老年冠心病、脑梗死患者血清同型半胱氨酸与血糖、脂蛋白、血尿酸之间的关系

目的探讨老年冠心病、脑梗死患者血清同型半胱氨酸(Hcy)与空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)、脂蛋白[Lp(a)]、尿酸(UA)的关系。方法测定107例住院老年冠心病和脑梗死患者血清Hcy、FBG、TC、TG、HDL-C、LDL-C、LP(a)、UA等指标,并根据Hcy升高与否分为两组,比较两组FBG、TC、TG、HDL-C、LDL-C、LP(a)、UA的数值。结果Hcy升高组(A组)患者FBG、LP(a)、UA高于Hcy正常组(B组)。A组:FBG(5.51±1.30)mmol/L,TC(4.15±0.71)mmol/L,TG(1.39±1.06)mmol/L,HDL-C(1.08±0.32)mmol/L,LDL-C(2.47±0.73)mmol/L,Lp(a)(34.67±4.08)mg/dl,UA(374.11±9.87)μmol/L。B组:FBG(4.44±0.71)mmol/L,TC(4.03±1.89)mmol/L,TG(1.22±0.76)mmol/L,HDL-C(1.12±0.36)mmol/L,LDL-C(2.35±0.60)mmol/L,LP(a)(24.09±3.93)mg/dl,UA(326.79±11.96)μmol/L。两组间:FBG、LP(a)、UA差异有统计学意义(P<0.05);两组间:TC、TG、HDL-C、LDL-C差异无统计学意义(P>0.05)。结论FBG、LP(a)、UA与血清Hcy密切相关。     

儿少卫生

032 6 2 9　 12 2 0名学生血清脂蛋白及低密度脂蛋白胆固醇含量 /薛　侃…∥中国学校卫生 2 0 0 2 ,2 3( 2 ) 12 2～ 12 3为了解青少年血清脂蛋白 [Lp(a) ]及低密度脂蛋白胆固醇 (LDL C)含量的变化。尽早发现青少年中血清高 [Lp(a) ]和高LDL C潜在危险因素 ,以期有效地预防早发性心脑血管疾病。Lp(a)采用酶免疫比浊法、LDL C采用抗原抗体直接测定法。用HITACH7150全自动生化分析仪进行检测。计量资料以 x±s表示 ,t检验。结果 ,在 12 2 0名被检学生中Lp(a)和LDL C均在合适水平的占 82 % ( 10 2 7 12 2 0 ) ,11%的学生 ( 134…     

北京市区儿童血脂谱水平及其影响因素研究

目的:为从儿童期开始进行心脑血管病的早期预防提供基础资料.方法:对北京市城区315名7～11岁儿童进行血脂谱水平测定及其影响因素调查.结果:TC、TG、LDL-C、HDL-C、apoB、apoAI、Lp(a)水平(-x±s)依次为4.17±0.70、0.87±0.37、2.19±0.59、1.46±0.29(单位均为mmol/L)和1 377.2±142.6、692.2±150.4、193.3±205.6(单位均为mg/L);TC、LDL-C的正常参考值范围分别为(3.11～5.35)mmol/L和(1.34～3.21)mmol/L.超重、血压偏高、心血管病家庭史等因素均对儿童血脂谱水平有较大影响;多因素分析表明,TC、LDL-C、apoB水平与皮褶厚度、超重度、血压、膳食中脂肪供能比、胆固醇及饱和脂肪酸摄入量均呈正相关;而HDL-C、apoAI水平与体脂指标呈负相关.结论:体重和收缩压是影响血脂谱水平的两个显著因素.     

北京市儿童血脂谱水平及其影响因素研究

目的为从儿童期开始进行心脑血管病的早期预防提供基础资料.方法对北京市城区315名7～11岁儿童进行血脂谱水平测定及其影响因素调查.结果TC、TG、LDL-C、HDL-C、apoB、apoAI、Lp(a)水平(-x±s)依次为4.17±0.70、0.87±0.37、2.19±0.59、1.46±0.29(单位均为mmol/L)和1 377.2±142.6、692.2±150.4、193.3±205.6(单位均为mg/L);TC、LDL-C的正常参考值范围分别为(3.11～5.35)mmol/L和(1.34～3.21)mmol/L.超重、血压偏高、心血管病家庭史等因素均对儿童血脂谱水平有较大影响;多因素分析表明,TC、LDL-C、apoB水平与皮褶厚度、超重度、血压、膳食中脂肪供能比、胆固醇及饱和脂肪酸摄入量均呈正相关;而HDL-C、apoAI水平与体脂指标呈负相关.结论体重和收缩压是影响血脂谱水平的两个显著因素.     

