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目的探讨应用颏下岛状皮瓣修复颊部软组织缺损的效果。方法对1999年6月至2010年9月南通大学附属医院口腔颌面外科收治的26例颊部软组织缺损病例(恶性肿瘤术后颊部软组织缺损22例,车祸外伤所致的颊部软组织缺损4例),应用颏下岛状皮瓣即刻修复,所采用组织瓣面积最大8cm×4cm,最小6cm×3cm。从功能恢复与缺损形态恢复的满意度评价术后修复效果。结果 26例皮瓣均完全成活,其中25例面部形态满意,1例外观欠佳。结论颏下岛状皮瓣是修复颊部软组织缺损的有效方法。     

颊部岛状皮瓣在口腔软组织缺损修复中的临床应用

目的 应用颊部岛状皮瓣修复口腔肿瘤根治性切除术后软组织缺损,并对其临床效果进行评定。方法 选择2006.07—2011.07口腔癌症患者23例,其中男13例,女10例,全部行病灶根治切除及颈淋巴清扫术,同期应用颊部岛状皮瓣修复舌、口底及其邻近组织缺损,皮瓣面积最大为10.4 cm×5.0 cm,最小为7.5 cm×3.5 cm,供区伤口直接拉拢缝合。术后观察皮瓣的成活、修复区外形及口腔与舌功能的恢复情况。结果 23例皮瓣均完全成活,创口一期愈合,术后外形满意,功能恢复良好,无明显面部畸形。结论 颊部岛状皮瓣是修复口腔内软组织缺损较为理想的组织瓣。     

额部岛状皮瓣的临床应用

额瓣的使用由来已久,全额瓣修复口腔颌面部大面积组织缺损屡有报道。但是,以滑车上动脉或颞浅动脉为蒂的额部岛状皮瓣在面部整复上的应用却甚少报道。近年来,我们先后采用该岛状皮瓣对8例鼻部,眼睑及眶下区组织缺损的患者进行了修复,均收到了较满意的效果。额部岛状皮瓣的应用解剖额部软组织由浅到深分为皮肤、皮下组     

逆行颏下动脉岛状肌皮瓣修复腭部恶性肿瘤术后缺损

目的探讨逆行颏下动脉岛状肌皮瓣同期修复腭部恶性肿瘤术后缺损的效果。方法2005年1月～2007年1月,采用逆行颏下动脉岛状皮瓣对8例腭部恶性肿瘤术后腭部缺损进行同期修复,皮瓣最小5cm×3cm,最大8cm×4cm。结果8例患者术后皮瓣完全存活,术后随访1年,未发现复发和转移,全部皮瓣形态质地良好,腭部形态满意。结论逆行颏下动脉岛状皮瓣具有可靠血供,操作简便安全,适合同期修复腭部恶性肿瘤术后缺损。     

额部岛状瓣在老年口腔癌术后缺损修复重建中的应用

目的:探讨额部岛状瓣在老年口腔癌术后缺损修复重建中的应用价值.方法:对13例老年口腔癌患者施行根治性手术,同期用额部岛状瓣行术后缺损重建.其中,8例额瓣经颧弓下进入口腔,5例经颧弓外侧转移进入口腔,分别修复颊部、舌部、磨牙后区和口底黏膜区组织缺损,重建口腔功能.结果:13例皮瓣均全部成活,修复区形态及功能良好.前额部供区缺损游离移植皮片全部成活,但植皮区皮肤移动度稍差,术后1年皮片色泽接近正常,额部畸形不明显.随访6个月～2a,未见复发和转移.结论:额部岛状瓣适合于老年口腔癌术后组织缺损的修复重建,尤其是面积较大的组织缺损.     

眶下蒂鼻唇沟瓣修复鼻缺损的临床研究

目的 :探索鼻缺损修复重建的新方法 ,评价眶下蒂鼻唇沟瓣修复鼻缺损的临床应用价值。方法 :对 10例患者应用眶下血管皮下蒂鼻唇沟瓣经皮下隧道转移修复其鼻部组织缺损。其中单纯皮肤皮下软组织缺损者 4例 ,鼻全层洞穿复合组织缺损者 6例。结果 :10例皮瓣全部存活 ,最大皮瓣面积 5cm× 2 .5cm ,皮瓣色泽、质地与周围皮肤相仿 ,触温觉存在 ,供区瘢痕隐蔽 ,形态恢复满意。结论 :眶下血管皮下蒂鼻唇沟瓣作为邻近轴形皮瓣 ,具有众多优点 ,是鼻缺损修复重建的理想方法之一。     

