Remote health monitoring system for detecting cardiac disorders

Remote health monitoring system with clinical decision support system as a key component could potentially quicken the response of medical specialists to critical health emergencies experienced by their patients. A monitoring system, specifically designed for cardiac care with electrocardiogram (ECG) signal analysis as the core diagnostic technique, could play a vital role in early detection of a wide range of cardiac ailments, from a simple arrhythmia to life threatening conditions such as myocardial infarction. The system that the authors have developed consists of three major components, namely, (a) mobile gateway, deployed on patient''s mobile device, that receives 12‐lead ECG signals from any ECG sensor, (b) remote server component that hosts algorithms for accurate annotation and analysis of the ECG signal and (c) point of care device of the doctor to receive a diagnostic report from the server based on the analysis of ECG signals. In the present study, their focus has been toward developing a system capable of detecting critical cardiac events well in advance using an advanced remote monitoring system. A system of this kind is expected to have applications ranging from tracking wellness/fitness to detection of symptoms leading to fatal cardiac events.Inspec keywords: cardiovascular system, diseases, patient monitoring, electrocardiography, medical signal processing, medical signal detection, electric sensing devices, medical disordersOther keywords: remote health monitoring system, cardiac disorder detection, clinical decision support system, cardiac care, electrocardiogram signal analysis, core diagnostic technique, cardiac ailments, arrhythmia, myocardial infarction, life threatening conditions, mobile gateway, patient mobile device, ECG signals, ECG sensor, remote server component, point‐of‐care device, fatal cardiac events     

Improved Bat Algorithm with Deep Learning-Based Biomedical ECG Signal Classification Model

With new developments experienced in Internet of Things (IoT), wearable, and sensing technology, the value of healthcare services has enhanced. This evolution has brought significant changes from conventional medicine-based healthcare to real-time observation-based healthcare. Bio-medical Electrocardiogram (ECG) signals are generally utilized in examination and diagnosis of Cardiovascular Diseases (CVDs) since it is quick and non-invasive in nature. Due to increasing number of patients in recent years, the classifier efficiency gets reduced due to high variances observed in ECG signal patterns obtained from patients. In such scenario computer-assisted automated diagnostic tools are important for classification of ECG signals. The current study devises an Improved Bat Algorithm with Deep Learning Based Biomedical ECG Signal Classification (IBADL-BECGC) approach. To accomplish this, the proposed IBADL-BECGC model initially pre-processes the input signals. Besides, IBADL-BECGC model applies NasNet model to derive the features from test ECG signals. In addition, Improved Bat Algorithm (IBA) is employed to optimally fine-tune the hyperparameters related to NasNet approach. Finally, Extreme Learning Machine (ELM) classification algorithm is executed to perform ECG classification method. The presented IBADL-BECGC model was experimentally validated utilizing benchmark dataset. The comparison study outcomes established the improved performance of IBADL-BECGC model over other existing methodologies since the former achieved a maximum accuracy of 97.49%.     

Effectiveness Assessment of the Search-Based Statistical Structural Testing

In this era of electronic health, healthcare data is very important because it contains information about human survival. In addition, the Internet of Things (IoT) revolution has redefined modern healthcare systems and management by providing continuous monitoring. In this case, the data related to the heart is more important and requires proper analysis. For the analysis of heart data, Electrocardiogram (ECG) is used. In this work, machine learning techniques, such as adaptive boosting (AdaBoost) is used for detecting normal sinus rhythm, atrial fibrillation (AF), and noise in ECG signals to improve the classification accuracy. The proposed model uses ECG signals as input and provides results in the form of the presence or absence of disease AF, and classifies other signals as normal, other, or noise. This article derives different features from the signal using Maximal Information Coefficient (MIC) and minimum Redundancy Maximum Relevance (mRMR) technique, and then classifies them based on their attributes. Since the ECG contains some kind of noise and irregular data streams so the purpose of this study is to remove artifacts from the ECG signal by deploying the method of Second-Order-Section (SOS) (filter) and correctly classify them. Several features were extracted to improve the detection of ECG data. Compared with existing methods, this work gives promising results and can help improve the classification accuracy of the ECG signals.     

