血管内皮生长因子与甲胎蛋白联合检测对原发性肝癌的价值

目的 探讨血清中血管内皮生长因子(VEGF)和甲胎蛋白(AFP)联合检测在原发性肝癌辅助诊断中的应用价值.方法 应用放射免疫法和双抗体夹心ELISA法对40例原发性肝癌患者进行血清AFP和VEGF水平测定,并以30例肝硬化患者和30名健康人做比较.结果 健康人血清VEGF水平为(78.9±24.2)pg/ml;肝硬化患者血清VEGF水平为(102.6±47.6)pg/ml;38例肝癌患者血清VEGF为(444.8±220.9)pg/ml.肝癌患者的外周血VEGF水平显著高于健康人和肝硬化患者(P＜0.01);肝硬化与健康人差异无统计学意义(P＞0.05).血清VEGF的水平与AFP无相关性;AFP联合VEGF检测时阳性率由单项的76.3%提高到84.9%.结论 VEGF是相对独立的指标,与AFP联合检测可以提高原发性肝癌的检出率.     

乳腺浸润性导管癌中EZH2、VEGF和MVD的表达及与临床病理学特征的关系

目的探讨果蝇zeste基因增强子同源物2(EZH2)表达及与乳腺浸润性导管癌血管内皮生长因子(VEGF)、血管生成及临床病理特征的关系。方法采用免疫组织化学SP两步法检测90例手术切除的原发性乳腺浸润性导管癌组织中EZH2、VEGF和CD34表达情况,用图像分析软件对EZH2、VEGF进行定量测试,计数400倍镜下CD34标记血管内皮细胞数即微血管密度(MVD),并分析EZH2、VEGF和MVD与乳腺浸润性导管癌临床病理特征的关系。用Spearman相关系数分析EZH2、VEGF及MVD表达的相关性。结果 EZH2在正常乳腺组织、乳腺低级别导管内癌、高级别导管内癌和浸润性导管癌中表达依次升高。90例乳腺浸润性导管癌组织中EZH2和VEGF的表达率分别为86.67%(78/90)和80%(72/90)。EZH2和VEGF蛋白与乳腺浸润性导管癌肿瘤直径、组织学分级、淋巴结转移状况、pTNM分期均有关(P<0.05)。MVD与乳腺浸润性导管癌组织学分级、淋巴结转移状况、pTNM分期均有关(P<0.05)。Spearman相关分析显示EZH2蛋白的表达和VEGF和MVD均呈显著正相关(rp=0.984,P=0.000;rp=0.346,P=0.000),VEGF和CD34的表达呈显著正相关(rp=0.321,P=0.000)。结论 EZH2可能直接参与了乳腺浸润性导管癌的演变过程,是肿瘤发生早期阶段的分子事件,EZH2的高表达促进了VEGF的表达和肿瘤血管密度的增加,进一步促进了肿瘤的发生发展。     

急性脑梗死患者血浆循环DNA测定的意义

目的探讨循环DNA在急性脑梗死患者中的应用价值。方法采集20例急性脑梗死患者(研究组)发病后24h内静脉血2ml,采用双重荧光定量PCR技术检测血浆DNA水平,同时检测血清超敏C-反应蛋白(hs-CRP)。采集同期20例健康体检者静脉血为对照组。结果治疗前研究组血浆循环DNA水平显著高于对照组(t=5.237,P=0.000),研究组hs-CRP显著高于对照组(t=4.890,P=0.000);治疗后循环DNA显著下降(t=4.461,P=0.000);hs-CRP治疗前后差异有统计学意义(t=3.964,P=0.000)。脑梗死患者血浆循环DNA水平与其血清hs-CRP水平呈正相关(r=0.613,P=0.022)。结论循环DNA可作为反映脑梗死后脑组织细胞出现损伤及严重程度的一项指标。     

T1DM合并DR患者糖化间隙与血清VEGF水平的相关性

目的 分析1型糖尿病(T1DM)合并糖尿病视网膜病变(DR)患者糖化间隙(GGap)与血清血管内皮生长因子(VEGF)水平的相关性.方法 T1DM患者65例分为两组;其中,24例合并DR(DR组),41例不合并DR(非DR组).比较两组相关资料,采用Spearman相关性分析GGap与血清VEGF水平的相关性.结果 与非DR组比较,DR组病程更长,GGap和血清VEGF水平更高(P＜0.05).Spearman相关性分析发现,GGap与血清VEGF水平呈正相关(rs=0.600,P＜0.01).根据GGap采用三分位法将患者分为三组,高GGap组血清VEGF水平高于低GGap组和中GGap组-202.60(162.60,260.95) ng/mL vs.80.10 (66.45,90.00) ng/mL和96.80(69.70,225.67) ng/mL](P＜0.05).结论 T1DM合并DR患者GGap和血清VEGF水平较高,且GGap与血清VEGF水平呈正相关.     

