中药制药工艺学课程改革与实践初探

中药制药工艺学是制药工程专业主干课程制药工艺学课程的重要组成部分。从课程教学内容、教学方法及实践教学等方面提出教改思路,为中药制药工艺学课程教学提供参考。     

“质量源于设计”理念在制药工艺学中教学的应用

制药工艺学是制药工程专业的专业主干课程之一。本文从"Qb D"理念与制药工艺学课程的关系、"Qb D"理念在制药工艺学教学过程中的应用、教学效果等方面进行分析,进行基于质量源于设计理念的制药工艺学课程教学方法、思路的研究,提高学生设计能力、实践能力和综合能力。结果表明,该方法能够显著提高学生的质量规范意识。     

“应用技术型”教育背景下制药工艺学改革初探

制药工艺学是制药工程专业的核心课程之一。本文立足地方,紧密围绕地方经济发展,探索应用技术型本科教育背景下、符合商洛学院学情的制药工艺学课程教学模式,从制药工艺学教学模式设计、教学手段、实践教学等方面进行改革,探求应用技术型教育背景下的制药工艺学教学的新方法、新思路,有效培养学生的工程意识,充分调动学生的主观能动性。结果表明,课程改革效果显著。     

制药工艺学在工艺课程设计中的重要作用

概括介绍了制药工艺学与制药专业课程设计教学之间的密切关系,以实例说明了制药工艺学在课程设计中所起到的核心和指导作用。     

《制药工艺学》课程实践教学内容改革探讨

制药工艺学是制药工程专业的主干课程,侧重实践和应用。通过课程的实践课教学内容改革,对制药工程专业人才培养具有重要作用。本文从开设设计性实验、研究性工艺优化实验和制药工艺仿真的重要性方面进行探讨,以适应当前制药工艺学课程教学目的和要求。     

应用型本科院校制药工艺学实践教学改革的探讨

制药工艺学是制药工程专业的一门专业性和实践性很强的课程,实践教学是该门课程教学的重要环节。文章结合教学实践,初步探讨了制药工艺学课程的实践教学,以满足社会对应用型人才的需求。     

制药工艺学教学模式的体会与教学改革的探索

本文针对制药工艺学课程的自身特点,结合近两年的教学实践,从教学内容的安排、教学方法的探索、辅助教学手段的引入等方面对民族院校制药工程专业本科生制药工艺学课程的教学和改革进行了尝试,初步取得教学效果,提高了学生的积极性,收获了课堂教学质量。     

工科高校制药工程专业中药制药工艺学课程教学改革探索

为了使中药制药工艺学课程教学适合工科高校学生,文章对教学内容和教学方法进行了改革,从自编教材着手,扩展与中药相关的教学内容,由浅入深。在教学方法上采用启发、讨论、案例分析、多媒体、网络等教学手段,结合实验和生产实践教学,努力提高学生在中药生产方面的工程技术能力。本项改革探索获得了良好效果,为工科制药工程专业中药制药工艺学的教学提供了良好的借鉴。     

制药工程专业化学制药工艺学教学探索

化学制药工艺学是制药工程专业一门核心的专业课,交叉综合性强,知识复杂,与制药企业生产实践结合紧密。教学中采取建立企业教室、案例教学、课程设计等手段,以培养学生工程工艺设计能力为出发点,切实提高学生发现问题、分析问题和解决问题的能力,为制药工程专业化学制药工艺学课程教学改革提供参考。     

制药工艺学课程教学的探索与实践

制药工艺学是制药工程专业本科生的一门主干课,这门课与药品工业化密切相关,施教时感到内容多、难点多、知识结构复杂,特别是制药一线工程师认为很重要的工艺操作部分,学生往往感觉枯燥乏味,难以把握.本文介绍了笔者在制药工艺学课程教学中,对教学内容的选择和课时安排、教学模式和考核方式等方面所进行的教改探索和实践.     