RETRACTED: Automatic Arrhythmia Detection Based on Convolutional Neural Networks

ECG signal is of great importance in the clinical diagnosis of various heart diseases. The abnormal origin or conduction of excitation is the electrophysiological mechanism leading to arrhythmia, but the type and frequency of arrhythmia is an important indicator reflecting the stability of cardiac electrical activity. In clinical practice, arrhythmic signals can be classified according to the origin of excitation, the frequency of excitation, or the transmission of excitation. Traditional heart disease diagnosis depends on doctors, and it is influenced by doctors' professional skills and the department's specialty. ECG signal has the characteristics of weak signal, low frequency, large variation, and easy to be interfered. In this investigation, an ECG anomaly automatic classification system based on the convolutional neural network is proposed. The training sets of the convolutional neural network are ECG beats extracted from the MIT-BIH database as training sets. A 36-layer convolutional neural network (CNN) is trained based on Caffe framework to classify ECG signals automatically. The experimental results show that it can reach or even exceed the level of a senior cardiologist in judging three diseases: FIB, AFL and IVR.     

Efficient Data Compression of ECG Signal Based on Modified Discrete Cosine Transform

This paper introduced an efficient compression technique that uses the compressive sensing (CS) method to obtain and recover sparse electrocardiography (ECG) signals. The recovery of the signal can be achieved by using sampling rates lower than the Nyquist frequency. A novel analysis was proposed in this paper. To apply CS on ECG signal, the first step is to generate a sparse signal, which can be obtained using Modified Discrete Cosine Transform (MDCT) on the given ECG signal. This transformation is a promising key for other transformations used in this search domain and can be considered as the main contribution of this paper. A small number of wavelet components can describe the ECG signal as related work to obtain a sparse ECG signal. A sensing technique for ECG signal compression, which is a novel area of research, is proposed. ECG signals are introduced randomly between any successive beats of the heart. MIT-BIH database can be represented as the experimental database in this domain of research. The MIT-BIH database consists of various ECG signals involving a patient and standard ECG signals. MATLAB can be considered as the simulation tool used in this work. The proposed method's uniqueness was inspired by the compression ratio (CR) and achieved by MDCT. The performance measurement of the recovered signal was done by calculating the percentage root mean difference (PRD), mean square error (MSE), and peak signal to noise ratio (PSNR) besides the calculation of CR. Finally, the simulation results indicated that this work is one of the most important works in ECG signal compression.     

Sparse electrocardiogram signals recovery based on solving a row echelon‐like form of system

The study of biology and medicine in a noise environment is an evolving direction in biological data analysis. Among these studies, analysis of electrocardiogram (ECG) signals in a noise environment is a challenging direction in personalized medicine. Due to its periodic characteristic, ECG signal can be roughly regarded as sparse biomedical signals. This study proposes a two‐stage recovery algorithm for sparse biomedical signals in time domain. In the first stage, the concentration subspaces are found in advance. Then by exploiting these subspaces, the mixing matrix is estimated accurately. In the second stage, based on the number of active sources at each time point, the time points are divided into different layers. Next, by constructing some transformation matrices, these time points form a row echelon‐like system. After that, the sources at each layer can be solved out explicitly by corresponding matrix operations. It is noting that all these operations are conducted under a weak sparse condition that the number of active sources is less than the number of observations. Experimental results show that the proposed method has a better performance for sparse ECG signal recovery problem.Inspec keywords: electrocardiography, matrix algebra, medical signal processingOther keywords: sparse electrocardiogram signal recovery, row echelon‐like form of system, noise environment, biological data analysis, personalised medicine, dictionary learning algorithm, transformation matrices, sparse biomedical signal recovery     

基于HRV非线性特征的心律不齐自动分析

心率变异性(HRV)信号包含大量心脏和心血管系统的生理和病理信息,对其进行深入分析可以帮助诊断和预警心律不齐等心脏疾病.论文利用MIT-BIH心电数据库,提取正常心律和心律不齐两种心电数据并进行信号预处理以消除噪声干扰;采用小波变换提取小波系数的模极值和过零点以得到心电R波信号,计算其一阶差分得到HRV序列.然后,提取HRV信号的小波熵、近似熵和基本尺度熵3种非线性特征,并对正常心电和心律不齐心电特征进行差异统计检验.仿真结果表明,HRV信号的非线性特征可以有效地识别正常心律和心律不齐心电信号.     

