中心性牙源性纤维瘤1例报告

中心性牙源性纤维瘤是一类非常少见的良性肿瘤,主要来自于形成上皮的间叶组织,由大量的胶原纤维构成,牙源性上皮细胞构成的上皮岛和上皮条索分布其间,组织内可能含有类似于发育异常的牙本质,发育不良的牙骨质及骨样物质所构成的钙化物。     

成釉细胞纤维瘤的临床特点和病理分析

成釉细胞纤维瘤由类似牙板和成釉器的牙源性上皮条索和类似牙乳头的牙源性外胚间充质组成,但没有成牙本质细胞,不含牙釉质和牙本质等牙齿硬组织,是一种真性、混合性牙源性良性肿瘤.     

牙源性肿瘤中骨形成蛋白分布的免疫组织化学分析

本文利用骨形成蛋白(BMP)单克隆抗体,采用免疫组化方法分析了7种25例牙源性肿瘤的 BMP分布。结果发现,根据有无 BMP,牙源性肿瘤可以分为两类:化牙骨质纤维瘤、良性牙骨质母细胞瘤、牙本质瘤、组合性牙瘤舍有丰富的 BMP;而造釉细胞瘤、牙源性腺样瘤、牙源性钙化上皮瘤则不含 BMP.BMP 与病理性牙齿硬组织同时存在,可能与牙源性肿瘤中硬组织的形成有关。各类牙源性肿瘤中 BMP抗原表达不一,可能是由于这些肿瘤发生于牙胚发育的不同阶段所致。     

外周性牙源性纤维瘤和外周性骨化性纤维瘤的临床病理研究

本文对外周性牙源性纤维瘤(POF—WHO型)和外周性骨化性纤维瘤(POF)的临床表现和组织形态特点进行比较研究,发现两者尽管均为发生于牙龈的局限性肿块,但POF的溃疡发生率和复发率均显著高于POF—WHO型。POF—WHO型纤维母细胞主质中散在多少不一的牙源性上皮团和发育不良牙本质等多种钙化物,属外周性牙源性肿瘤。而POF的纤维结缔组织中硬组织则以骨和牙骨质样物质多见,无牙源性上皮,但其纤维母细胞与邻近牙齿的牙周韧带主纤维束相移行,因而认为是一种与牙周膜有关的反应性,增生性瘤样病变。     

牙源性鳞状细胞瘤

牙源性■状细胞瘤(Squamous Odontogenic tumor,简称SOT)是一种较少见的真性良性牙源性肿瘤。该瘤曾被称作棘皮瘤型造釉细胞瘤(acanthomatous ameloblastoma),棘皮瘤型造釉细胞纤维瘤(acanthomatous amelohlastic fibroma),牙源性上皮瘤(epithelial odontogenic tumor)或良性牙源性上皮瘤(beaign epithelial odontogenic tumor)。1975年Pullon等首次描述和报告了6例发生于颌骨内的牙源性鳞状细胞瘸,并正式将该瘤命名为牙源性鳞状细胞瘤(SOT)。在此之     

骨外型牙源性钙化上皮瘤1例报告

牙源性钙化上皮瘤是一种良性肿瘤，也称Pindborg瘤，可分为骨内型和骨外型2种，主要发生于颌骨内，偶见于颌骨外。本文报告1例发生于口底的牙源性钙化上皮瘤，其临床症状与口底皮样囊肿相似．术后经组织病理学确诊，主要组织病理学特征是嗜酸性环状钙化团块。因其具有局部侵袭性，为避免复发，提倡完整切除肿物。     

44例牙源性纤维瘤临床病理分析

目的 研究牙源性纤维瘤的临床病理特点。方法 按世界卫生组织（WHO）1992年牙源性肿瘤分类标准对44例牙源性纤维瘤的临床病理特点及生物学行为进行回顾性研究。结果 本组44例中，女31例，男13例。发病年龄2－70岁，平均29岁。中心型5例，周边型39例。上颌19例，下颌25例。X线及手术中见4例牙槽骨明显破坏。术后有4例复发。组织学上表现为WHO型39例、单纯型4例和牙源性颗粒细胞瘤1例。肿瘤无明显包膜，边界尚清。结论 牙源性纤维瘤不是单一性肿瘤，组织学上表现为WHO型、单纯型和牙源性颗粒细胞瘤。诊断时应与增殖性牙滤泡、粘液瘤等相鉴别。     

牙源性上皮性联合瘤的临床病理和角蛋白表达研究

目的：研究4例牙源性上皮性联合瘤的临床病理和角蛋白免疫组化表达。方法：4例牙源性上皮性联合瘤均来源于武汉大学口腔医学院病理学教研室，10％福尔马林溶液固定，常规制片HE染色，免疫组化SP法检测肿瘤组织中CKl0、CKl0和13、CKl8和8、CKl9蛋白的表达。结果：全部4例中均显示牙源性腺样瘤的典型组织学特点，牙源性钙化上皮瘤样区大小不等，1例中的CEOT区为主要成分，CKl9呈阳性表达。结论：报告四例牙源性腺样瘤和牙源性钙化上皮瘤构成的牙源性上皮性联合瘤，其中一例为罕见的以牙源性钙化上皮瘤成分为主。     

牙源性黏液瘤的影像学特点

牙源性黏液瘤是发生于颌骨的良性肿瘤,具有局部侵润性,术前影像学检查往往不能准确定位肿瘤实际的边界,导致手术切除不彻底和较高的复发率,该文重点就近年来牙源性黏液瘤的影像学表现做一综述,以期对临床工作有一定的帮助。     

牙瘤的研究现状及发病机制探讨

牙瘤（odon＇toma）是牙源性的良性肿瘤,由成牙间充质和上皮的发育异常造成,瘤体内含有高分化的牙釉质,牙本质,牙骨质和牙髓等正常牙体组织的结构。     

Oral cancer: molecular technologies for risk assessment and diagnosis

Purpose: The effective biomarkers related to diagnosis, metastasis, drug resistance and irradiation sensitivity of oral cancers will help the pathologist and oncologist to determine the molecular taxonomy diagnosis and design the individualization treatment for the patients with oral cancers.     

