midline shift (MLS) evaluated by transcranial color-coded sonography (TCCS) in acute spontaneous supratentorial intracerebral hemorrhage (ICH). METHODS: Consecutive patients with acute (<24 hours after symptom onset) ICH were recruited for this TCCS study. Sonographic measurement of MLS and the pulsatility index (PI) of the middle cerebral arteries were compared with head computed tomographic (CT) data, including MLS, and hematoma volume. Poor functional outcome at 30 days after stroke onset was defined as modified Rankin scale greater than 2. RESULTS: There were 51 patients with spontaneous supratentorial ICH who received CT and TCCS studies within a 12-hour window. Correlation between MLS by TCCS (mean +/- SD, 3.2 +/- 2.6 mm) and CT (3.0 +/- 2.4 mm) was high (gamma = 0.91; P < .01). There was also a good linear correlation between hematoma volume and MLS by TCCS (gamma = 0.81; P < .01). Compared with ICH volume less than 25 mL, those with greater volume had more severe MLS and a higher PI of the ipsilateral middle cerebral artery (P < .001). Midline shift by TCCS was more sensitive and specific than the PI in detecting large ICH (accuracy = 0.82 if MLS > or = 2.5 mm), and it was also a significant predictor of poor outcome (odds ratio, 2.09 by 1-mm increase; 95% confidence interval, 1.06-4.13). CONCLUSIONS: Midline shift may be measured reliably by TCCS in spontaneous supratentorial ICH. Our study also showed that MLS on TCCS is a useful and convenient method to identify patients with large ICH and hematoma expansion and to predict short-term functional outcome.     

急性脑梗死静脉溶栓后脑出血的危险因素分析

目的 :探讨与急性脑梗死静脉溶栓治疗后继发脑出血 (ICH)有关的危险因素。方法 :82例急性脑梗死患者在发病 12 h内接受了尿激酶静脉溶栓治疗 ,选取溶栓前的临床和实验室资料作为 ICH的可能危险因素 ,分析与 ICH的关系。结果 :15例患者继发 ICH(18.3% ) ,其中 6例为出血性梗死 (7.3% ) ,9例为脑实质血肿(11.0 % )。发生症状性脑出血 (SICH) 7例 ,死亡 4例。统计学分析表明继发 ICH者有较低的神经功能缺损评分 (ESS) ,ESS评分 <6 0分、溶栓前头颅 CT可见早期缺血改变 (EIC)及存在心房纤颤的患者有更高的出血率。结论 :溶栓前的神经功能缺损程度、CT早期缺血改变和心房纤颤是 ICH的危险因素。     

Seasonality of stroke in Finland

Introduction: The burden of stroke is increasing globally. Reports on seasonal variations in stroke occurrence are conflicting and long-term data are absent.

Methods: A retrospective cohort study using discharge registry data of all acute stroke admissions in Finland during 2004–2014 for patients?≥18 years age. A total of 97,018 admissions for ischemic stroke (IS) were included, 18,252 admissions for intracerebral hemorrhage (ICH) and 11,271 admissions for subarachnoid hemorrhage (SAH).

Results: The rate of IS admissions increased (p?=?0.025) while SAH admission rate decreased (p?Conclusions: All major stroke subtypes occurred most commonly in autumn and most infrequently in summer. Seasonality of in-hospital mortality and length of hospital stay appears to vary by stroke subtype. The seasonal pattern of ischemic stroke occurrence appears to have changed during the past decades.

• Key messages

• All major stroke subtypes (ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage) occurred most frequently in autumn and least frequently in summer.

• Seasonal patterns of in-hospital mortality and length of stay differed markedly by stroke subtype.

• The seasonal pattern of ischemic stroke occurrence in Finland seems to have changed compared to 1982–1992.

     

Functional recovery following rehabilitation after hemorrhagic and ischemic stroke

OBJECTIVES: To quantify recovery after rehabilitation therapy and to identify factors that predicted functional outcome in survivors of intracerebral hemorrhage (ICH) compared with cerebral infarction. DESIGN: Retrospective study of consecutive ICH and cerebral infarction admissions to a rehabilitation hospital over a 4-year period. SETTING: Free-standing urban rehabilitation hospital. PARTICIPANTS: A total of 1064 cases met the inclusion criteria (545 women, 519 men; 871 with cerebral infarction, 193 with ICH). INTERVENTIONS: Not applicable.Main Outcome Measures: Functional status was measured using the FIM trade mark instrument, recorded at admission and discharge. Recovery was quantified by the change in FIM total score (DeltaFIM total score). Outcome measures were total discharge FIM score and DeltaFIM total score. Univariate and multivariate analyses were performed. RESULTS: Total admission FIM score was higher in patients with cerebral infarction than in patients with ICH (59 vs 51, P=.0001). No difference in total discharge FIM score was present. Patients with ICH made a significantly greater recovery than those with cerebral infarction (DeltaFIM total score, 28 vs 23.3; P=.002). On multivariate analysis, younger age, longer length of stay, and admission FIM cognitive subscore independently predicted total discharge FIM and DeltaFIM total score. The severity of disability at admission, indicated by total admission FIM score, independently predicted total discharge FIM score, but not DeltaFIM total score. The ICH patients with the most severely disabling strokes had significantly greater recovery than cerebral infarction patients with stroke of similar severity. CONCLUSIONS: The patients with ICH had greater functional impairment than the cerebral infarction patients at admission, but made greater gains. Patients with the most severely disabling ICH improved more than those with cerebral infarction of comparable severity. Initial severity of disability, age, and duration of therapy best predicted functional outcome after rehabilitation.     

Serum lipid levels and 3-month prognosis in Chinese patients with acute stroke

INTRODUCTION: The possible correlation between serum lipid levels and outcome after stroke is still controversial. Therefore we examined whether serum lipid levels at admission had any prognostic value in the 3-month outcome after stroke. METHODS: We performed a prospective, observational study of 649 patients with acute ischaemic stroke and intracerebral haemorrhagic stroke (ICH). Information on age, sex, history of arterial hypertension, diabetes mellitus, drinking, current smoking status, stroke type, Glasgow Coma Scale and Scandinavian Stroke Scale score, time from stroke onset, and presence of atrial fibrillation was obtained. Serum lipid levels were measured in blood samples taken from fasting patients 12 to 48 hours following ictus. Death and poor neurological outcome (Modified Rankin Scale score of >/=3 points) were defined as outcome events. A logistic regression model was performed to estimate the effect of the above variables on outcome after stroke. RESULTS: We found that the median levels of serum total cholesterol (TC), triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C) in good outcome patients with acute stroke were significantly higher (P<0.005) than those of poor outcome patients. The low levels of serum TC, TG and HDL-C (P<0.05) were independently related to increased 3-month poor outcome after acute ischaemic stroke and ICH. However, there was no significant relationship between LDL-C levels and 3-month outcome. CONCLUSION: The data from this study show that low levels of serum TC, TG and HDL-C are strong independent predictors of 3-month poor outcome in patients with acute ischaemic stroke and ICH.