折叠延长下斜方肌岛状皮瓣修复面颊部巨大洞穿性缺损

目的:探讨应用折叠延长下斜方肌岛状皮瓣修复面颊部巨大洞穿性缺损的可行性。方法:16例(男10例,女6例,年龄17～75岁,平均年龄55.4岁)面颊部恶性肿瘤扩大切除后面颊部巨大洞穿性缺损患者,采用折叠延长下斜方肌岛状皮瓣修复。皮岛宽7～8 cm,长8～31 cm,折叠修复面颊部洞穿性缺损,恢复口腔内衬里及外侧颊部皮肤。结果:16例皮瓣全部成活。患者面颈部外观良好,口腔功能满意。结论:折叠延长下斜方肌岛状肌皮瓣可作为修复口腔恶性肿瘤根治术后所致面颊部巨大洞穿性缺损的首选皮瓣,其操作简便,安全可靠。     

面动脉-颏下动脉岛状肌皮瓣修复口底癌术后缺损

目的评价面动脉一颏下动脉岛状肌皮瓣同期修复日底癌术后缺损的临床应用效果。方法对9例口底癌患者行口底癌根治术,同期采用面动脉一颏下动脉岛状肌皮瓣修复重建口底组织缺损。4例患者为TINOMO,5例患者T2NOM0。皮瓣最小4．0cm×10．0cm．最大5．5cm×11．0cm。结果8例皮瓣完全成活;1例皮瓣小部分坏死,经过坏死组织切除及抗炎治疗,二期愈合。随访6—25个月。所有病例语言及吞咽功能恢复良好,面部外形满意。结论面动脉一颏。卜动脉岛状肌皮瓣适合同期修复中小型口底组织缺损。     

颏下岛状皮瓣在口腔颌面部肿瘤切除后软组织缺损修复中的应用

目的探讨颏下岛状皮瓣在口腔颌面部肿瘤切除后软组织缺损修复中的应用。方法分析颏下岛状皮瓣修复口腔颌面部肿瘤切除后软组织缺损7例,观察其近期临床效果。结果应用颏下岛状皮瓣修复7例患者,6例全部成活,1例出现小部分坏死,外观与功能满意。结论颏下岛状皮瓣具有供区隐蔽、距离近、厚度适中、易于成活、手术便利等优点,是口腔颌面部肿瘤切除后软组织缺损修复的较理想选择。     

晚期口腔癌术后颊部大范围洞穿性缺损的修复

目的:评价延长锁骨上岛状筋膜皮瓣联合延长垂直下斜方肌岛状肌皮瓣修复晚期口腔癌术后颊部大范围洞穿性缺损的可行性。方法:对我院2008年6月—2012年2月施行的17例延长锁骨上岛状筋膜皮瓣联合延长垂直下斜方肌岛状肌皮瓣修复晚期口腔癌切除后颊部黏膜和皮肤巨大洞穿性缺损病例进行回顾分析。结果:17例患者均伴晚期口腔癌切除后的颊部软硬组织巨大洞穿性缺损,修复口腔衬里的延长锁骨上岛状筋膜皮瓣大小为10 cm×8 cm～14 cm×10 cm,修复外部缺损的延长垂直下斜方肌岛状肌皮瓣大小为15 cm×8 cm～25 cm×10 cm。所有病例均无严重并发症,随访6～34个月,9例患者无瘤生存,2例带瘤生存,6例死于局部复发及远处转移。结论:应用延长锁骨上岛状筋膜皮瓣复合延长垂直下斜方肌岛状肌皮瓣修复晚期口腔癌术后颊部大范围洞穿性缺损是一种可靠的修复方法,对于再次手术,以及放疗后病例,在一定程度上优于游离皮瓣等其他修复方法。     

Oral cancer: molecular technologies for risk assessment and diagnosis

Purpose: The effective biomarkers related to diagnosis, metastasis, drug resistance and irradiation sensitivity of oral cancers will help the pathologist and oncologist to determine the molecular taxonomy diagnosis and design the individualization treatment for the patients with oral cancers.     

Stimulated whole saliva components in children with Down syndrome

The authors report on the components of stimulated whole saliva from children with Down syndrome—including pH, flow rate, sialic acid and protein concentrations, and amylase and peroxidase activity. Saliva samples were collected from 35 children aged 6–10 years. Of the participants, 17 had Down syndrome and 18 did not. To stimulate saliva production, the children chewed a piece of parafilm for 10 minutes before the sample was collected. Soon after collecting the saliva sample, the authors measured pH using a portable pH-meter. Sialic acid levels were determined with a thiobarbituric acid assay. Protein content was determined with Folin's phenol reagent. Amylase was assayed and the authors measured the maltose produced by the breakdown of starch and peroxidase using ortho-dianisidine.
No statistically significant difference was observed in levels of sialic acid (free and total) between the two groups. Protein concentration was about 36% higher in the group with Down syndrome. However, the salivary flow rate, pH, and amylase and peroxidase activities were lower among the children with Down syndrome.     