稳定性COPD出现AECOPD时血清生物标志物水平的预测价值

目的探讨稳定期慢性阻塞性肺病(COPD)出现急性加重期COPD(AECOPD)时血清生物标志物水平的预测价值。方法本文测定了76例稳定期COPD和69例AECOPD患者血清尿酸(UA)、脂蛋白(a)[Lp(a)]、C-反应蛋白(CRP)和二聚体(D-D)水平并进行比较分析,ROC曲线评估了稳定性COPD出现AECOPD时血清生物标志物水平的临床价值。结果稳定期COPD患者血清UA、Lp(a)、CRP、D-D水平均高于正常对照组;AECOPD患者高于稳定期COPD患者,差异均有统计学意义(P0.05)。ROC曲线表明血清UA、Lp(a)、CRP和D-D的曲线下面积(AUC)分别为0.712、0.731、0.854和0.896;临界值分别为434.68μmol/L、47.25 mg/dl、17.34 mg/L和0.67 mg/L;敏感度分别为67.12%、68.34%、81.38%和85.67%;特异度分别为73.26%、74.29%、88.67%和91.25%。结论血清生物标志物UA、Lp(a)、CRP和D-D是评价稳定期COPD出现AECOPD时的有价值指标,以血清CRP和D-D为最佳。     

超敏C反应蛋白、脂蛋白(a)、总胆固醇与高密度脂蛋白胆固醇比值在冠心病检测中的意义

目的 分析血清超敏C反应蛋白(hs-CRP)、脂蛋白(a)[Lp(a)]、总胆固醇(TC)与高密度脂蛋白胆固醇(HDL-C)比值在冠心病检测中的临床意义.方法 2010年9月至2011年9月,分别检测176例冠心病患者(冠心病组,其中急性心肌梗死56例,稳定型心绞痛58例,不稳定型心绞痛62例)以及60例健康对照者(对照组)血清hs-CRP、Lp(a)水平和TC/HDL-C.结果 冠心病组血清hs-CRP、Lp (a)和TC/HDL-C分别为(34.51±9.65) mg/L、(295.16±104.57) mg/L和4.23±0.91,而对照组分别为( 1.26±0.69) mg/L、(145.26±42.19) mg/L和2.54±0.57,两组比较差异有统计学意义(P＜ 0.05).急性心肌梗死患者血清hs-CRP、Lp(a)和TC/HDL-C明显高于不稳定型心绞痛患者和稳定型心绞痛患者(P＜ 0.05);不稳定型心绞痛患者血清hs-CRP、Lp(a)和TC/HDL-C明显高于稳定型心绞痛患者(P＜ 0.05).结论血清hs-CRP、Lp(a)和TC/HDL-C在冠心病患者中明显升高,可以反映冠心病的严重程度.     

彰武县中学生血脂水平及异常分布特征调查

目的了解高血压及心脑血管疾病高发区中学生血脂水平及异常情况,以便采取干预措施。方法在彰武县农村随机抽取6所中学,对抽取的全部学生进行调查并测定血清胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及体格检查。结果(1)调查学生TC为(3.52±0.65)mmol/L,TG为(0.94±0.53)mmol/L,LDL-C为(1.71±0.49)mmol/L,HDL-C为(1.32±0.41)mmol/L。TC、TG和LDL-C女生均高于男生,差异有统计学意义。(2)各年龄组之间血脂呈交替高低变化。(3)肥胖组TC、TG水平均高于体重正常组,HDL-C水平则是肥胖组低于体重正常组,差异有统计学意义。(4)女生TC、TG和LDL-C的异常率略高于男生,而HDL-C异常率发生水平则男生略高于女生。(5)4种指标在不同年龄组中异常率的发生无随年龄增高而增高的趋势。(6)TG异常情况在肥胖组高于体重正常组,差异有统计学意义。结论该地区青少年空腹血TC、TG、LDL-C和HDL-C水平低于全国大部分地区城市健康青少年水平。     