Symbiotic Organisms Search with Deep Learning Driven Biomedical Osteosarcoma Detection and Classification

Osteosarcoma is one of the rare bone cancers that affect the individuals aged between 10 and 30 and it incurs high death rate. Early diagnosis of osteosarcoma is essential to improve the survivability rate and treatment protocols. Traditional physical examination procedure is not only a time-consuming process, but it also primarily relies upon the expert’s knowledge. In this background, the recently developed Deep Learning (DL) models can be applied to perform decision making. At the same time, hyperparameter optimization of DL models also plays an important role in influencing overall classification performance. The current study introduces a novel Symbiotic Organisms Search with Deep Learning-driven Osteosarcoma Detection and Classification (SOSDL-ODC) model. The presented SOSDL-ODC technique primarily focuses on recognition and classification of osteosarcoma using histopathological images. In order to achieve this, the presented SOSDL-ODC technique initially applies image pre-processing approach to enhance the quality of image. Also, MobileNetv2 model is applied to generate a suitable group of feature vectors whereas hyperparameter tuning of MobileNetv2 model is performed using SOS algorithm. At last, Gated Recurrent Unit (GRU) technique is applied as a classification model to determine proper class labels. In order to validate the enhanced osteosarcoma classification performance of the proposed SOSDL-ODC technique, a comprehensive comparative analysis was conducted. The obtained outcomes confirmed the betterment of SOSDL-ODC approach than the existing approaches as the former achieved a maximum accuracy of 97.73%.     

How to Apply Nonlinear Subspace Techniques to Univariate Biomedical Time Series

In this paper, we propose an embedding technique for univariate single-channel biomedical signals to apply projective subspace techniques. Biomedical signals are often recorded as 1-D time series; hence, they need to be transformed to multidimensional signal vectors for subspace techniques to be applicable. The transformation can be achieved by embedding an observed signal in its delayed coordinates. We propose the application of two nonlinear subspace techniques to embedded multidimensional signals and discuss their relation. The techniques consist of modified versions of singular-spectrum analysis (SSA) and kernel principal component analysis (KPCA). For illustrative purposes, both nonlinear subspace projection techniques are applied to an electroencephalogram (EEG) signal recorded in the frontal channel to extract its dominant electrooculogram (EOG) interference. Furthermore, to evaluate the performance of the algorithms, an experimental study with artificially mixed signals is presented and discussed.      

Evolutionary Algorithsm with Machine Learning Based Epileptic Seizure Detection Model

Machine learning (ML) becomes a familiar topic among decision makers in several domains, particularly healthcare. Effective design of ML models assists to detect and classify the occurrence of diseases using healthcare data. Besides, the parameter tuning of the ML models is also essential to accomplish effective classification results. This article develops a novel red colobuses monkey optimization with kernel extreme learning machine (RCMO-KELM) technique for epileptic seizure detection and classification. The proposed RCMO-KELM technique initially extracts the chaotic, time, and frequency domain features in the actual EEG signals. In addition, the min-max normalization approach is employed for the pre-processing of the EEG signals. Moreover, KELM model is used for the detection and classification of epileptic seizures utilizing EEG signal. Furthermore, the RCMO technique was utilized for the optimal parameter tuning of the KELM technique in such a way that the overall detection outcomes can be considerably enhanced. The experimental result analysis of the RCMO-KELM technique has been examined using benchmark dataset and the results are inspected under several aspects. The comparative result analysis reported the better outcomes of the RCMO-KELM technique over the recent approaches with the of 0.956.     

基于Frank导联和Hermite展开的心肌梗死检测

多数现有的计算机辅助心电(ECG)诊断技术研究通常是基于常规心电导联展开的,而正交Frank心电导联比常规心电导联有着与解剖学更为密切的联系.基于Frank导联的心肌梗死(MI)心电特征提取和分类检测的研究,对MI ECG信号进行Hermite非线性展开,以Hermite系数为心电特征,并对其进行分类测试.与常规心电导联相比,此方法对早期MI和急性期MI进行分类,检测精度可分别提高30.06%和19.33%.     

