影响脑室出血预后的若干因素分析

目的探讨影响脑室出血预后的因素。方法回顾性总结分析164例脑室出血患者的临床资料。结果原发性脑室出血66例，存活53例；继发性脑室出血98例，存活57例；单脑室出血62例，存活53例；双脑室以上出血102例，存活57例；血肿量60ml以上者43例，存活3例；血肿量60ml以下者121例，存活107例；昏迷57例，存活18例；清醒或意识障碍轻者107例，存活92例；脑疝63例，34例存活，无脑疝101例，76例存活。结论原发性脑室出血、单脑室出血、血肿量60ml以下、无脑疝及合并症者、年轻者及得到合理的治疗则效果良好。     

高血压性脑出血破入脑室的预后研究

本文报告经CT证实的高血压性脑出血破入脑室者32例,占同期脑出血的52.46％。从临床资料及CT所见,对脑出血合并脑室出血的预后进行了研究,提出影响预后的主要因素是脑室内血肿铸型,血肿大小超过3×3cm、血肿从Ⅲ、Ⅳ脑室穿破、来院时的意识水平和舒张压超过120mmHg及年龄在70岁以上者,预后差;若无以上情况,经过积极治疗预后可以是良好的。本文并讨论了内科治疗与手术治疗的适应症。     

外伤性基底节区因外科治疗预后判断与对策

目的：分析影响外伤性基底节区出血外科治疗预后的各种因素，探讨合适的治疗方法。方法：对手术治疗２６例外伤性基底区出血的临床资料进行回顾性分析。结果：意识障碍愈深、有发生脑疝者，血肿量愈大、血肿破入脑室特别是破入三、四脑室的死亡率愈高。结论：根据不同的病情和血肿是否破入脑室情况选择手术的方法。     

影响脑室出血预后的若干因素分析

目的：探讨影响脑室出血预后的因素。方法：回顾性总结分析915例脑室出血患者的临床资料。结果：原发性脑室出血28例，救活26例；继发性脑室出血67例，救活39例；单脑室出血42例，救活38例；双脑室以上出血53例，救活27例；血肿量60ml以上者27例，救活7例；血肿量60ml以下者40例，救活32例；脑疝18例，3例救活，无脑疝77例，53例救活。结论：原发性脑室出血、单脑室出血、血肿量60ml以下、无脑疝及合并症者、年轻者及得到合理的治疗则效果良好。     

影响脑室出血预后的若干因素分析

目的 探讨影响脑室出血预后的因素.方法 回顾性总结分析164例脑室出血患者的临床资料.结果 原发性脑室出血66例,存活53例;继发性脑室出血98例,存活57例;单脑室出血62例,存活53例;双脑室以上出血102例,存活57例;血肿量60ml以上者43例,存活3例;血肿量60ml以下者121例,存活107例;昏迷57例,存活18例;清醒或意识障碍轻者107例,存活92例;脑疝63例,34例存活,无脑疝101例,76例存活.结论 原发性脑室出血、单脑室出血、血肿量60ml以下、无脑疝及合并症者、年轻者及得到合理的治疗则效果良好.     

重症脑室出血21例治疗体会

目的 探讨重症脑室出血的治疗疗法及临床疗效 方法 选择原发性脑室出血5例，继发性脑室出血16例，全部病人采用双侧脑室前后角穿刺并注入尿激酶引流及间断腰椎穿刺引流血性脑脊液 结果 治愈者6例．显著进步者9例，进步4例，死亡2例，死亡率95％ 结论 双侧脑室穿刺引流，辅以尿激酶注入血肿腔溶解血块及间断腰椎穿刺引流血性脑脊液等多种治疗手段结合是目前治疗重症脑室出血极为有效的方法。     

丘脑出血急性期血肿定量与临床症状分析

目的研究丘脑血肿量与急性期主要临床症状的关系。方法对81例原发性丘脑出血患者的意识状态、头痛、失语症状与血肿CT表现进行统计分析。结果经比较,差异有显著性的指标有:①继发性脑室出血与单纯丘脑出血的昏迷发生率和头痛发生率;②不同意识状态病人组的丘脑出血量;③失语组与非失语组的血肿直径。结论继发性脑室出血患者容易发生昏迷,而单纯组患者出血量17~22ml者即可引起昏迷;血肿直径>3cm者常合并失语;继发性脑室出血患者头痛发生率高。     

丘脑出血急性期血肿定量与临床症状分析

目的研究丘脑血肿量与急性期主要临床症状的关系。方法对原发性丘脑出血81例患者的意识状态、头痛、失语症状与血肿CT表现进行统计分析。结果经比较,有统计学差异的指标有:(1)继发性脑室出血与单纯丘脑出血的昏迷发生率和头痛发生率;(2)不同意识状态病人组的丘脑出血量;(3)失语组与非失语组的血肿直径。结论继发性脑室出血患者容易发生昏迷,而单纯组患者出血量17～22ml者即可引起昏迷;血肿直径大于3cm者常合并失语;继发性脑室出血患者头痛发生率高。     

丘脑出血急性期血肿定量与临床症状分析

目的研究丘脑血肿量与急性期主要临床症状的关系.方法对原发性丘脑出血81例患者的意识状态、头痛、失语症状与血肿CT表现进行统计分析.结果经比较,有统计学差异的指标有(1)继发性脑室出血与单纯丘脑出血的昏迷发生率和头痛发生率;(2)不同意识状态病人组的丘脑出血量;(3)失语组与非失语组的血肿直径.结论继发性脑室出血患者容易发生昏迷,而单纯组患者出血量17～22ml者即可引起昏迷;血肿直径大于3 cm者常合并失语;继发性脑室出血患者头痛发生率高.     

双侧脑室微创穿刺引流加尿激酶灌注治疗重症脑室出血

目的：探讨重症脑室出血治疗的有效方法。方法：对25例重症脑室出血患者（Graves评分8分以上）采用YL-1型一次性颅内血肿粉碎穿刺针进行双侧脑室引流加尿激酶灌注及早期腰穿脑脊液置换。结果：治愈者7例，显著进步者9例，进步5例，死亡4例，病死率16％。结论：双侧脑室微创穿刺引流加尿激酶灌注及早期腰穿脑脊液置换是治疗重症脑室出血一种安全、有效方法。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.