原发性肝癌患者血脂检测的临床意义

目的 探讨原发性肝癌患者血脂变化的临床意义.方法 检测31例原发性肝癌、29例转移性肝癌、47例肝硬化及35例健康者的血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、脂蛋白(a)[Lp(a)]和载脂蛋白(Apo)A1、ApoB水平.结果 原发性肝癌、转移性肝癌、肝硬化患者的TC、HDL-C、Lp(a)、ApoA1、ApoB的含量明显低于相应的健嚎者(P＜0.05);原发性肝癌患者的TC、TG含量分别为(2.99±0.52)、(0.91±0.34)mmol/L,明显低于肝硬化患者的(3.46±1.31)、(1.08±0.40)mmol/L(P＜0.05).结论 血清TC、TG、HDL-C、Lp(a)、ApoA1、ApoB检测可以反映原发性肝癌患者的肝功能损害程度,可能成为原发性肝癌患者诊断、预后的一项检测指标.     

秦皇岛市12～15岁青少年血脂正常参考值的研究

[目的]通过对秦皇岛市12～15岁青少年血脂调查,建立秦皇岛市12～15岁青少年血脂正常值参考值.[方法]于2006年8～10月间随机选取秦皇岛市初中生4750人,应用日立7170全自动生化分析仪检测TG、TC、HDL-C和LDL-C.分别取TC、LDL-C第75及第90百分位点作为临界脂蛋白水平及高脂蛋白的浓度标准.取TG第90百分位点作为高甘油三酯血症浓度.取HDL-C第5百分点作为低高密度脂蛋白浓度,建立秦皇岛地区12～15岁青少年血脂正常参考值.[结果]秦皇岛市12～15岁青少年血脂浓度分别为TC(3.76±0.627)mmoL/L,TG(0.92±0.477)mmol/L,HDL-C(1.44±0.302)mmol/L,LDL-C(1.87±0.538)mmol/L,男生组和女生组之间HDL-C水平差异无统计学意义(P>0.05),男生组和女生组之间TG,TC和LDL-C水平差异有统计学意义(P<0.05).[结论]建议12～15岁秦皇岛市青少年血脂浓度临界标准为TC≤4.01mmol/L(男)TC≤4.32mmol/L(女)LDL-C≤2.32mmol/L(男)LDL-C≤2.53mmol/L(女)高甘油三酯血症浓度应≤1.27mmol/L(男)高甘油三酯血症浓度应≤1.36mmol/L(女)低高密度脂蛋白浓度≥1.09mmol/L.     

基于VAP+血脂分型检测的肥胖孕妇血脂亚组分与新生儿不良出生结局的相关性研究

目的 研究基于VAP+血脂分型检测的肥胖孕妇血脂亚组分与新生儿不良出生结局的相关性。方法 选取2021年1—10月在温州市中心医院进行产前检查的136例肥胖孕妇作为研究组，同期进行产前检查的健康孕妇150例作为对照组。通过试剂盒直接测定法检测两组孕妇血清高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平，采用GPO-PAP法检测血清三酰甘油(TG)、总胆固醇(TC)水平，采用VAP+血脂分型技术检测血清脂蛋白(a)[LP(a)]、残粒脂蛋白胆固醇(RLP-C)、载脂蛋白A(ApoA)、载脂蛋白B(ApoB)水平。采用Pearson法分析肥胖孕妇血脂水平与新生儿不良出生结局的相关性。结果 对照组HDL-C、LDL-C、TG、TC、LP(a)、RLP-C、ApoA、ApoB水平分别为(3.74±0.46)mmol/L、(2.39±0.52)mmol/L、(3.08±0.41)mmol/L、(4.36±0.80)mmol/L、(139.15±11.84)mg/L、(0.18±0.14)mmol/L、(1.90±0.37)g/L、(0.79±0.12)g/L;研究组HDL-C、LDL-C、TG、TC、LP(a)、RLP-C、ApoA、ApoB水平分别为(2.96±0.35)mmol/L、(3.72±0.49)mmol/L、(4.10±0.39)mmol/L、(6.79±0.62)mmol/L、(220.83±50.61)mg/L、(0.30±0.16)mmol/L、(2.20±0.45)g/L、(0.96±0.20)g/L。研究组孕妇的血清LDL-C、TG、TC、LP(a)、RLP-C、ApoA、ApoB水平均高于对照组，HDL-C水平低于对照组，差异均有统计学意义(均P<0.05)。研究组早产儿、巨大儿、高胆红素血症发生率均高于对照组，差异均有统计学意义(均P<0.05)。Pearson相关性分析发现：肥胖孕妇的血清HDL-C、LDL-C、TG、TC、LP(a)、RLP-C、ApoA、ApoB水平与早产儿、新生儿窒息、巨大儿、高胆红素血症及低出生体质量儿发生率均呈正相关(均P<0.05)。结论 肥胖孕妇的血脂水平明显增高，且和新生儿不良出生结局存在相关性，临床需强化孕期血脂监测，并给予针对性预防干预措施。     

