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V. A. Popkov E. Y. Plotnikov D. N. Silachev L. D. Zorova I. B. Pevzner S. S. Jankauskas S. D. Zorov N. V. Andrianova V. A. Babenko D. B. Zorov 《Biochemistry. Biokhimii?a》2017,82(12):1549-1556
Current methods for treatment of cellular and organ pathologies are extremely diverse and constantly evolving, going beyond the use of drugs, based on chemical interaction with biological targets to normalize the functions of the system. Because pharmacological approaches are often untenable, recent strategies in the therapy of different pathological conditions are of particular interest through introducing into the organism of some living system or its components, in particular, bacteria or isolated subcellular structures such as mitochondria. This review describes the most interesting and original examples of therapy using bacteria and mitochondria, which in perspective can dramatically change our views on the principles for the treatment of many diseases. Thus, we analyze such therapeutic effects from the perspective of the similarities between mitochondria and bacteria as the evolutionary ancestors of mitochondria. 相似文献
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Anti-fungal therapy at the HAART of viral therapy 总被引:5,自引:0,他引:5
HIV-positive patients receiving combination therapy (highly active anti-retroviral treatment, HAART) suffer significantly fewer oral infections with the opportunistic fungal pathogen Candida albicans than non-HAART-treated patients. One component of HAART is an inhibitor of the HIV proteinase, the enzyme required for correct processing of retroviral precursor proteins. It would appear that HIV proteinase inhibitors also have a direct effect on one of the key virulence factors of C. albicans, the secreted aspartic proteinases (Saps). This suggests that the reduction in C. albicans infections in HIV-positive patients might not be solely the result of improved immunological status but could also be caused by the HAART treatment directly inhibiting Candida proteinases. 相似文献
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CHANDLER CA 《The Yale journal of biology and medicine》1953,25(5):369-373
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Malaviya GN 《Plastic and reconstructive surgery》2008,121(2):676; author reply 676-676; author reply 677
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FISCHER B 《Polski tygodnik lekarski (Warsaw, Poland : 1960)》1954,9(37):1205-1206
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BOBER S 《Polski tygodnik lekarski (Warsaw, Poland : 1960)》1950,5(4):142-5; concl
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SZREDER W 《Polski tygodnik lekarski (Warsaw, Poland : 1960)》1951,6(18-19):609-613
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BOBER S 《Polski tygodnik lekarski (Warsaw, Poland : 1960)》1950,5(3):101-4; contd
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Martin J. Cline M.D. 《Molecular and cellular biochemistry》1984,59(1-2):3-10
Summary A number of techniques are available for insertion of new genetic information into mammalian cells. Some of these have been used successfully for genetic modification of germ line cells and somatic cells of living animals. Some of these techniques may be applicable to treatment of some of the genetic diseases of man, once problems related to the control of expression of introduced genes are solved. 相似文献