Genetics, aging, and the heart

Heart disease remains the most frequent cause of death in the general population and is intimately related to aging. Either extreme premature aging or marked longevity may be monogenic, but in most humans aging is a complex polygenic phenomenon. Hypercholesterolemia and hypertension are important factors. Cardiac amyloidosis and vascular elastin degradation may be separate factors. Humans with the greatest longevity are relatively refractory to atherosclerosis. Frequencies of heart deaths among relatives of a heart-death proband without dyslipoproteinemia conform to expectations of a polygenic trait. Careful, attentive medical management of major environmental factors and of heart senescence can result in more successful aging.     

Medicine, the media, and bioethics

The striatum of rats was lesioned by unilateral administration of MPP+. Two weeks later, a suspension of fetal mesencephalic cells (FMC), obtained from 14-day rat embryos, was injected into the lesioned striatum. Two weeks after grafting, the success of implantation and recovery of dopamine function were assessed by tyrosine hydroxylase immunocytochemistry (TH) and the measurement of striatal dopamine content. In addition, the extracellular concentrations of dopamine and dopamine metabolites were studied by microdialysis in vivo before and after perfusion of MPP+ to induce dopamine release from vesicular stores. TH+ cell bodies were seen in the lesioned grafted striata, indicating that fetal cells survived in these striata. In addition, there was a marked increase in TH-immunoreactivity in the neuronal fibers and terminals in the area surrounding the cell implant, suggesting a compensatory response of the host tissue which may involve fiber sprouting. Grafting induced a recovery in indices of dopamine function, including recovery in dopamine content, and basal and MPP+-induced dopamine release. Thus, grafts of FMC may provide a significant recovery of dopamine function in MPP+-lesioned striata.     

Attribution, the attractiveness stereotype, and the elderly.

The applicability of the physical attractiveness stereotype to perceptions of the elderly was tested in two studies. In the first study, college age and old observers rated the physical attractiveness of faces of elderly people (age 60–93). On the basis of these ratings, faces at three distinct levels of attractiveness were selected for use in the second study. In the second study, 72 young adult and 72 old volunteers viewed the selected faces and rated them in three areas of perceived social characteristics: personality factors, success in life experiences, and occupational achievements. The typical physical attractiveness stereotype was found for both groups of observers and in each of three areas of judgment. Multivariate analyses of variance for linear trends showed higher favorability of perceived social characteristics for faces with high perceived physical attractiveness. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Psychology, ideology, utopia, and the commons.

Argues that the failure of social scientists to seriously question their own ideological and methodological assumptions contributes to the complex interrelationship between global ecological and individual psychological problems. Much of the literature (e.g., G. Hardin, 1968) on the tragedy of the commons focuses on saving the global commons through increased centralization and regulation, at the expense of the individual's autonomy and psychological sense of community. It is suggested that utopian speculation in general and anarchist political analysis in particular are necessary correctives to misplaced attempts to rearrange the elements of the status quo rather than to alter it in a direction more in keeping with both survival and human dignity. (19 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Self-esteem, construal, and comparisons with the self, friends, and peers.

Extending the better than average effect, 3 studies examined self-, friend, and peer comparisons of personal attributes. Participants rated themselves as better off than friends, who they rated as superior to generalized peers. The exception was in direct comparisons, where the self and friends were not strongly differentiated on unambiguous negative attributes. Self-esteem and construal played moderating roles, with persons with high self-esteem (HSEs) exploiting both ambiguous positive and ambiguous negative traits to favor themselves. Persons lower in self-esteem exploited ambiguous positive traits in their favor but did not exploit ambiguous negative traits. Across self-esteem level, ratings of friends versus peers were exaggerated when attributes were ambiguous. HSEs seemed to take advantage of ambiguity more consistently to present favorable self-views; people with low self-esteem used ambiguity to favor their friends but were reluctant to minimize their own faults. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Meta-analytic methods, the Rorschach, and the MMPI.

In response to concerns described by H. N. Garb et al(see record 2001-05665-003), the authors present the weighted and unweighted means and medians of the effect sizes obtained by J. B. Hiller et al (see record 1999-11130-005). These indices of central tendency are presented separately for MMPI and Rorschach effect sizes, both for all the studies in the meta-analysis and for a 10% trimmed sample designed to obtain more robust estimates of central tendency. The variability of these 4 indices is noticeably greater for the MMPI than for the Rorschach. Meta-analysts must compute, compare, and evaluate a variety of indices of central tendency, and they must examine the effects of moderator variables. The authors also comment briefly on the use of phi versus kappa, combining correlated effect sizes and possible hindsight biases. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Symbiosis, empathy, suicidal behavior, and the family

This paper discusses the theoretical concept of symbiosis, as described by Mahler and her co-workers, and its clinical applications in suicidal situations. Symbiosis is defined as both a developmental phase characterized by a lack of differentiation between self and others and a relationship which is contingent upon the family and social network. A disturbed symbiosis is a major component in a suicide attempt. The destructive aspects of symbiosis are traced together with its relationship to empathy and the efforts to both restore and resolve a symbiotic conflict through suicidal behavior. In family therapy a repetition of older symbiotic relationships is frequently observed. These are repeated from one generation to the next in order to keep the old relationship alive. Finally, the practical implications of the concept of symbiosis for assessment and treatment are discussed.     

Heeding warnings ... from the canary, the whale, and the Jnuit, Part Two

There is a tension between traditional and modern definitions of reproductive risk and normalcy. These experts describe that tension as it plays out among the Inuit of Northern Canada from the perspective of a community midwife who has worked with the Inuit. She presents an analytical framework which classifies and illuminates the types of logic that compete in most birth settings around the world--a framework useful for showing how some types of logic can be supervalued while others, such as cultural or intuitive logic, are devalued or simply ignored, often at great cost. Part One presented political, scientific, clinical and cultural logic, and the influence of time. We now go on to look at professionalization and training and describe legal, personal, intuitive and economic logic. The author describes how the Inuit settlement of Povungnituk (POV) attempts to re-integrate the authoritative knowledge of the community by allowing Inuit midwives at The Maternity to choose their own criteria for balancing the imperatives of each kind of logic in decision-making for birth.     

Temperature, stability, and the hydrophobic interaction

Changes in free energy are normally used to track the effect of temperature on the stability of proteins and hydrophobic interactions. Use of this procedure on the aqueous solubility of hydrocarbons, a standard representation of the hydrophobic effect, leads to the conclusion that the hydrophobic effect increases in strength as the temperature is raised to approximately 140 degrees C. Acceptance of this interpretation leads to a number of far-reaching conclusions that are at variance with the original conception of the hydrophobic effect and add considerably to the complexity of interpretation. There are two legitimate thermodynamic functions that can be used to look at stability as a function of temperature: the standard Gibbs free energy change, deltaG degrees, and deltaG degrees/T. The latter is proportional to the log of the equilibrium constant and is sometimes called the Massieu-Planck function. Arguments are presented for using deltaG degrees/T rather than deltaG degrees for variations in stability with temperature. This makes a considerable difference in the interpretation of the hydrophobic interaction, but makes little change in the stability profile of proteins. Protein unfolding and the aqueous solubility of benzene are given as examples. The contrast between protein unfolding and the hydration of nonpolar molecules provides a rough estimate of the contribution of other factors that stabilize and destabilize protein structure.