The state of lipid control in patients with diabetes in a public health care centre

Achieving treatment targets has been difficult in treating diabetic patients. This cross-sectional study describes the lipid profiles of patients with diabetes mellitus at a public primary health care centre in Sarawak, Malaysia. The targets for lipid control were based on the International Diabetes Federation recommendation (2002). 1031 patients (98% Type 2 Diabetes) were studied. Fasting lipid profiles were available in 990 (96%) patients. The mean total cholesterol was 5.3 +/- 1.0 mmol/L, Triglycerides 1.90 +/- 1.26 mmol/L, HDL-C 1.28 +/- 0.33 mmol/L and LDL-C 3.2 +/- 0.9 mmol/L. Overall, 22% of patients achieved the treatment target for LDL-C level < 2.6mmol/L. 67% of patients had HDL-C > 1.1 mmol/L and 42% of patients had a target TG level below 1.5 mmol/L. Of the 40% of patients who received lipid-lowering drug, 17% achieved LDL-C target, 50% had LDL-C 2.6-4.4 mmol/ L and 33% have LDL-C > 4.0 mmol/L. For the remaining 60% not receiving any lipid lowering therapy, 68% had LDL-C between 2.6-4.0 mmol/L and 7% had LDL-C level > 4 mmol/L. Dyslipidemia is still under-treated despite the availability of effective pharmacological agents and the greatly increased risk of cardiovascular diseases in diabetic patients.     

Lipid profile in patients with systemic lupus erythematosus, with special focus on lipoprotein(a) in lupus nephritis

Systemic lupus erythematosus (SLE) is a multifactorial polysystemic autoimmune disorder. Although life expectance in SLE has been improved by adequate immune suppressive therapy, the importance of chronic renal failure has not been reduced. Among late complications of the disease accelerated atherosclerosis attempts increasing attention. Dyslipoproteinemia and increased concentration of lipoproteins are important risk factors of atherosclerotic cardiovascular complication in SLE. Serum lipid parameters of 50 patients with lupus were examined in the present work. Thirty patients had histologically proven lupus nephritis (LN+), while the other group did not have renal involvement (LN-). Serum triglyceride, total cholesterol, LDL-C and apolipoprotein B (apoB) concentrations were significantly higher in the lupus nephritis (LN+) group. On the other hand, HDL-C and apoAI levels were also elevated in patients with LN. As a consequence of that, LDL-C/HDL-C and the apoB/apoAI ratios did not differ between patients with or without kidney involvement. This concluded the authors to measure the concentration of lipoprotein (a) in SLE patients, as Lp(a) is known to be an independent risk factor of atherosclerosis. Results indicated a significantly increased Lp(a) concentration in patients with lupus nephritis as compared to the LN- group. All but 2 patients without kidney involvement had lower than 100 mg/L Lp(a) concentration, while 27% of patients with lupus nephritis has an Lp(a) level between 100-300 mg/L. Further more, Lp(a) concentration was higher than 300 mg/L in 13% of the LN+ group. In a good correlation of these observations patients with nephritis suffered more frequently from deep venous thrombosis and ischaemic heart disease. The frequencies of hypertension and non-insulin dependent diabetes mellitus were slightly elevated in patients with nephritis. Present results suggest the importance of elevated lipoprotein (a) concentration in patients with lupus nephritis, further increasing the risk of athero-thrombotic cardiovascular complications.     