原发性肝癌患者血清IL-18、VEGF和sVCAM-1水平变化及临床意义

目的 研究原发性肝癌( PHC)患者血清白细胞介素-18 (IL-18)、血管内皮生长因子(VEGF)与可溶性血管细胞粘附分子-1 (sVCAM-1)水平及临床意义.方法 采用双抗体夹心酶联免疫吸附法( ELISA)检测15例原发性肝癌患者治疗前后血清IL-18、VEGF、sVCAM-1水平,并与正常对照组比较.结果 PHC患者治疗前血清IL-18、VEGF、sVCAM-1较正常对照组明显升高(P均＜ 0.05); PHC患者治疗两周后血清IL-18、VEGF、sVCAM-1较治疗前降低(P均＜0.05),且较正常对照组仍有升高趋势(P均＜0.05).结论 原发性肝癌患者血清IL-18、VEGF、sVCAM-1水平增高,可能与原发性肝癌的发生、发展及侵袭有关.     

类风湿关节炎患者血清血管内皮细胞生长因子测定及临床意义

目的　了解类风湿关节炎 (RA)患者血清血管内皮细胞生长因子 (VEGF)与病情活动性的相关性以探讨其临床意义。方法　采用酶联免疫吸附试验 (ELISA)方法检测RA患者活动组 (30例 )、缓解组 (30例 )及正常对照组 (30名 )的血清VEGF ,并分析血清VEGF与RA病情活动指标之间的关系。结果　活动组RA患者血清VEGF(183± 5 6 )ng L显著高于缓解组 (84± 8)ng L及正常对照组 (82± 8)ng L (P <0 0 1) ;活动组患者血清VEGF浓度与RA病情活动指标C反应蛋白 (CRP) (r=0 711,P <0 0 0 1)及Stoke指数 (r=0 6 38,P <0 0 0 1)呈显著正相关 ,与类风湿因子 (RF) (r=0 16 1,P >0 0 5 )、血沉 (ESR) (r=0 12 8,P >0 0 5 )、双足双手X线狭窄侵蚀积分 (r=- 0 0 11,P >0 0 5 ;r=0 0 2 4 ,P >0 0 0 5 )无相关性。与反应RA活动期指标血清透明质酸 (HA)、可溶性白细胞介素 2受体 (sIL 2R)、白细胞介素 2 (IL 2 )相比 ,VEGF判断RA活动期的敏感性为 93 3% ,特异性为 93 3%。结论　血清VEGF与RA的病情活动性有关 ,检测血清VEGF有助于RA活动性判断     

血管生长相关因子的血清浓度与肝细胞癌预后的相关性研究

目的：探讨VEGF和endostatin与肝细胞癌患者手术预后的相关性研究。方法采用ELISA法检测37例肝细胞癌患者、30例肝硬变患者和32例健康者外周血清VEGF、内皮抑素水平。分析外周血VEGF、内皮抑素水平与肝细胞癌患者手术预后的关系。结果肝细胞癌患者外周血清VEGF水平、内皮抑素水平均明显高于肝硬变患者和健康者（P〈0.05）。肝硬变患者外周血清VEGF水平明显高于健康者（P〈0.05）。VEGF与生存时间显著负相关（r=-0.74; P〈0.001）。血清VEGF较高的肝癌患者的生存时间明显短于血清VEGF较低的肝癌患者（P=0.004）。结论肝细胞癌患者外周血清VEGF、内皮抑素水平升高。检测外周血清VEGF、内皮抑素水平有助于肝细胞癌患者预后评估。     

