输尿管镜下钬激光碎石术治疗输尿管结石的临床效果

目的观察输尿管镜下钬激光碎石术治疗输尿管结石的临床效果。方法选取2015年3月至2016年3月正阳县人民医院收治的68例输尿管结石患者,按手术方法将其分为两组,各34例。对照组接受输尿管镜下气压弹道碎石术治疗,观察组接受输尿管镜下钬激光碎石术治疗。对比两组的手术指标(手术时间和住院时间)、治疗效果(一次结石粉碎率和结石排尽率)及并发症发生情况。结果观察组手术时间[(45.34±12.27)min]及住院时间[(4.21±1.72)d]均短于对照组[(55.62±17.60)min、(6.20±2.12)d],差异有统计学意义(P均<0.05);观察组一次结石粉碎率与结石排尽率均高于对照组(97.06%比76.47%、94.12%比76.47%),差异有统计学意义(P均<0.05);两组输尿管损伤发生率比较,差异无统计学意义(P>0.05)。结论输尿管镜下钬激光碎石术治疗输尿管结石效果显著,可缩短患者手术时间及住院时间,提高一次结石粉碎率及结石排尽率,安全性高。     

两种方法治疗肾输尿管上段结石的疗效比较

目的比较经皮肾镜弹道碎石与钬激光碎石术治疗肾输尿管上段结石的疗效.方法将268例肾输尿管上段结石患者按术式进行分组,其中弹道碎石术组134例,采用经皮肾镜下气压弹道碎石术治疗,钬激光碎石术组134例,采用经皮肾镜下钬激光碎石术治疗,比较两组的治疗效果.结果弹道碎石术组的手术时间为(50.92±13.2)min、碎石成功率(92.2±0.5)%、结石排净率(93.2±0.2)%、术后住院时间(6.21±1.39)d,术后并发症发生率为(66.8±0.5)%;钬激光碎石术组的手术时间为(45.33±16.3)min、碎石成功率(97.3±0.3)%、结石排净率(98.6±0.1)%、术后住院时间(5.13±1.89)d,术后并发症发生率(47.3±0.7)%,两组比较差异具有统计学意义(P<0.05).结论钬激光碎石术治疗肾、输尿管上段结石的效果好,安全,不良反应少.     

输尿管镜钬激光和体外冲击波碎石术对输尿管上段结石的疗效比较

目的:比较输尿管镜钬激光碎石术与体外冲击波碎石术(ESWL)治疗输尿管上段结石的有效性和安全性。方法:采用输尿管镜钬激光碎石术治疗输尿管上段结石72例,ESWL治疗输尿管上段结石54例,比较两组碎石成功率、结石清除率、手术时间和并发症发生率。结果:输尿管镜钬激光碎石术平均手术时间为(40±9)min,ESWL平均手术时间为(42±8)min(P>0.05);输尿管镜钬激光碎石术碎石成功率为95.83%,高于ESWL组的83.33%(P<0.05);输尿管镜钬激光碎石术3个月后结石清除率为91.67%,高于ESWL组的74.07%(P<0.05);输尿管镜钬激光碎石术组并发症发生率为5.56%(4/72),ESWL组为3.70%(2/54),两组差异无统计学意义(P>0.05)。结论:输尿管镜钬激光碎石术治疗输尿管上段结石疗效优于ESWL。     

输尿管镜下钬激光碎石术治疗输尿管结石241例临床观察

目的观察输尿管镜下钬激光碎石术对于输尿管结石的疗效。方法采用输尿管镜下钬激光碎石术治疗我院2005年9月至2009年9月收治的241例输尿管结石患者,分析其手术时间、住院时间、一次性碎石成功率、并发症发生率及不同性质结石的碎石成功率,并与同期采取气压弹道碎石术治疗的233例患者的资料进行对比。结果钬激光组的手术时间（30.73±6.20）min及住院时间（6.31±1.70）d均小于气压弹道组,钬激光组的一次性碎石成功率（97.09%）高于气压弹道组,而并发症发生率（2.90%）均小于气压弹道组（P〈0.05）。而气压弹道组的胱氨酸结石成功率明显低于钬激光组。结论钬激光碎石术治疗输尿管结石尿疗效优于气压弹道碎石术,临床推荐应用钬激光碎石术来治疗输尿管结石。     