Effects of phytosterols in diacylglycerol as part of diet therapy on hyperlipidemia in children

BACKGROUND: The incidence of hyperlipidemia in children is increasing in Japan, but drug therapy for such children is limited. The ingestion of 4% phytosterols-containing diacylglycerol (PS/DAG) decreases serum total cholesterol and low density lipoprotein cholesterol (LDL-C) concentrations in adults. In the present study, we examined the effect of PS/DAG as part of a diet therapy in pediatric patients with hyperlipidemia. METHODS: Pediatric patients with hyperlipidemia with > or =5.18mmol (200 mg/dL) serum total cholesterol and/or >or =1.70mmol (150 mg/dL) triglycerides (N=22) ingested bread containing PS/DAG (total daily intake, 10g) for 6 months. Blood chemistry was examined prior to and 2, 4, 6 months after the initiation of ingestion, and 4 months after the ingestion period. RESULTS: No significant differences in energy intake or cholesterol intake during the study period were found. After 4 months of ingestion of PS/DAG, LDL-C, lipoprotein(a) [ Lp(a)], free fatty acids and total ketone bodies decreased significantly. In seven patients with familial hypercholesterolemia, total cholesterol and remnant-like lipoprotein particles (RLP)-cholesterol also significantly decreased in addition to LDL-C and Lp(a). CONCLUSIONS: PS/DAG improves serum lipid metabolism in pediatric patients with hyperlipidemia for whom drug therapy is limited, suggesting that PS/DAG may reduce the risk of developing various diseases induced by hyperlipidemia.     

Lipoprotein profiles,not anthropometric measures,correlate with serum lipoprotein(a) values in children: the Taipei children heart study

Objectives: Plasma lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular disease. The purpose of this study is to evaluate the correlation of anthropometric measures, lipids and lipoprotein profiles and serum Lp(a) values among children in Taiwan. We will attempt to find parameters that will be able to predict Lp(a) levels in children. Design and methods: After a probability-proportional-to size, multi-stages sampling procedure, we randomly sampled 1500 schoolchildren from 10 schools in Taipei city. Anthropometric measures including body weight, body height, waist and hip circumference and skinfolds were measured. We used standard methods to measure serum total cholesterol (CHOL), triglycerides (TG), high density lipoprotein-cholesterol (HDL-C), apolipoprotein A1 and B (ApoA1 and ApoB) and Lp(a) levels. We also calculated low density lipoprotein-cholesterol (LDL-C) and CHOL/HDL-C ratio (TCHR) by formula. Results: We sampled 1283 children (635 boys and 648 girls) with a mean age of 13.3 years (from 12 to 16 years) in this study. The mean and medium serum Lp(a) levels were 16.8 and 8.8 mg/dl among boys and 20.8 and 11.9 mg/dl among girls. Children in the highest quintile of Lp(a) (mean = 49.6 and 58.6 mg/dl for boys and girls, respectively) had higher CHOL, LDL-C, ApoB levels and TCHR than children in the lowest quintile (mean = 3.1 and 3.7 mg/dl for boys and girls, respectively). Lipids and lipoprotein profiles, such as CHOL, LDL-C, Apo-B and TCHR were positively correlated with Lp(a) levels in both genders. Furthermore, the children with Lp(a) levels greater than or equal to 30 mg/dl had higher CHOL, LDL-C and Apo-B levels when compared to children with Lp(a) levels less than 30 mg/dl. After adjusting for age, cigarette smoking, alcohol drinking, puberty development and heart rates, LDL-C and ApoB levels were significantly positively associated with Lp(a) levels while ApoA1 was negatively associated among boys. Among girls, only Apo-B was significantly positively associated with Lp(a) and TG was negatively associated with Lp(a) levels. Most importantly, none of the anthropometric measures were significantly correlated with Lp(a) levels. Conclusions: From this study, we found that lipids and lipoproteins profiles, rather than degree of adiposity as reflected by anthropometric measures, are significantly associated with serum Lp(a) levels among school children.     