妊娠中期糖尿病患者血清Cys-C、Hcy水平改变与胰岛素抵抗的相关性研究

目的 对比分析妊娠糖尿病(GDM)患者与健康孕妇血清胱抑素C(Cys-C)和同型半胱氨酸(Hcy)的水平差异及二者与胰岛素抵抗(IR)的相关性,探讨Cys-C和Hcy在GDM发病中的作用。方法 选择2013年5月至2015年5月在我院围产保健科常规产检的24~28周孕妇,经口服葡萄糖耐量试验(OGTT)诊断为GDM的患者68例纳入观察组,选择同期非GDM的健康孕妇72例纳入对照组。分别检测Cys-C、Hcy、空腹血糖(FPG)、1hPG、2hPG、3hPG、糖化血红蛋白(HbA_lC)、空腹胰岛素(FINS)临床指标。比较两组患者的血清Cys-C与Hcy的水平及与 IR的相关性。结果 两组患者的1hPG、HbA_lC相比,差异无统计学意义(P＞0.05)。观察组的Cys-C、Hcy、 FPG、2hPG、3hPG、FINS血清水平明显升高(P＜0.05);观察组的HOMA-IR较对照组明显升高(P＜0.05)。GDM组患者血清Cys-C与HOMA-IR呈显著地正相关(r=0.478,P=0.000),血清Hcy与HOMA-IR呈显著地正相关(r=0.355, P=0.003),血清Cys-C与Hcy也呈显著正相关(r=0.455, P=0.000)。 结论 GDM患者对血糖的调节能力下降,其血清Cys-C和Hcy的水平明显升高。     

肿瘤浸润性树突状细胞和血管内皮生长因子在非小细胞肺癌组织中的表达及意义

目的 探讨肿瘤浸润性树突状细胞(TIDC)和血管内皮生长因子(VEGF)在非小细胞肺癌组织中的表达水平及临床意义.方法 自2014年1月至2016年12月,连续性收集濮阳市油田总医院收治的非小细胞肺癌患者106例,术中取肿瘤标本,检测肿瘤组织中TIDC和VEGF水平,并分析其与患者其他临床特征的相关性.结果 与健康组织比较,肿瘤组织中TIDC数密度显著降低[(10.58±3.18)比(18.93±3.26),t=18.877,P=0.000];VEGF阳性率显著增高(43.45％比11.32％,χ2=26.131,P=0.000);MHC-Ⅱ阳性DC显著降低[(6.48±1.04)％比(12.57±2.57)％,t=22.615,P=0.000];CD54阳性DC显著降低[(7.12±1.59)％比(12.81±2.81)％,t=18.144,P=0.000].与TNM分期为Ⅰ或Ⅱ期的患者相比,Ⅲ或Ⅳ期患者TIDC数密度显著降低[(9.51±2.88)比(11.82±3.58),t=3.680,P=0.000];VEGF阳性率显著增加(61.40％比20.41％,χ2=18.126,P=0.000);MHC-Ⅱ阳性DC显著降低[(7.83±1.05)％比(5.32±0.91)％,t=13.186,P=0.000];CD54阳性DC显著降低[(6.26±1.01)％比(8.12±1.72)％,t=6.900,P=0.000].与肿瘤细胞为高分化的患者相比,中低分化的患者TIDC数密度显著降低[(9.58±2.58)比(12.37±3.13),t=4.941,P=0.000];MHC-Ⅱ阳性DC显著降低[(6.01±1.09)％比(7.32±0.93)％,t=6.244,P=0.000];CD54阳性DC显著降低[(6.66±1.68)％比(7.94±1.58)％,t=3.842,P=0.000].结论 TIDC在肿瘤组织中低表达,且多为不成熟的调节性DC细胞,VEGF在肿瘤组织中高表达,均与患者临床预后恶化有关.     

原发性肝癌患者HBVX基因与内分泌激素相关性的初步研究

为了解原发性肝癌（HCC）患者的内分泌激素水平与HBVX基因间的相互关系,探讨HBV相关性HCC发生中内分泌激素的作用,用聚合酶链反应技术-限制片段长度多肽性分析法（PCR－RFLP）检测48例原发性肝癌患者血清HBVX基因,并与用放射免疫法（RIA）检测的血清睾酮（T）、雌二醇（E2）、生长激素（HGH）、泌乳素（PRL）、C肽水平进行相关分析。结果表明,HBVX基因阳性原发性肝癌患者血清HGH水平显著高于阴性组（t=3．38,P＜0．01）;T水平显著低于阴性组（t=2.24,P＜0．05）。HBVX基因阳性肝癌患者C肽水平与E2高度正相关（r=0．861,P＜0．01）,与T正相关（r=0．380,P＜0．05）;血清HGH水平与E2正相关（r=0．471,P＜0．05）。结果提示：HGH、T、E2水平的改变与HBV相关性HCC发生有关;其中E2、胰岛素和HGH可能有协同作用。     