Feature Subset Selection with Artificial Intelligence-Based Classification Model for Biomedical Data

Recently, medical data classification becomes a hot research topic among healthcare professionals and research communities, which assist in the disease diagnosis and decision making process. The latest developments of artificial intelligence (AI) approaches paves a way for the design of effective medical data classification models. At the same time, the existence of numerous features in the medical dataset poses a curse of dimensionality problem. For resolving the issues, this article introduces a novel feature subset selection with artificial intelligence based classification model for biomedical data (FSS-AICBD) technique. The FSS-AICBD technique intends to derive a useful set of features and thereby improve the classifier results. Primarily, the FSS-AICBD technique undergoes min-max normalization technique to prevent data complexity. In addition, the information gain (IG) approach is applied for the optimal selection of feature subsets. Also, group search optimizer (GSO) with deep belief network (DBN) model is utilized for biomedical data classification where the hyperparameters of the DBN model can be optimally tuned by the GSO algorithm. The choice of IG and GSO approaches results in promising medical data classification results. The experimental result analysis of the FSS-AICBD technique takes place using different benchmark healthcare datasets. The simulation results reported the enhanced outcomes of the FSS-AICBD technique interms of several measures.     

Electrocardiogram de-noising based on forward wavelet transform translation invariant application in bionic wavelet domain

In this paper, we propose a new technique of Electrocardiogram (ECG) signal de-noising based on thresholding of the coefficients obtained from the application of the Forward Wavelet Transform Translation Invariant (FWT_TI) to each Bionic Wavelet coefficient. The De-noise De-noised ECG is obtained from the application of the inverse of BWT (B W T ^?1) to the de-noise de-noised bionic wavelet coefficients. For evaluating this new proposed de-noising technique, we have compared it to a thresholding technique in the FWT_TI domain. Preliminary tests of the application of the two de-noising techniques were constructed on a number of ECG signals taken from MIT-BIH database. The obtained results from Signal to Noise Ratio (SNR) and Mean Square Error (MSE) computations showed that our proposed de-noising technique outperforms the second technique. We have also compared the proposed technique to the thresholding technique in the bionic wavelet domain and this comparison was performed by SNR improvement computing. The obtained results from this evaluation showed that the proposed technique also outperforms the de-noising technique based on bionic wavelet coefficients thresholding.     

A Global Training Model for Beat Classification Using Basic Electrocardiogram Morphological Features

Clinical Study and automatic diagnosis of electrocardiogram (ECG) data always remain a challenge in diagnosing cardiovascular activities. The analysis of ECG data relies on various factors like morphological features, classification techniques, methods or models used to diagnose and its performance improvement. Another crucial factor in the methodology is how to train the model for each patient. Existing approaches use standard training model which faces challenges when training data has variation due to individual patient characteristics resulting in a lower detection accuracy. This paper proposes an adaptive approach to identify performance improvement in building a training model that analyze global training methodology against an individual training methodology and identifying a gap between them. We provide our investigation and comparative study on these methods and model with standard classification techniques with basic morphological features and Heart Rate Variability (HRV) that may aid real time application. This approach helps in analyzing and evaluating the performance of different techniques and can suggests adoption of a best model identification with efficient technique and efficient attribute set for real-time systems.

     

基于Bayes决策理论的表面肌电信号模式分类的研究

通过对采集的四通道表面肌电信号进行分析，对其建立AR（Autoregressive）参数模型，提取AR模型参数构建特征矢量。根据实际表面肌电（SEMG）信号的随机性特征，提出了一种采用Bayes决策理论对肌电信号的AR模型参数特征进行分类的新方法，并运用最小错误率Bayes分类器，很好地实现了对前臂八种动作表面肌电信号的模式分类。平均识别率为99．125％。此外，还提出采用动态聚类中心的方法对其进行了改进，使其平均识别率提高到99．5％。研究表明，采用Bayes分类器对肌电信号的AR模型参数特征进行分类，是一种有效的处理手段，并可直接应用到其它具有随机性特征的生理电信号的模式分类中。     

Metaheuristics with Deep Learning Empowered Biomedical Atherosclerosis Disease Diagnosis and Classification

Atherosclerosis diagnosis is an inarticulate and complicated cognitive process. Researches on medical diagnosis necessitate maximum accuracy and performance to make optimal clinical decisions. Since the medical diagnostic outcomes need to be prompt and accurate, the recently developed artificial intelligence (AI) and deep learning (DL) models have received considerable attention among research communities. This study develops a novel Metaheuristics with Deep Learning Empowered Biomedical Atherosclerosis Disease Diagnosis and Classification (MDL-BADDC) model. The proposed MDL-BADDC technique encompasses several stages of operations such as pre-processing, feature selection, classification, and parameter tuning. Besides, the proposed MDL-BADDC technique designs a novel Quasi-Oppositional Barnacles Mating Optimizer (QOBMO) based feature selection technique. Moreover, the deep stacked autoencoder (DSAE) based classification model is designed for the detection and classification of atherosclerosis disease. Furthermore, the krill herd algorithm (KHA) based parameter tuning technique is applied to properly adjust the parameter values. In order to showcase the enhanced classification performance of the MDL-BADDC technique, a wide range of simulations take place on three benchmarks biomedical datasets. The comparative result analysis reported the better performance of the MDL-BADDC technique over the compared methods.     