Metabolism of trideuterated iso-lignoceric acid in rats in Vivo and in human fibroblasts in culture

Saturated very long chain fatty acids (fatty acids with greater than 22 carbon atoms; VLCFA) accumulate in peroxisomal disorders, but there is little information on their turnover in patients. To determine the suitability of using stable isotope-labeled VLCFA in patients with these disorders, the metabolism of 22-methyl[23,23,23-²H₃]tricosanoic (iso-lignoceric) acid was studied in rats in vivo and in human skin fibroblasts in culture. The deuterated iso-VLCFA was degraded to the corresponding 16- and 18-carbon iso-fatty acids by rats in vivo and by normal human skin fibroblasts in culture, but there was little or no degradation in peroxisome-deficient (Zellweger’s syndrome) fibroblasts, indicating that its oxidation was peroxisomal. Neither the 14-, 20-, and 22-carbon iso-fatty acids nor the corresponding odd-chain metabolites could be detected. In the rat, the organ containing most of the iso-lignoceric acid, and its breakdown products, was the liver, whereas negligible amounts were detected in the brain, suggesting that little of the fatty acid crossed the blood-brain barrier. Our data indicate that VLCFA labeled with deuterium at the ω-position of the carbon chain are suitable derivatives for the in vivo investigation of patients with defects in peroxisomal β-oxidation because they are metabolized by the same pathways as the corresponding n-VLCFA. Moreover, as iso-VLCFA and their β-oxidation products are readily separated from the corresponding n-fatty acids by normal chromatographic procedures, the turnover of VLCFA can be more precisely measured. A preliminary report of part of this work (Reference 18) was presented at the 5th International Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds, Strasbourg, France, June 20–24, 1994.     

佛山市顺德新城区降水中污染物的监测和分析

为掌握佛山市顺德新城区降水中污染物的情况,2015年7月至8月,文章作者分别在雨天进行了降水取样,对降水中的pH、电导率、常见阴离子(F-、Cl~-、NO_3~(2-)、SO_4~(2-))及部分重金属(铅和镉)进行监测分析。选择有相关数据的珠江三角洲和石家庄、厦门等地的降水中污染物的情况进行对比。结果表明,顺德新城区降水中的p H和部分阴离子浓度优于珠江三角洲平均值,酸雨类型属于硫酸和硝酸混合型;其水体洁净程度略差于石家庄;铅和镉的浓度也高于厦门,甚至部分超出了人体能直接接触的安全范围。     

中国粉末涂料行业发展现状之2014

根据国家统计局以及国内外相关机构的数据统计资料,按照自2004年以来的相同数据统计口径,以原材料消耗为基础,编制出我国粉末涂料行业年度数据统计报告,以期为政府制定相关产业政策,企业制定发展规划提供翔实的数据支撑。     

Phospholipid metabolism in cells in culture

The proportions of the different lecithin fractions have been determined in HeLa and KB tissue culture cells and Ehrlich Ascites tumor. 82.8% of the total phosphatidyl choline phosphorus is found in fraction 3 of HeLa cells. The major phosphatidyl cholines found in KB cells and Ehrlich Ascites tumor are in fractions 3 and 4 and representing 66.6% and 88.7% of the total phosphatidyl choline P, respectively. The incorporation of 1,2-¹⁴C-choline and 1,2-¹⁴C-ethanolamine into the various phosphatidyl choline fractions has been assayed to determine their biosynthesis in Ehrlich Ascites tumor. The incorporation of 1,2-¹⁴C-choline into fractions 3 and 4 is 100 times the 1,2-¹⁴C-ethanolamine. This evidence indicates that the methylation pathway of phosphatidyl choline synthesis is very low in HeLa, KB and Ehrlich Ascites cells. One of 13 papers presented at the symposium “Lipid Metabolism in Cells in Culture,” AOCS Meeting, Houston, May 1971. Part of a thesis submitted to the Graduate School of the University of North Dakota in partial fulfillment of the Degree of Master of Science.