Cholesterol controversy: cutoff point of low-density lipoprotein cholesterol level in Guidelines by Japan Atherosclerosis Society

In 2007, the Japan Atherosclerosis Society published the Guidelines for prevention of atherosclerotic cardiovascular diseases. However, the guidelines have several flaws with regard to the cutoff level of serum low-density lipoprotein cholesterol (LDL-C). First, LDL-C level is used instead of serum total cholesterol (TC) level in the guidelines. In this case, they must show at least some basic data on the relationship between LDL-C level and mortality or morbidity from coronary heart disease (CHD). Second, it was recommended that the LDL-C level be below 140 mg/dL or 3.6 mmol/L (corresponding to a TC level of 220 mg/dL or 5.7 mmol/L, respectively). These levels are unreasonable considering that the TC levels of 240-260 mg/dL are optimal in terms of all-cause mortality for the Japanese population. Third, although there are big differences in mortality and morbidity from CHD between sexes, they discussed the matter without considering these differences. Last but not least, the conflict of interest of the editors of the guidelines has never been disclosed. The Japanese population has a lower CHD mortality and incidence than populations from other industrialized countries despite an increase in serum TC level in the former. In populations with a markedly lower coronary mortality or morbidity such as the Japanese population, it is still important to determine the optimal cutoff level of LDL-C to prevent the development of CHD and other atherosclerotic diseases.     

血清脂蛋白(a)与缺血性脑卒中

采用 1∶1配比病例对照研究方法 ,对 10 5对缺血性脑卒中病人和非脑卒中的对照组病人 ,进行了血清脂蛋白 (a)、总胆固醇、甘油三脂、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇的检测和分析 ,以评价它们与缺血性脑卒中的关系。结果显示 :病例组血清脂蛋白 (a)平均值为2 38.37mg/L ,明显高于对照组的 149.98mg/L ,t=3.97,P <0 .0 0 1,不同年龄组的比较中 ,只有 70岁以上年龄组血清脂蛋白 (a)明显高于 50岁以下年龄组 ,而性别在病例组内或对照组内均无显著性差异 ,将血清脂蛋白 (a)按不同等级进行分析 ,发现随着血清脂蛋白 (a)水平升高 ,缺血性脑卒中的危险性逐渐增加 ,有明显的剂量效应关系 ,多因素logistic回归分析表明 ,血清脂蛋白 (a)为缺血性脑卒中的独立危险因素 ,OR =1.93,其他危险因素还包括甘油三脂 ,而高密度脂蛋白胆固醇是缺血性脑卒中的保护因素 ,OR =0 .32。     

Lipoprotein(a) and other lipoproteins in hypothyroid patients before and after thyroid replacement therapy

AIMS: To analyse the influence of thyroid hormones on serum lipoprotein(a) (Lp(a)) concentration and other lipid parameters, and hence potentially on coronary artery disease (CAD) risk. METHODS: Thirty-six patients with hypothyroidism and 165 age-matched control euthyroid subjects were evaluated in a cross- sectional study, determining thyroid function tests and fasting serum lipids and lipoproteins. In a follow-up study for those hypothyroid patients the same determinations were repeated after normalization of thyroid state by levothyroxine (L-T(4)) replacement therapy. Patients needing other treatments were excluded. At baseline, patients with hypothyroidism had significantly higher levels of Lp(a), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), apolipoprotein (apo) A-I and apo B, and a higher TC/high-density lipoprotein cholesterol (HDL-C) ratio than control subjects. RESULTS: Severity of the hypothyroid state, expressed by serum thyroid-stimulating hormone, was correlated with serum levels of Lp(a), LDL-C, and TC (r= 0.64, 0.52, 0.49, P= 0.005, P= 0.033, P= 0. 048, respectively). The pretreatment Lp(a) levels were also correlated with those of posttreatment Lp(a)(r= 0.68, P= 0.002). All patients, who presented basal Lp(a) levels higher than 30 mg/dl, showed a decrease in Lp(a) concentrations by L-T(4)therapy, and these normalized in eight cases (22.2%). Euthyroid state gave rise to a significant reduction of serum Lp(a) by 32.3%, of LDL-C by 22. 8%, of TC by 17%, of apo A-I by 9.6%, and of apo B by 9.3%. After L-T(4)therapy, CAD risk, expressed as TC/HDL-C ratio, decreased by 19.9%. CONCLUSIONS: These results show that hypothyroidism is associated not only with elevated serum levels of LDL-C but also with elevated serum Lp(a) concentrations. Lp(a) levels may be at least partially modulated by thyroid hormone-dependent mechanisms, thus increasing the risk of developing premature atherosclerosis in hypothyroid state, that might be reduced by L-T(4)therapy.     