Stimulated whole saliva components in children with Down syndrome

The authors report on the components of stimulated whole saliva from children with Down syndrome—including pH, flow rate, sialic acid and protein concentrations, and amylase and peroxidase activity. Saliva samples were collected from 35 children aged 6–10 years. Of the participants, 17 had Down syndrome and 18 did not. To stimulate saliva production, the children chewed a piece of parafilm for 10 minutes before the sample was collected. Soon after collecting the saliva sample, the authors measured pH using a portable pH-meter. Sialic acid levels were determined with a thiobarbituric acid assay. Protein content was determined with Folin's phenol reagent. Amylase was assayed and the authors measured the maltose produced by the breakdown of starch and peroxidase using ortho-dianisidine.
No statistically significant difference was observed in levels of sialic acid (free and total) between the two groups. Protein concentration was about 36% higher in the group with Down syndrome. However, the salivary flow rate, pH, and amylase and peroxidase activities were lower among the children with Down syndrome.     

柠檬精油对牙周致病菌抑制作用及其安全性初步研究

目的:探讨柠檬精油对牙周致病菌的体外抗菌活性及对细胞增殖的影响。方法:采用微量液体稀释法测定柠檬精油对Pg、Fn、Aa、Pi的最小抑菌浓度(minimal inhibitory concentration,MIC)及最小杀菌浓度(minimum bactericidal concentration,MBC);以较低浓度的MIC为标准稀释LEO作为实验组,采用MTT法测定柠檬精油对HUVECs的毒性作用,明确抑菌浓度下LEO的安全性。结果:柠檬精油对牙周主要致病菌均有抑菌作用,Pg、Fn、Aa、Pi的MIC分别是9.0 g/L、4.5 g/L、4.5 g/L、9.0 g/L,Aa、Fn的 MBC是9.0 g/L,Pg、Pi的MBC未测得。1/2MIC、1/20MIC浓度的LEO能够抑制人脐静脉内皮细胞的生长,而低于1/200MIC浓度的LEO则对人脐静脉内皮细胞的生长没有影响,其中1/200MIC浓度的LEO作用明显优于0.02%的CHX。结论:体外环境中,柠檬精油对牙周致病菌Pg、Fn、Aa、Pi具有抗菌活性,低浓度应用对机体相对安全。     

Computer-assisted planning for maxillofacial prosthodontic rehabilitation

Computerized tomography (CT) planning and the use of CT derived surgical templates for implant placement have shown promise for restoring function within months after surgical reconstruction of acquired post-oncologic defects.     

牙髓再生的研究现状

目前,根管治疗术在临床上已得到了广泛的应用并成功的保存了患牙,但其仍有许多术后并发症。随着组织工程技术在口腔领域的应用,构建一种组织工程化牙髓进行牙髓-牙本质复合体的再生治疗成为可能。近年来国内外已有很多关于牙髓再生的研究,并且已经取得了一定成果。本文将对目前国内外牙髓再生的研究进展现状作一综述。     

Effect of Pingyangmycin on human venous malformation endothelial cells

Purpose: Venous malformations are common vascular anomalies with a propensity of the head and neck. Intralesional injection of Pingyangmycin (PYM, bleomycin A5 hydrochloride) is a widely used sclerotherapy method for the treatment of venous malformation.     

Clinical and pathological aspects on some odontogenic tumors

Odontogenic tumors constitute a very diverse group of lesions that reflects the complex processes of odontogenesis. Controversies over their classification/subtyping, terminology and diagnosis have been persisted, which has direct bearings on therapeutic and/or prognostic implications.     

Can you be too old for oral implants? An update on ageing and plasticity in the oro‐facial sensorimotor system

This review focuses on the capacity of the brain for plasticity and the utility and efficacy of oral implants in helping to restore oro‐facial sensorimotor functions, especially in elderly patients. The review first outlines the components of the oro‐facial sensorimotor system which encompasses both oro‐facial tissues and a number of brain regions. One such region is the sensorimotor cortex that controls the activity of the numerous oro‐facial skeletal muscles. These muscles are involved in a number of functions including reflexes and the more complex sensorimotor functions of mastication, swallowing and speech. The review outlines the use by the brain of sensory inputs from oro‐facial receptors in order to provide for exquisite sensorimotor control of the activity of the oro‐facial muscles. It highlights the role in this sensorimotor control played by periodontal mechanoreceptors and their sensory inputs to the brain, and how oral implants in concert with the plastic capacity of the brain may, at least in part, compensate for reduced sensorimotor functioning when teeth are lost. It outlines findings of ageing‐related decrements in oro‐facial sensorimotor functions and control. The changes in oro‐facial tissues and the brain that underlie these ageing‐related functional alterations are also considered, along with adaptive and compensatory processes that utilise the brain's capacity for plasticity. The review also notes the evidence t hat rehabilitation that incorporates adjunctive approaches such as sensorimotor training paradigms in addition to oral prostheses such as implants may enhance these processes and help maintain or facilitate recovery of sensorimotor functioning in the elderly.     

Tumor microenvironment in oral cancer: novel approaches for immunotherapy

Squamous cell carcinoma of the head and neck (SCCHN), which arises from the squamous mucosal epithelium of the oral cavity, pharynx and larynx, is a major health problem in the US and other parts of the world, especially in developing countries.