糖尿病肾病患者血清血管内皮生长因子影响因素分析

目的　分析影响 2型糖尿病肾病 (DN)患者血清血管内皮生长因子 (VEGF)水平的因素。方法　采用双抗夹心ELISA法检测 12 2例糖尿病患者血清VEGF水平并与 4 0例健康体检者的血清VEGF水平作对比分析。使用SPSS10 0统计软件包对糖化血红蛋白 (GHbAlc)、血糖、尿白蛋白 (UALB)和肌酐 (Cr)等影响因素进行统计比较分析。结果　非糖尿病肾病 (NDN)组和糖尿病肾病组患者血清VEGF水平明显高于正常对照组(P =0 0 33;P =0 0 0 0 ;P =0 0 0 0 ) ;DN组患者血清VEGF水平明显高于NDN组 (P =0 0 2 0 ;P =0 0 0 0 ) ;糖尿病肾病患者血清VEGF水平受糖化血红蛋白、尿白蛋白等因素影响 (P =0 0 0 0 ;P =0 0 0 0 )。结论　糖尿病患者血清VEGF水平明显升高 ,糖尿病肾病患者血清VEGF水平受糖化血红蛋白、尿白蛋白等因素的影响 ,且随尿白蛋白的增加而增高 ,高水平的血清VEGF有可能参与糖尿病肾病的发生、发展过程 ,并在一定程度上反映病情的严重程度。     

Relationship between leukocyte count and angiographical characteristics of coronary atherosclerosis

AIM: To explore the relationship between differential leucocyte count and coronary atherosclerosis. METHODS: The study population consisted of 507 consecutive patients (376 male and 131 female) who underwent coronary angiography for suspected or known coronary atherosclerosis. The patients' smoking and drinking habits were investigated, and anthropometric measurements, serum measurements, and hematological measurements were conducted for every patient. The severity of coronary atherosclerosis was defined by using Gensini's score system. One-way ANOVA, Spearman's correlation analysis, and multivariate stepwise linear regression analysis were employed to explore the relationship between differential leucocyte count and coronary atherosclerosis. RESULTS: One-way ANOVA indicated that the diastolic blood pressure, glucose, urea, creatinine, leukocyte count, neutrophil count, monocyte count, hemoglobin, and platelet count differed among the groups according to Gensini's score, the tertile values of which were used as cutoff points. Spearman's correlation analysis suggested that Gensini's score was significantly correlated with age, diastolic blood pressure, glucose, urea, creatinine, leukocyte count, neutrophil count, monocyte count, hemoglobin, and erythrocyte count, respectively. Multivariate stepwise linear regression analysis show that neutrophil count (beta=0.247, P=0.000), age (beta=0.141, P=0.001), glucose (beta=0.173, P=0.000), creatinine (beta=0.088, P=0.063), hemoglobin (beta=-0.168, P=0.013) and sex (men were coded as 1 and women were coded as 2; beta=-0.121, P=0.012) were significantly independently associated with the Gensini's score. CONCLUSION: The independent association of neutrophil count with the angiographical characteristics of coronary atherosclerosis, as estimated by Gensini's score, strongly suggests that granulocytosis may play a role in the development of coronary atherosclerosis.     

膀胱尿路上皮癌血管内皮生长因子的表达与微血管密度相关性研究

目的探讨膀胱尿路上皮癌血管内皮生长因子（VEGF）的表达和微血管密度（MVD）及临床病理特征的关系。方法采用免疫组化sP法对54例原发性膀胱尿路上皮癌组织中VEGF进行染色,同时计数肿瘤内的MVD,观察VEGF的表达与MVD的关系。结果54例原发性膀胱尿路上皮癌组织中VEGF阳性表达率为61．1％（33例）,在正常膀胱黏膜组织中未见表达。VEGF阳性组的MVD计数显著高于VEGF阴性组（P〈0．05）,而且随着VEGF阳性表达的增强,MVD计数显著增加（P〈0．05）;VEGF在癌组织中的表达随着肿瘤病理分级、TNM分期的增加和淋巴结转移的出现而显著增强（P〈O．05）。结论VEGF的异常表达与膀胱尿路上皮癌MVD增加及恶性进程有关,是判断膀胱癌预后有价值的指标。     