脑血管疾病中血清HCY和血脂检测结果相关性分析

目的：探讨脑血管疾病患者血清同型半胱氨酸（HCY）和血脂中各指标的含量与脑血管疾病发生的相关性。方法：检测66例脑血管患者和56例非脑血管疾病对照组人群血清同型半胱氨酸（HcY）、总胆固醇frC）、甘油三（TG）、低密度脂蛋白胆固醇（LDL—c）及高密度脂蛋白胆固醇（HDL—c）水平。结果：脑血管疾病患者血清HCY、TG、TCHO、LDL—c含量分别为（16．11±9．19）μmol／L、（1．26±0．40）mmol／L、（4．61±0．83）mmol／L、（3．20±0．75）mmol／L,而非脑血管疾病患者血清中其相应含量分别为（11．70±4．75）μmol／L、（1．02±0．34）mmol／L、（3．93±O．82）mmol／L、（2．64±0．70）mmol／L,各指标在两组血清中含量具有显著性差异（P〈0．05）;而HDL—C两组比较差异无统计学意义（P〉O．05）。结论：血清中HCY和TCHO、TG血脂指标水平与脑血管疾病两者有关联,可以作为相关危险因素为脑血管疾病进行研究和治疗提供参考依据。     

脑血管病脂蛋白（a）和其它脂类水平的研究

目的：探讨脑血管病患者脂脂蛋白（a)[Lp(a)]和其它脂类水平与脑血管病的关系。方法：采用试剂盒检测55例脑出血,57例脑梗塞患者Lp(a)水平及胆固醇（Ch)、甘三酯（TG）、高密度脂蛋白（HDL）、载脂蛋白A－I（Apo-A-I)和载脂蛋白B（ApoB),并与85例健康对照者作比较,结果：脑梗塞组Lp(a),Apo(B)及TG呈显著正相关,而脑出血组Lp(a)与Ch呈显著负相关,脑梗塞组Lp(a)、TG异常检出率分别高达59．65％、52．63％,脑出血组HDL异常检出率高达50．91％,结论Lp(a)和其它脂类代谢异常是脑血管病患者最常见和重要的致病因素之一。     

上海市嘉定区居民甲状腺疾病与心血管疾病及相关危险因素的相关性研究

目的 探讨甲状腺疾病与心血管疾病及相关危险因素的相关性。 方法 利用上海市公共卫生与预防医学“高峰计划”学科建设中健康人群队列项目数据,采用问卷调查和生化指标了解人群的基本情况、慢性病病史及相关生化指标分布。 结果 本次共调查10 051人,892人(8.87%)患有甲状腺疾病,女性患病率(12.18%)高于男性(3.91%)(P=0.000)。被诊断为患有高血压、糖尿病及发生过脑卒中患者与未患有该类疾病患者其甲状腺疾病患病情况均无差异(9.15% vs. 8.71%、9.20% vs. 8.84%、10.73% vs. 8.77%)(P均>0.05);高脂血症患者甲状腺疾病患病率(11.79%)高于未患有高血脂者(8.38%),冠心病患者甲状腺疾病患病率(14.46%)高于未患有冠心病者(8.54%)(P<0.05)。女性甲状腺疾病患者其高脂血症、冠心病及脑卒中患病率均明显高于未患有这三种疾病者(16.89% vs. 11.44%、20.53% vs. 11.68%、16.18% vs. 11.94%)(P均<0.05),以上指标在男性中均无差异。甲状腺疾病患者的LDL-C、HDL-C及TC水平均高于未患有该病者[(2.75±0.84)mmol/L vs. (2.63±0.81)mmol/L、(1.42±0.33)mmol/L vs. (1.36±0.33)mmol/L、(5.00±0.95)mmol/L vs. (4.84±0.91)mmol/L,P均<0.001]。 结论 甲状腺疾病与心血管疾病及其危险因素之间存在相关,对于有心血管疾病或有相关危险因素者,尤其是患甲状腺疾病女性,应密切监测其甲状腺功能,积极预防心血管病的发生。