A composite high-frame-rate system for clinical cardiovascular imaging

High frame-rate ultrasound RF data acquisition has been proved to be critical for novel cardiovascular imaging techniques, such as high-precision myocardial elastography, pulse wave imaging (PWI), and electromechanical wave imaging (EWI). To overcome the frame-rate limitations on standard clinical ultrasound systems, we developed an automated method for multi-sector ultrasound imaging through retrospective electrocardiogram (ECG) gating on a clinically used open architecture system. The method achieved both high spatial (64 beam density) and high temporal resolution (frame rate of 481 Hz) at an imaging depth up to 11 cm and a 100% field of view in a single breath-hold duration. Full-view imaging of the left ventricle and the abdominal aorta of healthy human subjects was performed using the proposed technique in vivo. ECG and ultrasound RF signals were simultaneously acquired on a personal computer (PC). Composite, full-view frames both in RF- and B-mode were reconstructed through retrospective combination of seven small (20%) juxtaposed sectors using an ECG-gating technique. The axial displacement of the left ventricle, in both long-axis and short-axis views, and that of the abdominal aorta, in a long-axis view, were estimated using a RF-based speckle tracking technique. The electromechanical wave and the pulse wave propagation were imaged in a cineloop using the proposed imaging technique. Abnormal patterns of such wave propagation can serve as indicators of early cardiovascular disease. This clinical system could thus expand the range of applications in cardiovascular elasticity imaging for quantitative, noninvasive diagnosis of myocardial ischemia or infarction, arrhythmia, abdominal aortic aneurysms, and early-stage atherosclerosis.     

Detection of Number of Wideband Signals Based on Support Vector Machine

In array signal processing, number of signals is often a premise of estimating other parameters. For the sake of determining signal number in the condition of strong additive noise or a little sample data, an algorithm for detecting number of wideband signals is provided. First, technique of focusing is used for transforming signals into a same focusing subspace. Then the support vector machine (SVM) can be deduced by the information of eigenvalues and corresponding eigenvectors. At last, the signal number can be determined with the obtained decision function. Several simulations have been carried on verifying the proposed algorithm.     

扩频信号的声光谱相关检测

传统检测扩频信号的声光技术,是将扩频信号建模为随机平稳过程,而扩频信号是被伪随机码调制的周期信号,应建模为循环平稳随机过程。基于声光技术与循环谱相关技术,提出了扩频信号的声光谱相关检测方法。建立了基于声光时间积分的声光谱相关检测模型,分析了当干扰瞄准扩频接收机时,扩频信号在循环频率α=1/Tc的循环谱,给出了循环谱峰的检测公式TcRs1/。仿真实验结果表明,与传统的声光技术检测扩频信号的功率谱相比,在光电检测阵列上检测的循环谱峰,谱峰旁瓣几乎为零,并可多获得约3dB的增益,表明声光谱相关检测方法具有更优异的检测和抗干扰性能。     

Image-based cardiac phase retrieval in intravascular ultrasound sequences

Longitudinal motion during in vivo pullbacks acquisition of intravascular ultrasound (IVUS) sequences is a major artifact for 3-D exploring of coronary arteries. Most current techniques are based on the electrocardiogram (ECG) signal to obtain a gated pullback without longitudinal motion by using specific hardware or the ECG signal itself. We present an image-based approach for cardiac phase retrieval from coronary IVUS sequences without an ECG signal. A signal reflecting cardiac motion is computed by exploring the image intensity local mean evolution. The signal is filtered by a band-pass filter centered at the main cardiac frequency. Phase is retrieved by computing signal extrema. The average frame processing time using our setup is 36 ms. Comparison to manually sampled sequences encourages a deeper study comparing them to ECG signals.