拦石网联合输尿管镜钬激光碎石术治疗输尿管上段结石的临床研究

目的探讨拦石网联合输尿管镜钬激光碎石术治疗输尿管上段结石的临床疗效。方法该院2010年1月—2013年12月收治的输尿管上段结石患者55例,随机分为观察组（30例）和对照组（25例）,观察组采取N-TRAP拦石网联合输尿管镜钬激光碎石术进行治疗,对照组采取输尿管镜钬激光碎石术进行治疗,观察两组患者手术成功率、术中出血量、手术时间、术后住院时间以及并发症情况。结果观察组患者手术成功率为96.66%,对照组组患者手术成功率为72%,组间差异有统计学意义（P〈0.05）;观察组患者手术时间、术中出血量、术后住院时间分别为（41.91±11.15）min、（13.21±4.19）m L、（4.87±1.39）d,对照组患者手术时间、术中出血量、术后住院时间分别为（31.68±12.55）min、（12.98±6.21）m L、4.79±1.63）d,两组手术时间差异有统计学意义（P〈0.05）,两组术中出血量、术后住院时间组间差异无统计学意义（P〉0.05）;观察组患者术后并发症发生率为13.33%,对照组患者术后并发症发生率为12.00%,组间差异无统计学意义（P〉0.05）。结论拦石网联合输尿管镜钬激光碎石术治疗输尿管上段结石可以提高手术成功率,无不良反应,值得临床推广应用。     

输尿管软镜钬激光碎石与经皮肾镜取石术治疗输尿管上段大结石比较

目的比较输尿管软镜钬激光碎石术(f-URS)和经皮肾镜取石术(PCNL)治疗输尿管上段大结石的临床疗效。方法回顾性分析2017年6月～2018年5月治疗的114例输尿管上段大结石患者的临床资料,根据治疗方式不同分为观察组、对照组,各57例。对照组接受PCNL治疗,观察组行f-URS治疗。观察两组围手术期指标、结石清除率、并发症发生情况。结果观察组与对照组手术时间[(46.38±20.06)min、(43.87±19.54)min]、结石清除率(100.00%、96.49%)、并发症发生率(1.75%、5.26%)对比,差异无统计学意义(P>0.05);观察组术中出血量(19.87±5.39)mL、术后住院时间(3.01±0.92)d低于对照组(40.87±6.41)mL、(6.89±2.27)d,差异有统计学意义(P<0.001)。结论 f-URS相对于PCNL治疗输尿管上段大结石有创伤小和住院时间短的优点。     

输尿管镜下钬激光碎石术临床疗效观察

目的:观察输尿管镜下钬激光碎石术治疗输尿管结石的临床疗效。方法:选取太原市中心医院2012年7月~2014年6月收治的126例输尿管结石患者,随机分为两组,观察组采用钬激光碎石治疗,对照组采用气压弹道碎石治疗,观察其临床疗效。结果:观察组平均手术时间为(29.2±4.2)min,平均术后住院时间(3.6±1.2)d均短于对照组(P<0.05);观察组结石的一次碎石率(95.23%)、结石排净率(98.41%)优于对照组(P<0.05),且观察组的并发症发生率低于对照组(P<0.05)。结论:经输尿管镜钬激光碎石具有一次成功率高,结石残留率低、术后并发症少等优势,是一种安全高效的治疗方法,值得临床推广应用。     

经输尿管镜钬激光碎石治疗输尿管结石

目的:探讨经输尿管镜钬激光碎石治疗输尿管结石的临床效果。方法:自2005年12月～2006年10月,应用经输尿管镜钬激光碎石治疗输尿管结石17例。结果:2例进镜失败改开放手术,15例碎石成功,单次钬激光碎石成功率为88.2%。手术时间40～70min,平均55min。术后住院3～6d,平均3.8d。结论:经输尿管镜钬激光碎石治疗输尿管结石效果良好,创伤小,并发症少,可作为输尿管结石的理想治疗方法。     

输尿管镜下钬激光碎石术治疗输尿管结石的疗效观察

目的:观察输尿管镜下钬激光碎石术治疗输尿管结石的疗效。方法:选取输尿管结石患者50例作为研究对象,按照随机数表法分成对照组和观察组,每组25例。对照组患者给予体外冲击波碎石术治疗,观察组患者给予输尿管镜下钬激光碎石术治疗,比较两组患者碎石成功率、手术时间、结石排净率以及并发症发生率。结果:与对照组比较,观察组碎石成功率、结石排净率高于对照组,手术时间短于对照组,并发症发生率低于对照组,组间差异均有统计学意义(P<0.05)。结论:输尿管镜下钬激光碎石术治疗输尿管结石患者的临床疗效优于体外冲击波碎石术的疗效。     

输尿管镜钬激光碎石术治疗输尿管结石的疗效观察

目的:探讨输尿管镜钬激光碎石术(LL)治疗输尿管结石的临床治疗效果。方法:将2014年1月至2015年3月该院收治的130例输尿管结石患者,随机分为观察组65例(采用输尿管镜钬激光碎石术进行治疗)和对照组65例(采用体外冲击波碎石术进行治疗),对比两组患者的临床治疗效果。结果:观察组的碎石成功率96.92%(63/65)、结石排净率98.46%(64/65)均高于对照组,手术时间(47.51±13.45)min也少于对照组,两组相比差异具有显著性(P0.05),两组住院天数差异不明显。结论:输尿管镜钬激光碎石术治疗输尿管结石安全、高效,值得在临床中进行推广应用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.