柠檬精油对牙周致病菌抑制作用及其安全性初步研究

目的:探讨柠檬精油对牙周致病菌的体外抗菌活性及对细胞增殖的影响。方法:采用微量液体稀释法测定柠檬精油对Pg、Fn、Aa、Pi的最小抑菌浓度(minimal inhibitory concentration,MIC)及最小杀菌浓度(minimum bactericidal concentration,MBC);以较低浓度的MIC为标准稀释LEO作为实验组,采用MTT法测定柠檬精油对HUVECs的毒性作用,明确抑菌浓度下LEO的安全性。结果:柠檬精油对牙周主要致病菌均有抑菌作用,Pg、Fn、Aa、Pi的MIC分别是9.0 g/L、4.5 g/L、4.5 g/L、9.0 g/L,Aa、Fn的 MBC是9.0 g/L,Pg、Pi的MBC未测得。1/2MIC、1/20MIC浓度的LEO能够抑制人脐静脉内皮细胞的生长,而低于1/200MIC浓度的LEO则对人脐静脉内皮细胞的生长没有影响,其中1/200MIC浓度的LEO作用明显优于0.02%的CHX。结论:体外环境中,柠檬精油对牙周致病菌Pg、Fn、Aa、Pi具有抗菌活性,低浓度应用对机体相对安全。     

Computer-assisted planning for maxillofacial prosthodontic rehabilitation

Computerized tomography (CT) planning and the use of CT derived surgical templates for implant placement have shown promise for restoring function within months after surgical reconstruction of acquired post-oncologic defects.     

牙髓再生的研究现状

目前,根管治疗术在临床上已得到了广泛的应用并成功的保存了患牙,但其仍有许多术后并发症。随着组织工程技术在口腔领域的应用,构建一种组织工程化牙髓进行牙髓-牙本质复合体的再生治疗成为可能。近年来国内外已有很多关于牙髓再生的研究,并且已经取得了一定成果。本文将对目前国内外牙髓再生的研究进展现状作一综述。     

Effect of Pingyangmycin on human venous malformation endothelial cells

Purpose: Venous malformations are common vascular anomalies with a propensity of the head and neck. Intralesional injection of Pingyangmycin (PYM, bleomycin A5 hydrochloride) is a widely used sclerotherapy method for the treatment of venous malformation.     

Clinical and pathological aspects on some odontogenic tumors

Odontogenic tumors constitute a very diverse group of lesions that reflects the complex processes of odontogenesis. Controversies over their classification/subtyping, terminology and diagnosis have been persisted, which has direct bearings on therapeutic and/or prognostic implications.     

Can you be too old for oral implants? An update on ageing and plasticity in the oro‐facial sensorimotor system

This review focuses on the capacity of the brain for plasticity and the utility and efficacy of oral implants in helping to restore oro‐facial sensorimotor functions, especially in elderly patients. The review first outlines the components of the oro‐facial sensorimotor system which encompasses both oro‐facial tissues and a number of brain regions. One such region is the sensorimotor cortex that controls the activity of the numerous oro‐facial skeletal muscles. These muscles are involved in a number of functions including reflexes and the more complex sensorimotor functions of mastication, swallowing and speech. The review outlines the use by the brain of sensory inputs from oro‐facial receptors in order to provide for exquisite sensorimotor control of the activity of the oro‐facial muscles. It highlights the role in this sensorimotor control played by periodontal mechanoreceptors and their sensory inputs to the brain, and how oral implants in concert with the plastic capacity of the brain may, at least in part, compensate for reduced sensorimotor functioning when teeth are lost. It outlines findings of ageing‐related decrements in oro‐facial sensorimotor functions and control. The changes in oro‐facial tissues and the brain that underlie these ageing‐related functional alterations are also considered, along with adaptive and compensatory processes that utilise the brain's capacity for plasticity. The review also notes the evidence t hat rehabilitation that incorporates adjunctive approaches such as sensorimotor training paradigms in addition to oral prostheses such as implants may enhance these processes and help maintain or facilitate recovery of sensorimotor functioning in the elderly.     

Tumor microenvironment in oral cancer: novel approaches for immunotherapy

Squamous cell carcinoma of the head and neck (SCCHN), which arises from the squamous mucosal epithelium of the oral cavity, pharynx and larynx, is a major health problem in the US and other parts of the world, especially in developing countries.