肝癌患者癌组织及血清中CD163的表达水平及意义

目的 探究CD163在原发性肝癌患者癌组织及血清中的表达水平及其临床意义.方法 选取2013年9月至2016年9月于本院诊治的100例原发性肝癌患者为观察组研究对象,同期本院体检正常者50例为对照组研究对象,比较两组研究对象癌组织(正常肝组织)及血清中CD163的表达水平.结果 观察组CD163在癌组织中的表达水平显著高于对照组CD163在正常肝组织中的表达水平[(47.96±13.35) ng/ml比(20.50±6.57) ng/ml],差异具有统计学意义(t=13.721 0,P=0.000 0);观察组CD163在血清中的表达水平显著高于对照组[(2000.25±833.11) ng/ml比(307.76±140.18) ng/ml],差异具有统计学意义(t=14.241 5,P=0.000 0).结论 原发性肝癌患者癌组织及血清中CD163表达水平均显著升高,可为临床诊断肝癌提供重要参考.     

Serum sodium concentration is significantly associated with the angiographic characteristics of coronary atherosclerosis

AIM: To explore the relationship between serum sodium concentration and coronary atherosclerosis. METHODS: The study population consisted of 896 consecutive patients (684 males and 212 females) who underwent coronary angiography for suspected or known coronary atherosclerosis. Smoking and drinking were investigated. The anthropometric measurements, including body mass index, systolic blood pressure and diastolic blood pressure, and the serum measurements, including sodium, potassium, chlorine, lipids, blood glucose, urea, creatinine, and uric acid for every patient were conducted. The severity of coronary atherosclerosis was defined by the Gensini score system. The statistical methods, including one-way ANOVA, Kruskal-Wallis test, Spearman correlation analysis, partial correlation analysis, multivariate stepwise linear regression analysis, and multinomial logistic regression analysis were employed to explore the relationship between serum sodium concentration and the Gensini score. RESULTS: The analysis of the Kruskal-Wallis test indicated that the distribution of the Gensini score (P=0.000) differed among the groups according to serum sodium concentration, quartile values of which were used as cut-off points. The Spearman correlation and partial correlation analysis controlling for gender, smoking status, and drinking status indicated that the Gensini score significantly correlated with the sodium concentration (r=-0.241, P=0.000 for the Spearman correlation, r=-0.114, P=0.000 for the partial correlation). The results from the multivariate stepwise linear regression analysis showed that the left ventricular ejection fraction (beta=-0.228, P=0.000), age (beta=0.137, P=0.010), glucose level (beta=0.129, P=0.000), and sodium level (beta=-0.106, P=0.004) were significantly and independently associated with the Gensini score. The results of the multinomial logistic regression analysis suggested that the hyponatremia was the risk factor for the higher Gensini score. CONCLUSION: The serum sodium concentration was significantly and negatively associated with the Gensini score; and the actual mechanism underlying the association needs further study.     

宫颈癌患者组织和血清中血管内皮生长因子C（VEGF—C）的检测及意义

目的探讨宫颈癌患者癌组织与血清中血管内皮生长因C（VEGF—C）的表达及相关性。方法收集72例血清、组织样本：对照组13例、宫颈上皮内瘤变CINⅡ／Ⅲ18例、无淋巴结转移宫颈癌31例、淋巴结转移宫颈癌10例。免疫组化方法检测组织中VEGF—C水平，ELISA法检测血清中VEGF—C水平。结果①宫颈癌淋巴转移组VEGF—C水平高于无淋巴转移组，无淋巴转移组VEGF—C水平高于CIN组及对照组，差异有显著意义（P〈0．05）VEGF—C表达还与癌浸润深度相关，差异有显著意义（P〈0．05），CIN组与对照组之间无显著差异（P〉0．05）。②组织和血清中VEGF—C表达呈正相关，经Pearson相关性分析R=0．725。结论宫颈癌患者组织和血清中VEGF—C含量与宫颈组织恶变、浸润深度及淋巴转移有关，检测其表达可能成为宫颈癌早期诊断的有用指标之一，可能成为术前判定淋巴结转移的有用指标；组织和血清中VEGF—C表达呈明显正相关，血清中的VEGF—C的检测可能成为替代组织检测的一种创伤性更小，更简便且可重复性强的检测方式。     

不同TNM分期肝癌患者微血管密度与肿瘤标志物水平相关性研究

目的 探讨不同TNM分期肝癌患者微血管密度(microvessel density,MVD)与肿瘤标志物水平的相关性.方法 选取我院接受肝癌手术治疗的患者70例,同期因外伤接受肝脏手术的患者20例,健康体检者20例,采用免疫组织化学法检测不同分期肿瘤组织、癌旁组织以及正常肝脏组织中的MVD水平,采用酶联免疫分析法(ELISA)检测血清甲胎蛋白(AFP)、恶性肿瘤特异性生长因子(TSGF)、血管内皮细胞生长因子(VEGF)水平.结果 与正常肝脏组织比较,肿瘤组织及癌旁组织中MVD水平较高,且肿瘤组织高于癌旁组织(P<0.05);肿瘤组织中MVD水平随TNM分期增高而增加,且不同分期间比较差异有统计学意义(P<0.05);与健康体检者比较,肝癌患者血清AFP、TS-GF、VEGF水平明显较高(P<0.05);肝癌患者血清AFP、TSGF、VEGF水平随TNM分期增高而增加,且不同分期比较差异有统计学意义(P<0.05);肝癌患者血清AFP、TSGF、VEGF水平分别与MVD呈正相关(r值分别为0.853,0.920,0.846,P<0.05).结论 肝癌患者肿瘤组织的MVD及肿瘤标志物AFP、TSGF、VEGF水平与临床TNM分期有关,TNM分期越高,MVD及AFP、TSGF、VEGF水平越高,且患者血清AFP、TSGF、VEGF水平分别与MVD呈正相关关系,提示肿瘤标志物AFP、TSGF、VEGF水平与肝癌侵袭、转移能力有关.     

Plasma protein binding of azapropazone in patients with kidney and liver disease.

1 The free fraction of azapropazone in the plasma of 37 healthy volunteers ranged from 0.0027 to 0.0070 (0.0044 +/- 0.0009, mean +/- s.d.). The principal binding protein was found to be albumin. 2 In 27 patients with various degrees of renal failure the free fraction values of azapropazone were markedly enhanced (0.0260 +/- 0.0239, mean +/- s.d.) and increased more than tenfold in some patients. There was a weak correlation (r = 0.46, P less than 0.05) between the free fraction and the clearance of endogenous creatinine. Such correlation was not found for serum creatinine, serum albumin, serum uric acid and serum urea nitrogen. 3 In 32 patients with chronic liver disease the free fraction values of azapropazone were also markedly higher (0.0210 +/- 0.0242, mean +/- s.d.) than in healthy subjects. There were statistical significant correlation between free fraction values and the prothrombin complex activity in the plasma (r = 0.40, P less than 0.05) and the total bilirubin concentration in the plasma (r = 0.90, P less than 0.001), respectively. Such correlation was not found for serum albumin, serum glutamic oxalacetic transaminase, serum gamma-glutamyl transpeptidase and serum alkaline phosphatase. 4 In patients with kidney and liver disease the free fraction values of azapropazone correlated well with those of the anticoagulant drug phenprocoumon (r = 0.93, P less than 0.001). However, the binding of the latter drug was less impaired. Bilirubin, when added in vitro, displaced both drugs from plasma proteins but this displacing effect was much smaller than the binding changes observed in patients with liver disease. 5 Kidney and liver disease caused a marked impairment of the plasma protein binding of azapropazone. In patients with kidney disease the degree of impairment of azapropazone binding cannot or only poorly (creatinine clearance) be predicted from the biochemical parameters of kidney function whereas in patients with chronic liver disease the total bilirubin concentration in the plasma may serve as an index of the binding defect.     

直肠癌伴同时性肝转移危险因素分析

目的探讨直肠癌同时性肝转移患者与临床病理因素间关系。方法收集安徽医科大学第一附属医院2006年1月1日～2009年12月31日直肠癌患者359例。回顾性分析直肠癌肝转移患者与临床病理因素关系。选择性别、年龄、血清CEA水平、血清CA19-9水平、病程、大体类型、组织类型、肠壁侵袭深度、病理淋巴结转移和肿瘤大小等10个可能影响肝转移的因素,单因素用χ2检验及t检验,多因素用Logistic回归(SPSS17.0统计软件)进行分析。结果单因素分析显示,年龄(P=0.037)、血清CEA水平(P=0.000)、肠壁侵袭深度(P=0.022)、病理淋巴结转移(P=0.000)与直肠癌同时性肝转移有关。多因素分析显示仅血清CEA水平及病理淋巴结转移与肝转移相关,无论是单因素、还是多因素回归分析,性别、血清CA19-9水平、大体类型、组织类型、肿瘤大小均与肝转移无关。结论血清CEA水平及病理淋巴结转移是直肠癌伴同时性肝转移的2个显著性危险因素。性别、血清CA19-9水平、病程、大体类型、组织类型及肿瘤大小与肝转移无关。